Table 4 Open in new tab Studies...

Study

Country

Sample size

Study population

Type of survey

Dimensions and measures

Main findings

Halverson 2016

U.S.

Advanced-stage cancer and conditions that were presumed to be genetic but without diagnosis

Exhausted standard treatments

Semistructured interviews

Satisfaction with primary results and overall process

Found sequencing helpful because of the personal utility and ability to make more informed decisions about health care

Gave significant weight to their own interpretations that differed from health care providers

Found satisfaction in being able to contribute knowledge to a new field regardless of clinical utility of the results

Miller 2014

Canada

Advanced stage

Multiple tumor types

Semistructured interviews

Satisfaction with primary results and overall process

Those who had hoped for novel and targeted treatment resulting from testing were challenged by nonfindings or limited access to relevant trials

Roberts 2018

U.S.

297

Advanced stage

Multiple tumor types

In-person or Web-based self-administered questionnaire

Satisfaction with primary results and overall process

Low levels of regret

Mean satisfaction score 4.06 (1 = not at all satisfied; 5 = extremely satisfied), and most would make the same choice again if they had to do it over (mean score 4.37; 1 = strongly disagree; 5 = strongly agree)

Gornick 2018

U.S.

Advanced stage

Multiple tumor types

Mailed survey

Recollection of disclosure of results

25% to whom there was documentation of results disclosure reported that disclosure had not taken place

Table 4

Open in new tab

Studies evaluating cancer patients who had received results of tumor next-generation sequencing

Study	Country	Sample size	Study population	Type of survey	Dimensions and measures	Main findings
Halverson 2016	U.S.	39	Advanced-stage cancer and conditions that were presumed to be genetic but without diagnosis Exhausted standard treatments	Semistructured interviews	Satisfaction with primary results and overall process	Found sequencing helpful because of the personal utility and ability to make more informed decisions about health care Gave significant weight to their own interpretations that differed from health care providers Found satisfaction in being able to contribute knowledge to a new field regardless of clinical utility of the results
Miller 2014	Canada	29	Advanced stage Multiple tumor types	Semistructured interviews	Satisfaction with primary results and overall process	Those who had hoped for novel and targeted treatment resulting from testing were challenged by nonfindings or limited access to relevant trials
Roberts 2018	U.S.	297	Advanced stage Multiple tumor types	In-person or Web-based self-administered questionnaire	Satisfaction with primary results and overall process	Low levels of regret Mean satisfaction score 4.06 (1 = not at all satisfied; 5 = extremely satisfied), and most would make the same choice again if they had to do it over (mean score 4.37; 1 = strongly disagree; 5 = strongly agree)
Gornick 2018	U.S.	57	Advanced stage Multiple tumor types	Mailed survey	Recollection of disclosure of results	25% to whom there was documentation of results disclosure reported that disclosure had not taken place

Study	Country	Sample size	Study population	Type of survey	Dimensions and measures	Main findings
Halverson 2016	U.S.	39	Advanced-stage cancer and conditions that were presumed to be genetic but without diagnosis Exhausted standard treatments	Semistructured interviews	Satisfaction with primary results and overall process	Found sequencing helpful because of the personal utility and ability to make more informed decisions about health care Gave significant weight to their own interpretations that differed from health care providers Found satisfaction in being able to contribute knowledge to a new field regardless of clinical utility of the results
Miller 2014	Canada	29	Advanced stage Multiple tumor types	Semistructured interviews	Satisfaction with primary results and overall process	Those who had hoped for novel and targeted treatment resulting from testing were challenged by nonfindings or limited access to relevant trials
Roberts 2018	U.S.	297	Advanced stage Multiple tumor types	In-person or Web-based self-administered questionnaire	Satisfaction with primary results and overall process	Low levels of regret Mean satisfaction score 4.06 (1 = not at all satisfied; 5 = extremely satisfied), and most would make the same choice again if they had to do it over (mean score 4.37; 1 = strongly disagree; 5 = strongly agree)
Gornick 2018	U.S.	57	Advanced stage Multiple tumor types	Mailed survey	Recollection of disclosure of results	25% to whom there was documentation of results disclosure reported that disclosure had not taken place

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