Table 1. Open in new tab Differentially...

		mLi vs pCRC	mLu vs pCRC	PM vs pCRC
Mir-191_5p	13630	23253	0.74 (0.15)	3.67E-06	26989	0.74 (0.16)	9.81E-06	20429	0.61 (0.15)	2.42E-04
Mir-210_3p	291	685	1.26 (0.18)	4.73E-11	693	1.15 (0.19)	1.55E-08	491	0.71 (0.18)	3.37E-04
Mir-1307_5p	492	887	0.85 (0.17)	2.99E-06				797	0.62 (0.17)	8.29E-04
Mir-8-P1b_3p (mir-141–3p)	7518	11957	0.64 (0.19)	4.07E-03	15111	0.75 (0.21)	1.12E-03
Mir-155_5p	387				733	0.76 (0.18)	7.24E-05	654	0.70 (0.17)	1.59E-04
Mir-10-P1a_5p (mir-10a-5p)	97123	164925	0.86 (0.19)	8.04E-05
Mir-592_5p	75	137	0.98 (0.27)	4.88E-03
Mir-1247_5p	69	127	0.85 (0.28)	2.58E-02
Mir-425_5p	700	1117	0.73 (0.12)	2.90E-08
Mir-486_5p	2013	1489	-0.66 (0.23)	3.47E-02
Mir-142_5p	3453				7117	0.84 (0.18)	2.01E-05
Mir-19-P2a/P2b_3p	1297				2345	0.80 (0.15)	9.38E-07
Mir-374-P1_5p	115				217	0.72 (0.12)	9.07E-09
Mir-19-P1_3p	379				597	0.65 (0.16)	3.42E-04
Mir-423_5p	433				202	-1.17 (0.17)	1.35E-10
Let-7-P1b_5p	1057				650	-0.86 (0.16)	2.55E-07
Mir-197_3p	181				113	-0.74 (0.13)	1.76E-07
Mir-92-P1c_3p	1398				981	-0.72 (0.18)	2.22E-04
Mir-362-P2/P4_3p	441				302	-0.65 (0.14)	2.36E-05
Mir-221-P2_3p	1633				1101	-0.60 (0.14)	8.50E-05
Mir-506-P3_3p	6							112	2.69 (0.29)	6.35E-09
Mir-506 P4a1/P4a2/P4b_3p	14							191	2.72 (0.29)	5.75E-11
Mir-154-P9_3p	253							455	0.85 (0.14)	1.43E-08
Mir-127_3p	2263							2888	0.61 (0.20)	1.42E-02
Mir-154-P36_3p	195							330	0.74 (0.13)	7.13E-07
Mir-223_3p	619							280	-0.94 (0.21)	4.62E-05

mLi vs pCRC

mLu vs pCRC

PM vs pCRC

MirGeneDB ID (miRBase ID)

pCRC RPM

RPM

LFC (SE)

FDR

RPM

LFC (SE)

FDR

RPM

LFC (SE)

FDR

Mir-191_5p

13630

23253

0.74 (0.15)

3.67E-06

26989

0.74 (0.16)

9.81E-06

20429

0.61 (0.15)

2.42E-04

Mir-210_3p

291

685

1.26 (0.18)

4.73E-11

693

1.15 (0.19)

1.55E-08

491

0.71 (0.18)

3.37E-04

Mir-1307_5p

492

887

0.85 (0.17)

2.99E-06

797

0.62 (0.17)

8.29E-04

Mir-8-P1b_3p (mir-141–3p)

7518

11957

0.64 (0.19)

4.07E-03

15111

0.75 (0.21)

1.12E-03

Mir-155_5p

387

733

0.76 (0.18)

7.24E-05

654

0.70 (0.17)

1.59E-04

Mir-10-P1a_5p (mir-10a-5p)

97123

164925

0.86 (0.19)

8.04E-05

Mir-592_5p

137

0.98 (0.27)

4.88E-03

Mir-1247_5p

127

0.85 (0.28)

2.58E-02

Mir-425_5p

700

1117

0.73 (0.12)

2.90E-08

Mir-486_5p

2013

1489

-0.66 (0.23)

3.47E-02

Mir-142_5p

3453

7117

0.84 (0.18)

2.01E-05

Mir-19-P2a/P2b_3p

1297

2345

0.80 (0.15)

9.38E-07

Mir-374-P1_5p

115

217

0.72 (0.12)

9.07E-09

Mir-19-P1_3p

379

597

0.65 (0.16)

3.42E-04

Mir-423_5p

433

202

-1.17 (0.17)

1.35E-10

Let-7-P1b_5p

1057

650

-0.86 (0.16)

2.55E-07

Mir-197_3p

181

113

-0.74 (0.13)

1.76E-07

Mir-92-P1c_3p

1398

981

-0.72 (0.18)

2.22E-04

Mir-362-P2/P4_3p

441

302

-0.65 (0.14)

2.36E-05

Mir-221-P2_3p

1633

1101

-0.60 (0.14)

8.50E-05

Mir-506-P3_3p

112

2.69 (0.29)

6.35E-09

Mir-506 P4a1/P4a2/P4b_3p

191

2.72 (0.29)

5.75E-11

Mir-154-P9_3p

253

455

0.85 (0.14)

1.43E-08

Mir-127_3p

2263

2888

0.61 (0.20)

1.42E-02

Mir-154-P36_3p

195

330

0.74 (0.13)

7.13E-07

Mir-223_3p

619

280

-0.94 (0.21)

4.62E-05

		mLi vs pCRC	mLu vs pCRC	PM vs pCRC
Mir-191_5p	13630	23253	0.74 (0.15)	3.67E-06	26989	0.74 (0.16)	9.81E-06	20429	0.61 (0.15)	2.42E-04
Mir-210_3p	291	685	1.26 (0.18)	4.73E-11	693	1.15 (0.19)	1.55E-08	491	0.71 (0.18)	3.37E-04
Mir-1307_5p	492	887	0.85 (0.17)	2.99E-06				797	0.62 (0.17)	8.29E-04
Mir-8-P1b_3p (mir-141–3p)	7518	11957	0.64 (0.19)	4.07E-03	15111	0.75 (0.21)	1.12E-03
Mir-155_5p	387				733	0.76 (0.18)	7.24E-05	654	0.70 (0.17)	1.59E-04
Mir-10-P1a_5p (mir-10a-5p)	97123	164925	0.86 (0.19)	8.04E-05
Mir-592_5p	75	137	0.98 (0.27)	4.88E-03
Mir-1247_5p	69	127	0.85 (0.28)	2.58E-02
Mir-425_5p	700	1117	0.73 (0.12)	2.90E-08
Mir-486_5p	2013	1489	-0.66 (0.23)	3.47E-02
Mir-142_5p	3453				7117	0.84 (0.18)	2.01E-05
Mir-19-P2a/P2b_3p	1297				2345	0.80 (0.15)	9.38E-07
Mir-374-P1_5p	115				217	0.72 (0.12)	9.07E-09
Mir-19-P1_3p	379				597	0.65 (0.16)	3.42E-04
Mir-423_5p	433				202	-1.17 (0.17)	1.35E-10
Let-7-P1b_5p	1057				650	-0.86 (0.16)	2.55E-07
Mir-197_3p	181				113	-0.74 (0.13)	1.76E-07
Mir-92-P1c_3p	1398				981	-0.72 (0.18)	2.22E-04
Mir-362-P2/P4_3p	441				302	-0.65 (0.14)	2.36E-05
Mir-221-P2_3p	1633				1101	-0.60 (0.14)	8.50E-05
Mir-506-P3_3p	6							112	2.69 (0.29)	6.35E-09
Mir-506 P4a1/P4a2/P4b_3p	14							191	2.72 (0.29)	5.75E-11
Mir-154-P9_3p	253							455	0.85 (0.14)	1.43E-08
Mir-127_3p	2263							2888	0.61 (0.20)	1.42E-02
Mir-154-P36_3p	195							330	0.74 (0.13)	7.13E-07
Mir-223_3p	619							280	-0.94 (0.21)	4.62E-05

Table 1.

Open in new tab

Differentially expressed miRNAs in mCRC compared to pCRC according to metastatic site. Reads per million (RPM); log2 fold change (LFC) estimated using DESeq2; standard error (SE); primary colorectal cancer (pCRC); normal colorectal tissue (nCR); CRC liver metastasis (mLi); normal adjacent liver tissue (nLi); CRC lung metastasis (mLu); normal adjacent lung tissue (nLu); CRC peritoneal metastasis (PM); false discovery rate (FDR)

		mLi vs pCRC			mLu vs pCRC			PM vs pCRC
MirGeneDB ID (miRBase ID)	pCRC RPM	RPM	LFC (SE)	FDR	RPM	LFC (SE)	FDR	RPM	LFC (SE)	FDR
Mir-191_5p	13630	23253	0.74 (0.15)	3.67E-06	26989	0.74 (0.16)	9.81E-06	20429	0.61 (0.15)	2.42E-04
Mir-210_3p	291	685	1.26 (0.18)	4.73E-11	693	1.15 (0.19)	1.55E-08	491	0.71 (0.18)	3.37E-04
Mir-1307_5p	492	887	0.85 (0.17)	2.99E-06				797	0.62 (0.17)	8.29E-04
Mir-8-P1b_3p (mir-141–3p)	7518	11957	0.64 (0.19)	4.07E-03	15111	0.75 (0.21)	1.12E-03
Mir-155_5p	387				733	0.76 (0.18)	7.24E-05	654	0.70 (0.17)	1.59E-04
Mir-10-P1a_5p (mir-10a-5p)	97123	164925	0.86 (0.19)	8.04E-05
Mir-592_5p	75	137	0.98 (0.27)	4.88E-03
Mir-1247_5p	69	127	0.85 (0.28)	2.58E-02
Mir-425_5p	700	1117	0.73 (0.12)	2.90E-08
Mir-486_5p	2013	1489	-0.66 (0.23)	3.47E-02
Mir-142_5p	3453				7117	0.84 (0.18)	2.01E-05
Mir-19-P2a/P2b_3p	1297				2345	0.80 (0.15)	9.38E-07
Mir-374-P1_5p	115				217	0.72 (0.12)	9.07E-09
Mir-19-P1_3p	379				597	0.65 (0.16)	3.42E-04
Mir-423_5p	433				202	-1.17 (0.17)	1.35E-10
Let-7-P1b_5p	1057				650	-0.86 (0.16)	2.55E-07
Mir-197_3p	181				113	-0.74 (0.13)	1.76E-07
Mir-92-P1c_3p	1398				981	-0.72 (0.18)	2.22E-04
Mir-362-P2/P4_3p	441				302	-0.65 (0.14)	2.36E-05
Mir-221-P2_3p	1633				1101	-0.60 (0.14)	8.50E-05
Mir-506-P3_3p	6							112	2.69 (0.29)	6.35E-09
Mir-506 P4a1/P4a2/P4b_3p	14							191	2.72 (0.29)	5.75E-11
Mir-154-P9_3p	253							455	0.85 (0.14)	1.43E-08
Mir-127_3p	2263							2888	0.61 (0.20)	1.42E-02
Mir-154-P36_3p	195							330	0.74 (0.13)	7.13E-07
Mir-223_3p	619							280	-0.94 (0.21)	4.62E-05

		mLi vs pCRC			mLu vs pCRC			PM vs pCRC
MirGeneDB ID (miRBase ID)	pCRC RPM	RPM	LFC (SE)	FDR	RPM	LFC (SE)	FDR	RPM	LFC (SE)	FDR
Mir-191_5p	13630	23253	0.74 (0.15)	3.67E-06	26989	0.74 (0.16)	9.81E-06	20429	0.61 (0.15)	2.42E-04
Mir-210_3p	291	685	1.26 (0.18)	4.73E-11	693	1.15 (0.19)	1.55E-08	491	0.71 (0.18)	3.37E-04
Mir-1307_5p	492	887	0.85 (0.17)	2.99E-06				797	0.62 (0.17)	8.29E-04
Mir-8-P1b_3p (mir-141–3p)	7518	11957	0.64 (0.19)	4.07E-03	15111	0.75 (0.21)	1.12E-03
Mir-155_5p	387				733	0.76 (0.18)	7.24E-05	654	0.70 (0.17)	1.59E-04
Mir-10-P1a_5p (mir-10a-5p)	97123	164925	0.86 (0.19)	8.04E-05
Mir-592_5p	75	137	0.98 (0.27)	4.88E-03
Mir-1247_5p	69	127	0.85 (0.28)	2.58E-02
Mir-425_5p	700	1117	0.73 (0.12)	2.90E-08
Mir-486_5p	2013	1489	-0.66 (0.23)	3.47E-02
Mir-142_5p	3453				7117	0.84 (0.18)	2.01E-05
Mir-19-P2a/P2b_3p	1297				2345	0.80 (0.15)	9.38E-07
Mir-374-P1_5p	115				217	0.72 (0.12)	9.07E-09
Mir-19-P1_3p	379				597	0.65 (0.16)	3.42E-04
Mir-423_5p	433				202	-1.17 (0.17)	1.35E-10
Let-7-P1b_5p	1057				650	-0.86 (0.16)	2.55E-07
Mir-197_3p	181				113	-0.74 (0.13)	1.76E-07
Mir-92-P1c_3p	1398				981	-0.72 (0.18)	2.22E-04
Mir-362-P2/P4_3p	441				302	-0.65 (0.14)	2.36E-05
Mir-221-P2_3p	1633				1101	-0.60 (0.14)	8.50E-05
Mir-506-P3_3p	6							112	2.69 (0.29)	6.35E-09
Mir-506 P4a1/P4a2/P4b_3p	14							191	2.72 (0.29)	5.75E-11
Mir-154-P9_3p	253							455	0.85 (0.14)	1.43E-08
Mir-127_3p	2263							2888	0.61 (0.20)	1.42E-02
Mir-154-P36_3p	195							330	0.74 (0.13)	7.13E-07
Mir-223_3p	619							280	-0.94 (0.21)	4.62E-05

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