Lead results for gene-based aggregate tests, for burden and SMMAT tests, with PLT and MPV
| Gene_name . | OMIM Mendelian platelet disorder gene . | Number of included sites . | Number of alternate alleles . | P-value . | Trait . | Test . | Filter . | Maximum P-value post conditioning . |
|---|---|---|---|---|---|---|---|---|
| GFI1B | Yes | 36 | 197 | 4.48E-08 | MPV | SMMAT | 2 | 3.02E-07 |
| GP9 | Yes | 27 | 171 | 4.23E-08 | MPV | SMMAT | 3 | 6.62E-06 |
| IQGAP2 | No | 66 | 298 | 2.52E-07 | MPV | Burden | 1 | 0.24 |
| TUBB1 | Yes | 59 | 254 | 6.21E-15 | MPV | SMMAT | 2 | 5.52E-03 |
| CD36 | Yes | 248 | 2886 | 5.66E-08 | PLT | SMMAT | 2 | 8.06E-08 |
| CHEK2 | No | 193 | 2520 | 3.06E-07 | PLT | Burden | 3 | 3.13E-06 |
| GP9 | Yes | 42 | 487 | 5.96E-17 | PLT | SMMAT | 3 | 1.03E-09 |
| ITGA2B | Yes | 232 | 2565 | 4.11E-10 | PLT | SMMAT | 3 | 5.13E-09 |
| ITGB3 | Yes | 203 | 1693 | 5.40E-10 | PLT | SMMAT | 3 | 1.10E-06 |
| MPL | Yes | 73 | 414 | 2.92E-11 | PLT | Burden | 1 | 1.61E-11 |
| PTPRH | No | 91 | 1303 | 2.76E-08 | PLT | Burden | 1 | 2.39E-05 |
| SH2B3 | Yes | 71 | 585 | 1.15E-07 | PLT | SMMAT | 2 | 2.17E-07 |
| TET2 | No | 134 | 138 | 8.67E-07 | PLT | SMMAT | 1 | 8.52E-07 |
| TNFRSF13B | No | 89 | 1560 | 3.24E-07 | PLT | Burden | 1 | 0.17 |
| TUBB1 | Yes | 107 | 635 | 1.95E-24 | PLT | SMMAT | 2 | 1.29E-06 |
| Gene_name . | OMIM Mendelian platelet disorder gene . | Number of included sites . | Number of alternate alleles . | P-value . | Trait . | Test . | Filter . | Maximum P-value post conditioning . |
|---|---|---|---|---|---|---|---|---|
| GFI1B | Yes | 36 | 197 | 4.48E-08 | MPV | SMMAT | 2 | 3.02E-07 |
| GP9 | Yes | 27 | 171 | 4.23E-08 | MPV | SMMAT | 3 | 6.62E-06 |
| IQGAP2 | No | 66 | 298 | 2.52E-07 | MPV | Burden | 1 | 0.24 |
| TUBB1 | Yes | 59 | 254 | 6.21E-15 | MPV | SMMAT | 2 | 5.52E-03 |
| CD36 | Yes | 248 | 2886 | 5.66E-08 | PLT | SMMAT | 2 | 8.06E-08 |
| CHEK2 | No | 193 | 2520 | 3.06E-07 | PLT | Burden | 3 | 3.13E-06 |
| GP9 | Yes | 42 | 487 | 5.96E-17 | PLT | SMMAT | 3 | 1.03E-09 |
| ITGA2B | Yes | 232 | 2565 | 4.11E-10 | PLT | SMMAT | 3 | 5.13E-09 |
| ITGB3 | Yes | 203 | 1693 | 5.40E-10 | PLT | SMMAT | 3 | 1.10E-06 |
| MPL | Yes | 73 | 414 | 2.92E-11 | PLT | Burden | 1 | 1.61E-11 |
| PTPRH | No | 91 | 1303 | 2.76E-08 | PLT | Burden | 1 | 2.39E-05 |
| SH2B3 | Yes | 71 | 585 | 1.15E-07 | PLT | SMMAT | 2 | 2.17E-07 |
| TET2 | No | 134 | 138 | 8.67E-07 | PLT | SMMAT | 1 | 8.52E-07 |
| TNFRSF13B | No | 89 | 1560 | 3.24E-07 | PLT | Burden | 1 | 0.17 |
| TUBB1 | Yes | 107 | 635 | 1.95E-24 | PLT | SMMAT | 2 | 1.29E-06 |
Only the most significant test (burden or SMMAT) and variant filter combination are displayed for each gene, full results can be found in Supplementary Material, Table S8. The maximum P-value post-conditioning is taken from either the GWAS catalog (Supplementary Material, Table S6) or the BCX (Supplementary Material, Table S10) identified variant conditional analysis.
Lead results for gene-based aggregate tests, for burden and SMMAT tests, with PLT and MPV
| Gene_name . | OMIM Mendelian platelet disorder gene . | Number of included sites . | Number of alternate alleles . | P-value . | Trait . | Test . | Filter . | Maximum P-value post conditioning . |
|---|---|---|---|---|---|---|---|---|
| GFI1B | Yes | 36 | 197 | 4.48E-08 | MPV | SMMAT | 2 | 3.02E-07 |
| GP9 | Yes | 27 | 171 | 4.23E-08 | MPV | SMMAT | 3 | 6.62E-06 |
| IQGAP2 | No | 66 | 298 | 2.52E-07 | MPV | Burden | 1 | 0.24 |
| TUBB1 | Yes | 59 | 254 | 6.21E-15 | MPV | SMMAT | 2 | 5.52E-03 |
| CD36 | Yes | 248 | 2886 | 5.66E-08 | PLT | SMMAT | 2 | 8.06E-08 |
| CHEK2 | No | 193 | 2520 | 3.06E-07 | PLT | Burden | 3 | 3.13E-06 |
| GP9 | Yes | 42 | 487 | 5.96E-17 | PLT | SMMAT | 3 | 1.03E-09 |
| ITGA2B | Yes | 232 | 2565 | 4.11E-10 | PLT | SMMAT | 3 | 5.13E-09 |
| ITGB3 | Yes | 203 | 1693 | 5.40E-10 | PLT | SMMAT | 3 | 1.10E-06 |
| MPL | Yes | 73 | 414 | 2.92E-11 | PLT | Burden | 1 | 1.61E-11 |
| PTPRH | No | 91 | 1303 | 2.76E-08 | PLT | Burden | 1 | 2.39E-05 |
| SH2B3 | Yes | 71 | 585 | 1.15E-07 | PLT | SMMAT | 2 | 2.17E-07 |
| TET2 | No | 134 | 138 | 8.67E-07 | PLT | SMMAT | 1 | 8.52E-07 |
| TNFRSF13B | No | 89 | 1560 | 3.24E-07 | PLT | Burden | 1 | 0.17 |
| TUBB1 | Yes | 107 | 635 | 1.95E-24 | PLT | SMMAT | 2 | 1.29E-06 |
| Gene_name . | OMIM Mendelian platelet disorder gene . | Number of included sites . | Number of alternate alleles . | P-value . | Trait . | Test . | Filter . | Maximum P-value post conditioning . |
|---|---|---|---|---|---|---|---|---|
| GFI1B | Yes | 36 | 197 | 4.48E-08 | MPV | SMMAT | 2 | 3.02E-07 |
| GP9 | Yes | 27 | 171 | 4.23E-08 | MPV | SMMAT | 3 | 6.62E-06 |
| IQGAP2 | No | 66 | 298 | 2.52E-07 | MPV | Burden | 1 | 0.24 |
| TUBB1 | Yes | 59 | 254 | 6.21E-15 | MPV | SMMAT | 2 | 5.52E-03 |
| CD36 | Yes | 248 | 2886 | 5.66E-08 | PLT | SMMAT | 2 | 8.06E-08 |
| CHEK2 | No | 193 | 2520 | 3.06E-07 | PLT | Burden | 3 | 3.13E-06 |
| GP9 | Yes | 42 | 487 | 5.96E-17 | PLT | SMMAT | 3 | 1.03E-09 |
| ITGA2B | Yes | 232 | 2565 | 4.11E-10 | PLT | SMMAT | 3 | 5.13E-09 |
| ITGB3 | Yes | 203 | 1693 | 5.40E-10 | PLT | SMMAT | 3 | 1.10E-06 |
| MPL | Yes | 73 | 414 | 2.92E-11 | PLT | Burden | 1 | 1.61E-11 |
| PTPRH | No | 91 | 1303 | 2.76E-08 | PLT | Burden | 1 | 2.39E-05 |
| SH2B3 | Yes | 71 | 585 | 1.15E-07 | PLT | SMMAT | 2 | 2.17E-07 |
| TET2 | No | 134 | 138 | 8.67E-07 | PLT | SMMAT | 1 | 8.52E-07 |
| TNFRSF13B | No | 89 | 1560 | 3.24E-07 | PLT | Burden | 1 | 0.17 |
| TUBB1 | Yes | 107 | 635 | 1.95E-24 | PLT | SMMAT | 2 | 1.29E-06 |
Only the most significant test (burden or SMMAT) and variant filter combination are displayed for each gene, full results can be found in Supplementary Material, Table S8. The maximum P-value post-conditioning is taken from either the GWAS catalog (Supplementary Material, Table S6) or the BCX (Supplementary Material, Table S10) identified variant conditional analysis.
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