Table 1.
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Candidate genes at detected loci have diverse cellular functions.

Candidate gene(s)Summary of associated function(s)
AFR1Pheromone-induced projection (shmoo) formation; Septin architecture during mating
HOS2Histone deacetylase, subunit of Set3 and Rpd3L complexes
YGL193CHaploid specific gene
IME4Methyltransferase, conditionally essential for meiosis
SDH1Flavoprotein involved in TCA cycle in mitochondria
BPT1Vacuolar transmembrane protein
RNH203Ribonuclease H2 subunit, ribonucleotide excision repair
BOP2Unknown
ECM7Putative integral membrane protein with a role in calcium uptake
YMR090WUnknown
NPL6Component of the RSC chromatin remodeling complex
ECM5Subunit of Snt2C complex involved in gene regulation in response to oxidative stress
AEP2Mitochondrial protein; likely involved in translation 
PBR1Putative oxidoreductase; required for cell viability
SAL1ADP/ATP transporter in mitochondria
PMS1ATP-binding protein required for mismatch repair; required for both mitosis and meiosis
BRX1Nucleolar protein involved in rRNA processing
YOR008C-AUnknown, potential transmembrane domain
TIR4Cell wall mannoprotein; required for anaerobic growth
ISN1Ionosine metabolism
ISW2ATP-dependent DNA translocase involved in chromatin remodeling
Candidate gene(s)Summary of associated function(s)
AFR1Pheromone-induced projection (shmoo) formation; Septin architecture during mating
HOS2Histone deacetylase, subunit of Set3 and Rpd3L complexes
YGL193CHaploid specific gene
IME4Methyltransferase, conditionally essential for meiosis
SDH1Flavoprotein involved in TCA cycle in mitochondria
BPT1Vacuolar transmembrane protein
RNH203Ribonuclease H2 subunit, ribonucleotide excision repair
BOP2Unknown
ECM7Putative integral membrane protein with a role in calcium uptake
YMR090WUnknown
NPL6Component of the RSC chromatin remodeling complex
ECM5Subunit of Snt2C complex involved in gene regulation in response to oxidative stress
AEP2Mitochondrial protein; likely involved in translation 
PBR1Putative oxidoreductase; required for cell viability
SAL1ADP/ATP transporter in mitochondria
PMS1ATP-binding protein required for mismatch repair; required for both mitosis and meiosis
BRX1Nucleolar protein involved in rRNA processing
YOR008C-AUnknown, potential transmembrane domain
TIR4Cell wall mannoprotein; required for anaerobic growth
ISN1Ionosine metabolism
ISW2ATP-dependent DNA translocase involved in chromatin remodeling

Candidate genes were identified by looking at all genes within an interval that contained markers showing maximal significance. For this analysis, we considered all SNPs within an interval, not just the subset used in linkage mapping. Candidate genes in these intervals are listed with brief annotations for the candidates are provided here from the Saccharomyces Genome Database (Cherry et al. 2012). More information about these loci is provided in Supplementary Tables 3 and 4.

Table 1.
Open in new tab

Candidate genes at detected loci have diverse cellular functions.

Candidate gene(s)Summary of associated function(s)
AFR1Pheromone-induced projection (shmoo) formation; Septin architecture during mating
HOS2Histone deacetylase, subunit of Set3 and Rpd3L complexes
YGL193CHaploid specific gene
IME4Methyltransferase, conditionally essential for meiosis
SDH1Flavoprotein involved in TCA cycle in mitochondria
BPT1Vacuolar transmembrane protein
RNH203Ribonuclease H2 subunit, ribonucleotide excision repair
BOP2Unknown
ECM7Putative integral membrane protein with a role in calcium uptake
YMR090WUnknown
NPL6Component of the RSC chromatin remodeling complex
ECM5Subunit of Snt2C complex involved in gene regulation in response to oxidative stress
AEP2Mitochondrial protein; likely involved in translation 
PBR1Putative oxidoreductase; required for cell viability
SAL1ADP/ATP transporter in mitochondria
PMS1ATP-binding protein required for mismatch repair; required for both mitosis and meiosis
BRX1Nucleolar protein involved in rRNA processing
YOR008C-AUnknown, potential transmembrane domain
TIR4Cell wall mannoprotein; required for anaerobic growth
ISN1Ionosine metabolism
ISW2ATP-dependent DNA translocase involved in chromatin remodeling
Candidate gene(s)Summary of associated function(s)
AFR1Pheromone-induced projection (shmoo) formation; Septin architecture during mating
HOS2Histone deacetylase, subunit of Set3 and Rpd3L complexes
YGL193CHaploid specific gene
IME4Methyltransferase, conditionally essential for meiosis
SDH1Flavoprotein involved in TCA cycle in mitochondria
BPT1Vacuolar transmembrane protein
RNH203Ribonuclease H2 subunit, ribonucleotide excision repair
BOP2Unknown
ECM7Putative integral membrane protein with a role in calcium uptake
YMR090WUnknown
NPL6Component of the RSC chromatin remodeling complex
ECM5Subunit of Snt2C complex involved in gene regulation in response to oxidative stress
AEP2Mitochondrial protein; likely involved in translation 
PBR1Putative oxidoreductase; required for cell viability
SAL1ADP/ATP transporter in mitochondria
PMS1ATP-binding protein required for mismatch repair; required for both mitosis and meiosis
BRX1Nucleolar protein involved in rRNA processing
YOR008C-AUnknown, potential transmembrane domain
TIR4Cell wall mannoprotein; required for anaerobic growth
ISN1Ionosine metabolism
ISW2ATP-dependent DNA translocase involved in chromatin remodeling

Candidate genes were identified by looking at all genes within an interval that contained markers showing maximal significance. For this analysis, we considered all SNPs within an interval, not just the subset used in linkage mapping. Candidate genes in these intervals are listed with brief annotations for the candidates are provided here from the Saccharomyces Genome Database (Cherry et al. 2012). More information about these loci is provided in Supplementary Tables 3 and 4.

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