Residues with largest average ΔΔG annotated with information from cBioPortal
| Residue position . | Wild-type amino acid . | Annotated mutant amino acid . | Number of missense annotations . | Cancer type . | Location within PTEN structure . |
|---|---|---|---|---|---|
| 83 | C | NA | NA | NA | Phosphatase domain |
| 95 | P | S, L | 5 | Glioblastoma multiforme, uterine endometrioid carcinoma, colorectal adenocarcinoma and mixed germ cell tumor | Phosphatase domain |
| 96 | P | A, L, S, T | 4 | Uterine endometrioid carcinoma, chromophobe renal cell carcinoma, glioblastoma multiforme and uterine endometrioid carcinoma | Phosphatase domain |
| 127 | G | E, R, V | 15 | Lung adenocarcinoma, glioblastoma multiforme, hepatocellular carcinoma, cutaneous melanoma, uterine endometrioid carcinoma, colorectal adenocarcinoma, ampullary carcinoma, teratoma, uterine clear cell carcinoma and uterine serous carcinoma | Phosphatase domain |
| 132 | G | A, C, D, S, V | 23 | Solitary fibrous tumor, uterine carcinosarcoma, glioblastoma multiforme, cutaneous melanoma, colorectal adenocarcinoma, lung adenocarcinoma, astrocytoma, uterine endometrioid carcinoma, esophageal squamous cell carcinoma, medulloblastoma, prostate adenocarcinoma and rectal adenocarcino | Phosphatase domain |
| 151 | A | G, T, D, V | 4 | Breast invasive lobular carcinoma, colorectal adenocarcinoma, uterine carcinosarcoma and glioblastoma multiforme | Phosphatase domain |
| 165 | G | E, R | 15 | Small cell lung cancer, renal non-clear cell carcinoma, medulloblastoma, cutaneous melanoma, glioblastoma multiforme, rectal adenocarcinoma and uterine endometrioid carcinoma | Phosphatase domain |
| 204 | P | L, R, S | 7 | Melanoma, glioblastoma multiforme, uterine endometrioid carcinoma, uterine carcinosarcoma, colorectal adenocarcinoma and cutaneous melanoma | C2 domain |
| 213 | P | R | 1 | Prostate adenocarcinoma | C2 domain |
| 328 | A | NA | NA | NA | C2 domain |
| Residue position . | Wild-type amino acid . | Annotated mutant amino acid . | Number of missense annotations . | Cancer type . | Location within PTEN structure . |
|---|---|---|---|---|---|
| 83 | C | NA | NA | NA | Phosphatase domain |
| 95 | P | S, L | 5 | Glioblastoma multiforme, uterine endometrioid carcinoma, colorectal adenocarcinoma and mixed germ cell tumor | Phosphatase domain |
| 96 | P | A, L, S, T | 4 | Uterine endometrioid carcinoma, chromophobe renal cell carcinoma, glioblastoma multiforme and uterine endometrioid carcinoma | Phosphatase domain |
| 127 | G | E, R, V | 15 | Lung adenocarcinoma, glioblastoma multiforme, hepatocellular carcinoma, cutaneous melanoma, uterine endometrioid carcinoma, colorectal adenocarcinoma, ampullary carcinoma, teratoma, uterine clear cell carcinoma and uterine serous carcinoma | Phosphatase domain |
| 132 | G | A, C, D, S, V | 23 | Solitary fibrous tumor, uterine carcinosarcoma, glioblastoma multiforme, cutaneous melanoma, colorectal adenocarcinoma, lung adenocarcinoma, astrocytoma, uterine endometrioid carcinoma, esophageal squamous cell carcinoma, medulloblastoma, prostate adenocarcinoma and rectal adenocarcino | Phosphatase domain |
| 151 | A | G, T, D, V | 4 | Breast invasive lobular carcinoma, colorectal adenocarcinoma, uterine carcinosarcoma and glioblastoma multiforme | Phosphatase domain |
| 165 | G | E, R | 15 | Small cell lung cancer, renal non-clear cell carcinoma, medulloblastoma, cutaneous melanoma, glioblastoma multiforme, rectal adenocarcinoma and uterine endometrioid carcinoma | Phosphatase domain |
| 204 | P | L, R, S | 7 | Melanoma, glioblastoma multiforme, uterine endometrioid carcinoma, uterine carcinosarcoma, colorectal adenocarcinoma and cutaneous melanoma | C2 domain |
| 213 | P | R | 1 | Prostate adenocarcinoma | C2 domain |
| 328 | A | NA | NA | NA | C2 domain |
Residues with largest average ΔΔG annotated with information from cBioPortal
| Residue position . | Wild-type amino acid . | Annotated mutant amino acid . | Number of missense annotations . | Cancer type . | Location within PTEN structure . |
|---|---|---|---|---|---|
| 83 | C | NA | NA | NA | Phosphatase domain |
| 95 | P | S, L | 5 | Glioblastoma multiforme, uterine endometrioid carcinoma, colorectal adenocarcinoma and mixed germ cell tumor | Phosphatase domain |
| 96 | P | A, L, S, T | 4 | Uterine endometrioid carcinoma, chromophobe renal cell carcinoma, glioblastoma multiforme and uterine endometrioid carcinoma | Phosphatase domain |
| 127 | G | E, R, V | 15 | Lung adenocarcinoma, glioblastoma multiforme, hepatocellular carcinoma, cutaneous melanoma, uterine endometrioid carcinoma, colorectal adenocarcinoma, ampullary carcinoma, teratoma, uterine clear cell carcinoma and uterine serous carcinoma | Phosphatase domain |
| 132 | G | A, C, D, S, V | 23 | Solitary fibrous tumor, uterine carcinosarcoma, glioblastoma multiforme, cutaneous melanoma, colorectal adenocarcinoma, lung adenocarcinoma, astrocytoma, uterine endometrioid carcinoma, esophageal squamous cell carcinoma, medulloblastoma, prostate adenocarcinoma and rectal adenocarcino | Phosphatase domain |
| 151 | A | G, T, D, V | 4 | Breast invasive lobular carcinoma, colorectal adenocarcinoma, uterine carcinosarcoma and glioblastoma multiforme | Phosphatase domain |
| 165 | G | E, R | 15 | Small cell lung cancer, renal non-clear cell carcinoma, medulloblastoma, cutaneous melanoma, glioblastoma multiforme, rectal adenocarcinoma and uterine endometrioid carcinoma | Phosphatase domain |
| 204 | P | L, R, S | 7 | Melanoma, glioblastoma multiforme, uterine endometrioid carcinoma, uterine carcinosarcoma, colorectal adenocarcinoma and cutaneous melanoma | C2 domain |
| 213 | P | R | 1 | Prostate adenocarcinoma | C2 domain |
| 328 | A | NA | NA | NA | C2 domain |
| Residue position . | Wild-type amino acid . | Annotated mutant amino acid . | Number of missense annotations . | Cancer type . | Location within PTEN structure . |
|---|---|---|---|---|---|
| 83 | C | NA | NA | NA | Phosphatase domain |
| 95 | P | S, L | 5 | Glioblastoma multiforme, uterine endometrioid carcinoma, colorectal adenocarcinoma and mixed germ cell tumor | Phosphatase domain |
| 96 | P | A, L, S, T | 4 | Uterine endometrioid carcinoma, chromophobe renal cell carcinoma, glioblastoma multiforme and uterine endometrioid carcinoma | Phosphatase domain |
| 127 | G | E, R, V | 15 | Lung adenocarcinoma, glioblastoma multiforme, hepatocellular carcinoma, cutaneous melanoma, uterine endometrioid carcinoma, colorectal adenocarcinoma, ampullary carcinoma, teratoma, uterine clear cell carcinoma and uterine serous carcinoma | Phosphatase domain |
| 132 | G | A, C, D, S, V | 23 | Solitary fibrous tumor, uterine carcinosarcoma, glioblastoma multiforme, cutaneous melanoma, colorectal adenocarcinoma, lung adenocarcinoma, astrocytoma, uterine endometrioid carcinoma, esophageal squamous cell carcinoma, medulloblastoma, prostate adenocarcinoma and rectal adenocarcino | Phosphatase domain |
| 151 | A | G, T, D, V | 4 | Breast invasive lobular carcinoma, colorectal adenocarcinoma, uterine carcinosarcoma and glioblastoma multiforme | Phosphatase domain |
| 165 | G | E, R | 15 | Small cell lung cancer, renal non-clear cell carcinoma, medulloblastoma, cutaneous melanoma, glioblastoma multiforme, rectal adenocarcinoma and uterine endometrioid carcinoma | Phosphatase domain |
| 204 | P | L, R, S | 7 | Melanoma, glioblastoma multiforme, uterine endometrioid carcinoma, uterine carcinosarcoma, colorectal adenocarcinoma and cutaneous melanoma | C2 domain |
| 213 | P | R | 1 | Prostate adenocarcinoma | C2 domain |
| 328 | A | NA | NA | NA | C2 domain |
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