BMI as a mediator between PCOS genetic risk score and cardiometabolic and androgenic outcomes
| Cardiometabolic phenotypes . | Direct effect independent of BMI (95% CI) . | P . | Indirect effect mediated by BMI (95% CI) . | P . | Estimated proportion of total effect . |
|---|---|---|---|---|---|
| Continuous | |||||
| HbA1c (mmol/mol) | 0.040 (0.0053-0.074) | .022 | 0.076 (0.067-0.084) | 1 × 10-63 | 0.66 |
| HDL cholesterol (mmol/L) | -0.000834 (-0.0025 to 0.00068) | .27 | -0.0047 (-0.0053 to -0.0042) | 9 × 10-65 | 0.85 |
| Triglycerides (mmol/L) | 0.0039 (-0.0017 to 0.0092) | .18 | 0.014 (0.012-0.015) | 4 × 10-70 | 0.78 |
| Dichotomous | |||||
| Type 2 diabetes mellitus | 0.0033 (0.0013-0.0052) | .0011 | 0.0028 (0.0024-0.0032) | 2 × 10-37 | 0.46 |
| Coronary artery disease | 0.00096 (-0.00049 to 0.0023) | .18 | 0.0010 (0.00089-0.0011) | 4 × 10-58 | 0.51 |
| Androgenic phenotypes | |||||
| Continuous | |||||
| SHBG (nmol/L) | -0.15 (-0.23 to -0.073) | .00012 | -0.22 (-0.25 to -0.20) | 9 × 10-71 | 0.59 |
| Free androgen index | 0.095 (0.020-0.17) | .014 | 0.054 (0.047-0.061) | 4 × 10-50 | 0.36 |
| Dichotomous | |||||
| Androgenic alopecia | 0.0061 (0.0026-0.0093) | .00034 | 0.00076 (0.00059-0.00095) | 3 × 10-16 | 0.11 |
| Cardiometabolic phenotypes . | Direct effect independent of BMI (95% CI) . | P . | Indirect effect mediated by BMI (95% CI) . | P . | Estimated proportion of total effect . |
|---|---|---|---|---|---|
| Continuous | |||||
| HbA1c (mmol/mol) | 0.040 (0.0053-0.074) | .022 | 0.076 (0.067-0.084) | 1 × 10-63 | 0.66 |
| HDL cholesterol (mmol/L) | -0.000834 (-0.0025 to 0.00068) | .27 | -0.0047 (-0.0053 to -0.0042) | 9 × 10-65 | 0.85 |
| Triglycerides (mmol/L) | 0.0039 (-0.0017 to 0.0092) | .18 | 0.014 (0.012-0.015) | 4 × 10-70 | 0.78 |
| Dichotomous | |||||
| Type 2 diabetes mellitus | 0.0033 (0.0013-0.0052) | .0011 | 0.0028 (0.0024-0.0032) | 2 × 10-37 | 0.46 |
| Coronary artery disease | 0.00096 (-0.00049 to 0.0023) | .18 | 0.0010 (0.00089-0.0011) | 4 × 10-58 | 0.51 |
| Androgenic phenotypes | |||||
| Continuous | |||||
| SHBG (nmol/L) | -0.15 (-0.23 to -0.073) | .00012 | -0.22 (-0.25 to -0.20) | 9 × 10-71 | 0.59 |
| Free androgen index | 0.095 (0.020-0.17) | .014 | 0.054 (0.047-0.061) | 4 × 10-50 | 0.36 |
| Dichotomous | |||||
| Androgenic alopecia | 0.0061 (0.0026-0.0093) | .00034 | 0.00076 (0.00059-0.00095) | 3 × 10-16 | 0.11 |
Abbreviations: BMI, body mass index; HbA1c, hemoglobin A1c; HDL, high-density lipoprotein; PCOS, polycystic ovary syndrome.
BMI as a mediator between PCOS genetic risk score and cardiometabolic and androgenic outcomes
| Cardiometabolic phenotypes . | Direct effect independent of BMI (95% CI) . | P . | Indirect effect mediated by BMI (95% CI) . | P . | Estimated proportion of total effect . |
|---|---|---|---|---|---|
| Continuous | |||||
| HbA1c (mmol/mol) | 0.040 (0.0053-0.074) | .022 | 0.076 (0.067-0.084) | 1 × 10-63 | 0.66 |
| HDL cholesterol (mmol/L) | -0.000834 (-0.0025 to 0.00068) | .27 | -0.0047 (-0.0053 to -0.0042) | 9 × 10-65 | 0.85 |
| Triglycerides (mmol/L) | 0.0039 (-0.0017 to 0.0092) | .18 | 0.014 (0.012-0.015) | 4 × 10-70 | 0.78 |
| Dichotomous | |||||
| Type 2 diabetes mellitus | 0.0033 (0.0013-0.0052) | .0011 | 0.0028 (0.0024-0.0032) | 2 × 10-37 | 0.46 |
| Coronary artery disease | 0.00096 (-0.00049 to 0.0023) | .18 | 0.0010 (0.00089-0.0011) | 4 × 10-58 | 0.51 |
| Androgenic phenotypes | |||||
| Continuous | |||||
| SHBG (nmol/L) | -0.15 (-0.23 to -0.073) | .00012 | -0.22 (-0.25 to -0.20) | 9 × 10-71 | 0.59 |
| Free androgen index | 0.095 (0.020-0.17) | .014 | 0.054 (0.047-0.061) | 4 × 10-50 | 0.36 |
| Dichotomous | |||||
| Androgenic alopecia | 0.0061 (0.0026-0.0093) | .00034 | 0.00076 (0.00059-0.00095) | 3 × 10-16 | 0.11 |
| Cardiometabolic phenotypes . | Direct effect independent of BMI (95% CI) . | P . | Indirect effect mediated by BMI (95% CI) . | P . | Estimated proportion of total effect . |
|---|---|---|---|---|---|
| Continuous | |||||
| HbA1c (mmol/mol) | 0.040 (0.0053-0.074) | .022 | 0.076 (0.067-0.084) | 1 × 10-63 | 0.66 |
| HDL cholesterol (mmol/L) | -0.000834 (-0.0025 to 0.00068) | .27 | -0.0047 (-0.0053 to -0.0042) | 9 × 10-65 | 0.85 |
| Triglycerides (mmol/L) | 0.0039 (-0.0017 to 0.0092) | .18 | 0.014 (0.012-0.015) | 4 × 10-70 | 0.78 |
| Dichotomous | |||||
| Type 2 diabetes mellitus | 0.0033 (0.0013-0.0052) | .0011 | 0.0028 (0.0024-0.0032) | 2 × 10-37 | 0.46 |
| Coronary artery disease | 0.00096 (-0.00049 to 0.0023) | .18 | 0.0010 (0.00089-0.0011) | 4 × 10-58 | 0.51 |
| Androgenic phenotypes | |||||
| Continuous | |||||
| SHBG (nmol/L) | -0.15 (-0.23 to -0.073) | .00012 | -0.22 (-0.25 to -0.20) | 9 × 10-71 | 0.59 |
| Free androgen index | 0.095 (0.020-0.17) | .014 | 0.054 (0.047-0.061) | 4 × 10-50 | 0.36 |
| Dichotomous | |||||
| Androgenic alopecia | 0.0061 (0.0026-0.0093) | .00034 | 0.00076 (0.00059-0.00095) | 3 × 10-16 | 0.11 |
Abbreviations: BMI, body mass index; HbA1c, hemoglobin A1c; HDL, high-density lipoprotein; PCOS, polycystic ovary syndrome.
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