Workflow for Performing a Consortium Meta-Analysis Using COMETS Analytics (Web App or Local Ra Package)
| Step . | Actions in Step . |
|---|---|
| Standardized data and models | Project coordinatorb prepares and sends an Excel sheet with “VarMap” and “Models” tabs to cohort analysts. Cohort analysts add their data to the “Metabolites,” “Subject Metabolites,” and “Subjects” tabs to complete the input file. |
| Input integrity check and harmonization | Cohort analysts open COMETS Analytics, select their input file, and click “check integrity.” If the data set passes the quality control check, cohort analysts continue to the analysis. If the data set fails the quality control check, cohort analysts read the error messages and make appropriate fixes. |
| Cohort-specific analyses with model validity check | Cohort analysts add their e-mail address (online app only). Cohort analysts click “run model.” Cohort analysts forward results and documentation from COMETS Analytics to project coordinator. |
| Standardized results aggregation | Project coordinator oversees harmonization of metabolite names from COMETS Analytics files. Project coordinator oversees meta-analysis. Project coordinator prepares manuscript based on meta-analysis results. |
| Step . | Actions in Step . |
|---|---|
| Standardized data and models | Project coordinatorb prepares and sends an Excel sheet with “VarMap” and “Models” tabs to cohort analysts. Cohort analysts add their data to the “Metabolites,” “Subject Metabolites,” and “Subjects” tabs to complete the input file. |
| Input integrity check and harmonization | Cohort analysts open COMETS Analytics, select their input file, and click “check integrity.” If the data set passes the quality control check, cohort analysts continue to the analysis. If the data set fails the quality control check, cohort analysts read the error messages and make appropriate fixes. |
| Cohort-specific analyses with model validity check | Cohort analysts add their e-mail address (online app only). Cohort analysts click “run model.” Cohort analysts forward results and documentation from COMETS Analytics to project coordinator. |
| Standardized results aggregation | Project coordinator oversees harmonization of metabolite names from COMETS Analytics files. Project coordinator oversees meta-analysis. Project coordinator prepares manuscript based on meta-analysis results. |
Abbreviations: app, application; COMETS, Consortium of Metabolomics Studies.
a R Foundation for Statistical Computing, Vienna, Austria.
b “Project coordinator” refers to an investigator or project lead.
Workflow for Performing a Consortium Meta-Analysis Using COMETS Analytics (Web App or Local Ra Package)
| Step . | Actions in Step . |
|---|---|
| Standardized data and models | Project coordinatorb prepares and sends an Excel sheet with “VarMap” and “Models” tabs to cohort analysts. Cohort analysts add their data to the “Metabolites,” “Subject Metabolites,” and “Subjects” tabs to complete the input file. |
| Input integrity check and harmonization | Cohort analysts open COMETS Analytics, select their input file, and click “check integrity.” If the data set passes the quality control check, cohort analysts continue to the analysis. If the data set fails the quality control check, cohort analysts read the error messages and make appropriate fixes. |
| Cohort-specific analyses with model validity check | Cohort analysts add their e-mail address (online app only). Cohort analysts click “run model.” Cohort analysts forward results and documentation from COMETS Analytics to project coordinator. |
| Standardized results aggregation | Project coordinator oversees harmonization of metabolite names from COMETS Analytics files. Project coordinator oversees meta-analysis. Project coordinator prepares manuscript based on meta-analysis results. |
| Step . | Actions in Step . |
|---|---|
| Standardized data and models | Project coordinatorb prepares and sends an Excel sheet with “VarMap” and “Models” tabs to cohort analysts. Cohort analysts add their data to the “Metabolites,” “Subject Metabolites,” and “Subjects” tabs to complete the input file. |
| Input integrity check and harmonization | Cohort analysts open COMETS Analytics, select their input file, and click “check integrity.” If the data set passes the quality control check, cohort analysts continue to the analysis. If the data set fails the quality control check, cohort analysts read the error messages and make appropriate fixes. |
| Cohort-specific analyses with model validity check | Cohort analysts add their e-mail address (online app only). Cohort analysts click “run model.” Cohort analysts forward results and documentation from COMETS Analytics to project coordinator. |
| Standardized results aggregation | Project coordinator oversees harmonization of metabolite names from COMETS Analytics files. Project coordinator oversees meta-analysis. Project coordinator prepares manuscript based on meta-analysis results. |
Abbreviations: app, application; COMETS, Consortium of Metabolomics Studies.
a R Foundation for Statistical Computing, Vienna, Austria.
b “Project coordinator” refers to an investigator or project lead.
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