Table 1. Open in new tab HIV-RNA and...

Subject ID	Regimen type	Semen HIV-1- RNA (log₁₀ copies/mL)	Semen total HIV-1-DNA (log₁₀ copies/10⁶ cells)	Plasma HIV-1- RNA (log₁₀ copies/mL)	Blood total HIV-1-DNA (log₁₀ copies/10⁶ PBMCs)	Observations
#1	DTG	(W2) 2.75	1.79	(W2) 2.84	<3.20	4.16	<0.52	3.22	2.76	self-reported correct treatment adherence until W24; no response for W48
#2	DTG	6.48	2.94	NA	NA	6.39	1.69	3.72	2.83	self-reported adherence failures at W4 and W48
#3	DRV	NA	2.40	NA	1.88	6.45	detected <0.52	4.21	2.74	self-reported adherence failures at W4 and W24
#4	DRV	6.04	1.57	1.59	<1.50	5.74	1.00	3.96	2.80	self-reported adherence failures at W8 and W24
#5	DRV	NA	3.28	NA	<2.11	6.89	2.20	4.26	3.56	self-reported correct treatment adherence until W12; no responses for W24 and W48; STI W24, W36 and W48
#6	DRV	NA	1.50	NA	<1.99	5.85	1.75	4.05	3.15	self-reported adherence failures at W8, W24, W36 and W48; STI W24
#7	DRV	(W2) <1.71	<2.13	(W2) <1.71	2.36	4.94	0.48	3.18	2.39	self-reported adherence failures at W4, W8, W36 and W48; STI W36
#8	DTG	NA	<2.01	NA	2.57	5.31	1.18	3.76	2.76	self-reported adherence failures at each timepoint

Subject ID

Regimen type

Semen HIV-1- RNA (log₁₀ copies/mL)

Semen total HIV-1-DNA (log₁₀ copies/10⁶ cells)

Plasma HIV-1- RNA (log₁₀ copies/mL)

Blood total HIV-1-DNA (log₁₀ copies/10⁶ PBMCs)

Observations

W48

DTG

(W2) 2.75

1.79

(W2) 2.84

<3.20

4.16

<0.52

3.22

2.76

self-reported correct treatment adherence until W24; no response for W48

DTG

6.48

2.94

6.39

1.69

3.72

2.83

self-reported adherence failures at W4 and W48

DRV

2.40

1.88

6.45

detected <0.52

4.21

2.74

self-reported adherence failures at W4 and W24

DRV

6.04

1.57

1.59

<1.50

5.74

1.00

3.96

2.80

self-reported adherence failures at W8 and W24

DRV

3.28

<2.11

6.89

2.20

4.26

3.56

self-reported correct treatment adherence until W12; no responses for W24 and W48; STI W24, W36 and W48

DRV

1.50

<1.99

5.85

1.75

4.05

3.15

self-reported adherence failures at W8, W24, W36 and W48; STI W24

DRV

(W2) <1.71

<2.13

(W2) <1.71

2.36

4.94

0.48

3.18

2.39

self-reported adherence failures at W4, W8, W36 and W48; STI W36

DTG

<2.01

2.57

5.31

1.18

3.76

2.76

self-reported adherence failures at each timepoint

Subject ID	Regimen type	Semen HIV-1- RNA (log₁₀ copies/mL)	Semen total HIV-1-DNA (log₁₀ copies/10⁶ cells)	Plasma HIV-1- RNA (log₁₀ copies/mL)	Blood total HIV-1-DNA (log₁₀ copies/10⁶ PBMCs)	Observations
#1	DTG	(W2) 2.75	1.79	(W2) 2.84	<3.20	4.16	<0.52	3.22	2.76	self-reported correct treatment adherence until W24; no response for W48
#2	DTG	6.48	2.94	NA	NA	6.39	1.69	3.72	2.83	self-reported adherence failures at W4 and W48
#3	DRV	NA	2.40	NA	1.88	6.45	detected <0.52	4.21	2.74	self-reported adherence failures at W4 and W24
#4	DRV	6.04	1.57	1.59	<1.50	5.74	1.00	3.96	2.80	self-reported adherence failures at W8 and W24
#5	DRV	NA	3.28	NA	<2.11	6.89	2.20	4.26	3.56	self-reported correct treatment adherence until W12; no responses for W24 and W48; STI W24, W36 and W48
#6	DRV	NA	1.50	NA	<1.99	5.85	1.75	4.05	3.15	self-reported adherence failures at W8, W24, W36 and W48; STI W24
#7	DRV	(W2) <1.71	<2.13	(W2) <1.71	2.36	4.94	0.48	3.18	2.39	self-reported adherence failures at W4, W8, W36 and W48; STI W36
#8	DTG	NA	<2.01	NA	2.57	5.31	1.18	3.76	2.76	self-reported adherence failures at each timepoint

Table 1.

Open in new tab

HIV-RNA and total HIV-DNA loads in plasma and semen in patients with detectable HIV-RNA or HIV-DNA in semen at W48

Subject ID	Regimen type	Semen HIV-1- RNA (log₁₀ copies/mL)		Semen total HIV-1-DNA (log₁₀ copies/10⁶ cells)		Plasma HIV-1- RNA (log₁₀ copies/mL)		Blood total HIV-1-DNA (log₁₀ copies/10⁶ PBMCs)		Observations
Subject ID	Regimen type	W0	W48	W0	W48	W0	W48	W0	W48	Observations
#1	DTG	(W2) 2.75	1.79	(W2) 2.84	<3.20	4.16	<0.52	3.22	2.76	self-reported correct treatment adherence until W24; no response for W48
#2	DTG	6.48	2.94	NA	NA	6.39	1.69	3.72	2.83	self-reported adherence failures at W4 and W48
#3	DRV	NA	2.40	NA	1.88	6.45	detected <0.52	4.21	2.74	self-reported adherence failures at W4 and W24
#4	DRV	6.04	1.57	1.59	<1.50	5.74	1.00	3.96	2.80	self-reported adherence failures at W8 and W24
#5	DRV	NA	3.28	NA	<2.11	6.89	2.20	4.26	3.56	self-reported correct treatment adherence until W12; no responses for W24 and W48; STI W24, W36 and W48
#6	DRV	NA	1.50	NA	<1.99	5.85	1.75	4.05	3.15	self-reported adherence failures at W8, W24, W36 and W48; STI W24
#7	DRV	(W2) <1.71	<2.13	(W2) <1.71	2.36	4.94	0.48	3.18	2.39	self-reported adherence failures at W4, W8, W36 and W48; STI W36
#8	DTG	NA	<2.01	NA	2.57	5.31	1.18	3.76	2.76	self-reported adherence failures at each timepoint

Subject ID	Regimen type	Semen HIV-1- RNA (log₁₀ copies/mL)		Semen total HIV-1-DNA (log₁₀ copies/10⁶ cells)		Plasma HIV-1- RNA (log₁₀ copies/mL)		Blood total HIV-1-DNA (log₁₀ copies/10⁶ PBMCs)		Observations
Subject ID	Regimen type	W0	W48	W0	W48	W0	W48	W0	W48	Observations
#1	DTG	(W2) 2.75	1.79	(W2) 2.84	<3.20	4.16	<0.52	3.22	2.76	self-reported correct treatment adherence until W24; no response for W48
#2	DTG	6.48	2.94	NA	NA	6.39	1.69	3.72	2.83	self-reported adherence failures at W4 and W48
#3	DRV	NA	2.40	NA	1.88	6.45	detected <0.52	4.21	2.74	self-reported adherence failures at W4 and W24
#4	DRV	6.04	1.57	1.59	<1.50	5.74	1.00	3.96	2.80	self-reported adherence failures at W8 and W24
#5	DRV	NA	3.28	NA	<2.11	6.89	2.20	4.26	3.56	self-reported correct treatment adherence until W12; no responses for W24 and W48; STI W24, W36 and W48
#6	DRV	NA	1.50	NA	<1.99	5.85	1.75	4.05	3.15	self-reported adherence failures at W8, W24, W36 and W48; STI W24
#7	DRV	(W2) <1.71	<2.13	(W2) <1.71	2.36	4.94	0.48	3.18	2.39	self-reported adherence failures at W4, W8, W36 and W48; STI W36
#8	DTG	NA	<2.01	NA	2.57	5.31	1.18	3.76	2.76	self-reported adherence failures at each timepoint

NA, not available; DTG, dolutegravir-based regimen; DRV, darunavir-based regimen; STI, sexually transmitted infection.

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