Table 2.

Comparison of the Bayesian analysis models with respect to the analogue of type I error rate: null hypothesis is erroneously rejected under scenarios of any |$\theta_k =0$|⁠, setting |$\delta_U=0.25$| and |$\zeta = 0.975$|⁠.

Subtrial
 123456Overall
Scenario 7Standard HM0.00000.00000.00000.00000.0000
 No borrowing0.00360.00770.00560.01000.0269
 EXNEX0.00010.00030.00020.00000.0006
 Proposed approach0.00730.00890.00020.00020.0166
Scenario 8Standard HM0.01550.00800.0207
 No borrowing0.00770.00080.0085
 EXNEX0.01950.00560.0251
 Proposed approach0.01550.00170.0172
Scenario 9Standard HM0.00000.00000.00000.00000.00000.00000.0000
 No borrowing0.00360.00770.00560.01000.00080.00060.0283
 EXNEX0.00000.00010.00000.00000.00000.00000.0001
 Proposed approach0.00140.00280.00000.00000.00020.00200.0064
Subtrial
 123456Overall
Scenario 7Standard HM0.00000.00000.00000.00000.0000
 No borrowing0.00360.00770.00560.01000.0269
 EXNEX0.00010.00030.00020.00000.0006
 Proposed approach0.00730.00890.00020.00020.0166
Scenario 8Standard HM0.01550.00800.0207
 No borrowing0.00770.00080.0085
 EXNEX0.01950.00560.0251
 Proposed approach0.01550.00170.0172
Scenario 9Standard HM0.00000.00000.00000.00000.00000.00000.0000
 No borrowing0.00360.00770.00560.01000.00080.00060.0283
 EXNEX0.00000.00010.00000.00000.00000.00000.0001
 Proposed approach0.00140.00280.00000.00000.00020.00200.0064

Overall: the proportion of trials with erroneous Go decision for at least one subtrial.

Table 2.

Comparison of the Bayesian analysis models with respect to the analogue of type I error rate: null hypothesis is erroneously rejected under scenarios of any |$\theta_k =0$|⁠, setting |$\delta_U=0.25$| and |$\zeta = 0.975$|⁠.

Subtrial
 123456Overall
Scenario 7Standard HM0.00000.00000.00000.00000.0000
 No borrowing0.00360.00770.00560.01000.0269
 EXNEX0.00010.00030.00020.00000.0006
 Proposed approach0.00730.00890.00020.00020.0166
Scenario 8Standard HM0.01550.00800.0207
 No borrowing0.00770.00080.0085
 EXNEX0.01950.00560.0251
 Proposed approach0.01550.00170.0172
Scenario 9Standard HM0.00000.00000.00000.00000.00000.00000.0000
 No borrowing0.00360.00770.00560.01000.00080.00060.0283
 EXNEX0.00000.00010.00000.00000.00000.00000.0001
 Proposed approach0.00140.00280.00000.00000.00020.00200.0064
Subtrial
 123456Overall
Scenario 7Standard HM0.00000.00000.00000.00000.0000
 No borrowing0.00360.00770.00560.01000.0269
 EXNEX0.00010.00030.00020.00000.0006
 Proposed approach0.00730.00890.00020.00020.0166
Scenario 8Standard HM0.01550.00800.0207
 No borrowing0.00770.00080.0085
 EXNEX0.01950.00560.0251
 Proposed approach0.01550.00170.0172
Scenario 9Standard HM0.00000.00000.00000.00000.00000.00000.0000
 No borrowing0.00360.00770.00560.01000.00080.00060.0283
 EXNEX0.00000.00010.00000.00000.00000.00000.0001
 Proposed approach0.00140.00280.00000.00000.00020.00200.0064

Overall: the proportion of trials with erroneous Go decision for at least one subtrial.

Close
This Feature Is Available To Subscribers Only

Sign In or Create an Account

Close

This PDF is available to Subscribers Only

View Article Abstract & Purchase Options

For full access to this pdf, sign in to an existing account, or purchase an annual subscription.

Close