| Test [Reference] . | Sample Type . | Sensitivity/Specificity Compared to NAAT . | Complexity/Time . | Costa . |
|---|---|---|---|---|
| Culture [65, 66] | Women: Vaginal swab Men: Urethral or penile-meatal swabs or semen | Women: Sensitivity: 75%–96% Specificity: 100% Men: Sensitivity: 50%–80% Specificity: 100% | Incubator and microscope with ×40 objective. Results in 5–7 days. | $$ |
| Hologic Aptima T. vaginalis assay [65] | Women: Vaginal or endocervical swab or urine Men: Urethral or urine specimens (if test is internally validated) | Women: Sensitivity: 88%–100% Specificity: 98%–100% | Panther, Viper, or Tigris instrumentation needed. Results in <8 hours. | $$ |
| BD Probe Tec TV NAAT [71] | Women: Vaginal or endocervical swab or urine Men: Urethral or urine specimens (if test is internally validated) | Sensitivity: 98%–100% Specificity: 98%–100% | CLIA high complexity. Requires Viper system. Results available in <8 hours. | $$ |
| BD Max CT/GC/TV2 assay [72] | Women: Vaginal or endocervical swab or urine Men: Urine | Women: Sensitivity: 89.8%–99.7% Specificity: 98.1%–99.5% Men: Sensitivity: 81.1%–100% Specificity: 98.7%–100% | Requires BD MAX system equipment. | $$ |
| Roche Cobas TV/MG assay [73, 74] | Women: Vaginal or endocervical swab Men: Urine, meatal swab | Women: Sensitivity: 96.4%–100% Specificity: 96.5%– 98.8% Men: Sensitivity: 77.2%–100% Specificity: 97.2%–99.9% | For use on Cobas 6800/8800 systems. | $$ |
| BD Affirm VPIII [70] | Women: Vaginal specimen | Women: Sensitivity: 91%–100% Specificity: 93%–96% | Uses direct hybridization technology. | $$ |
| Test [Reference] . | Sample Type . | Sensitivity/Specificity Compared to NAAT . | Complexity/Time . | Costa . |
|---|---|---|---|---|
| Culture [65, 66] | Women: Vaginal swab Men: Urethral or penile-meatal swabs or semen | Women: Sensitivity: 75%–96% Specificity: 100% Men: Sensitivity: 50%–80% Specificity: 100% | Incubator and microscope with ×40 objective. Results in 5–7 days. | $$ |
| Hologic Aptima T. vaginalis assay [65] | Women: Vaginal or endocervical swab or urine Men: Urethral or urine specimens (if test is internally validated) | Women: Sensitivity: 88%–100% Specificity: 98%–100% | Panther, Viper, or Tigris instrumentation needed. Results in <8 hours. | $$ |
| BD Probe Tec TV NAAT [71] | Women: Vaginal or endocervical swab or urine Men: Urethral or urine specimens (if test is internally validated) | Sensitivity: 98%–100% Specificity: 98%–100% | CLIA high complexity. Requires Viper system. Results available in <8 hours. | $$ |
| BD Max CT/GC/TV2 assay [72] | Women: Vaginal or endocervical swab or urine Men: Urine | Women: Sensitivity: 89.8%–99.7% Specificity: 98.1%–99.5% Men: Sensitivity: 81.1%–100% Specificity: 98.7%–100% | Requires BD MAX system equipment. | $$ |
| Roche Cobas TV/MG assay [73, 74] | Women: Vaginal or endocervical swab Men: Urine, meatal swab | Women: Sensitivity: 96.4%–100% Specificity: 96.5%– 98.8% Men: Sensitivity: 77.2%–100% Specificity: 97.2%–99.9% | For use on Cobas 6800/8800 systems. | $$ |
| BD Affirm VPIII [70] | Women: Vaginal specimen | Women: Sensitivity: 91%–100% Specificity: 93%–96% | Uses direct hybridization technology. | $$ |
Abbreviations: CLIA, Clinical Laboratory Improvement Amendments; CT, Chlamydia trachomatis; GC, Neisseria gonorrhoeae; MG, Mycoplasma genitalium; NAAT, nucleic acid amplification test; TV, Trichomonas vaginalis.
$, lower cost; $$, midrange; $$$, expensive. Cost estimates may vary depending on availability of equipment and volume of testing.
| Test [Reference] . | Sample Type . | Sensitivity/Specificity Compared to NAAT . | Complexity/Time . | Costa . |
|---|---|---|---|---|
| Culture [65, 66] | Women: Vaginal swab Men: Urethral or penile-meatal swabs or semen | Women: Sensitivity: 75%–96% Specificity: 100% Men: Sensitivity: 50%–80% Specificity: 100% | Incubator and microscope with ×40 objective. Results in 5–7 days. | $$ |
| Hologic Aptima T. vaginalis assay [65] | Women: Vaginal or endocervical swab or urine Men: Urethral or urine specimens (if test is internally validated) | Women: Sensitivity: 88%–100% Specificity: 98%–100% | Panther, Viper, or Tigris instrumentation needed. Results in <8 hours. | $$ |
| BD Probe Tec TV NAAT [71] | Women: Vaginal or endocervical swab or urine Men: Urethral or urine specimens (if test is internally validated) | Sensitivity: 98%–100% Specificity: 98%–100% | CLIA high complexity. Requires Viper system. Results available in <8 hours. | $$ |
| BD Max CT/GC/TV2 assay [72] | Women: Vaginal or endocervical swab or urine Men: Urine | Women: Sensitivity: 89.8%–99.7% Specificity: 98.1%–99.5% Men: Sensitivity: 81.1%–100% Specificity: 98.7%–100% | Requires BD MAX system equipment. | $$ |
| Roche Cobas TV/MG assay [73, 74] | Women: Vaginal or endocervical swab Men: Urine, meatal swab | Women: Sensitivity: 96.4%–100% Specificity: 96.5%– 98.8% Men: Sensitivity: 77.2%–100% Specificity: 97.2%–99.9% | For use on Cobas 6800/8800 systems. | $$ |
| BD Affirm VPIII [70] | Women: Vaginal specimen | Women: Sensitivity: 91%–100% Specificity: 93%–96% | Uses direct hybridization technology. | $$ |
| Test [Reference] . | Sample Type . | Sensitivity/Specificity Compared to NAAT . | Complexity/Time . | Costa . |
|---|---|---|---|---|
| Culture [65, 66] | Women: Vaginal swab Men: Urethral or penile-meatal swabs or semen | Women: Sensitivity: 75%–96% Specificity: 100% Men: Sensitivity: 50%–80% Specificity: 100% | Incubator and microscope with ×40 objective. Results in 5–7 days. | $$ |
| Hologic Aptima T. vaginalis assay [65] | Women: Vaginal or endocervical swab or urine Men: Urethral or urine specimens (if test is internally validated) | Women: Sensitivity: 88%–100% Specificity: 98%–100% | Panther, Viper, or Tigris instrumentation needed. Results in <8 hours. | $$ |
| BD Probe Tec TV NAAT [71] | Women: Vaginal or endocervical swab or urine Men: Urethral or urine specimens (if test is internally validated) | Sensitivity: 98%–100% Specificity: 98%–100% | CLIA high complexity. Requires Viper system. Results available in <8 hours. | $$ |
| BD Max CT/GC/TV2 assay [72] | Women: Vaginal or endocervical swab or urine Men: Urine | Women: Sensitivity: 89.8%–99.7% Specificity: 98.1%–99.5% Men: Sensitivity: 81.1%–100% Specificity: 98.7%–100% | Requires BD MAX system equipment. | $$ |
| Roche Cobas TV/MG assay [73, 74] | Women: Vaginal or endocervical swab Men: Urine, meatal swab | Women: Sensitivity: 96.4%–100% Specificity: 96.5%– 98.8% Men: Sensitivity: 77.2%–100% Specificity: 97.2%–99.9% | For use on Cobas 6800/8800 systems. | $$ |
| BD Affirm VPIII [70] | Women: Vaginal specimen | Women: Sensitivity: 91%–100% Specificity: 93%–96% | Uses direct hybridization technology. | $$ |
Abbreviations: CLIA, Clinical Laboratory Improvement Amendments; CT, Chlamydia trachomatis; GC, Neisseria gonorrhoeae; MG, Mycoplasma genitalium; NAAT, nucleic acid amplification test; TV, Trichomonas vaginalis.
$, lower cost; $$, midrange; $$$, expensive. Cost estimates may vary depending on availability of equipment and volume of testing.
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