Table 3 Open in new tab Systems and...

System

Conditions

Nervous

• Attenuated WM development and accelerated GM volume reductions have been evidenced in young binge drinkers.
• BD has also been shown to produce oral microbiome dysbiosis, which may subsequently lead to changes in the blood
brain barrier permeability and the development of Alzheimer’s disease.

Cardiovascular

• BD has been associated with higher blood pressure and an increased risk of CHD.
• It may also prompt different types of arrhythmias and prolong the QTc by causing a ‘holiday heart syndrome’.
• Furthermore, BD has been linked to a higher sudden cardiac death risk.

Digestive

• Although most of the evidence regarding liver diseases comes from studies of chronic consumption, BD may also
represent a risk factor for advanced liver disease and alcoholic hepatitis.
• Regarding intestinal disorders, BD has been shown to increase gastrointestinal symptoms in IBS patients.

Endocrine

• BD has been associated with an increased risk of T2D.
• Moreover, hypoglycemia risk is higher in T2D patients with a history of BD.

Others

• BD may prompt the appearance of several hydroelectrolytic disorders, transient hematological disturbances and
sleeping bruxism.
• Furthermore, it tends to increase risky sexual behavior. Thus, it has been shown to double the risk of HIV infection.
• BD has also been linked to higher rates of suicide in teenagers.

Table 3

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Systems and medical conditions affected by binge drinking

System	Conditions
Nervous	• Attenuated WM development and accelerated GM volume reductions have been evidenced in young binge drinkers. • BD has also been shown to produce oral microbiome dysbiosis, which may subsequently lead to changes in the blood brain barrier permeability and the development of Alzheimer’s disease.
Cardiovascular	• BD has been associated with higher blood pressure and an increased risk of CHD. • It may also prompt different types of arrhythmias and prolong the QTc by causing a ‘holiday heart syndrome’. • Furthermore, BD has been linked to a higher sudden cardiac death risk.
Digestive	• Although most of the evidence regarding liver diseases comes from studies of chronic consumption, BD may also represent a risk factor for advanced liver disease and alcoholic hepatitis. • Regarding intestinal disorders, BD has been shown to increase gastrointestinal symptoms in IBS patients.
Endocrine	• BD has been associated with an increased risk of T2D. • Moreover, hypoglycemia risk is higher in T2D patients with a history of BD.
Others	• BD may prompt the appearance of several hydroelectrolytic disorders, transient hematological disturbances and sleeping bruxism. • Furthermore, it tends to increase risky sexual behavior. Thus, it has been shown to double the risk of HIV infection. • BD has also been linked to higher rates of suicide in teenagers.

System	Conditions
Nervous	• Attenuated WM development and accelerated GM volume reductions have been evidenced in young binge drinkers. • BD has also been shown to produce oral microbiome dysbiosis, which may subsequently lead to changes in the blood brain barrier permeability and the development of Alzheimer’s disease.
Cardiovascular	• BD has been associated with higher blood pressure and an increased risk of CHD. • It may also prompt different types of arrhythmias and prolong the QTc by causing a ‘holiday heart syndrome’. • Furthermore, BD has been linked to a higher sudden cardiac death risk.
Digestive	• Although most of the evidence regarding liver diseases comes from studies of chronic consumption, BD may also represent a risk factor for advanced liver disease and alcoholic hepatitis. • Regarding intestinal disorders, BD has been shown to increase gastrointestinal symptoms in IBS patients.
Endocrine	• BD has been associated with an increased risk of T2D. • Moreover, hypoglycemia risk is higher in T2D patients with a history of BD.
Others	• BD may prompt the appearance of several hydroelectrolytic disorders, transient hematological disturbances and sleeping bruxism. • Furthermore, it tends to increase risky sexual behavior. Thus, it has been shown to double the risk of HIV infection. • BD has also been linked to higher rates of suicide in teenagers.

Abbreviations: QTc, QT interval corrected for heart rate; T2D, type 2 diabetes.

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