Table 5. Open in new tab Gene Sets With...

GO/Pathway/Gene Set/Gene Name	Fisher’s Exact 2-Tailed	BMD Median (mg/kg bw/day)
Crypt—day 8
Eukaryotic Translation Elongation	0.09	1.74
Chylomicron clearance	0.09	2.51
Biosynthesis of maresins	0.003	3.05
Mitochondrial translation elongation	0.06	3.21
Mitochondrial translation termination	0.07	3.21
Crypt—day 91
Chemokine receptors bind chemokines	1.31E-04	1.60
Utilization of ketone bodies	0.05	2.65
PERK [protein kinase R (PKR)-like endoplasmic reticulum kinase] regulates gene expression	0.02	2.75
OAS [oligoadenylate synthetase] antiviral response	0.01	2.78
Glutathione conjugation	0.08	2.92
Villus—day 8
Pyrimidine catabolism	0.04	1.34
Butyrophilin family interactions	0.09	1.95
Gluconeogenesis	0.04	2.64
Nucleotide salvage	0.005	2.89
Eukaryotic Translation Elongation	0.004	2.95
Villus—day 91
0.08	0.16
HDMs demethylate histones	0.01	0.62
Drug-mediated inhibition of ERBB2 signaling	0.01	0.67
Nonhomologous end-joining	0.002	0.67
DDX58/IFIH1-mediated induction of interferon-alpha/beta	0.06	0.67

GO/Pathway/Gene Set/Gene Name

Fisher’s Exact 2-Tailed

BMD Median (mg/kg bw/day)

Crypt—day 8

Eukaryotic Translation Elongation

0.09

1.74

Chylomicron clearance

0.09

2.51

Biosynthesis of maresins

0.003

3.05

Mitochondrial translation elongation

0.06

3.21

Mitochondrial translation termination

0.07

3.21

Crypt—day 91

Chemokine receptors bind chemokines

1.31E-04

1.60

Utilization of ketone bodies

0.05

2.65

PERK [protein kinase R (PKR)-like endoplasmic reticulum kinase] regulates gene expression

0.02

2.75

OAS [oligoadenylate synthetase] antiviral response

0.01

2.78

Glutathione conjugation

0.08

2.92

Villus—day 8

Pyrimidine catabolism

0.04

1.34

Butyrophilin family interactions

0.09

1.95

Gluconeogenesis

0.04

2.64

Nucleotide salvage

0.005

2.89

Eukaryotic Translation Elongation

0.004

2.95

Villus—day 91

0.08

0.16

HDMs demethylate histones

0.01

0.62

Drug-mediated inhibition of ERBB2 signaling

0.01

0.67

Nonhomologous end-joining

0.002

0.67

DDX58/IFIH1-mediated induction of interferon-alpha/beta

0.06

0.67

GO/Pathway/Gene Set/Gene Name	Fisher’s Exact 2-Tailed	BMD Median (mg/kg bw/day)
Crypt—day 8
Eukaryotic Translation Elongation	0.09	1.74
Chylomicron clearance	0.09	2.51
Biosynthesis of maresins	0.003	3.05
Mitochondrial translation elongation	0.06	3.21
Mitochondrial translation termination	0.07	3.21
Crypt—day 91
Chemokine receptors bind chemokines	1.31E-04	1.60
Utilization of ketone bodies	0.05	2.65
PERK [protein kinase R (PKR)-like endoplasmic reticulum kinase] regulates gene expression	0.02	2.75
OAS [oligoadenylate synthetase] antiviral response	0.01	2.78
Glutathione conjugation	0.08	2.92
Villus—day 8
Pyrimidine catabolism	0.04	1.34
Butyrophilin family interactions	0.09	1.95
Gluconeogenesis	0.04	2.64
Nucleotide salvage	0.005	2.89
Eukaryotic Translation Elongation	0.004	2.95
Villus—day 91
0.08	0.16
HDMs demethylate histones	0.01	0.62
Drug-mediated inhibition of ERBB2 signaling	0.01	0.67
Nonhomologous end-joining	0.002	0.67
DDX58/IFIH1-mediated induction of interferon-alpha/beta	0.06	0.67

Table 5.

Open in new tab

Gene Sets With the Lowest 5 BMD Median Values Among the Significantly Enriched Gene Sets by Functional Classification Within BMD Analysis (Defined by p Value < .1 From Fisher’s Exact Two-Tailed Test Considering Significantly Dose-Responsive Genes as Determined by BMDExpress) for Each Tissue Compartment at Each Timepoint

Sialic acid metabolism

GO/Pathway/Gene Set/Gene Name	Fisher’s Exact 2-Tailed	BMD Median (mg/kg bw/day)
Crypt—day 8
Eukaryotic Translation Elongation	0.09	1.74
Chylomicron clearance	0.09	2.51
Biosynthesis of maresins	0.003	3.05
Mitochondrial translation elongation	0.06	3.21
Mitochondrial translation termination	0.07	3.21
Crypt—day 91
Chemokine receptors bind chemokines	1.31E-04	1.60
Utilization of ketone bodies	0.05	2.65
PERK [protein kinase R (PKR)-like endoplasmic reticulum kinase] regulates gene expression	0.02	2.75
OAS [oligoadenylate synthetase] antiviral response	0.01	2.78
Glutathione conjugation	0.08	2.92
Villus—day 8
Pyrimidine catabolism	0.04	1.34
Butyrophilin family interactions	0.09	1.95
Gluconeogenesis	0.04	2.64
Nucleotide salvage	0.005	2.89
Eukaryotic Translation Elongation	0.004	2.95
Villus—day 91
0.08	0.16
HDMs demethylate histones	0.01	0.62
Drug-mediated inhibition of ERBB2 signaling	0.01	0.67
Nonhomologous end-joining	0.002	0.67
DDX58/IFIH1-mediated induction of interferon-alpha/beta	0.06	0.67

GO/Pathway/Gene Set/Gene Name	Fisher’s Exact 2-Tailed	BMD Median (mg/kg bw/day)
Crypt—day 8
Eukaryotic Translation Elongation	0.09	1.74
Chylomicron clearance	0.09	2.51
Biosynthesis of maresins	0.003	3.05
Mitochondrial translation elongation	0.06	3.21
Mitochondrial translation termination	0.07	3.21
Crypt—day 91
Chemokine receptors bind chemokines	1.31E-04	1.60
Utilization of ketone bodies	0.05	2.65
PERK [protein kinase R (PKR)-like endoplasmic reticulum kinase] regulates gene expression	0.02	2.75
OAS [oligoadenylate synthetase] antiviral response	0.01	2.78
Glutathione conjugation	0.08	2.92
Villus—day 8
Pyrimidine catabolism	0.04	1.34
Butyrophilin family interactions	0.09	1.95
Gluconeogenesis	0.04	2.64
Nucleotide salvage	0.005	2.89
Eukaryotic Translation Elongation	0.004	2.95
Villus—day 91
0.08	0.16
HDMs demethylate histones	0.01	0.62
Drug-mediated inhibition of ERBB2 signaling	0.01	0.67
Nonhomologous end-joining	0.002	0.67
DDX58/IFIH1-mediated induction of interferon-alpha/beta	0.06	0.67

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