Table 1.
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Results of Pharmacokinetic Analysis (n = 2 per Time Point)

Drug T  max, hC  max, range, ng/mLAUC0–24, mean (SEM), ng/mL⋅h)
Bedaquiline (25 mg/kg)1.001920–131019 661 (1121)
N-Desmethyl-bedaquiline0.755960–8700111 273 (6312)
Delamanid (2.5 mg/kg)0.75864–108011 234 (841.7)
DM-67050.2518.9–23.7352.4 (34.9)
Linezolid (100 mg/kg)2.0090 500a251 269 (14 931)
Drug T  max, hC  max, range, ng/mLAUC0–24, mean (SEM), ng/mL⋅h)
Bedaquiline (25 mg/kg)1.001920–131019 661 (1121)
N-Desmethyl-bedaquiline0.755960–8700111 273 (6312)
Delamanid (2.5 mg/kg)0.75864–108011 234 (841.7)
DM-67050.2518.9–23.7352.4 (34.9)
Linezolid (100 mg/kg)2.0090 500a251 269 (14 931)

Abbreviations: AUC0–24, 24-hour area under the receiver operating characteristic curve; Cmax, maximum plasma concentration; SEM, standard error of the mean; Tmax, time to maximum plasma concentration.

aFor linezolid, the drug concentration was assessed in only 1 mouse.

Table 1.
Open in new tab

Results of Pharmacokinetic Analysis (n = 2 per Time Point)

Drug T  max, hC  max, range, ng/mLAUC0–24, mean (SEM), ng/mL⋅h)
Bedaquiline (25 mg/kg)1.001920–131019 661 (1121)
N-Desmethyl-bedaquiline0.755960–8700111 273 (6312)
Delamanid (2.5 mg/kg)0.75864–108011 234 (841.7)
DM-67050.2518.9–23.7352.4 (34.9)
Linezolid (100 mg/kg)2.0090 500a251 269 (14 931)
Drug T  max, hC  max, range, ng/mLAUC0–24, mean (SEM), ng/mL⋅h)
Bedaquiline (25 mg/kg)1.001920–131019 661 (1121)
N-Desmethyl-bedaquiline0.755960–8700111 273 (6312)
Delamanid (2.5 mg/kg)0.75864–108011 234 (841.7)
DM-67050.2518.9–23.7352.4 (34.9)
Linezolid (100 mg/kg)2.0090 500a251 269 (14 931)

Abbreviations: AUC0–24, 24-hour area under the receiver operating characteristic curve; Cmax, maximum plasma concentration; SEM, standard error of the mean; Tmax, time to maximum plasma concentration.

aFor linezolid, the drug concentration was assessed in only 1 mouse.

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