Significant correlations between increases in connectivity between pairs of brain regions and behavioral improvement in at least two out of three clinical outcome measures
| . | Vineland socialization . | Expressive One Word Picture Vocabulary . | Clinical Global Impression-Improvement . | ||||
|---|---|---|---|---|---|---|---|
| r . | p . | r . | p . | r . | p . | ||
| R frontal pole | R pallidum | .51 | .03 | .48 | .04 | −.60 | .006 |
| L fusiform | L sup temporal | .47 | .04 | .47 | .04 | −.47 | .04 |
| L superior temporal | L putamen | .49 | .03 | .50 | .03 | — | — |
| L inferior temporal | L superior temporal | .60 | .0065 | — | — | −.49 | .04 |
| L thalamus | L hippocampus | .59 | .009 | — | — | −.48 | .04 |
| L temporal pole | L pallidum | .55 | .02 | — | — | −.52 | .02 |
| R frontal pole | R temporal pole | — | — | .64 | .003 | −.70 | .0009 |
| R superior temporal | R pallidum | — | — | .50 | .03 | −.50 | .03 |
| R rostral middle frontal | R pallidum | — | — | .49 | .03 | −.55 | .02 |
| L fusiform | L middle temporal | — | — | .46 | .046 | −.47 | .04 |
| . | Vineland socialization . | Expressive One Word Picture Vocabulary . | Clinical Global Impression-Improvement . | ||||
|---|---|---|---|---|---|---|---|
| r . | p . | r . | p . | r . | p . | ||
| R frontal pole | R pallidum | .51 | .03 | .48 | .04 | −.60 | .006 |
| L fusiform | L sup temporal | .47 | .04 | .47 | .04 | −.47 | .04 |
| L superior temporal | L putamen | .49 | .03 | .50 | .03 | — | — |
| L inferior temporal | L superior temporal | .60 | .0065 | — | — | −.49 | .04 |
| L thalamus | L hippocampus | .59 | .009 | — | — | −.48 | .04 |
| L temporal pole | L pallidum | .55 | .02 | — | — | −.52 | .02 |
| R frontal pole | R temporal pole | — | — | .64 | .003 | −.70 | .0009 |
| R superior temporal | R pallidum | — | — | .50 | .03 | −.50 | .03 |
| R rostral middle frontal | R pallidum | — | — | .49 | .03 | −.55 | .02 |
| L fusiform | L middle temporal | — | — | .46 | .046 | −.47 | .04 |
Associations between changes in frontal, temporal, and subcortical region of interest connectivity and changes in behavior between baseline and 6 month visits were examined using the Spearman rank correlations. Higher scores on the Vineland socialization subscale and Expressive One-Word Picture Vocabulary Test and lower scores on the Clinical Global Impression-Improvement represent improved functioning.
Abbreviation: R, right hemisphere; L, Left hemisphere.
Significant correlations between increases in connectivity between pairs of brain regions and behavioral improvement in at least two out of three clinical outcome measures
| . | Vineland socialization . | Expressive One Word Picture Vocabulary . | Clinical Global Impression-Improvement . | ||||
|---|---|---|---|---|---|---|---|
| r . | p . | r . | p . | r . | p . | ||
| R frontal pole | R pallidum | .51 | .03 | .48 | .04 | −.60 | .006 |
| L fusiform | L sup temporal | .47 | .04 | .47 | .04 | −.47 | .04 |
| L superior temporal | L putamen | .49 | .03 | .50 | .03 | — | — |
| L inferior temporal | L superior temporal | .60 | .0065 | — | — | −.49 | .04 |
| L thalamus | L hippocampus | .59 | .009 | — | — | −.48 | .04 |
| L temporal pole | L pallidum | .55 | .02 | — | — | −.52 | .02 |
| R frontal pole | R temporal pole | — | — | .64 | .003 | −.70 | .0009 |
| R superior temporal | R pallidum | — | — | .50 | .03 | −.50 | .03 |
| R rostral middle frontal | R pallidum | — | — | .49 | .03 | −.55 | .02 |
| L fusiform | L middle temporal | — | — | .46 | .046 | −.47 | .04 |
| . | Vineland socialization . | Expressive One Word Picture Vocabulary . | Clinical Global Impression-Improvement . | ||||
|---|---|---|---|---|---|---|---|
| r . | p . | r . | p . | r . | p . | ||
| R frontal pole | R pallidum | .51 | .03 | .48 | .04 | −.60 | .006 |
| L fusiform | L sup temporal | .47 | .04 | .47 | .04 | −.47 | .04 |
| L superior temporal | L putamen | .49 | .03 | .50 | .03 | — | — |
| L inferior temporal | L superior temporal | .60 | .0065 | — | — | −.49 | .04 |
| L thalamus | L hippocampus | .59 | .009 | — | — | −.48 | .04 |
| L temporal pole | L pallidum | .55 | .02 | — | — | −.52 | .02 |
| R frontal pole | R temporal pole | — | — | .64 | .003 | −.70 | .0009 |
| R superior temporal | R pallidum | — | — | .50 | .03 | −.50 | .03 |
| R rostral middle frontal | R pallidum | — | — | .49 | .03 | −.55 | .02 |
| L fusiform | L middle temporal | — | — | .46 | .046 | −.47 | .04 |
Associations between changes in frontal, temporal, and subcortical region of interest connectivity and changes in behavior between baseline and 6 month visits were examined using the Spearman rank correlations. Higher scores on the Vineland socialization subscale and Expressive One-Word Picture Vocabulary Test and lower scores on the Clinical Global Impression-Improvement represent improved functioning.
Abbreviation: R, right hemisphere; L, Left hemisphere.
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