| . | Peak VO2 . | Cardiac output (MR or echo) . | Adverse events . | Distance walked (6MWT) . | Activity levels . | Quality of life patient report . | Quality of life parent report . |
|---|---|---|---|---|---|---|---|
| Studies including children only: | |||||||
| Jacobsen17,23 | ↑ | – | No | – | = | ↓ | ↑ |
| Sutherland (home/hospital)25 | = | – | Yes | ↑ | – | ↑ | ↑ |
| Wittekind26 | ↑ | = | Yes | – | – | – | – |
| Hedlund28,39 | = | – | – | ↑ | ↑ | ↑ | ↑ |
| Laohachai30 | = | ↑ | No | – | – | – | – |
| Longmuir24 | ↑ | – | – | – | ↑ | – | – |
| Opocher19 | ↑ | – | No | – | – | – | – |
| Studies including adults only: | |||||||
| Fritz21 | = | – | Yes | – | – | – | – |
| Wu31 | = | – | No | – | – | = | – |
| Cordina32 | ↑ | ↑ | Yes | – | – | – | – |
| Lichtman20 | ↑ | – | – | – | – | ↑ | – |
| Studies including children and adults: | |||||||
| Ait Ali18 | ↑ | – | – | – | – | – | – |
| Duppen9,13–16 | = | = | – | – | = | ↑ | ↑ |
| Brassard22 | = | – | – | – | – | – | – |
| Minamisawa29 | ↑ | – | No | – | – | – | – |
| Balfour27 | ↑ | – | No | – | – | – | – |
| . | Peak VO2 . | Cardiac output (MR or echo) . | Adverse events . | Distance walked (6MWT) . | Activity levels . | Quality of life patient report . | Quality of life parent report . |
|---|---|---|---|---|---|---|---|
| Studies including children only: | |||||||
| Jacobsen17,23 | ↑ | – | No | – | = | ↓ | ↑ |
| Sutherland (home/hospital)25 | = | – | Yes | ↑ | – | ↑ | ↑ |
| Wittekind26 | ↑ | = | Yes | – | – | – | – |
| Hedlund28,39 | = | – | – | ↑ | ↑ | ↑ | ↑ |
| Laohachai30 | = | ↑ | No | – | – | – | – |
| Longmuir24 | ↑ | – | – | – | ↑ | – | – |
| Opocher19 | ↑ | – | No | – | – | – | – |
| Studies including adults only: | |||||||
| Fritz21 | = | – | Yes | – | – | – | – |
| Wu31 | = | – | No | – | – | = | – |
| Cordina32 | ↑ | ↑ | Yes | – | – | – | – |
| Lichtman20 | ↑ | – | – | – | – | ↑ | – |
| Studies including children and adults: | |||||||
| Ait Ali18 | ↑ | – | – | – | – | – | – |
| Duppen9,13–16 | = | = | – | – | = | ↑ | ↑ |
| Brassard22 | = | – | – | – | – | – | – |
| Minamisawa29 | ↑ | – | No | – | – | – | – |
| Balfour27 | ↑ | – | No | – | – | – | – |
6MWT: six-minute walk test; MR: magnetic resonance; VO2: oxygen uptake.
Symbol ↑ indicates a significant increase; = indicates no significant change; ↓ indicates significant decrease; – indicates not provided.
| . | Peak VO2 . | Cardiac output (MR or echo) . | Adverse events . | Distance walked (6MWT) . | Activity levels . | Quality of life patient report . | Quality of life parent report . |
|---|---|---|---|---|---|---|---|
| Studies including children only: | |||||||
| Jacobsen17,23 | ↑ | – | No | – | = | ↓ | ↑ |
| Sutherland (home/hospital)25 | = | – | Yes | ↑ | – | ↑ | ↑ |
| Wittekind26 | ↑ | = | Yes | – | – | – | – |
| Hedlund28,39 | = | – | – | ↑ | ↑ | ↑ | ↑ |
| Laohachai30 | = | ↑ | No | – | – | – | – |
| Longmuir24 | ↑ | – | – | – | ↑ | – | – |
| Opocher19 | ↑ | – | No | – | – | – | – |
| Studies including adults only: | |||||||
| Fritz21 | = | – | Yes | – | – | – | – |
| Wu31 | = | – | No | – | – | = | – |
| Cordina32 | ↑ | ↑ | Yes | – | – | – | – |
| Lichtman20 | ↑ | – | – | – | – | ↑ | – |
| Studies including children and adults: | |||||||
| Ait Ali18 | ↑ | – | – | – | – | – | – |
| Duppen9,13–16 | = | = | – | – | = | ↑ | ↑ |
| Brassard22 | = | – | – | – | – | – | – |
| Minamisawa29 | ↑ | – | No | – | – | – | – |
| Balfour27 | ↑ | – | No | – | – | – | – |
| . | Peak VO2 . | Cardiac output (MR or echo) . | Adverse events . | Distance walked (6MWT) . | Activity levels . | Quality of life patient report . | Quality of life parent report . |
|---|---|---|---|---|---|---|---|
| Studies including children only: | |||||||
| Jacobsen17,23 | ↑ | – | No | – | = | ↓ | ↑ |
| Sutherland (home/hospital)25 | = | – | Yes | ↑ | – | ↑ | ↑ |
| Wittekind26 | ↑ | = | Yes | – | – | – | – |
| Hedlund28,39 | = | – | – | ↑ | ↑ | ↑ | ↑ |
| Laohachai30 | = | ↑ | No | – | – | – | – |
| Longmuir24 | ↑ | – | – | – | ↑ | – | – |
| Opocher19 | ↑ | – | No | – | – | – | – |
| Studies including adults only: | |||||||
| Fritz21 | = | – | Yes | – | – | – | – |
| Wu31 | = | – | No | – | – | = | – |
| Cordina32 | ↑ | ↑ | Yes | – | – | – | – |
| Lichtman20 | ↑ | – | – | – | – | ↑ | – |
| Studies including children and adults: | |||||||
| Ait Ali18 | ↑ | – | – | – | – | – | – |
| Duppen9,13–16 | = | = | – | – | = | ↑ | ↑ |
| Brassard22 | = | – | – | – | – | – | – |
| Minamisawa29 | ↑ | – | No | – | – | – | – |
| Balfour27 | ↑ | – | No | – | – | – | – |
6MWT: six-minute walk test; MR: magnetic resonance; VO2: oxygen uptake.
Symbol ↑ indicates a significant increase; = indicates no significant change; ↓ indicates significant decrease; – indicates not provided.
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