Sex-stratified results for variants identified in joint and sex specific analyses of genotyped rare variants in UK Biobank
| Variant . | rsID . | P sex interaction . | P Women . | P Men . | β Women . | β Men . | SE Women . | SE Men . |
|---|---|---|---|---|---|---|---|---|
| PLIN1 p.L90P | rs139271800 | 4.07 × 10–3 | 1.90 × 10–13 | 4.50 × 10–3 | –0.273 | –0.126 | 0.039 | 0.042 |
| PDE3B p.R783X | rs150090666 | 5.66 × 10–5 | 1.00 × 10–19 | 4.10 × 10–2 | –0.392 | –0.102 | 0.042 | 0.048 |
| ACVR1C p.I195T | rs56188432 | 0.36 × 10–1 | 1.10 × 10–8 | 3.40 × 10–4 | –0.16 | –0.109 | 0.028 | 0.032 |
| CALCRL p.L87P | rs61739909 | 4.30 × 10–3 | 4.30 × 10–13 | 2.50 × 10–3 | –0.171 | –0.082 | 0.024 | 0.026 |
| ABHD15 p.G147D | rs141385558 | 4.53 × 10–3 | 3.40 × 10–10 | 3.80 × 10–2 | 0.168 | 0.057 | 0.026 | 0.029 |
| PYGM p.R50X | rs116987552 | 0.36 × 10–1 | 2.90 × 10–4 | 5.40 × 10–5 | 0.079 | 0.095 | 0.021 | 0.024 |
| PLCB3 p.V806I | rs145502455 | 2.34 × 10–2 | 1.60 × 10–10 | 0.20 × 10–1 | 0.126 | 0.029 | 0.021 | 0.024 |
| FNIP1 p.R518Q | rs115209326 | 6.09 × 10–4 | 4.80 × 10–9 | 0.84 × 10–1 | –0.128 | –0.003 | 0.023 | 0.026 |
| Variant . | rsID . | P sex interaction . | P Women . | P Men . | β Women . | β Men . | SE Women . | SE Men . |
|---|---|---|---|---|---|---|---|---|
| PLIN1 p.L90P | rs139271800 | 4.07 × 10–3 | 1.90 × 10–13 | 4.50 × 10–3 | –0.273 | –0.126 | 0.039 | 0.042 |
| PDE3B p.R783X | rs150090666 | 5.66 × 10–5 | 1.00 × 10–19 | 4.10 × 10–2 | –0.392 | –0.102 | 0.042 | 0.048 |
| ACVR1C p.I195T | rs56188432 | 0.36 × 10–1 | 1.10 × 10–8 | 3.40 × 10–4 | –0.16 | –0.109 | 0.028 | 0.032 |
| CALCRL p.L87P | rs61739909 | 4.30 × 10–3 | 4.30 × 10–13 | 2.50 × 10–3 | –0.171 | –0.082 | 0.024 | 0.026 |
| ABHD15 p.G147D | rs141385558 | 4.53 × 10–3 | 3.40 × 10–10 | 3.80 × 10–2 | 0.168 | 0.057 | 0.026 | 0.029 |
| PYGM p.R50X | rs116987552 | 0.36 × 10–1 | 2.90 × 10–4 | 5.40 × 10–5 | 0.079 | 0.095 | 0.021 | 0.024 |
| PLCB3 p.V806I | rs145502455 | 2.34 × 10–2 | 1.60 × 10–10 | 0.20 × 10–1 | 0.126 | 0.029 | 0.021 | 0.024 |
| FNIP1 p.R518Q | rs115209326 | 6.09 × 10–4 | 4.80 × 10–9 | 0.84 × 10–1 | –0.128 | –0.003 | 0.023 | 0.026 |
Unshaded rows present results discovered from the sex-combined analysis, and gray-shaded rows represent results from variants identified only in the sex-stratified (women) analysis.
Abbreviations: β Men, effect size in men; β Women, effect size in women; P Men, BOLT LMM P value in men; P Women, BOLT LMM P value in women.
Sex-stratified results for variants identified in joint and sex specific analyses of genotyped rare variants in UK Biobank
| Variant . | rsID . | P sex interaction . | P Women . | P Men . | β Women . | β Men . | SE Women . | SE Men . |
|---|---|---|---|---|---|---|---|---|
| PLIN1 p.L90P | rs139271800 | 4.07 × 10–3 | 1.90 × 10–13 | 4.50 × 10–3 | –0.273 | –0.126 | 0.039 | 0.042 |
| PDE3B p.R783X | rs150090666 | 5.66 × 10–5 | 1.00 × 10–19 | 4.10 × 10–2 | –0.392 | –0.102 | 0.042 | 0.048 |
| ACVR1C p.I195T | rs56188432 | 0.36 × 10–1 | 1.10 × 10–8 | 3.40 × 10–4 | –0.16 | –0.109 | 0.028 | 0.032 |
| CALCRL p.L87P | rs61739909 | 4.30 × 10–3 | 4.30 × 10–13 | 2.50 × 10–3 | –0.171 | –0.082 | 0.024 | 0.026 |
| ABHD15 p.G147D | rs141385558 | 4.53 × 10–3 | 3.40 × 10–10 | 3.80 × 10–2 | 0.168 | 0.057 | 0.026 | 0.029 |
| PYGM p.R50X | rs116987552 | 0.36 × 10–1 | 2.90 × 10–4 | 5.40 × 10–5 | 0.079 | 0.095 | 0.021 | 0.024 |
| PLCB3 p.V806I | rs145502455 | 2.34 × 10–2 | 1.60 × 10–10 | 0.20 × 10–1 | 0.126 | 0.029 | 0.021 | 0.024 |
| FNIP1 p.R518Q | rs115209326 | 6.09 × 10–4 | 4.80 × 10–9 | 0.84 × 10–1 | –0.128 | –0.003 | 0.023 | 0.026 |
| Variant . | rsID . | P sex interaction . | P Women . | P Men . | β Women . | β Men . | SE Women . | SE Men . |
|---|---|---|---|---|---|---|---|---|
| PLIN1 p.L90P | rs139271800 | 4.07 × 10–3 | 1.90 × 10–13 | 4.50 × 10–3 | –0.273 | –0.126 | 0.039 | 0.042 |
| PDE3B p.R783X | rs150090666 | 5.66 × 10–5 | 1.00 × 10–19 | 4.10 × 10–2 | –0.392 | –0.102 | 0.042 | 0.048 |
| ACVR1C p.I195T | rs56188432 | 0.36 × 10–1 | 1.10 × 10–8 | 3.40 × 10–4 | –0.16 | –0.109 | 0.028 | 0.032 |
| CALCRL p.L87P | rs61739909 | 4.30 × 10–3 | 4.30 × 10–13 | 2.50 × 10–3 | –0.171 | –0.082 | 0.024 | 0.026 |
| ABHD15 p.G147D | rs141385558 | 4.53 × 10–3 | 3.40 × 10–10 | 3.80 × 10–2 | 0.168 | 0.057 | 0.026 | 0.029 |
| PYGM p.R50X | rs116987552 | 0.36 × 10–1 | 2.90 × 10–4 | 5.40 × 10–5 | 0.079 | 0.095 | 0.021 | 0.024 |
| PLCB3 p.V806I | rs145502455 | 2.34 × 10–2 | 1.60 × 10–10 | 0.20 × 10–1 | 0.126 | 0.029 | 0.021 | 0.024 |
| FNIP1 p.R518Q | rs115209326 | 6.09 × 10–4 | 4.80 × 10–9 | 0.84 × 10–1 | –0.128 | –0.003 | 0.023 | 0.026 |
Unshaded rows present results discovered from the sex-combined analysis, and gray-shaded rows represent results from variants identified only in the sex-stratified (women) analysis.
Abbreviations: β Men, effect size in men; β Women, effect size in women; P Men, BOLT LMM P value in men; P Women, BOLT LMM P value in women.
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