Table 5
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Univariate and multivariate analysis between trial characteristics and request for new biopsies

Studies requiring new biopsies (n = 59)n (%)Univariate analysisMultivariate analysis
p valueOR (95% CI)p valueOR (95% CI)
Sponsor.111.96 (0.86–4.44)——
Academic9 (23)
Industry50 (36)
Year.021.30 (1.05–1.61) for an increment of 1 year.011.41 (1.11–1.80) for an increment of 1 year
20157 (17)
20169 (26)
201713 (46)
201813 (42)
201917 (39)
Phase<.0015.80 (2.81–11.96)<.0016.37 (2.93–13.83)
Early-phase studies29 (63)
Non–early-phase studies30 (23)
Experimental treatment<.012.65 (1.30–5.42).022.51 (1.15–5.45)
Innovative therapy46 (40)
Other therapy13 (20)
Randomized<.0013.37 (1.73–6.55)——
No (n = 89)64 (72)
Yes (n = 89)55 (62)
Studies requiring new biopsies (n = 59)n (%)Univariate analysisMultivariate analysis
p valueOR (95% CI)p valueOR (95% CI)
Sponsor.111.96 (0.86–4.44)——
Academic9 (23)
Industry50 (36)
Year.021.30 (1.05–1.61) for an increment of 1 year.011.41 (1.11–1.80) for an increment of 1 year
20157 (17)
20169 (26)
201713 (46)
201813 (42)
201917 (39)
Phase<.0015.80 (2.81–11.96)<.0016.37 (2.93–13.83)
Early-phase studies29 (63)
Non–early-phase studies30 (23)
Experimental treatment<.012.65 (1.30–5.42).022.51 (1.15–5.45)
Innovative therapy46 (40)
Other therapy13 (20)
Randomized<.0013.37 (1.73–6.55)——
No (n = 89)64 (72)
Yes (n = 89)55 (62)

Abbreviations: —, characteristics that do not bring independent information in multivariate analysis; CI, confidence interval; OR, odds ratio.

Table 5
Open in new tab

Univariate and multivariate analysis between trial characteristics and request for new biopsies

Studies requiring new biopsies (n = 59)n (%)Univariate analysisMultivariate analysis
p valueOR (95% CI)p valueOR (95% CI)
Sponsor.111.96 (0.86–4.44)——
Academic9 (23)
Industry50 (36)
Year.021.30 (1.05–1.61) for an increment of 1 year.011.41 (1.11–1.80) for an increment of 1 year
20157 (17)
20169 (26)
201713 (46)
201813 (42)
201917 (39)
Phase<.0015.80 (2.81–11.96)<.0016.37 (2.93–13.83)
Early-phase studies29 (63)
Non–early-phase studies30 (23)
Experimental treatment<.012.65 (1.30–5.42).022.51 (1.15–5.45)
Innovative therapy46 (40)
Other therapy13 (20)
Randomized<.0013.37 (1.73–6.55)——
No (n = 89)64 (72)
Yes (n = 89)55 (62)
Studies requiring new biopsies (n = 59)n (%)Univariate analysisMultivariate analysis
p valueOR (95% CI)p valueOR (95% CI)
Sponsor.111.96 (0.86–4.44)——
Academic9 (23)
Industry50 (36)
Year.021.30 (1.05–1.61) for an increment of 1 year.011.41 (1.11–1.80) for an increment of 1 year
20157 (17)
20169 (26)
201713 (46)
201813 (42)
201917 (39)
Phase<.0015.80 (2.81–11.96)<.0016.37 (2.93–13.83)
Early-phase studies29 (63)
Non–early-phase studies30 (23)
Experimental treatment<.012.65 (1.30–5.42).022.51 (1.15–5.45)
Innovative therapy46 (40)
Other therapy13 (20)
Randomized<.0013.37 (1.73–6.55)——
No (n = 89)64 (72)
Yes (n = 89)55 (62)

Abbreviations: —, characteristics that do not bring independent information in multivariate analysis; CI, confidence interval; OR, odds ratio.

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