Biomarkers and clinical parameters in adults born preterm according to history of BPD
| . | No BPD (n = 63) . | BPD (n = 37) . | . | ||
|---|---|---|---|---|---|
| Characteristics . | Missing, n (%) . | Median (IQR) or n (%) . | Missing, n (%) . | Median (IQR) or n (%) . | P-value . |
| Reno vascular biomarkers | |||||
| Plasma renin activity (ng/mL/h) | 9 (14) | 1.39 (0.77–2.14) | 17 (46) | 1.71 (0.65–2.03) | 0.81 |
| Plasma angiotensin II (pg/mL) | 22 (35) | 2.83 (2.33–3.5) | 20 (54) | 3.17 (2.17–4.5) | 0.82 |
| Plasma aldosterone (pg/mL) | 9 (14) | 68.8 (52.7–92.5) | 17 (46) | 58.5 (50–87.8) | 0.51 |
| Copeptin (pmol/L) | 2 (3) | 5.9 (3.9–8.2) | 6 (16) | 8.9 (6.5–12.1) | 0.001 |
| Apelin (ng/mL) | 4 (6) | 0.756 (0.565–0.849) | 6 (16) | 0.705 (0.536–0.879) | 0.78 |
| Neonatal characteristics | |||||
| Gestational age (weeks) | 0 (0) | 27.6 (26.1–28.4) | 0 (0) | 27.3 (26.2–27.9) | 0.115 |
| Birthweight (g) | 0 (0) | 1000 (875–1170) | 0 (0) | 860 (720–950) | 0.002 |
| Birthweight percentile | 0 (0) | 35 (25–52) | 0 (0) | 29 (14–49) | 0.057 |
| Indometacin use | 6 (10) | 14 (25) | 1 (3) | 28 (78) | <0.001 |
| Neonatal sepsis | 0 (0) | 9 (14) | 1 (3) | 6 (17) | 0.78 |
| Clinical characteristics | |||||
| ACR (mg/mmol) | 1 (2) | 0.586 (0.451–0.934) | 1 (3) | 0.877 (0.629–1.577) | 0.002 |
| TKV corrected for height (cm3/m) | 7 (11) | 165 (151–192) | 5 (14) | 152 (135–173) | 0.064 |
| . | No BPD (n = 63) . | BPD (n = 37) . | . | ||
|---|---|---|---|---|---|
| Characteristics . | Missing, n (%) . | Median (IQR) or n (%) . | Missing, n (%) . | Median (IQR) or n (%) . | P-value . |
| Reno vascular biomarkers | |||||
| Plasma renin activity (ng/mL/h) | 9 (14) | 1.39 (0.77–2.14) | 17 (46) | 1.71 (0.65–2.03) | 0.81 |
| Plasma angiotensin II (pg/mL) | 22 (35) | 2.83 (2.33–3.5) | 20 (54) | 3.17 (2.17–4.5) | 0.82 |
| Plasma aldosterone (pg/mL) | 9 (14) | 68.8 (52.7–92.5) | 17 (46) | 58.5 (50–87.8) | 0.51 |
| Copeptin (pmol/L) | 2 (3) | 5.9 (3.9–8.2) | 6 (16) | 8.9 (6.5–12.1) | 0.001 |
| Apelin (ng/mL) | 4 (6) | 0.756 (0.565–0.849) | 6 (16) | 0.705 (0.536–0.879) | 0.78 |
| Neonatal characteristics | |||||
| Gestational age (weeks) | 0 (0) | 27.6 (26.1–28.4) | 0 (0) | 27.3 (26.2–27.9) | 0.115 |
| Birthweight (g) | 0 (0) | 1000 (875–1170) | 0 (0) | 860 (720–950) | 0.002 |
| Birthweight percentile | 0 (0) | 35 (25–52) | 0 (0) | 29 (14–49) | 0.057 |
| Indometacin use | 6 (10) | 14 (25) | 1 (3) | 28 (78) | <0.001 |
| Neonatal sepsis | 0 (0) | 9 (14) | 1 (3) | 6 (17) | 0.78 |
| Clinical characteristics | |||||
| ACR (mg/mmol) | 1 (2) | 0.586 (0.451–0.934) | 1 (3) | 0.877 (0.629–1.577) | 0.002 |
| TKV corrected for height (cm3/m) | 7 (11) | 165 (151–192) | 5 (14) | 152 (135–173) | 0.064 |
P-values are calculated using the Mann–Whitney U test.
Biomarkers and clinical parameters in adults born preterm according to history of BPD
| . | No BPD (n = 63) . | BPD (n = 37) . | . | ||
|---|---|---|---|---|---|
| Characteristics . | Missing, n (%) . | Median (IQR) or n (%) . | Missing, n (%) . | Median (IQR) or n (%) . | P-value . |
| Reno vascular biomarkers | |||||
| Plasma renin activity (ng/mL/h) | 9 (14) | 1.39 (0.77–2.14) | 17 (46) | 1.71 (0.65–2.03) | 0.81 |
| Plasma angiotensin II (pg/mL) | 22 (35) | 2.83 (2.33–3.5) | 20 (54) | 3.17 (2.17–4.5) | 0.82 |
| Plasma aldosterone (pg/mL) | 9 (14) | 68.8 (52.7–92.5) | 17 (46) | 58.5 (50–87.8) | 0.51 |
| Copeptin (pmol/L) | 2 (3) | 5.9 (3.9–8.2) | 6 (16) | 8.9 (6.5–12.1) | 0.001 |
| Apelin (ng/mL) | 4 (6) | 0.756 (0.565–0.849) | 6 (16) | 0.705 (0.536–0.879) | 0.78 |
| Neonatal characteristics | |||||
| Gestational age (weeks) | 0 (0) | 27.6 (26.1–28.4) | 0 (0) | 27.3 (26.2–27.9) | 0.115 |
| Birthweight (g) | 0 (0) | 1000 (875–1170) | 0 (0) | 860 (720–950) | 0.002 |
| Birthweight percentile | 0 (0) | 35 (25–52) | 0 (0) | 29 (14–49) | 0.057 |
| Indometacin use | 6 (10) | 14 (25) | 1 (3) | 28 (78) | <0.001 |
| Neonatal sepsis | 0 (0) | 9 (14) | 1 (3) | 6 (17) | 0.78 |
| Clinical characteristics | |||||
| ACR (mg/mmol) | 1 (2) | 0.586 (0.451–0.934) | 1 (3) | 0.877 (0.629–1.577) | 0.002 |
| TKV corrected for height (cm3/m) | 7 (11) | 165 (151–192) | 5 (14) | 152 (135–173) | 0.064 |
| . | No BPD (n = 63) . | BPD (n = 37) . | . | ||
|---|---|---|---|---|---|
| Characteristics . | Missing, n (%) . | Median (IQR) or n (%) . | Missing, n (%) . | Median (IQR) or n (%) . | P-value . |
| Reno vascular biomarkers | |||||
| Plasma renin activity (ng/mL/h) | 9 (14) | 1.39 (0.77–2.14) | 17 (46) | 1.71 (0.65–2.03) | 0.81 |
| Plasma angiotensin II (pg/mL) | 22 (35) | 2.83 (2.33–3.5) | 20 (54) | 3.17 (2.17–4.5) | 0.82 |
| Plasma aldosterone (pg/mL) | 9 (14) | 68.8 (52.7–92.5) | 17 (46) | 58.5 (50–87.8) | 0.51 |
| Copeptin (pmol/L) | 2 (3) | 5.9 (3.9–8.2) | 6 (16) | 8.9 (6.5–12.1) | 0.001 |
| Apelin (ng/mL) | 4 (6) | 0.756 (0.565–0.849) | 6 (16) | 0.705 (0.536–0.879) | 0.78 |
| Neonatal characteristics | |||||
| Gestational age (weeks) | 0 (0) | 27.6 (26.1–28.4) | 0 (0) | 27.3 (26.2–27.9) | 0.115 |
| Birthweight (g) | 0 (0) | 1000 (875–1170) | 0 (0) | 860 (720–950) | 0.002 |
| Birthweight percentile | 0 (0) | 35 (25–52) | 0 (0) | 29 (14–49) | 0.057 |
| Indometacin use | 6 (10) | 14 (25) | 1 (3) | 28 (78) | <0.001 |
| Neonatal sepsis | 0 (0) | 9 (14) | 1 (3) | 6 (17) | 0.78 |
| Clinical characteristics | |||||
| ACR (mg/mmol) | 1 (2) | 0.586 (0.451–0.934) | 1 (3) | 0.877 (0.629–1.577) | 0.002 |
| TKV corrected for height (cm3/m) | 7 (11) | 165 (151–192) | 5 (14) | 152 (135–173) | 0.064 |
P-values are calculated using the Mann–Whitney U test.
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