| Key clinical findings . | BBCI cohort . | Markowitz et al. 2002 [3] . | Li and Verani 2008 [5] . | Wu et al. 2014 [4] . | Hamrahian et al. 2018 [6] . | Salvatore et al. 2015 [7] . | Pooled data . |
|---|---|---|---|---|---|---|---|
| N | 48 | 23 | 15 | 20 | 17 | 4 | 127 |
| Study period | 2001–16 | 1996–2001 | 1998–2007 | 2009–11 | 1999–2014 | 2003–12 | – |
| Mean age, years | 68.1 | 68 | 64 | 55.5 | 60.2 | 62 | 64.2 |
| Gender (M:F) | 26:22 | 18:05 | 5:10 | 16:04 | 13:04 | 4:0 | 82:45 |
| Ethnicity (White:Black:Hispanic:other) | 36:6:0:6 | 17:6:0:0 | 11:3:1:0 | 20 Asian | 7:7:1:2 | 4:0:0:0 | 75:22:2:28 |
| Average proteinuria, g/day | 4.0 | 4.7 | 5.6 | 2.85 | 3.53 | 3.0 | 4.1 |
| Nephrotic range,a % | 60.4 | 69.6 | 73 | 35 | 40 | Unknown | 56.7 |
| Mean Cr at time of biopsy,b mg/dL | 3.21 | 2.4 | 2.8 | 4.23 | 2.35 | 1.9 | 3.03 |
| Renal insufficiency (Cr >1.2 mg/dL),b % | 81.3 | 82.6 | 93 | 95 | 94 | 100 | 87.1 |
| Hyperlipidemia, % | 60.4 | 90 | Unknown | 50 | Unknown | Unknown | 65.3 |
| Hypertension, % | 95.8 | 95 | 93 | 90 | 100 | 100 | 95.3 |
| Smoking, % | 66.7 | 91 | 67 | 85 | 65 | 50 | 73.8 |
| Obesity, % | 42.9c | 13 | 60 | 40 | 37.5c | Unknown | 37.3 |
| Key clinical findings . | BBCI cohort . | Markowitz et al. 2002 [3] . | Li and Verani 2008 [5] . | Wu et al. 2014 [4] . | Hamrahian et al. 2018 [6] . | Salvatore et al. 2015 [7] . | Pooled data . |
|---|---|---|---|---|---|---|---|
| N | 48 | 23 | 15 | 20 | 17 | 4 | 127 |
| Study period | 2001–16 | 1996–2001 | 1998–2007 | 2009–11 | 1999–2014 | 2003–12 | – |
| Mean age, years | 68.1 | 68 | 64 | 55.5 | 60.2 | 62 | 64.2 |
| Gender (M:F) | 26:22 | 18:05 | 5:10 | 16:04 | 13:04 | 4:0 | 82:45 |
| Ethnicity (White:Black:Hispanic:other) | 36:6:0:6 | 17:6:0:0 | 11:3:1:0 | 20 Asian | 7:7:1:2 | 4:0:0:0 | 75:22:2:28 |
| Average proteinuria, g/day | 4.0 | 4.7 | 5.6 | 2.85 | 3.53 | 3.0 | 4.1 |
| Nephrotic range,a % | 60.4 | 69.6 | 73 | 35 | 40 | Unknown | 56.7 |
| Mean Cr at time of biopsy,b mg/dL | 3.21 | 2.4 | 2.8 | 4.23 | 2.35 | 1.9 | 3.03 |
| Renal insufficiency (Cr >1.2 mg/dL),b % | 81.3 | 82.6 | 93 | 95 | 94 | 100 | 87.1 |
| Hyperlipidemia, % | 60.4 | 90 | Unknown | 50 | Unknown | Unknown | 65.3 |
| Hypertension, % | 95.8 | 95 | 93 | 90 | 100 | 100 | 95.3 |
| Smoking, % | 66.7 | 91 | 67 | 85 | 65 | 50 | 73.8 |
| Obesity, % | 42.9c | 13 | 60 | 40 | 37.5c | Unknown | 37.3 |
Comparison of the clinical characteristics between this study’s cohort and those of prior case series including Markowitz et al., Li and Verani, Wu et al. and Hamrahian et al.
Normal range for proteinuria is ˂0.3 g/day.
Normal range for serum Cr varies by age and race, but is generally ≤1.2 mg/dL. Glomerular filtration rates were not available across studies.
Incomplete data are available. Data on obesity were available for 28 subjects in the BBCI cohort and 16 subjects in the Hamrahian cohort.
| Key clinical findings . | BBCI cohort . | Markowitz et al. 2002 [3] . | Li and Verani 2008 [5] . | Wu et al. 2014 [4] . | Hamrahian et al. 2018 [6] . | Salvatore et al. 2015 [7] . | Pooled data . |
|---|---|---|---|---|---|---|---|
| N | 48 | 23 | 15 | 20 | 17 | 4 | 127 |
| Study period | 2001–16 | 1996–2001 | 1998–2007 | 2009–11 | 1999–2014 | 2003–12 | – |
| Mean age, years | 68.1 | 68 | 64 | 55.5 | 60.2 | 62 | 64.2 |
| Gender (M:F) | 26:22 | 18:05 | 5:10 | 16:04 | 13:04 | 4:0 | 82:45 |
| Ethnicity (White:Black:Hispanic:other) | 36:6:0:6 | 17:6:0:0 | 11:3:1:0 | 20 Asian | 7:7:1:2 | 4:0:0:0 | 75:22:2:28 |
| Average proteinuria, g/day | 4.0 | 4.7 | 5.6 | 2.85 | 3.53 | 3.0 | 4.1 |
| Nephrotic range,a % | 60.4 | 69.6 | 73 | 35 | 40 | Unknown | 56.7 |
| Mean Cr at time of biopsy,b mg/dL | 3.21 | 2.4 | 2.8 | 4.23 | 2.35 | 1.9 | 3.03 |
| Renal insufficiency (Cr >1.2 mg/dL),b % | 81.3 | 82.6 | 93 | 95 | 94 | 100 | 87.1 |
| Hyperlipidemia, % | 60.4 | 90 | Unknown | 50 | Unknown | Unknown | 65.3 |
| Hypertension, % | 95.8 | 95 | 93 | 90 | 100 | 100 | 95.3 |
| Smoking, % | 66.7 | 91 | 67 | 85 | 65 | 50 | 73.8 |
| Obesity, % | 42.9c | 13 | 60 | 40 | 37.5c | Unknown | 37.3 |
| Key clinical findings . | BBCI cohort . | Markowitz et al. 2002 [3] . | Li and Verani 2008 [5] . | Wu et al. 2014 [4] . | Hamrahian et al. 2018 [6] . | Salvatore et al. 2015 [7] . | Pooled data . |
|---|---|---|---|---|---|---|---|
| N | 48 | 23 | 15 | 20 | 17 | 4 | 127 |
| Study period | 2001–16 | 1996–2001 | 1998–2007 | 2009–11 | 1999–2014 | 2003–12 | – |
| Mean age, years | 68.1 | 68 | 64 | 55.5 | 60.2 | 62 | 64.2 |
| Gender (M:F) | 26:22 | 18:05 | 5:10 | 16:04 | 13:04 | 4:0 | 82:45 |
| Ethnicity (White:Black:Hispanic:other) | 36:6:0:6 | 17:6:0:0 | 11:3:1:0 | 20 Asian | 7:7:1:2 | 4:0:0:0 | 75:22:2:28 |
| Average proteinuria, g/day | 4.0 | 4.7 | 5.6 | 2.85 | 3.53 | 3.0 | 4.1 |
| Nephrotic range,a % | 60.4 | 69.6 | 73 | 35 | 40 | Unknown | 56.7 |
| Mean Cr at time of biopsy,b mg/dL | 3.21 | 2.4 | 2.8 | 4.23 | 2.35 | 1.9 | 3.03 |
| Renal insufficiency (Cr >1.2 mg/dL),b % | 81.3 | 82.6 | 93 | 95 | 94 | 100 | 87.1 |
| Hyperlipidemia, % | 60.4 | 90 | Unknown | 50 | Unknown | Unknown | 65.3 |
| Hypertension, % | 95.8 | 95 | 93 | 90 | 100 | 100 | 95.3 |
| Smoking, % | 66.7 | 91 | 67 | 85 | 65 | 50 | 73.8 |
| Obesity, % | 42.9c | 13 | 60 | 40 | 37.5c | Unknown | 37.3 |
Comparison of the clinical characteristics between this study’s cohort and those of prior case series including Markowitz et al., Li and Verani, Wu et al. and Hamrahian et al.
Normal range for proteinuria is ˂0.3 g/day.
Normal range for serum Cr varies by age and race, but is generally ≤1.2 mg/dL. Glomerular filtration rates were not available across studies.
Incomplete data are available. Data on obesity were available for 28 subjects in the BBCI cohort and 16 subjects in the Hamrahian cohort.
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