Table 1 Open in new tab Characteristics...

Variable	Not frail (CFS 1–3) n = 94	Frail (CFS > 3) n = 104	P value
Baseline characteristics and investigations
Age (years), mean (SD)	75.7 (4.3)	80.4 (5.9)	<0.001
Female, % (n)	41.5 (39)	61.5 (64)	0.005
Race, % (n)
Chinese	80.9 (76)	69.2 (72)	0.240
Malay	10.6 (10)	22.1 (23)	0.120
Indian	5.3 (5)	6.7 (7)	1.000
Others	3.2 (3)	1.9 (2)	1.000
Co-morbidities
Hypertension, % (n)	77.7 (73)	90.4 (94)	0.014
Diabetes mellitus, % (n)	30.9 (29)	35.6 (37)	0.481
Dyslipidaemia, % (n)	64.9 (61)	70.2 (73)	0.426
Ischaemic heart disease, % (n)	25.5 (24)	26.9 (28)	0.824
Smoking, % (n)	6.4 (6)	1.9 (2)	0.153
Atrial fibrillation, % (n)	52.1 (49)	71.2 (74)	0.006
Previous stroke/TIA, % (n)	8.6 (8)	21.2 (22)	0.014
Cognitive impairment, % (n)	4.3 (4)	18.3 (19)	0.002
NIHSS on arrival, median (IQR)	18 (13–23)	20 (16–23)	1.000
TOAST, % (n)
Large artery atherosclerosis	33.0 (30)	17.6 (18)	0.014
Cardioembolism	51.6 (47)	70.6 (72)	0.007
Small vessel occlusion	0	0	N/A
Stroke of other determined aetiology	0.0 (0)	1.0 (1)	1.000
Stroke of undetermined aetiology	15.4 (14)	2.0 10.8 (11)	0.342
Site of occlusion, % (n)
M1-MCA	48.9 (46)	49.0 (51)	0.989
M2-MCA	9.6 (9)	6.7 (7)	0.463
M3-MCA	3.2 (3)	2.9 (3)	1.000
Carotid T	16.0 (15)	22.1 (23)	0.272
Tandem	11.7 (11)	8.7 (9)	0.477
Basilar artery	8.5 (8)	9.6 (10)	0.787
Multi-vessel	2.1 (2)	1.0 (1)	0.605
Procedure timings
Time from onset to arrival (min), median (IQR)	85 (42–184)	73 (38–177)	0.355
Time from door to imaging (min), median (IQR)	1 (0–12)	2 (0–13)	0.580
Time from door to needle (min), median (IQR)	48 (40–57)	49 (42–59)	0.560
Time from onset to puncture (min), median (IQR)	214 (165–308)	210 (161–310)	0.897
Time taken for clot retrieval (min), median (IQR)	35 (21–58)	35 (20–60)	0.889
Bridging thrombolysis, % (n)	62.8 (59)	57.7 (60)	0.467
Laboratory findings, mean (SD)
Creatinine (μmol/l)	94.3 (105.1)	111.5 (81.2)	0.198
Haemoglobin (g/dl)	13.0 (1.7)	12.2 (2.2)	0.005
Albumin (g/l)	34.0 (4.0)	32.3 (4.6)	0.018
Outcomes
Outcomes in hospital
Duration of hospitalisation (days), median (IQR)	15 (8–28)	15 (8–24)	0.539
In-hospital mortality, % (n)	9.6 (9)	18.3 (19)	0.080
Carer required, % (n)	72.8 (59)	91.6 (76)	0.002
mRS at 3 months, % (n)
0	14.9 (14)	4.8 (5)	0.016
1	8.5 (8)	3.8 (4)	0.170
2	7.4 (7)	7.7 (8)	0.948
3	21.3 (20)	14.4 (15)	0.207
4	25.5 (24)	29.8 (31)	0.502
5	9.6 (9)	16.3 (17)	0.159
6	12.8 (12)	23.1 (24)	0.060
Stroke outcomes
Functional independence at 3 months (mRS 0–2), % (n)	30.9 (29)	16.3 (17)	0.016
Successful reperfusion (mTICI ≥2b), % (n)	87.8 (79)	80.0 (80)	0.147
Symptomatic ICH, % (n)	5.3 (5)	2.9 (3)	0.481
Haemorrhagic transformation, % (n)	26.1 (24)	29.7 (30)	0.576

Variable

Not frail (CFS 1–3) n = 94

Frail (CFS > 3) n = 104

P value

Baseline characteristics and investigations

Age (years), mean (SD)

75.7 (4.3)

80.4 (5.9)

<0.001

Female, % (n)

41.5 (39)

61.5 (64)

0.005

Race, % (n)

Chinese

80.9 (76)

69.2 (72)

0.240

Malay

10.6 (10)

22.1 (23)

0.120

Indian

5.3 (5)

6.7 (7)

1.000

Others

3.2 (3)

1.9 (2)

1.000

Co-morbidities

Hypertension, % (n)

77.7 (73)

90.4 (94)

0.014

Diabetes mellitus, % (n)

30.9 (29)

35.6 (37)

0.481

Dyslipidaemia, % (n)

64.9 (61)

70.2 (73)

0.426

Ischaemic heart disease, % (n)

25.5 (24)

26.9 (28)

0.824

Smoking, % (n)

6.4 (6)

1.9 (2)

0.153

Atrial fibrillation, % (n)

52.1 (49)

71.2 (74)

0.006

Previous stroke/TIA, % (n)

8.6 (8)

21.2 (22)

0.014

Cognitive impairment, % (n)

4.3 (4)

18.3 (19)

0.002

NIHSS on arrival, median (IQR)

18 (13–23)

20 (16–23)

1.000

TOAST, % (n)

Large artery atherosclerosis

33.0 (30)

17.6 (18)

0.014

Cardioembolism

51.6 (47)

70.6 (72)

0.007

Small vessel occlusion

N/A

Stroke of other determined aetiology

0.0 (0)

1.0 (1)

1.000

Stroke of undetermined aetiology

15.4 (14)

2.0 10.8 (11)

0.342

Site of occlusion, % (n)

M1-MCA

48.9 (46)

49.0 (51)

0.989

M2-MCA

9.6 (9)

6.7 (7)

0.463

M3-MCA

3.2 (3)

2.9 (3)

1.000

Carotid T

16.0 (15)

22.1 (23)

0.272

Tandem

11.7 (11)

8.7 (9)

0.477

Basilar artery

8.5 (8)

9.6 (10)

0.787

Multi-vessel

2.1 (2)

1.0 (1)

0.605

Procedure timings

Time from onset to arrival (min), median (IQR)

85 (42–184)

73 (38–177)

0.355

Time from door to imaging (min), median (IQR)

1 (0–12)

2 (0–13)

0.580

Time from door to needle (min), median (IQR)

48 (40–57)

49 (42–59)

0.560

Time from onset to puncture (min), median (IQR)

214 (165–308)

210 (161–310)

0.897

Time taken for clot retrieval (min), median (IQR)

35 (21–58)

35 (20–60)

0.889

Bridging thrombolysis, % (n)

62.8 (59)

57.7 (60)

0.467

Laboratory findings, mean (SD)

Creatinine (μmol/l)

94.3 (105.1)

111.5 (81.2)

0.198

Haemoglobin (g/dl)

13.0 (1.7)

12.2 (2.2)

0.005

Albumin (g/l)

34.0 (4.0)

32.3 (4.6)

0.018

Outcomes

Outcomes in hospital

Duration of hospitalisation (days), median (IQR)

15 (8–28)

15 (8–24)

0.539

In-hospital mortality, % (n)

9.6 (9)

18.3 (19)

0.080

Carer required, % (n)

72.8 (59)

91.6 (76)

0.002

mRS at 3 months, % (n)

14.9 (14)

4.8 (5)

0.016

8.5 (8)

3.8 (4)

0.170

7.4 (7)

7.7 (8)

0.948

21.3 (20)

14.4 (15)

0.207

25.5 (24)

29.8 (31)

0.502

9.6 (9)

16.3 (17)

0.159

12.8 (12)

23.1 (24)

0.060

Stroke outcomes

Functional independence at 3 months (mRS 0–2), % (n)

30.9 (29)

16.3 (17)

0.016

Successful reperfusion (mTICI ≥2b), % (n)

87.8 (79)

80.0 (80)

0.147

Symptomatic ICH, % (n)

5.3 (5)

2.9 (3)

0.481

Haemorrhagic transformation, % (n)

26.1 (24)

29.7 (30)

0.576

Variable	Not frail (CFS 1–3) n = 94	Frail (CFS > 3) n = 104	P value
Baseline characteristics and investigations
Age (years), mean (SD)	75.7 (4.3)	80.4 (5.9)	<0.001
Female, % (n)	41.5 (39)	61.5 (64)	0.005
Race, % (n)
Chinese	80.9 (76)	69.2 (72)	0.240
Malay	10.6 (10)	22.1 (23)	0.120
Indian	5.3 (5)	6.7 (7)	1.000
Others	3.2 (3)	1.9 (2)	1.000
Co-morbidities
Hypertension, % (n)	77.7 (73)	90.4 (94)	0.014
Diabetes mellitus, % (n)	30.9 (29)	35.6 (37)	0.481
Dyslipidaemia, % (n)	64.9 (61)	70.2 (73)	0.426
Ischaemic heart disease, % (n)	25.5 (24)	26.9 (28)	0.824
Smoking, % (n)	6.4 (6)	1.9 (2)	0.153
Atrial fibrillation, % (n)	52.1 (49)	71.2 (74)	0.006
Previous stroke/TIA, % (n)	8.6 (8)	21.2 (22)	0.014
Cognitive impairment, % (n)	4.3 (4)	18.3 (19)	0.002
NIHSS on arrival, median (IQR)	18 (13–23)	20 (16–23)	1.000
TOAST, % (n)
Large artery atherosclerosis	33.0 (30)	17.6 (18)	0.014
Cardioembolism	51.6 (47)	70.6 (72)	0.007
Small vessel occlusion	0	0	N/A
Stroke of other determined aetiology	0.0 (0)	1.0 (1)	1.000
Stroke of undetermined aetiology	15.4 (14)	2.0 10.8 (11)	0.342
Site of occlusion, % (n)
M1-MCA	48.9 (46)	49.0 (51)	0.989
M2-MCA	9.6 (9)	6.7 (7)	0.463
M3-MCA	3.2 (3)	2.9 (3)	1.000
Carotid T	16.0 (15)	22.1 (23)	0.272
Tandem	11.7 (11)	8.7 (9)	0.477
Basilar artery	8.5 (8)	9.6 (10)	0.787
Multi-vessel	2.1 (2)	1.0 (1)	0.605
Procedure timings
Time from onset to arrival (min), median (IQR)	85 (42–184)	73 (38–177)	0.355
Time from door to imaging (min), median (IQR)	1 (0–12)	2 (0–13)	0.580
Time from door to needle (min), median (IQR)	48 (40–57)	49 (42–59)	0.560
Time from onset to puncture (min), median (IQR)	214 (165–308)	210 (161–310)	0.897
Time taken for clot retrieval (min), median (IQR)	35 (21–58)	35 (20–60)	0.889
Bridging thrombolysis, % (n)	62.8 (59)	57.7 (60)	0.467
Laboratory findings, mean (SD)
Creatinine (μmol/l)	94.3 (105.1)	111.5 (81.2)	0.198
Haemoglobin (g/dl)	13.0 (1.7)	12.2 (2.2)	0.005
Albumin (g/l)	34.0 (4.0)	32.3 (4.6)	0.018
Outcomes
Outcomes in hospital
Duration of hospitalisation (days), median (IQR)	15 (8–28)	15 (8–24)	0.539
In-hospital mortality, % (n)	9.6 (9)	18.3 (19)	0.080
Carer required, % (n)	72.8 (59)	91.6 (76)	0.002
mRS at 3 months, % (n)
0	14.9 (14)	4.8 (5)	0.016
1	8.5 (8)	3.8 (4)	0.170
2	7.4 (7)	7.7 (8)	0.948
3	21.3 (20)	14.4 (15)	0.207
4	25.5 (24)	29.8 (31)	0.502
5	9.6 (9)	16.3 (17)	0.159
6	12.8 (12)	23.1 (24)	0.060
Stroke outcomes
Functional independence at 3 months (mRS 0–2), % (n)	30.9 (29)	16.3 (17)	0.016
Successful reperfusion (mTICI ≥2b), % (n)	87.8 (79)	80.0 (80)	0.147
Symptomatic ICH, % (n)	5.3 (5)	2.9 (3)	0.481
Haemorrhagic transformation, % (n)	26.1 (24)	29.7 (30)	0.576

Variable

Not frail (CFS 1–3) n = 94

Frail (CFS > 3) n = 104

P value

Baseline characteristics and investigations

Age (years), mean (SD)

75.7 (4.3)

80.4 (5.9)

<0.001

Female, % (n)

41.5 (39)

61.5 (64)

0.005

Race, % (n)

Chinese

80.9 (76)

69.2 (72)

0.240

Malay

10.6 (10)

22.1 (23)

0.120

Indian

5.3 (5)

6.7 (7)

1.000

Others

3.2 (3)

1.9 (2)

1.000

Co-morbidities

Hypertension, % (n)

77.7 (73)

90.4 (94)

0.014

Diabetes mellitus, % (n)

30.9 (29)

35.6 (37)

0.481

Dyslipidaemia, % (n)

64.9 (61)

70.2 (73)

0.426

Ischaemic heart disease, % (n)

25.5 (24)

26.9 (28)

0.824

Smoking, % (n)

6.4 (6)

1.9 (2)

0.153

Atrial fibrillation, % (n)

52.1 (49)

71.2 (74)

0.006

Previous stroke/TIA, % (n)

8.6 (8)

21.2 (22)

0.014

Cognitive impairment, % (n)

4.3 (4)

18.3 (19)

0.002

NIHSS on arrival, median (IQR)

18 (13–23)

20 (16–23)

1.000

TOAST, % (n)

Large artery atherosclerosis

33.0 (30)

17.6 (18)

0.014

Cardioembolism

51.6 (47)

70.6 (72)

0.007

Small vessel occlusion

N/A

Stroke of other determined aetiology

0.0 (0)

1.0 (1)

1.000

Stroke of undetermined aetiology

15.4 (14)

2.0 10.8 (11)

0.342

Site of occlusion, % (n)

M1-MCA

48.9 (46)

49.0 (51)

0.989

M2-MCA

9.6 (9)

6.7 (7)

0.463

M3-MCA

3.2 (3)

2.9 (3)

1.000

Carotid T

16.0 (15)

22.1 (23)

0.272

Tandem

11.7 (11)

8.7 (9)

0.477

Basilar artery

8.5 (8)

9.6 (10)

0.787

Multi-vessel

2.1 (2)

1.0 (1)

0.605

Procedure timings

Time from onset to arrival (min), median (IQR)

85 (42–184)

73 (38–177)

0.355

Time from door to imaging (min), median (IQR)

1 (0–12)

2 (0–13)

0.580

Time from door to needle (min), median (IQR)

48 (40–57)

49 (42–59)

0.560

Time from onset to puncture (min), median (IQR)

214 (165–308)

210 (161–310)

0.897

Time taken for clot retrieval (min), median (IQR)

35 (21–58)

35 (20–60)

0.889

Bridging thrombolysis, % (n)

62.8 (59)

57.7 (60)

0.467

Laboratory findings, mean (SD)

Creatinine (μmol/l)

94.3 (105.1)

111.5 (81.2)

0.198

Haemoglobin (g/dl)

13.0 (1.7)

12.2 (2.2)

0.005

Albumin (g/l)

34.0 (4.0)

32.3 (4.6)

0.018

Outcomes

Outcomes in hospital

Duration of hospitalisation (days), median (IQR)

15 (8–28)

15 (8–24)

0.539

In-hospital mortality, % (n)

9.6 (9)

18.3 (19)

0.080

Carer required, % (n)

72.8 (59)

91.6 (76)

0.002

mRS at 3 months, % (n)

14.9 (14)

4.8 (5)

0.016

8.5 (8)

3.8 (4)

0.170

7.4 (7)

7.7 (8)

0.948

21.3 (20)

14.4 (15)

0.207

25.5 (24)

29.8 (31)

0.502

9.6 (9)

16.3 (17)

0.159

12.8 (12)

23.1 (24)

0.060

Stroke outcomes

Functional independence at 3 months (mRS 0–2), % (n)

30.9 (29)

16.3 (17)

0.016

Successful reperfusion (mTICI ≥2b), % (n)

87.8 (79)

80.0 (80)

0.147

Symptomatic ICH, % (n)

5.3 (5)

2.9 (3)

0.481

Haemorrhagic transformation, % (n)

26.1 (24)

29.7 (30)

0.576

Table 1

Open in new tab

Characteristics of frail and non-frail older acute ischaemic stroke patients that underwent endovascular thrombectomy

Variable	Not frail (CFS 1–3) n = 94	Frail (CFS > 3) n = 104	P value
Baseline characteristics and investigations
Age (years), mean (SD)	75.7 (4.3)	80.4 (5.9)	<0.001
Female, % (n)	41.5 (39)	61.5 (64)	0.005
Race, % (n)
Chinese	80.9 (76)	69.2 (72)	0.240
Malay	10.6 (10)	22.1 (23)	0.120
Indian	5.3 (5)	6.7 (7)	1.000
Others	3.2 (3)	1.9 (2)	1.000
Co-morbidities
Hypertension, % (n)	77.7 (73)	90.4 (94)	0.014
Diabetes mellitus, % (n)	30.9 (29)	35.6 (37)	0.481
Dyslipidaemia, % (n)	64.9 (61)	70.2 (73)	0.426
Ischaemic heart disease, % (n)	25.5 (24)	26.9 (28)	0.824
Smoking, % (n)	6.4 (6)	1.9 (2)	0.153
Atrial fibrillation, % (n)	52.1 (49)	71.2 (74)	0.006
Previous stroke/TIA, % (n)	8.6 (8)	21.2 (22)	0.014
Cognitive impairment, % (n)	4.3 (4)	18.3 (19)	0.002
NIHSS on arrival, median (IQR)	18 (13–23)	20 (16–23)	1.000
TOAST, % (n)
Large artery atherosclerosis	33.0 (30)	17.6 (18)	0.014
Cardioembolism	51.6 (47)	70.6 (72)	0.007
Small vessel occlusion	0	0	N/A
Stroke of other determined aetiology	0.0 (0)	1.0 (1)	1.000
Stroke of undetermined aetiology	15.4 (14)	2.0 10.8 (11)	0.342
Site of occlusion, % (n)
M1-MCA	48.9 (46)	49.0 (51)	0.989
M2-MCA	9.6 (9)	6.7 (7)	0.463
M3-MCA	3.2 (3)	2.9 (3)	1.000
Carotid T	16.0 (15)	22.1 (23)	0.272
Tandem	11.7 (11)	8.7 (9)	0.477
Basilar artery	8.5 (8)	9.6 (10)	0.787
Multi-vessel	2.1 (2)	1.0 (1)	0.605
Procedure timings
Time from onset to arrival (min), median (IQR)	85 (42–184)	73 (38–177)	0.355
Time from door to imaging (min), median (IQR)	1 (0–12)	2 (0–13)	0.580
Time from door to needle (min), median (IQR)	48 (40–57)	49 (42–59)	0.560
Time from onset to puncture (min), median (IQR)	214 (165–308)	210 (161–310)	0.897
Time taken for clot retrieval (min), median (IQR)	35 (21–58)	35 (20–60)	0.889
Bridging thrombolysis, % (n)	62.8 (59)	57.7 (60)	0.467
Laboratory findings, mean (SD)
Creatinine (μmol/l)	94.3 (105.1)	111.5 (81.2)	0.198
Haemoglobin (g/dl)	13.0 (1.7)	12.2 (2.2)	0.005
Albumin (g/l)	34.0 (4.0)	32.3 (4.6)	0.018
Outcomes
Outcomes in hospital
Duration of hospitalisation (days), median (IQR)	15 (8–28)	15 (8–24)	0.539
In-hospital mortality, % (n)	9.6 (9)	18.3 (19)	0.080
Carer required, % (n)	72.8 (59)	91.6 (76)	0.002
mRS at 3 months, % (n)
0	14.9 (14)	4.8 (5)	0.016
1	8.5 (8)	3.8 (4)	0.170
2	7.4 (7)	7.7 (8)	0.948
3	21.3 (20)	14.4 (15)	0.207
4	25.5 (24)	29.8 (31)	0.502
5	9.6 (9)	16.3 (17)	0.159
6	12.8 (12)	23.1 (24)	0.060
Stroke outcomes
Functional independence at 3 months (mRS 0–2), % (n)	30.9 (29)	16.3 (17)	0.016
Successful reperfusion (mTICI ≥2b), % (n)	87.8 (79)	80.0 (80)	0.147
Symptomatic ICH, % (n)	5.3 (5)	2.9 (3)	0.481
Haemorrhagic transformation, % (n)	26.1 (24)	29.7 (30)	0.576

Variable	Not frail (CFS 1–3) n = 94	Frail (CFS > 3) n = 104	P value
Baseline characteristics and investigations
Age (years), mean (SD)	75.7 (4.3)	80.4 (5.9)	<0.001
Female, % (n)	41.5 (39)	61.5 (64)	0.005
Race, % (n)
Chinese	80.9 (76)	69.2 (72)	0.240
Malay	10.6 (10)	22.1 (23)	0.120
Indian	5.3 (5)	6.7 (7)	1.000
Others	3.2 (3)	1.9 (2)	1.000
Co-morbidities
Hypertension, % (n)	77.7 (73)	90.4 (94)	0.014
Diabetes mellitus, % (n)	30.9 (29)	35.6 (37)	0.481
Dyslipidaemia, % (n)	64.9 (61)	70.2 (73)	0.426
Ischaemic heart disease, % (n)	25.5 (24)	26.9 (28)	0.824
Smoking, % (n)	6.4 (6)	1.9 (2)	0.153
Atrial fibrillation, % (n)	52.1 (49)	71.2 (74)	0.006
Previous stroke/TIA, % (n)	8.6 (8)	21.2 (22)	0.014
Cognitive impairment, % (n)	4.3 (4)	18.3 (19)	0.002
NIHSS on arrival, median (IQR)	18 (13–23)	20 (16–23)	1.000
TOAST, % (n)
Large artery atherosclerosis	33.0 (30)	17.6 (18)	0.014
Cardioembolism	51.6 (47)	70.6 (72)	0.007
Small vessel occlusion	0	0	N/A
Stroke of other determined aetiology	0.0 (0)	1.0 (1)	1.000
Stroke of undetermined aetiology	15.4 (14)	2.0 10.8 (11)	0.342
Site of occlusion, % (n)
M1-MCA	48.9 (46)	49.0 (51)	0.989
M2-MCA	9.6 (9)	6.7 (7)	0.463
M3-MCA	3.2 (3)	2.9 (3)	1.000
Carotid T	16.0 (15)	22.1 (23)	0.272
Tandem	11.7 (11)	8.7 (9)	0.477
Basilar artery	8.5 (8)	9.6 (10)	0.787
Multi-vessel	2.1 (2)	1.0 (1)	0.605
Procedure timings
Time from onset to arrival (min), median (IQR)	85 (42–184)	73 (38–177)	0.355
Time from door to imaging (min), median (IQR)	1 (0–12)	2 (0–13)	0.580
Time from door to needle (min), median (IQR)	48 (40–57)	49 (42–59)	0.560
Time from onset to puncture (min), median (IQR)	214 (165–308)	210 (161–310)	0.897
Time taken for clot retrieval (min), median (IQR)	35 (21–58)	35 (20–60)	0.889
Bridging thrombolysis, % (n)	62.8 (59)	57.7 (60)	0.467
Laboratory findings, mean (SD)
Creatinine (μmol/l)	94.3 (105.1)	111.5 (81.2)	0.198
Haemoglobin (g/dl)	13.0 (1.7)	12.2 (2.2)	0.005
Albumin (g/l)	34.0 (4.0)	32.3 (4.6)	0.018
Outcomes
Outcomes in hospital
Duration of hospitalisation (days), median (IQR)	15 (8–28)	15 (8–24)	0.539
In-hospital mortality, % (n)	9.6 (9)	18.3 (19)	0.080
Carer required, % (n)	72.8 (59)	91.6 (76)	0.002
mRS at 3 months, % (n)
0	14.9 (14)	4.8 (5)	0.016
1	8.5 (8)	3.8 (4)	0.170
2	7.4 (7)	7.7 (8)	0.948
3	21.3 (20)	14.4 (15)	0.207
4	25.5 (24)	29.8 (31)	0.502
5	9.6 (9)	16.3 (17)	0.159
6	12.8 (12)	23.1 (24)	0.060
Stroke outcomes
Functional independence at 3 months (mRS 0–2), % (n)	30.9 (29)	16.3 (17)	0.016
Successful reperfusion (mTICI ≥2b), % (n)	87.8 (79)	80.0 (80)	0.147
Symptomatic ICH, % (n)	5.3 (5)	2.9 (3)	0.481
Haemorrhagic transformation, % (n)	26.1 (24)	29.7 (30)	0.576

Abbreviations: CFS, Clinical Frailty Scale; ICH, intracerebral haemorrhage; IQR, interquartile range; MCA, middle cerebral artery; mRS, Modified Rankin Score; mTICI, Modified Treatment in Cerebral Infarction; NIHSS, National Institutes of Health Stroke Scale; SD, standard deviation; TIA, transient ischaemic attack; TOAST, Trial of Org 10,172 in Acute Stroke Treatment.

Bold: p < 0.05.

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