| Histologic/clinical feature . | ING (n = 48) . | DN (n = 751) . | P-value . |
|---|---|---|---|
| Mean glomerular obsolescence, % | 33 ± 23.7 (n = 48) | 34.4 ± 23 (n = 672) | 0.733 |
| RPS classification,a % | n = 48 | n = 672 | 0.15 |
| Class II | 33.3 | 21.9 | |
| Class III | 43.8 | 55.9 | |
| Class IV | 22.9 | 22.2 | |
| Interstitial fibrosis/tubular atrophy, % | n = 45 | n = 568 | 0.63 |
| None | 0 | 0 | |
| Mild | 11.1 | 8.0 | |
| Moderate | 48.9 | 53.5 | |
| Severe | 40.0 | 38.2 | |
| Arteriolosclerosis, % | n = 44 | n = 601 | <0.001 |
| None | 2.3 | 1.5 | |
| Mild | 18.2 | 6.8 | |
| Moderate | 61.3 | 44.9 | |
| Severe | 18.2 | 46.8 | |
| Extra efferent neovascularization, % | n = 46 | n = 10 | |
| Any neoarteriole present (Y) | 65.2 | 40.0 | 0.29 |
| Proportion of glomeruli with neoarteriolesb | 36.4 ± 28.1 | 30.7 ± 16.1 | 0.70 |
| Number of arterioles presentb | 7.0 ± 4.3 | 4.4 ± 1.6 | 0.05 |
| Podocyte effacement, % | n = 48 | n = 749 | 0.088 |
| Widespread or >75% | 37.5 | 25.4 | |
| Patchy or nonspecific | 62.5 | 74.4 | |
| GBM thickness | n = 48 | n = 601 | |
| GBM >520 nm in men or >471 nm in women, % | 79.2 | 93.1 | <0.001 |
| Mean GBM thickness, nm | 836 ± 322 | 857 ± 222 | 0.76 |
| Concomitant ATN, % | 18.9 | 15.4 | 0.54 |
| Concomitant FSGS | 14.6 | 6.1 | 0.034 |
| Mean age, years | 68.1 ± 13.1 | 55.6 ± 12.7 | <0.001 |
| Gender (M:F) | 26:22 | 415:336 | 0.88 |
| Ethnicity (White:Black:Hispanic:other) | 36:6:0:6 | 491:173:9:78 | 0.33 |
| Average proteinuria, g/day | 4.0 ± 3.5 (n = 42) | 7.5 ± 7.3 (n = 246) | <0.001 |
| Nephrotic range, % | 40.5 (n = 42) | 63.4 (n = 246) | <0.001 |
| Mean Cr at time of biopsy, mg/dL | 3.21 ± 1.3 (n = 46) | 3.09 ± 1.9 (n = 415) | 0.56 |
| Renal insufficiency (Cr >1.2 mg/dL), % | 81.3 (n = 46) | 90.1 (n = 415) | 0.081 |
| Hypertension, % | 95.8 | 86.6 | 0.073 |
| Smoking, % | 66.7 (n = 40) | 49.2 (n = 415) | 0.023 |
| Mean BMI, kg/m2 | 28.3 ± 5.4 (n = 28) | 31.6 ± 6.9 (n = 228) | 0.004 |
| Histologic/clinical feature . | ING (n = 48) . | DN (n = 751) . | P-value . |
|---|---|---|---|
| Mean glomerular obsolescence, % | 33 ± 23.7 (n = 48) | 34.4 ± 23 (n = 672) | 0.733 |
| RPS classification,a % | n = 48 | n = 672 | 0.15 |
| Class II | 33.3 | 21.9 | |
| Class III | 43.8 | 55.9 | |
| Class IV | 22.9 | 22.2 | |
| Interstitial fibrosis/tubular atrophy, % | n = 45 | n = 568 | 0.63 |
| None | 0 | 0 | |
| Mild | 11.1 | 8.0 | |
| Moderate | 48.9 | 53.5 | |
| Severe | 40.0 | 38.2 | |
| Arteriolosclerosis, % | n = 44 | n = 601 | <0.001 |
| None | 2.3 | 1.5 | |
| Mild | 18.2 | 6.8 | |
| Moderate | 61.3 | 44.9 | |
| Severe | 18.2 | 46.8 | |
| Extra efferent neovascularization, % | n = 46 | n = 10 | |
| Any neoarteriole present (Y) | 65.2 | 40.0 | 0.29 |
| Proportion of glomeruli with neoarteriolesb | 36.4 ± 28.1 | 30.7 ± 16.1 | 0.70 |
| Number of arterioles presentb | 7.0 ± 4.3 | 4.4 ± 1.6 | 0.05 |
| Podocyte effacement, % | n = 48 | n = 749 | 0.088 |
| Widespread or >75% | 37.5 | 25.4 | |
| Patchy or nonspecific | 62.5 | 74.4 | |
| GBM thickness | n = 48 | n = 601 | |
| GBM >520 nm in men or >471 nm in women, % | 79.2 | 93.1 | <0.001 |
| Mean GBM thickness, nm | 836 ± 322 | 857 ± 222 | 0.76 |
| Concomitant ATN, % | 18.9 | 15.4 | 0.54 |
| Concomitant FSGS | 14.6 | 6.1 | 0.034 |
| Mean age, years | 68.1 ± 13.1 | 55.6 ± 12.7 | <0.001 |
| Gender (M:F) | 26:22 | 415:336 | 0.88 |
| Ethnicity (White:Black:Hispanic:other) | 36:6:0:6 | 491:173:9:78 | 0.33 |
| Average proteinuria, g/day | 4.0 ± 3.5 (n = 42) | 7.5 ± 7.3 (n = 246) | <0.001 |
| Nephrotic range, % | 40.5 (n = 42) | 63.4 (n = 246) | <0.001 |
| Mean Cr at time of biopsy, mg/dL | 3.21 ± 1.3 (n = 46) | 3.09 ± 1.9 (n = 415) | 0.56 |
| Renal insufficiency (Cr >1.2 mg/dL), % | 81.3 (n = 46) | 90.1 (n = 415) | 0.081 |
| Hypertension, % | 95.8 | 86.6 | 0.073 |
| Smoking, % | 66.7 (n = 40) | 49.2 (n = 415) | 0.023 |
| Mean BMI, kg/m2 | 28.3 ± 5.4 (n = 28) | 31.6 ± 6.9 (n = 228) | 0.004 |
Comparison of the histopathologic and clinical characteristics of the subjects with a primary diagnosis of ING versus subjects with a primary diagnosis of nodular DN. All available data were used, with the sample size for each group indicated when data was available for less than the entire cohort. aRPS guidelines for classification of DN were applied to DN and adapted for ING specimens. bThe proportion of glomeruli with neoarterioles and total arterioles in samples with any neoarterioles, samples with no neoarterioles were excluded. The number of arterioles includes the first afferent and efferent arteriole as well as neoarterioles.
| Histologic/clinical feature . | ING (n = 48) . | DN (n = 751) . | P-value . |
|---|---|---|---|
| Mean glomerular obsolescence, % | 33 ± 23.7 (n = 48) | 34.4 ± 23 (n = 672) | 0.733 |
| RPS classification,a % | n = 48 | n = 672 | 0.15 |
| Class II | 33.3 | 21.9 | |
| Class III | 43.8 | 55.9 | |
| Class IV | 22.9 | 22.2 | |
| Interstitial fibrosis/tubular atrophy, % | n = 45 | n = 568 | 0.63 |
| None | 0 | 0 | |
| Mild | 11.1 | 8.0 | |
| Moderate | 48.9 | 53.5 | |
| Severe | 40.0 | 38.2 | |
| Arteriolosclerosis, % | n = 44 | n = 601 | <0.001 |
| None | 2.3 | 1.5 | |
| Mild | 18.2 | 6.8 | |
| Moderate | 61.3 | 44.9 | |
| Severe | 18.2 | 46.8 | |
| Extra efferent neovascularization, % | n = 46 | n = 10 | |
| Any neoarteriole present (Y) | 65.2 | 40.0 | 0.29 |
| Proportion of glomeruli with neoarteriolesb | 36.4 ± 28.1 | 30.7 ± 16.1 | 0.70 |
| Number of arterioles presentb | 7.0 ± 4.3 | 4.4 ± 1.6 | 0.05 |
| Podocyte effacement, % | n = 48 | n = 749 | 0.088 |
| Widespread or >75% | 37.5 | 25.4 | |
| Patchy or nonspecific | 62.5 | 74.4 | |
| GBM thickness | n = 48 | n = 601 | |
| GBM >520 nm in men or >471 nm in women, % | 79.2 | 93.1 | <0.001 |
| Mean GBM thickness, nm | 836 ± 322 | 857 ± 222 | 0.76 |
| Concomitant ATN, % | 18.9 | 15.4 | 0.54 |
| Concomitant FSGS | 14.6 | 6.1 | 0.034 |
| Mean age, years | 68.1 ± 13.1 | 55.6 ± 12.7 | <0.001 |
| Gender (M:F) | 26:22 | 415:336 | 0.88 |
| Ethnicity (White:Black:Hispanic:other) | 36:6:0:6 | 491:173:9:78 | 0.33 |
| Average proteinuria, g/day | 4.0 ± 3.5 (n = 42) | 7.5 ± 7.3 (n = 246) | <0.001 |
| Nephrotic range, % | 40.5 (n = 42) | 63.4 (n = 246) | <0.001 |
| Mean Cr at time of biopsy, mg/dL | 3.21 ± 1.3 (n = 46) | 3.09 ± 1.9 (n = 415) | 0.56 |
| Renal insufficiency (Cr >1.2 mg/dL), % | 81.3 (n = 46) | 90.1 (n = 415) | 0.081 |
| Hypertension, % | 95.8 | 86.6 | 0.073 |
| Smoking, % | 66.7 (n = 40) | 49.2 (n = 415) | 0.023 |
| Mean BMI, kg/m2 | 28.3 ± 5.4 (n = 28) | 31.6 ± 6.9 (n = 228) | 0.004 |
| Histologic/clinical feature . | ING (n = 48) . | DN (n = 751) . | P-value . |
|---|---|---|---|
| Mean glomerular obsolescence, % | 33 ± 23.7 (n = 48) | 34.4 ± 23 (n = 672) | 0.733 |
| RPS classification,a % | n = 48 | n = 672 | 0.15 |
| Class II | 33.3 | 21.9 | |
| Class III | 43.8 | 55.9 | |
| Class IV | 22.9 | 22.2 | |
| Interstitial fibrosis/tubular atrophy, % | n = 45 | n = 568 | 0.63 |
| None | 0 | 0 | |
| Mild | 11.1 | 8.0 | |
| Moderate | 48.9 | 53.5 | |
| Severe | 40.0 | 38.2 | |
| Arteriolosclerosis, % | n = 44 | n = 601 | <0.001 |
| None | 2.3 | 1.5 | |
| Mild | 18.2 | 6.8 | |
| Moderate | 61.3 | 44.9 | |
| Severe | 18.2 | 46.8 | |
| Extra efferent neovascularization, % | n = 46 | n = 10 | |
| Any neoarteriole present (Y) | 65.2 | 40.0 | 0.29 |
| Proportion of glomeruli with neoarteriolesb | 36.4 ± 28.1 | 30.7 ± 16.1 | 0.70 |
| Number of arterioles presentb | 7.0 ± 4.3 | 4.4 ± 1.6 | 0.05 |
| Podocyte effacement, % | n = 48 | n = 749 | 0.088 |
| Widespread or >75% | 37.5 | 25.4 | |
| Patchy or nonspecific | 62.5 | 74.4 | |
| GBM thickness | n = 48 | n = 601 | |
| GBM >520 nm in men or >471 nm in women, % | 79.2 | 93.1 | <0.001 |
| Mean GBM thickness, nm | 836 ± 322 | 857 ± 222 | 0.76 |
| Concomitant ATN, % | 18.9 | 15.4 | 0.54 |
| Concomitant FSGS | 14.6 | 6.1 | 0.034 |
| Mean age, years | 68.1 ± 13.1 | 55.6 ± 12.7 | <0.001 |
| Gender (M:F) | 26:22 | 415:336 | 0.88 |
| Ethnicity (White:Black:Hispanic:other) | 36:6:0:6 | 491:173:9:78 | 0.33 |
| Average proteinuria, g/day | 4.0 ± 3.5 (n = 42) | 7.5 ± 7.3 (n = 246) | <0.001 |
| Nephrotic range, % | 40.5 (n = 42) | 63.4 (n = 246) | <0.001 |
| Mean Cr at time of biopsy, mg/dL | 3.21 ± 1.3 (n = 46) | 3.09 ± 1.9 (n = 415) | 0.56 |
| Renal insufficiency (Cr >1.2 mg/dL), % | 81.3 (n = 46) | 90.1 (n = 415) | 0.081 |
| Hypertension, % | 95.8 | 86.6 | 0.073 |
| Smoking, % | 66.7 (n = 40) | 49.2 (n = 415) | 0.023 |
| Mean BMI, kg/m2 | 28.3 ± 5.4 (n = 28) | 31.6 ± 6.9 (n = 228) | 0.004 |
Comparison of the histopathologic and clinical characteristics of the subjects with a primary diagnosis of ING versus subjects with a primary diagnosis of nodular DN. All available data were used, with the sample size for each group indicated when data was available for less than the entire cohort. aRPS guidelines for classification of DN were applied to DN and adapted for ING specimens. bThe proportion of glomeruli with neoarterioles and total arterioles in samples with any neoarterioles, samples with no neoarterioles were excluded. The number of arterioles includes the first afferent and efferent arteriole as well as neoarterioles.
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