Relationship between rectal and bladder dose and late GI, vaginal and GU toxicity
| . | Late GI toxicity ≥ G1 . | Late GI toxicity ≥ G2 . | Late GI toxicity ≥ G3 . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Yes (n = 130) | No (n = 339) | P-value | Yes (n = 48) | No (n = 421) | P-value | Yes (n = 17) | No (n = 452) | P-value | |
| Mean total rectum D2cc (EQD2, α/β = 3, Gy) | 58.8 | 53.2 | <0.001* | 59.6 | 54.2 | 0.001* | 61.9 | 54.5 | 0.007* |
| Late Vaginal toxicity ≥ G1 | Late Vaginal toxicity ≥ G2 | Late Vaginal toxicity ≥ G3 | |||||||
| Mean total rectum D2cc (EQD2, α/β = 3, Gy) | Yes (n = 53) | No (n = 416) | P-value | Yes (n = 15) | No (n = 454) | P-value | Yes (n = 8) | No (n = 461) | P-value |
| 59.6 | 54.2 | <0.001* | 59.3 | 54.7 | 0.111 | 59.1 | 54.7 | 0.266 | |
| Late GU toxicity ≥ G1 | Late GU toxicity ≥ G2 | Late GU toxicity ≥ G3 | |||||||
| Mean total bladder D2cc (EQD2, α/β = 3, Gy) | Yes (n = 77) | No (n = 392) | P-value | Yes (n = 36) | No (n = 433) | P-value | Yes (n = 9) | No (n = 460) | P-value |
| 71.2 | 64.1 | <0.001* | 73.4 | 64.6 | 0.001* | 72.3 | 65.1 | 0.155 | |
| . | Late GI toxicity ≥ G1 . | Late GI toxicity ≥ G2 . | Late GI toxicity ≥ G3 . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Yes (n = 130) | No (n = 339) | P-value | Yes (n = 48) | No (n = 421) | P-value | Yes (n = 17) | No (n = 452) | P-value | |
| Mean total rectum D2cc (EQD2, α/β = 3, Gy) | 58.8 | 53.2 | <0.001* | 59.6 | 54.2 | 0.001* | 61.9 | 54.5 | 0.007* |
| Late Vaginal toxicity ≥ G1 | Late Vaginal toxicity ≥ G2 | Late Vaginal toxicity ≥ G3 | |||||||
| Mean total rectum D2cc (EQD2, α/β = 3, Gy) | Yes (n = 53) | No (n = 416) | P-value | Yes (n = 15) | No (n = 454) | P-value | Yes (n = 8) | No (n = 461) | P-value |
| 59.6 | 54.2 | <0.001* | 59.3 | 54.7 | 0.111 | 59.1 | 54.7 | 0.266 | |
| Late GU toxicity ≥ G1 | Late GU toxicity ≥ G2 | Late GU toxicity ≥ G3 | |||||||
| Mean total bladder D2cc (EQD2, α/β = 3, Gy) | Yes (n = 77) | No (n = 392) | P-value | Yes (n = 36) | No (n = 433) | P-value | Yes (n = 9) | No (n = 460) | P-value |
| 71.2 | 64.1 | <0.001* | 73.4 | 64.6 | 0.001* | 72.3 | 65.1 | 0.155 | |
EQD2: equivalent doses delivered in 2 Gy fractions
GI toxicity: gastrointestinal toxicity
GU toxicity: genitourinary toxicity
*Statistical significance was defined as a P-value of <0.05.
Relationship between rectal and bladder dose and late GI, vaginal and GU toxicity
| . | Late GI toxicity ≥ G1 . | Late GI toxicity ≥ G2 . | Late GI toxicity ≥ G3 . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Yes (n = 130) | No (n = 339) | P-value | Yes (n = 48) | No (n = 421) | P-value | Yes (n = 17) | No (n = 452) | P-value | |
| Mean total rectum D2cc (EQD2, α/β = 3, Gy) | 58.8 | 53.2 | <0.001* | 59.6 | 54.2 | 0.001* | 61.9 | 54.5 | 0.007* |
| Late Vaginal toxicity ≥ G1 | Late Vaginal toxicity ≥ G2 | Late Vaginal toxicity ≥ G3 | |||||||
| Mean total rectum D2cc (EQD2, α/β = 3, Gy) | Yes (n = 53) | No (n = 416) | P-value | Yes (n = 15) | No (n = 454) | P-value | Yes (n = 8) | No (n = 461) | P-value |
| 59.6 | 54.2 | <0.001* | 59.3 | 54.7 | 0.111 | 59.1 | 54.7 | 0.266 | |
| Late GU toxicity ≥ G1 | Late GU toxicity ≥ G2 | Late GU toxicity ≥ G3 | |||||||
| Mean total bladder D2cc (EQD2, α/β = 3, Gy) | Yes (n = 77) | No (n = 392) | P-value | Yes (n = 36) | No (n = 433) | P-value | Yes (n = 9) | No (n = 460) | P-value |
| 71.2 | 64.1 | <0.001* | 73.4 | 64.6 | 0.001* | 72.3 | 65.1 | 0.155 | |
| . | Late GI toxicity ≥ G1 . | Late GI toxicity ≥ G2 . | Late GI toxicity ≥ G3 . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Yes (n = 130) | No (n = 339) | P-value | Yes (n = 48) | No (n = 421) | P-value | Yes (n = 17) | No (n = 452) | P-value | |
| Mean total rectum D2cc (EQD2, α/β = 3, Gy) | 58.8 | 53.2 | <0.001* | 59.6 | 54.2 | 0.001* | 61.9 | 54.5 | 0.007* |
| Late Vaginal toxicity ≥ G1 | Late Vaginal toxicity ≥ G2 | Late Vaginal toxicity ≥ G3 | |||||||
| Mean total rectum D2cc (EQD2, α/β = 3, Gy) | Yes (n = 53) | No (n = 416) | P-value | Yes (n = 15) | No (n = 454) | P-value | Yes (n = 8) | No (n = 461) | P-value |
| 59.6 | 54.2 | <0.001* | 59.3 | 54.7 | 0.111 | 59.1 | 54.7 | 0.266 | |
| Late GU toxicity ≥ G1 | Late GU toxicity ≥ G2 | Late GU toxicity ≥ G3 | |||||||
| Mean total bladder D2cc (EQD2, α/β = 3, Gy) | Yes (n = 77) | No (n = 392) | P-value | Yes (n = 36) | No (n = 433) | P-value | Yes (n = 9) | No (n = 460) | P-value |
| 71.2 | 64.1 | <0.001* | 73.4 | 64.6 | 0.001* | 72.3 | 65.1 | 0.155 | |
EQD2: equivalent doses delivered in 2 Gy fractions
GI toxicity: gastrointestinal toxicity
GU toxicity: genitourinary toxicity
*Statistical significance was defined as a P-value of <0.05.
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