Diagnostic accuracy of clinical, laboratory and imaging findings for the identification of EGPA-related cardiomyopathy
| Findings . | EGPA-CM (n = 70) . | No CM (n = 106) . | Sensitivity (95% CI), % . | Specificity (95% CI), % . | PPV (95% CI), % . | NPV (95% CI), % . | Diagnostic OR (95% CI) . | P . |
|---|---|---|---|---|---|---|---|---|
| Extra-cardiac features | ||||||||
| Peripheral neuropathy | 33/70 (47) | 69/106 (65) | 47.2 (35.9, 58.7) | 34.9 (26.5, 44.4) | 32.3 (24.1, 41.9) | 50.0 (38.9, 61.1) | 0.48 (0.26, 0.90) | 0.02 |
| Eosinophils >3000/mm3 | 49/63 (78) | 57/88 (65) | 77.8 (66.1, 86.3) | 35.2 (26.1, 45.6) | 46.2 (37.0, 55.7) | 68.9 (54.3, 80.5) | 1.90 (0.91, 3.85) | 0.10 |
| Eosinophils >5000/mm3 | 42/63 (67) | 37/88 (42) | 66.7 (54.4, 77.1) | 58.0 (47.5, 67.7) | 53.2 (42.2, 63.8) | 70.8 (59.5, 80.1) | 2.76 (1.39, 5.46) | 0.003 |
| Positive ANCA | 16/63 (25) | 45/92 (49) | 25.4 (16.3, 37.3) | 51.1 (41.0, 61.1) | 26.2 (16.8, 38.4) | 50.0 (40.0, 59.9) | 0.36 (0.18, 0.73) | 0.004 |
| Positive MPO-ANCA | 12/63 (19) | 35/92 (38) | 19.1 (11.3, 30.4) | 62.0 (51.8, 71.2) | 25.5 (15.3, 39.5) | 52.8 (43.4, 61.9) | 0.38 (0.18, 0.81) | 0.01 |
| ECG | 68 | 96 | ||||||
| Abnormal ECG | 49 (72) | 31 (32) | 72.1 (60.4, 81.3) | 67.7 (57.8, 76.2) | 61.3 (50.3, 71.2) | 77.4 (67.4, 85.0) | 5.41 (2.73, 10.24) | <0.0001 |
| Repolarization abnormalities | 25 (37) | 12 (13) | 36.8 (26.3, 48.6) | 87.5 (79.4, 92.7) | 67.6 (51.5, 80.4) | 66.1 (57.6, 73.8) | 4.07 (1.93, 9.05) | 0.0005 |
| Rhythm abnormalities | 19 (28) | 10 (10) | 27.9 (18.7, 39.6) | 89.6 (81.9, 94.2) | 65.5 (47.4, 80.1) | 63.7 (55.3, 71.3) | 3.34 (1.40, 7.69) | 0.006 |
| Conduction abnormalities | 13 (19) | 12 (13) | 19.1 (11.5, 30.0) | 87.5 (79.4, 92.7) | 52.0 (33.5, 70.0) | 60.4 (52.1, 68.2) | 1.66 (0.68, 3.72) | 0.28 |
| Q wave abnormalities | 5 (7) | 4 (4) | 7.4 (3.2, 16.1) | 95.8 (90.0, 98.4) | 55.6 (26.7, 81.1) | 59.4 (51.5, 66.8) | 1.83 (0.52, 6.12) | 0.49 |
| Laboratory findings | ||||||||
| Increased troponin | 44/51 (86) | 6/52 (12) | 86.3 (74.3, 93.2) | 88.5 (77.0, 94.6) | 88.0 (76.2, 94.4) | 86.8 (75.2, 93.5) | 48.2 (14.87, 133) | <0.0001 |
| Increased NT-pro-BNP | 38/43 (88) | 10/46 (22) | 88.4 (75.5, 94.9) | 78.3 (64.4, 87.7) | 79.2 (65.7, 94.7) | 87.8 (74.5, 94.7) | 27.4 (8.46, 77.0) | <0.0001 |
| Transthoracic echography | 68 | 89 | ||||||
| Abnormal TTE | 49 (72) | 34 (38) | 72.1 (60.4, 81.3) | 61.8 (51.4, 71.2) | 59.0 (48.3, 69.0) | 74.3 (63.4, 82.9) | 4.17 (2.10, 7.98) | <0.0001 |
| Pericardial effusion | 28 (41) | 12 (13) | 41.2 (30.3, 53.0) | 86.5 (77.9, 92.1) | 70.0 (54.6, 81.9) | 65.8 (56.8, 73.8) | 4.49 (2.02, 9.94) | <0.0001 |
| Left ventricular dysfunction | 21 (31) | 2 (2) | 30.9 (21.2, 42.6) | 97.8 (92.2, 99.6) | 91.3 (73.2, 98.5) | 64.9 (56.5, 72.5) | 19.44 (4.65, 85.5) | <0.0001 |
| Hypokinetic areas | 22 (32) | 2 (2) | 32.4 (22.4, 44.2) | 97.8 (92.2, 99.6) | 91.7 (74.2, 98.5) | 65.4 (57.0, 73.0) | 20.80 (5.01, 91.3) | <0.0001 |
| Cardiac MRI | 67 | 60 | ||||||
| Abnormal CMRI | 66 (99) | 36 (60) | 98.5 (92.0, 99.9) | 40.0 (28.6, 52.6) | 64.7 (55.1, 73.3) | 96.0 (80.5, 99.8) | 44.0 (7.24, 461) | <0.0001 |
| Pericardial effusion | 27 (40) | 25 (42) | 40.3 (29.4, 52.3) | 58.3 (45.7, 69.9) | 51.9 (38.7, 64.9) | 46.7 (35.8, 57.8) | 0.95 (0.46, 1.95) | >0.99 |
| Pericardial GE | 18 (27) | 13 (22) | 26.9 (17.7, 38.5) | 78.3 (66.4, 86.9) | 58.1 (40.8, 73.6) | 49.0 (39.2, 58.8) | 1.33 (0.61, 3.07) | 0.54 |
| Left ventricular dysfunction | 32 (48) | 6 (10) | 47.8 (36.3, 59.5) | 90.0 (79.9, 95.3) | 84.2 (69.6, 92.6) | 60.7 (50.3, 70.2) | 8.23 (3.26, 20.97) | <0.0001 |
| Dilated left ventricle | 7 (10) | 3 (5) | 10.5 (5.2, 20.0) | 95.0 (86.3, 98.6) | 70.0 (39.7, 89.2) | 48.7 (39.9, 57.7) | 2.22 (0.57, 8.14) | 0.33 |
| Myocardial oedema | 15 (22) | 4 (7) | 22.4 (14.1, 33.7) | 93.3 (84.1, 97.4) | 79.0 (56.7, 91.5) | 51.9 (42.5, 61.1) | 4.04 (1.28, 11.66) | 0.02 |
| EGE | 24 (36) | 8 (13) | 35.8 (25.4, 47.8) | 86.7 (75.8, 93.1) | 75.0 (57.9, 86.9) | 54.7 (44.7, 64.4) | 3.63 (1.43, 8.60) | 0.004 |
| LGE | 47 (70) | 13 (22) | 70.2 (58.3, 79.8) | 78.3 (66.4, 86.9) | 78.3 (66.4, 86.9) | 70.2 (58.3, 79.8) | 8.50 (3.88, 18.41) | <0.0001 |
| Findings . | EGPA-CM (n = 70) . | No CM (n = 106) . | Sensitivity (95% CI), % . | Specificity (95% CI), % . | PPV (95% CI), % . | NPV (95% CI), % . | Diagnostic OR (95% CI) . | P . |
|---|---|---|---|---|---|---|---|---|
| Extra-cardiac features | ||||||||
| Peripheral neuropathy | 33/70 (47) | 69/106 (65) | 47.2 (35.9, 58.7) | 34.9 (26.5, 44.4) | 32.3 (24.1, 41.9) | 50.0 (38.9, 61.1) | 0.48 (0.26, 0.90) | 0.02 |
| Eosinophils >3000/mm3 | 49/63 (78) | 57/88 (65) | 77.8 (66.1, 86.3) | 35.2 (26.1, 45.6) | 46.2 (37.0, 55.7) | 68.9 (54.3, 80.5) | 1.90 (0.91, 3.85) | 0.10 |
| Eosinophils >5000/mm3 | 42/63 (67) | 37/88 (42) | 66.7 (54.4, 77.1) | 58.0 (47.5, 67.7) | 53.2 (42.2, 63.8) | 70.8 (59.5, 80.1) | 2.76 (1.39, 5.46) | 0.003 |
| Positive ANCA | 16/63 (25) | 45/92 (49) | 25.4 (16.3, 37.3) | 51.1 (41.0, 61.1) | 26.2 (16.8, 38.4) | 50.0 (40.0, 59.9) | 0.36 (0.18, 0.73) | 0.004 |
| Positive MPO-ANCA | 12/63 (19) | 35/92 (38) | 19.1 (11.3, 30.4) | 62.0 (51.8, 71.2) | 25.5 (15.3, 39.5) | 52.8 (43.4, 61.9) | 0.38 (0.18, 0.81) | 0.01 |
| ECG | 68 | 96 | ||||||
| Abnormal ECG | 49 (72) | 31 (32) | 72.1 (60.4, 81.3) | 67.7 (57.8, 76.2) | 61.3 (50.3, 71.2) | 77.4 (67.4, 85.0) | 5.41 (2.73, 10.24) | <0.0001 |
| Repolarization abnormalities | 25 (37) | 12 (13) | 36.8 (26.3, 48.6) | 87.5 (79.4, 92.7) | 67.6 (51.5, 80.4) | 66.1 (57.6, 73.8) | 4.07 (1.93, 9.05) | 0.0005 |
| Rhythm abnormalities | 19 (28) | 10 (10) | 27.9 (18.7, 39.6) | 89.6 (81.9, 94.2) | 65.5 (47.4, 80.1) | 63.7 (55.3, 71.3) | 3.34 (1.40, 7.69) | 0.006 |
| Conduction abnormalities | 13 (19) | 12 (13) | 19.1 (11.5, 30.0) | 87.5 (79.4, 92.7) | 52.0 (33.5, 70.0) | 60.4 (52.1, 68.2) | 1.66 (0.68, 3.72) | 0.28 |
| Q wave abnormalities | 5 (7) | 4 (4) | 7.4 (3.2, 16.1) | 95.8 (90.0, 98.4) | 55.6 (26.7, 81.1) | 59.4 (51.5, 66.8) | 1.83 (0.52, 6.12) | 0.49 |
| Laboratory findings | ||||||||
| Increased troponin | 44/51 (86) | 6/52 (12) | 86.3 (74.3, 93.2) | 88.5 (77.0, 94.6) | 88.0 (76.2, 94.4) | 86.8 (75.2, 93.5) | 48.2 (14.87, 133) | <0.0001 |
| Increased NT-pro-BNP | 38/43 (88) | 10/46 (22) | 88.4 (75.5, 94.9) | 78.3 (64.4, 87.7) | 79.2 (65.7, 94.7) | 87.8 (74.5, 94.7) | 27.4 (8.46, 77.0) | <0.0001 |
| Transthoracic echography | 68 | 89 | ||||||
| Abnormal TTE | 49 (72) | 34 (38) | 72.1 (60.4, 81.3) | 61.8 (51.4, 71.2) | 59.0 (48.3, 69.0) | 74.3 (63.4, 82.9) | 4.17 (2.10, 7.98) | <0.0001 |
| Pericardial effusion | 28 (41) | 12 (13) | 41.2 (30.3, 53.0) | 86.5 (77.9, 92.1) | 70.0 (54.6, 81.9) | 65.8 (56.8, 73.8) | 4.49 (2.02, 9.94) | <0.0001 |
| Left ventricular dysfunction | 21 (31) | 2 (2) | 30.9 (21.2, 42.6) | 97.8 (92.2, 99.6) | 91.3 (73.2, 98.5) | 64.9 (56.5, 72.5) | 19.44 (4.65, 85.5) | <0.0001 |
| Hypokinetic areas | 22 (32) | 2 (2) | 32.4 (22.4, 44.2) | 97.8 (92.2, 99.6) | 91.7 (74.2, 98.5) | 65.4 (57.0, 73.0) | 20.80 (5.01, 91.3) | <0.0001 |
| Cardiac MRI | 67 | 60 | ||||||
| Abnormal CMRI | 66 (99) | 36 (60) | 98.5 (92.0, 99.9) | 40.0 (28.6, 52.6) | 64.7 (55.1, 73.3) | 96.0 (80.5, 99.8) | 44.0 (7.24, 461) | <0.0001 |
| Pericardial effusion | 27 (40) | 25 (42) | 40.3 (29.4, 52.3) | 58.3 (45.7, 69.9) | 51.9 (38.7, 64.9) | 46.7 (35.8, 57.8) | 0.95 (0.46, 1.95) | >0.99 |
| Pericardial GE | 18 (27) | 13 (22) | 26.9 (17.7, 38.5) | 78.3 (66.4, 86.9) | 58.1 (40.8, 73.6) | 49.0 (39.2, 58.8) | 1.33 (0.61, 3.07) | 0.54 |
| Left ventricular dysfunction | 32 (48) | 6 (10) | 47.8 (36.3, 59.5) | 90.0 (79.9, 95.3) | 84.2 (69.6, 92.6) | 60.7 (50.3, 70.2) | 8.23 (3.26, 20.97) | <0.0001 |
| Dilated left ventricle | 7 (10) | 3 (5) | 10.5 (5.2, 20.0) | 95.0 (86.3, 98.6) | 70.0 (39.7, 89.2) | 48.7 (39.9, 57.7) | 2.22 (0.57, 8.14) | 0.33 |
| Myocardial oedema | 15 (22) | 4 (7) | 22.4 (14.1, 33.7) | 93.3 (84.1, 97.4) | 79.0 (56.7, 91.5) | 51.9 (42.5, 61.1) | 4.04 (1.28, 11.66) | 0.02 |
| EGE | 24 (36) | 8 (13) | 35.8 (25.4, 47.8) | 86.7 (75.8, 93.1) | 75.0 (57.9, 86.9) | 54.7 (44.7, 64.4) | 3.63 (1.43, 8.60) | 0.004 |
| LGE | 47 (70) | 13 (22) | 70.2 (58.3, 79.8) | 78.3 (66.4, 86.9) | 78.3 (66.4, 86.9) | 70.2 (58.3, 79.8) | 8.50 (3.88, 18.41) | <0.0001 |
CM: cardiomyopathy; CMRI: cardiac MRI; EGE: early gadolinium enhancement; EGPA: eosinophilic granulomatosis with polyangiitis; LGE: late gadolinium enhancement; NPV: negative predictive value; NT-pro-BNP: N-terminal (NT)-pro hormone brain natriuretic peptide; OR: odds ratio; Pericardial GE: pericardial gadolinium enhancement; PPV: positive predictive value; TTE: transthoracic echocardiogram.
Diagnostic accuracy of clinical, laboratory and imaging findings for the identification of EGPA-related cardiomyopathy
| Findings . | EGPA-CM (n = 70) . | No CM (n = 106) . | Sensitivity (95% CI), % . | Specificity (95% CI), % . | PPV (95% CI), % . | NPV (95% CI), % . | Diagnostic OR (95% CI) . | P . |
|---|---|---|---|---|---|---|---|---|
| Extra-cardiac features | ||||||||
| Peripheral neuropathy | 33/70 (47) | 69/106 (65) | 47.2 (35.9, 58.7) | 34.9 (26.5, 44.4) | 32.3 (24.1, 41.9) | 50.0 (38.9, 61.1) | 0.48 (0.26, 0.90) | 0.02 |
| Eosinophils >3000/mm3 | 49/63 (78) | 57/88 (65) | 77.8 (66.1, 86.3) | 35.2 (26.1, 45.6) | 46.2 (37.0, 55.7) | 68.9 (54.3, 80.5) | 1.90 (0.91, 3.85) | 0.10 |
| Eosinophils >5000/mm3 | 42/63 (67) | 37/88 (42) | 66.7 (54.4, 77.1) | 58.0 (47.5, 67.7) | 53.2 (42.2, 63.8) | 70.8 (59.5, 80.1) | 2.76 (1.39, 5.46) | 0.003 |
| Positive ANCA | 16/63 (25) | 45/92 (49) | 25.4 (16.3, 37.3) | 51.1 (41.0, 61.1) | 26.2 (16.8, 38.4) | 50.0 (40.0, 59.9) | 0.36 (0.18, 0.73) | 0.004 |
| Positive MPO-ANCA | 12/63 (19) | 35/92 (38) | 19.1 (11.3, 30.4) | 62.0 (51.8, 71.2) | 25.5 (15.3, 39.5) | 52.8 (43.4, 61.9) | 0.38 (0.18, 0.81) | 0.01 |
| ECG | 68 | 96 | ||||||
| Abnormal ECG | 49 (72) | 31 (32) | 72.1 (60.4, 81.3) | 67.7 (57.8, 76.2) | 61.3 (50.3, 71.2) | 77.4 (67.4, 85.0) | 5.41 (2.73, 10.24) | <0.0001 |
| Repolarization abnormalities | 25 (37) | 12 (13) | 36.8 (26.3, 48.6) | 87.5 (79.4, 92.7) | 67.6 (51.5, 80.4) | 66.1 (57.6, 73.8) | 4.07 (1.93, 9.05) | 0.0005 |
| Rhythm abnormalities | 19 (28) | 10 (10) | 27.9 (18.7, 39.6) | 89.6 (81.9, 94.2) | 65.5 (47.4, 80.1) | 63.7 (55.3, 71.3) | 3.34 (1.40, 7.69) | 0.006 |
| Conduction abnormalities | 13 (19) | 12 (13) | 19.1 (11.5, 30.0) | 87.5 (79.4, 92.7) | 52.0 (33.5, 70.0) | 60.4 (52.1, 68.2) | 1.66 (0.68, 3.72) | 0.28 |
| Q wave abnormalities | 5 (7) | 4 (4) | 7.4 (3.2, 16.1) | 95.8 (90.0, 98.4) | 55.6 (26.7, 81.1) | 59.4 (51.5, 66.8) | 1.83 (0.52, 6.12) | 0.49 |
| Laboratory findings | ||||||||
| Increased troponin | 44/51 (86) | 6/52 (12) | 86.3 (74.3, 93.2) | 88.5 (77.0, 94.6) | 88.0 (76.2, 94.4) | 86.8 (75.2, 93.5) | 48.2 (14.87, 133) | <0.0001 |
| Increased NT-pro-BNP | 38/43 (88) | 10/46 (22) | 88.4 (75.5, 94.9) | 78.3 (64.4, 87.7) | 79.2 (65.7, 94.7) | 87.8 (74.5, 94.7) | 27.4 (8.46, 77.0) | <0.0001 |
| Transthoracic echography | 68 | 89 | ||||||
| Abnormal TTE | 49 (72) | 34 (38) | 72.1 (60.4, 81.3) | 61.8 (51.4, 71.2) | 59.0 (48.3, 69.0) | 74.3 (63.4, 82.9) | 4.17 (2.10, 7.98) | <0.0001 |
| Pericardial effusion | 28 (41) | 12 (13) | 41.2 (30.3, 53.0) | 86.5 (77.9, 92.1) | 70.0 (54.6, 81.9) | 65.8 (56.8, 73.8) | 4.49 (2.02, 9.94) | <0.0001 |
| Left ventricular dysfunction | 21 (31) | 2 (2) | 30.9 (21.2, 42.6) | 97.8 (92.2, 99.6) | 91.3 (73.2, 98.5) | 64.9 (56.5, 72.5) | 19.44 (4.65, 85.5) | <0.0001 |
| Hypokinetic areas | 22 (32) | 2 (2) | 32.4 (22.4, 44.2) | 97.8 (92.2, 99.6) | 91.7 (74.2, 98.5) | 65.4 (57.0, 73.0) | 20.80 (5.01, 91.3) | <0.0001 |
| Cardiac MRI | 67 | 60 | ||||||
| Abnormal CMRI | 66 (99) | 36 (60) | 98.5 (92.0, 99.9) | 40.0 (28.6, 52.6) | 64.7 (55.1, 73.3) | 96.0 (80.5, 99.8) | 44.0 (7.24, 461) | <0.0001 |
| Pericardial effusion | 27 (40) | 25 (42) | 40.3 (29.4, 52.3) | 58.3 (45.7, 69.9) | 51.9 (38.7, 64.9) | 46.7 (35.8, 57.8) | 0.95 (0.46, 1.95) | >0.99 |
| Pericardial GE | 18 (27) | 13 (22) | 26.9 (17.7, 38.5) | 78.3 (66.4, 86.9) | 58.1 (40.8, 73.6) | 49.0 (39.2, 58.8) | 1.33 (0.61, 3.07) | 0.54 |
| Left ventricular dysfunction | 32 (48) | 6 (10) | 47.8 (36.3, 59.5) | 90.0 (79.9, 95.3) | 84.2 (69.6, 92.6) | 60.7 (50.3, 70.2) | 8.23 (3.26, 20.97) | <0.0001 |
| Dilated left ventricle | 7 (10) | 3 (5) | 10.5 (5.2, 20.0) | 95.0 (86.3, 98.6) | 70.0 (39.7, 89.2) | 48.7 (39.9, 57.7) | 2.22 (0.57, 8.14) | 0.33 |
| Myocardial oedema | 15 (22) | 4 (7) | 22.4 (14.1, 33.7) | 93.3 (84.1, 97.4) | 79.0 (56.7, 91.5) | 51.9 (42.5, 61.1) | 4.04 (1.28, 11.66) | 0.02 |
| EGE | 24 (36) | 8 (13) | 35.8 (25.4, 47.8) | 86.7 (75.8, 93.1) | 75.0 (57.9, 86.9) | 54.7 (44.7, 64.4) | 3.63 (1.43, 8.60) | 0.004 |
| LGE | 47 (70) | 13 (22) | 70.2 (58.3, 79.8) | 78.3 (66.4, 86.9) | 78.3 (66.4, 86.9) | 70.2 (58.3, 79.8) | 8.50 (3.88, 18.41) | <0.0001 |
| Findings . | EGPA-CM (n = 70) . | No CM (n = 106) . | Sensitivity (95% CI), % . | Specificity (95% CI), % . | PPV (95% CI), % . | NPV (95% CI), % . | Diagnostic OR (95% CI) . | P . |
|---|---|---|---|---|---|---|---|---|
| Extra-cardiac features | ||||||||
| Peripheral neuropathy | 33/70 (47) | 69/106 (65) | 47.2 (35.9, 58.7) | 34.9 (26.5, 44.4) | 32.3 (24.1, 41.9) | 50.0 (38.9, 61.1) | 0.48 (0.26, 0.90) | 0.02 |
| Eosinophils >3000/mm3 | 49/63 (78) | 57/88 (65) | 77.8 (66.1, 86.3) | 35.2 (26.1, 45.6) | 46.2 (37.0, 55.7) | 68.9 (54.3, 80.5) | 1.90 (0.91, 3.85) | 0.10 |
| Eosinophils >5000/mm3 | 42/63 (67) | 37/88 (42) | 66.7 (54.4, 77.1) | 58.0 (47.5, 67.7) | 53.2 (42.2, 63.8) | 70.8 (59.5, 80.1) | 2.76 (1.39, 5.46) | 0.003 |
| Positive ANCA | 16/63 (25) | 45/92 (49) | 25.4 (16.3, 37.3) | 51.1 (41.0, 61.1) | 26.2 (16.8, 38.4) | 50.0 (40.0, 59.9) | 0.36 (0.18, 0.73) | 0.004 |
| Positive MPO-ANCA | 12/63 (19) | 35/92 (38) | 19.1 (11.3, 30.4) | 62.0 (51.8, 71.2) | 25.5 (15.3, 39.5) | 52.8 (43.4, 61.9) | 0.38 (0.18, 0.81) | 0.01 |
| ECG | 68 | 96 | ||||||
| Abnormal ECG | 49 (72) | 31 (32) | 72.1 (60.4, 81.3) | 67.7 (57.8, 76.2) | 61.3 (50.3, 71.2) | 77.4 (67.4, 85.0) | 5.41 (2.73, 10.24) | <0.0001 |
| Repolarization abnormalities | 25 (37) | 12 (13) | 36.8 (26.3, 48.6) | 87.5 (79.4, 92.7) | 67.6 (51.5, 80.4) | 66.1 (57.6, 73.8) | 4.07 (1.93, 9.05) | 0.0005 |
| Rhythm abnormalities | 19 (28) | 10 (10) | 27.9 (18.7, 39.6) | 89.6 (81.9, 94.2) | 65.5 (47.4, 80.1) | 63.7 (55.3, 71.3) | 3.34 (1.40, 7.69) | 0.006 |
| Conduction abnormalities | 13 (19) | 12 (13) | 19.1 (11.5, 30.0) | 87.5 (79.4, 92.7) | 52.0 (33.5, 70.0) | 60.4 (52.1, 68.2) | 1.66 (0.68, 3.72) | 0.28 |
| Q wave abnormalities | 5 (7) | 4 (4) | 7.4 (3.2, 16.1) | 95.8 (90.0, 98.4) | 55.6 (26.7, 81.1) | 59.4 (51.5, 66.8) | 1.83 (0.52, 6.12) | 0.49 |
| Laboratory findings | ||||||||
| Increased troponin | 44/51 (86) | 6/52 (12) | 86.3 (74.3, 93.2) | 88.5 (77.0, 94.6) | 88.0 (76.2, 94.4) | 86.8 (75.2, 93.5) | 48.2 (14.87, 133) | <0.0001 |
| Increased NT-pro-BNP | 38/43 (88) | 10/46 (22) | 88.4 (75.5, 94.9) | 78.3 (64.4, 87.7) | 79.2 (65.7, 94.7) | 87.8 (74.5, 94.7) | 27.4 (8.46, 77.0) | <0.0001 |
| Transthoracic echography | 68 | 89 | ||||||
| Abnormal TTE | 49 (72) | 34 (38) | 72.1 (60.4, 81.3) | 61.8 (51.4, 71.2) | 59.0 (48.3, 69.0) | 74.3 (63.4, 82.9) | 4.17 (2.10, 7.98) | <0.0001 |
| Pericardial effusion | 28 (41) | 12 (13) | 41.2 (30.3, 53.0) | 86.5 (77.9, 92.1) | 70.0 (54.6, 81.9) | 65.8 (56.8, 73.8) | 4.49 (2.02, 9.94) | <0.0001 |
| Left ventricular dysfunction | 21 (31) | 2 (2) | 30.9 (21.2, 42.6) | 97.8 (92.2, 99.6) | 91.3 (73.2, 98.5) | 64.9 (56.5, 72.5) | 19.44 (4.65, 85.5) | <0.0001 |
| Hypokinetic areas | 22 (32) | 2 (2) | 32.4 (22.4, 44.2) | 97.8 (92.2, 99.6) | 91.7 (74.2, 98.5) | 65.4 (57.0, 73.0) | 20.80 (5.01, 91.3) | <0.0001 |
| Cardiac MRI | 67 | 60 | ||||||
| Abnormal CMRI | 66 (99) | 36 (60) | 98.5 (92.0, 99.9) | 40.0 (28.6, 52.6) | 64.7 (55.1, 73.3) | 96.0 (80.5, 99.8) | 44.0 (7.24, 461) | <0.0001 |
| Pericardial effusion | 27 (40) | 25 (42) | 40.3 (29.4, 52.3) | 58.3 (45.7, 69.9) | 51.9 (38.7, 64.9) | 46.7 (35.8, 57.8) | 0.95 (0.46, 1.95) | >0.99 |
| Pericardial GE | 18 (27) | 13 (22) | 26.9 (17.7, 38.5) | 78.3 (66.4, 86.9) | 58.1 (40.8, 73.6) | 49.0 (39.2, 58.8) | 1.33 (0.61, 3.07) | 0.54 |
| Left ventricular dysfunction | 32 (48) | 6 (10) | 47.8 (36.3, 59.5) | 90.0 (79.9, 95.3) | 84.2 (69.6, 92.6) | 60.7 (50.3, 70.2) | 8.23 (3.26, 20.97) | <0.0001 |
| Dilated left ventricle | 7 (10) | 3 (5) | 10.5 (5.2, 20.0) | 95.0 (86.3, 98.6) | 70.0 (39.7, 89.2) | 48.7 (39.9, 57.7) | 2.22 (0.57, 8.14) | 0.33 |
| Myocardial oedema | 15 (22) | 4 (7) | 22.4 (14.1, 33.7) | 93.3 (84.1, 97.4) | 79.0 (56.7, 91.5) | 51.9 (42.5, 61.1) | 4.04 (1.28, 11.66) | 0.02 |
| EGE | 24 (36) | 8 (13) | 35.8 (25.4, 47.8) | 86.7 (75.8, 93.1) | 75.0 (57.9, 86.9) | 54.7 (44.7, 64.4) | 3.63 (1.43, 8.60) | 0.004 |
| LGE | 47 (70) | 13 (22) | 70.2 (58.3, 79.8) | 78.3 (66.4, 86.9) | 78.3 (66.4, 86.9) | 70.2 (58.3, 79.8) | 8.50 (3.88, 18.41) | <0.0001 |
CM: cardiomyopathy; CMRI: cardiac MRI; EGE: early gadolinium enhancement; EGPA: eosinophilic granulomatosis with polyangiitis; LGE: late gadolinium enhancement; NPV: negative predictive value; NT-pro-BNP: N-terminal (NT)-pro hormone brain natriuretic peptide; OR: odds ratio; Pericardial GE: pericardial gadolinium enhancement; PPV: positive predictive value; TTE: transthoracic echocardiogram.
This PDF is available to Subscribers Only
View Article Abstract & Purchase OptionsFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.
