Multivariable-adjusted hazard ratios (95% CIs) for incidence of diabetes based on a linear dose model
| Variables . | Hazard ratio (95% CI) . | P-value . |
|---|---|---|
| Women (vs men) | 0.68 (0.59-0.79) | <0.001 |
| Nagasaki (vs Hiroshima) | 0.94 (0.82-1.09) | 0.42 |
| AHS groups | ||
| Expansion cohort (vs original) | 1.01 (0.87-1.18) | 0.86 |
| Smoking statusa | ||
| Current (vs never) | 1.16 (0.98-1.36) | 0.09 |
| Former (vs never) | 1.10 (0.93-1.30) | 0.28 |
| Unknown (vs never) | 0.93 (0.67-1.31) | 0.69 |
| Alcohol drinking statusa | ||
| Current (vs never) | 1.01 (0.88-1.15) | 0.90 |
| Former (vs never) | 1.18 (0.90-1.54) | 0.24 |
| Unknown (vs never) | 0.76 (0.56-1.02) | 0.07 |
| Radiation dose of 1Gyb | 1.24 (1.10-1.39) | <0.001 |
| Effect modification of radiation | ||
| Radiation dose × Nagasaki | 0.77 (0.63-0.94) | 0.01 |
| Radiation dose × age ATB | 0.99 (0.98-1.00) | 0.002 |
| Variables . | Hazard ratio (95% CI) . | P-value . |
|---|---|---|
| Women (vs men) | 0.68 (0.59-0.79) | <0.001 |
| Nagasaki (vs Hiroshima) | 0.94 (0.82-1.09) | 0.42 |
| AHS groups | ||
| Expansion cohort (vs original) | 1.01 (0.87-1.18) | 0.86 |
| Smoking statusa | ||
| Current (vs never) | 1.16 (0.98-1.36) | 0.09 |
| Former (vs never) | 1.10 (0.93-1.30) | 0.28 |
| Unknown (vs never) | 0.93 (0.67-1.31) | 0.69 |
| Alcohol drinking statusa | ||
| Current (vs never) | 1.01 (0.88-1.15) | 0.90 |
| Former (vs never) | 1.18 (0.90-1.54) | 0.24 |
| Unknown (vs never) | 0.76 (0.56-1.02) | 0.07 |
| Radiation dose of 1Gyb | 1.24 (1.10-1.39) | <0.001 |
| Effect modification of radiation | ||
| Radiation dose × Nagasaki | 0.77 (0.63-0.94) | 0.01 |
| Radiation dose × age ATB | 0.99 (0.98-1.00) | 0.002 |
The model is adjusted for all variables listed in the table.
Abbreviation: ATB, at time of bombing.
aTime-varying covariates.
bEstimated for Hiroshima residents at the median age at time of bombing (23 years old).
Multivariable-adjusted hazard ratios (95% CIs) for incidence of diabetes based on a linear dose model
| Variables . | Hazard ratio (95% CI) . | P-value . |
|---|---|---|
| Women (vs men) | 0.68 (0.59-0.79) | <0.001 |
| Nagasaki (vs Hiroshima) | 0.94 (0.82-1.09) | 0.42 |
| AHS groups | ||
| Expansion cohort (vs original) | 1.01 (0.87-1.18) | 0.86 |
| Smoking statusa | ||
| Current (vs never) | 1.16 (0.98-1.36) | 0.09 |
| Former (vs never) | 1.10 (0.93-1.30) | 0.28 |
| Unknown (vs never) | 0.93 (0.67-1.31) | 0.69 |
| Alcohol drinking statusa | ||
| Current (vs never) | 1.01 (0.88-1.15) | 0.90 |
| Former (vs never) | 1.18 (0.90-1.54) | 0.24 |
| Unknown (vs never) | 0.76 (0.56-1.02) | 0.07 |
| Radiation dose of 1Gyb | 1.24 (1.10-1.39) | <0.001 |
| Effect modification of radiation | ||
| Radiation dose × Nagasaki | 0.77 (0.63-0.94) | 0.01 |
| Radiation dose × age ATB | 0.99 (0.98-1.00) | 0.002 |
| Variables . | Hazard ratio (95% CI) . | P-value . |
|---|---|---|
| Women (vs men) | 0.68 (0.59-0.79) | <0.001 |
| Nagasaki (vs Hiroshima) | 0.94 (0.82-1.09) | 0.42 |
| AHS groups | ||
| Expansion cohort (vs original) | 1.01 (0.87-1.18) | 0.86 |
| Smoking statusa | ||
| Current (vs never) | 1.16 (0.98-1.36) | 0.09 |
| Former (vs never) | 1.10 (0.93-1.30) | 0.28 |
| Unknown (vs never) | 0.93 (0.67-1.31) | 0.69 |
| Alcohol drinking statusa | ||
| Current (vs never) | 1.01 (0.88-1.15) | 0.90 |
| Former (vs never) | 1.18 (0.90-1.54) | 0.24 |
| Unknown (vs never) | 0.76 (0.56-1.02) | 0.07 |
| Radiation dose of 1Gyb | 1.24 (1.10-1.39) | <0.001 |
| Effect modification of radiation | ||
| Radiation dose × Nagasaki | 0.77 (0.63-0.94) | 0.01 |
| Radiation dose × age ATB | 0.99 (0.98-1.00) | 0.002 |
The model is adjusted for all variables listed in the table.
Abbreviation: ATB, at time of bombing.
aTime-varying covariates.
bEstimated for Hiroshima residents at the median age at time of bombing (23 years old).
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