Performance of Pneumocystis jirovecii Polymerase Chain Reaction With Reference to Pathology
| Pathology . | Positive, No. (%) . | Negative, No. (%) . | Pneumocystis jirovecii PCR . | |||
|---|---|---|---|---|---|---|
| Sensitivity (95% CI) . | Specificity (95% CI) . | PPV (95% CI) . | NPV (95% CI) . | |||
| BAL | 15 | 519 | 0.93 (.68–1.00) | 0.94 (.91–.96) | 0.30 (.17–.45) | 1.00 (.99–1.00) |
| P jirovecii PCR+ | 14 (93.3) | 33 (6.4) | … | … | … | … |
| P jirovecii PCR– | 1 (6.7) | 486 (93.6) | … | … | … | … |
| Transbronchial biopsy | 3 | 59 | 1.00 (.29–1.00) | 0.97 (.88–1.00) | 0.60 (.28–.85) | 1.00 |
| P jirovecii PCR+ | 3 (100) | 2 (3.4) | … | … | … | … |
| P jirovecii PCR– | 0 (0) | 57 (97) | … | … | … | … |
| Pathology . | Positive, No. (%) . | Negative, No. (%) . | Pneumocystis jirovecii PCR . | |||
|---|---|---|---|---|---|---|
| Sensitivity (95% CI) . | Specificity (95% CI) . | PPV (95% CI) . | NPV (95% CI) . | |||
| BAL | 15 | 519 | 0.93 (.68–1.00) | 0.94 (.91–.96) | 0.30 (.17–.45) | 1.00 (.99–1.00) |
| P jirovecii PCR+ | 14 (93.3) | 33 (6.4) | … | … | … | … |
| P jirovecii PCR– | 1 (6.7) | 486 (93.6) | … | … | … | … |
| Transbronchial biopsy | 3 | 59 | 1.00 (.29–1.00) | 0.97 (.88–1.00) | 0.60 (.28–.85) | 1.00 |
| P jirovecii PCR+ | 3 (100) | 2 (3.4) | … | … | … | … |
| P jirovecii PCR– | 0 (0) | 57 (97) | … | … | … | … |
Abbreviations: BAL, bronchoalveolar lavage; CI, confidence interval; NPV, negative predictive value; PCR, polymerase chain reaction; PPV, positive predictive value.
Performance of Pneumocystis jirovecii Polymerase Chain Reaction With Reference to Pathology
| Pathology . | Positive, No. (%) . | Negative, No. (%) . | Pneumocystis jirovecii PCR . | |||
|---|---|---|---|---|---|---|
| Sensitivity (95% CI) . | Specificity (95% CI) . | PPV (95% CI) . | NPV (95% CI) . | |||
| BAL | 15 | 519 | 0.93 (.68–1.00) | 0.94 (.91–.96) | 0.30 (.17–.45) | 1.00 (.99–1.00) |
| P jirovecii PCR+ | 14 (93.3) | 33 (6.4) | … | … | … | … |
| P jirovecii PCR– | 1 (6.7) | 486 (93.6) | … | … | … | … |
| Transbronchial biopsy | 3 | 59 | 1.00 (.29–1.00) | 0.97 (.88–1.00) | 0.60 (.28–.85) | 1.00 |
| P jirovecii PCR+ | 3 (100) | 2 (3.4) | … | … | … | … |
| P jirovecii PCR– | 0 (0) | 57 (97) | … | … | … | … |
| Pathology . | Positive, No. (%) . | Negative, No. (%) . | Pneumocystis jirovecii PCR . | |||
|---|---|---|---|---|---|---|
| Sensitivity (95% CI) . | Specificity (95% CI) . | PPV (95% CI) . | NPV (95% CI) . | |||
| BAL | 15 | 519 | 0.93 (.68–1.00) | 0.94 (.91–.96) | 0.30 (.17–.45) | 1.00 (.99–1.00) |
| P jirovecii PCR+ | 14 (93.3) | 33 (6.4) | … | … | … | … |
| P jirovecii PCR– | 1 (6.7) | 486 (93.6) | … | … | … | … |
| Transbronchial biopsy | 3 | 59 | 1.00 (.29–1.00) | 0.97 (.88–1.00) | 0.60 (.28–.85) | 1.00 |
| P jirovecii PCR+ | 3 (100) | 2 (3.4) | … | … | … | … |
| P jirovecii PCR– | 0 (0) | 57 (97) | … | … | … | … |
Abbreviations: BAL, bronchoalveolar lavage; CI, confidence interval; NPV, negative predictive value; PCR, polymerase chain reaction; PPV, positive predictive value.
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