Table 3.

Impact of circadian gene deletion on the LH surge and female fertility

ModelFemale fertilityLH surgeReference
Clock mutantSubfertileNot detected (OVX + E or endogenous)(85, 86)
Bmal1 KOInfertileNot detected (OVX + E or endogenous)(17, 87, 88)
Bmal1flox/flox:GnRHcreFertileNormal/mistimed (OVX + E)(88, 89)
Bmal1flox/flox:KisscreFertileNormal/mistimed (OVX + E)(88, 89)
Bmal1flox/flox:AvpcreFertileNormal/mistimed (OVX + E)(88, 89)
Bmal1flox/flox:VipcreFertileNormal (OVX + E)(88)
Bmal1flox/flox:Vipcre + AvpcreFertileNormal (OVX + E)(88)
ModelFemale fertilityLH surgeReference
Clock mutantSubfertileNot detected (OVX + E or endogenous)(85, 86)
Bmal1 KOInfertileNot detected (OVX + E or endogenous)(17, 87, 88)
Bmal1flox/flox:GnRHcreFertileNormal/mistimed (OVX + E)(88, 89)
Bmal1flox/flox:KisscreFertileNormal/mistimed (OVX + E)(88, 89)
Bmal1flox/flox:AvpcreFertileNormal/mistimed (OVX + E)(88, 89)
Bmal1flox/flox:VipcreFertileNormal (OVX + E)(88)
Bmal1flox/flox:Vipcre + AvpcreFertileNormal (OVX + E)(88)
Table 3.

Impact of circadian gene deletion on the LH surge and female fertility

ModelFemale fertilityLH surgeReference
Clock mutantSubfertileNot detected (OVX + E or endogenous)(85, 86)
Bmal1 KOInfertileNot detected (OVX + E or endogenous)(17, 87, 88)
Bmal1flox/flox:GnRHcreFertileNormal/mistimed (OVX + E)(88, 89)
Bmal1flox/flox:KisscreFertileNormal/mistimed (OVX + E)(88, 89)
Bmal1flox/flox:AvpcreFertileNormal/mistimed (OVX + E)(88, 89)
Bmal1flox/flox:VipcreFertileNormal (OVX + E)(88)
Bmal1flox/flox:Vipcre + AvpcreFertileNormal (OVX + E)(88)
ModelFemale fertilityLH surgeReference
Clock mutantSubfertileNot detected (OVX + E or endogenous)(85, 86)
Bmal1 KOInfertileNot detected (OVX + E or endogenous)(17, 87, 88)
Bmal1flox/flox:GnRHcreFertileNormal/mistimed (OVX + E)(88, 89)
Bmal1flox/flox:KisscreFertileNormal/mistimed (OVX + E)(88, 89)
Bmal1flox/flox:AvpcreFertileNormal/mistimed (OVX + E)(88, 89)
Bmal1flox/flox:VipcreFertileNormal (OVX + E)(88)
Bmal1flox/flox:Vipcre + AvpcreFertileNormal (OVX + E)(88)
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