Table 1.
Open in new tab

Baseline characteristics and laboratory findings in the two groups

Total
Age ≤ 70
Age >70
P value
(n = 437)(n = 298)(n = 139)
Age0.001
 Ages, median (IQR)656077
 Minimum age202065
 Maximum age956495
Gender0.023
 Female19713265
 Male24016674
Death10256460.001
Disease severity<0.001
 Non-severe29722275
 Severe1407664
WBC (×109/l)6.3 (4.8–9.9)6.0 (4.6–9.3)7.1 (5.3–10.1)0.010
RBC (×109/l)4.1 (3.7–4.6)4.10 (3.7–4.6)4.04 (3.7–4.6)0.639
Platelet (×109/l)202 (146–270)211.5 (149–280)184 (1135–259)0.401
Hemoglobin (×109/l)126 (113–139)125 (112.7–138)126 (114–143)0.459
Neutrophil (×109/l)4.56 (3.2–8.5)4.2 (2.7–7.3)5.4 (3.8–9.8)<0.001
Lymphocyte (×109/l)0.9 (0.6–1.4)1.0 (0.6–1.6)0.8 (0.6–1.2)<0.001
Monocyte (×109/l)0.5 (0.3–0.6)0.4 (0.3–0.6)0.5 (0.3–0.7)0.729
Hematocrit (vol%)36.6 (33.1–40.3)36.9 (33.1–40.3)36.4 (33.1–41.4)0.962
Glucose (mmol/l)6.56 (5.46–8.92)6.30 (5.3–8.42)7.06 (5.82–10.33)0.001
ESR (mm/h)36 (16–62)34 (14–60)41 (20–63)0.079
NT-proBN (pg/ml)377 (129–1241.5)254 (80.5–1090)633 (225–1843)<0.001
Hs-CTnT (pg/ml)11 (3.3–51.7)6.1 (2.2–32.5)18.35 (6.53–82.4)<0.001
Procalcitonin (μg/ml)0.09 (0.04–0.25)0.08 (0.03–0.23)0.12 (0.05–0.47)0.003
ALT (U/ml)24 (16–41)26 (15–44)22 (16–37)0.154
AST (U/ml)30 (20–46)28 (20–45)34 (20–49)0.107
Total protein (g/l)67.8 (63.9–72.4)68.15 (63.98–72.63)67.5 (63.7–72.1)0.338
Albumin (g/l)33.1 (29.8–36.7)33.5 (29.8–36.9)31.9 (28.9–34.9)<0.001
Globulin (g/l)34.49 ± 5.8033.62 (±5.99)35.28 ± 5.500.002
TBIL (μmol/l)10.5 (7.5–14.95)9.95 (7.1–14.2)11.8 (8.7–17.6)<0.001
DBIL (μmol/l)4.7 (3.2–6.8)4.4 (2.97–6.2)5.4 (3.5–8.30)<0.001
ALP (U/l)70 (56–91.5)72 (56.75–92.25)67 (55–91)0.160
GGT (U/l)31 (20–56)33 (20–58)28 (20–51)0.150
TCHO (mmol/l)3.7 (3.07–4.32)3.8 (3.14–4.43)3.58 (2.96–4.14)0.007
LDH (U/l)330 (235.5–490.5)302.5 (223–479.25)363 (274–498)0.004
K4.36 (3.9–4.68)4.36 (3.91–4.65)4.35 (3.85–4.81)0.814
Na140.2 (137.3–142.7)140.3 (137.2–142.4)139.8 (137.3–143.6)0.546
CL101.2 (98.4–103.7)101.2 (98.2–103.6)101. (98.8–104.4)0.205
Ca2.13 (2.04–2.23)2.14 (2.04–2.24)2.1 (2.04–2.19)0.081
UREA (mmol/l)5.4 (3.7–8.4)5 (3.4–7.03)6.9 (4.6–11.1)<0.001
Creatinine (μmol/l)74 (59–93)71 (58–88)84 (66–110)<0.001
Uric acid (μmol/l)259 (187–325)246.5 (179.75–320.25)270 (209–343)0.033
HCO3−24 (21.6–26.05)24.25 (22.27–26.23)23.4 (19.7–25.4)0.001
hs-CRP (μmol/l)38.5 (7.2–92.8)27.5 (4.75–83.55)56 (13.3–99.6)<0.001
PT (s)14.2 (13.5–15.3)14.1 (13.5–15.1)14.6 (13.8–15.9)0.002
Fibrinogen (g/l)4.84 (±1.79)4.73 (±1.74)4.94 (±1.82)0.124
D-Dimer (mg/l)1.52 (0.6–5.9)1.3 (0.4–4.0)2.1 (1.2–7.6)<0.001
IL-2R (Pg/ml)740 (433–1179)666.5 (393.5–1063.5)973 (566–1376)<0.001
IL-6 (Pg/ml)12.3 (3.2–51.5)9.8 (2.28–45.43)25.6 (5.8–72.0)<0.001
IL-8 (Pg/ml)13.4 (6.2–28.4)12.3 (6.2–26.1)19.0 (6.5–42.2)0.012
IL-10 (Pg/ml)5.0 (5.0–9.1)5.0 (5.0–8.4)5.0 (5.0–10.7)0.081
TNF-α (Pg/ml)8.3 (5.7–12.0)7.5 (5.5–11.3)10.7 (6.7–14.4)<0.001
Total
Age ≤ 70
Age >70
P value
(n = 437)(n = 298)(n = 139)
Age0.001
 Ages, median (IQR)656077
 Minimum age202065
 Maximum age956495
Gender0.023
 Female19713265
 Male24016674
Death10256460.001
Disease severity<0.001
 Non-severe29722275
 Severe1407664
WBC (×109/l)6.3 (4.8–9.9)6.0 (4.6–9.3)7.1 (5.3–10.1)0.010
RBC (×109/l)4.1 (3.7–4.6)4.10 (3.7–4.6)4.04 (3.7–4.6)0.639
Platelet (×109/l)202 (146–270)211.5 (149–280)184 (1135–259)0.401
Hemoglobin (×109/l)126 (113–139)125 (112.7–138)126 (114–143)0.459
Neutrophil (×109/l)4.56 (3.2–8.5)4.2 (2.7–7.3)5.4 (3.8–9.8)<0.001
Lymphocyte (×109/l)0.9 (0.6–1.4)1.0 (0.6–1.6)0.8 (0.6–1.2)<0.001
Monocyte (×109/l)0.5 (0.3–0.6)0.4 (0.3–0.6)0.5 (0.3–0.7)0.729
Hematocrit (vol%)36.6 (33.1–40.3)36.9 (33.1–40.3)36.4 (33.1–41.4)0.962
Glucose (mmol/l)6.56 (5.46–8.92)6.30 (5.3–8.42)7.06 (5.82–10.33)0.001
ESR (mm/h)36 (16–62)34 (14–60)41 (20–63)0.079
NT-proBN (pg/ml)377 (129–1241.5)254 (80.5–1090)633 (225–1843)<0.001
Hs-CTnT (pg/ml)11 (3.3–51.7)6.1 (2.2–32.5)18.35 (6.53–82.4)<0.001
Procalcitonin (μg/ml)0.09 (0.04–0.25)0.08 (0.03–0.23)0.12 (0.05–0.47)0.003
ALT (U/ml)24 (16–41)26 (15–44)22 (16–37)0.154
AST (U/ml)30 (20–46)28 (20–45)34 (20–49)0.107
Total protein (g/l)67.8 (63.9–72.4)68.15 (63.98–72.63)67.5 (63.7–72.1)0.338
Albumin (g/l)33.1 (29.8–36.7)33.5 (29.8–36.9)31.9 (28.9–34.9)<0.001
Globulin (g/l)34.49 ± 5.8033.62 (±5.99)35.28 ± 5.500.002
TBIL (μmol/l)10.5 (7.5–14.95)9.95 (7.1–14.2)11.8 (8.7–17.6)<0.001
DBIL (μmol/l)4.7 (3.2–6.8)4.4 (2.97–6.2)5.4 (3.5–8.30)<0.001
ALP (U/l)70 (56–91.5)72 (56.75–92.25)67 (55–91)0.160
GGT (U/l)31 (20–56)33 (20–58)28 (20–51)0.150
TCHO (mmol/l)3.7 (3.07–4.32)3.8 (3.14–4.43)3.58 (2.96–4.14)0.007
LDH (U/l)330 (235.5–490.5)302.5 (223–479.25)363 (274–498)0.004
K4.36 (3.9–4.68)4.36 (3.91–4.65)4.35 (3.85–4.81)0.814
Na140.2 (137.3–142.7)140.3 (137.2–142.4)139.8 (137.3–143.6)0.546
CL101.2 (98.4–103.7)101.2 (98.2–103.6)101. (98.8–104.4)0.205
Ca2.13 (2.04–2.23)2.14 (2.04–2.24)2.1 (2.04–2.19)0.081
UREA (mmol/l)5.4 (3.7–8.4)5 (3.4–7.03)6.9 (4.6–11.1)<0.001
Creatinine (μmol/l)74 (59–93)71 (58–88)84 (66–110)<0.001
Uric acid (μmol/l)259 (187–325)246.5 (179.75–320.25)270 (209–343)0.033
HCO3−24 (21.6–26.05)24.25 (22.27–26.23)23.4 (19.7–25.4)0.001
hs-CRP (μmol/l)38.5 (7.2–92.8)27.5 (4.75–83.55)56 (13.3–99.6)<0.001
PT (s)14.2 (13.5–15.3)14.1 (13.5–15.1)14.6 (13.8–15.9)0.002
Fibrinogen (g/l)4.84 (±1.79)4.73 (±1.74)4.94 (±1.82)0.124
D-Dimer (mg/l)1.52 (0.6–5.9)1.3 (0.4–4.0)2.1 (1.2–7.6)<0.001
IL-2R (Pg/ml)740 (433–1179)666.5 (393.5–1063.5)973 (566–1376)<0.001
IL-6 (Pg/ml)12.3 (3.2–51.5)9.8 (2.28–45.43)25.6 (5.8–72.0)<0.001
IL-8 (Pg/ml)13.4 (6.2–28.4)12.3 (6.2–26.1)19.0 (6.5–42.2)0.012
IL-10 (Pg/ml)5.0 (5.0–9.1)5.0 (5.0–8.4)5.0 (5.0–10.7)0.081
TNF-α (Pg/ml)8.3 (5.7–12.0)7.5 (5.5–11.3)10.7 (6.7–14.4)<0.001
Table 1.
Open in new tab

Baseline characteristics and laboratory findings in the two groups

Total
Age ≤ 70
Age >70
P value
(n = 437)(n = 298)(n = 139)
Age0.001
 Ages, median (IQR)656077
 Minimum age202065
 Maximum age956495
Gender0.023
 Female19713265
 Male24016674
Death10256460.001
Disease severity<0.001
 Non-severe29722275
 Severe1407664
WBC (×109/l)6.3 (4.8–9.9)6.0 (4.6–9.3)7.1 (5.3–10.1)0.010
RBC (×109/l)4.1 (3.7–4.6)4.10 (3.7–4.6)4.04 (3.7–4.6)0.639
Platelet (×109/l)202 (146–270)211.5 (149–280)184 (1135–259)0.401
Hemoglobin (×109/l)126 (113–139)125 (112.7–138)126 (114–143)0.459
Neutrophil (×109/l)4.56 (3.2–8.5)4.2 (2.7–7.3)5.4 (3.8–9.8)<0.001
Lymphocyte (×109/l)0.9 (0.6–1.4)1.0 (0.6–1.6)0.8 (0.6–1.2)<0.001
Monocyte (×109/l)0.5 (0.3–0.6)0.4 (0.3–0.6)0.5 (0.3–0.7)0.729
Hematocrit (vol%)36.6 (33.1–40.3)36.9 (33.1–40.3)36.4 (33.1–41.4)0.962
Glucose (mmol/l)6.56 (5.46–8.92)6.30 (5.3–8.42)7.06 (5.82–10.33)0.001
ESR (mm/h)36 (16–62)34 (14–60)41 (20–63)0.079
NT-proBN (pg/ml)377 (129–1241.5)254 (80.5–1090)633 (225–1843)<0.001
Hs-CTnT (pg/ml)11 (3.3–51.7)6.1 (2.2–32.5)18.35 (6.53–82.4)<0.001
Procalcitonin (μg/ml)0.09 (0.04–0.25)0.08 (0.03–0.23)0.12 (0.05–0.47)0.003
ALT (U/ml)24 (16–41)26 (15–44)22 (16–37)0.154
AST (U/ml)30 (20–46)28 (20–45)34 (20–49)0.107
Total protein (g/l)67.8 (63.9–72.4)68.15 (63.98–72.63)67.5 (63.7–72.1)0.338
Albumin (g/l)33.1 (29.8–36.7)33.5 (29.8–36.9)31.9 (28.9–34.9)<0.001
Globulin (g/l)34.49 ± 5.8033.62 (±5.99)35.28 ± 5.500.002
TBIL (μmol/l)10.5 (7.5–14.95)9.95 (7.1–14.2)11.8 (8.7–17.6)<0.001
DBIL (μmol/l)4.7 (3.2–6.8)4.4 (2.97–6.2)5.4 (3.5–8.30)<0.001
ALP (U/l)70 (56–91.5)72 (56.75–92.25)67 (55–91)0.160
GGT (U/l)31 (20–56)33 (20–58)28 (20–51)0.150
TCHO (mmol/l)3.7 (3.07–4.32)3.8 (3.14–4.43)3.58 (2.96–4.14)0.007
LDH (U/l)330 (235.5–490.5)302.5 (223–479.25)363 (274–498)0.004
K4.36 (3.9–4.68)4.36 (3.91–4.65)4.35 (3.85–4.81)0.814
Na140.2 (137.3–142.7)140.3 (137.2–142.4)139.8 (137.3–143.6)0.546
CL101.2 (98.4–103.7)101.2 (98.2–103.6)101. (98.8–104.4)0.205
Ca2.13 (2.04–2.23)2.14 (2.04–2.24)2.1 (2.04–2.19)0.081
UREA (mmol/l)5.4 (3.7–8.4)5 (3.4–7.03)6.9 (4.6–11.1)<0.001
Creatinine (μmol/l)74 (59–93)71 (58–88)84 (66–110)<0.001
Uric acid (μmol/l)259 (187–325)246.5 (179.75–320.25)270 (209–343)0.033
HCO3−24 (21.6–26.05)24.25 (22.27–26.23)23.4 (19.7–25.4)0.001
hs-CRP (μmol/l)38.5 (7.2–92.8)27.5 (4.75–83.55)56 (13.3–99.6)<0.001
PT (s)14.2 (13.5–15.3)14.1 (13.5–15.1)14.6 (13.8–15.9)0.002
Fibrinogen (g/l)4.84 (±1.79)4.73 (±1.74)4.94 (±1.82)0.124
D-Dimer (mg/l)1.52 (0.6–5.9)1.3 (0.4–4.0)2.1 (1.2–7.6)<0.001
IL-2R (Pg/ml)740 (433–1179)666.5 (393.5–1063.5)973 (566–1376)<0.001
IL-6 (Pg/ml)12.3 (3.2–51.5)9.8 (2.28–45.43)25.6 (5.8–72.0)<0.001
IL-8 (Pg/ml)13.4 (6.2–28.4)12.3 (6.2–26.1)19.0 (6.5–42.2)0.012
IL-10 (Pg/ml)5.0 (5.0–9.1)5.0 (5.0–8.4)5.0 (5.0–10.7)0.081
TNF-α (Pg/ml)8.3 (5.7–12.0)7.5 (5.5–11.3)10.7 (6.7–14.4)<0.001
Total
Age ≤ 70
Age >70
P value
(n = 437)(n = 298)(n = 139)
Age0.001
 Ages, median (IQR)656077
 Minimum age202065
 Maximum age956495
Gender0.023
 Female19713265
 Male24016674
Death10256460.001
Disease severity<0.001
 Non-severe29722275
 Severe1407664
WBC (×109/l)6.3 (4.8–9.9)6.0 (4.6–9.3)7.1 (5.3–10.1)0.010
RBC (×109/l)4.1 (3.7–4.6)4.10 (3.7–4.6)4.04 (3.7–4.6)0.639
Platelet (×109/l)202 (146–270)211.5 (149–280)184 (1135–259)0.401
Hemoglobin (×109/l)126 (113–139)125 (112.7–138)126 (114–143)0.459
Neutrophil (×109/l)4.56 (3.2–8.5)4.2 (2.7–7.3)5.4 (3.8–9.8)<0.001
Lymphocyte (×109/l)0.9 (0.6–1.4)1.0 (0.6–1.6)0.8 (0.6–1.2)<0.001
Monocyte (×109/l)0.5 (0.3–0.6)0.4 (0.3–0.6)0.5 (0.3–0.7)0.729
Hematocrit (vol%)36.6 (33.1–40.3)36.9 (33.1–40.3)36.4 (33.1–41.4)0.962
Glucose (mmol/l)6.56 (5.46–8.92)6.30 (5.3–8.42)7.06 (5.82–10.33)0.001
ESR (mm/h)36 (16–62)34 (14–60)41 (20–63)0.079
NT-proBN (pg/ml)377 (129–1241.5)254 (80.5–1090)633 (225–1843)<0.001
Hs-CTnT (pg/ml)11 (3.3–51.7)6.1 (2.2–32.5)18.35 (6.53–82.4)<0.001
Procalcitonin (μg/ml)0.09 (0.04–0.25)0.08 (0.03–0.23)0.12 (0.05–0.47)0.003
ALT (U/ml)24 (16–41)26 (15–44)22 (16–37)0.154
AST (U/ml)30 (20–46)28 (20–45)34 (20–49)0.107
Total protein (g/l)67.8 (63.9–72.4)68.15 (63.98–72.63)67.5 (63.7–72.1)0.338
Albumin (g/l)33.1 (29.8–36.7)33.5 (29.8–36.9)31.9 (28.9–34.9)<0.001
Globulin (g/l)34.49 ± 5.8033.62 (±5.99)35.28 ± 5.500.002
TBIL (μmol/l)10.5 (7.5–14.95)9.95 (7.1–14.2)11.8 (8.7–17.6)<0.001
DBIL (μmol/l)4.7 (3.2–6.8)4.4 (2.97–6.2)5.4 (3.5–8.30)<0.001
ALP (U/l)70 (56–91.5)72 (56.75–92.25)67 (55–91)0.160
GGT (U/l)31 (20–56)33 (20–58)28 (20–51)0.150
TCHO (mmol/l)3.7 (3.07–4.32)3.8 (3.14–4.43)3.58 (2.96–4.14)0.007
LDH (U/l)330 (235.5–490.5)302.5 (223–479.25)363 (274–498)0.004
K4.36 (3.9–4.68)4.36 (3.91–4.65)4.35 (3.85–4.81)0.814
Na140.2 (137.3–142.7)140.3 (137.2–142.4)139.8 (137.3–143.6)0.546
CL101.2 (98.4–103.7)101.2 (98.2–103.6)101. (98.8–104.4)0.205
Ca2.13 (2.04–2.23)2.14 (2.04–2.24)2.1 (2.04–2.19)0.081
UREA (mmol/l)5.4 (3.7–8.4)5 (3.4–7.03)6.9 (4.6–11.1)<0.001
Creatinine (μmol/l)74 (59–93)71 (58–88)84 (66–110)<0.001
Uric acid (μmol/l)259 (187–325)246.5 (179.75–320.25)270 (209–343)0.033
HCO3−24 (21.6–26.05)24.25 (22.27–26.23)23.4 (19.7–25.4)0.001
hs-CRP (μmol/l)38.5 (7.2–92.8)27.5 (4.75–83.55)56 (13.3–99.6)<0.001
PT (s)14.2 (13.5–15.3)14.1 (13.5–15.1)14.6 (13.8–15.9)0.002
Fibrinogen (g/l)4.84 (±1.79)4.73 (±1.74)4.94 (±1.82)0.124
D-Dimer (mg/l)1.52 (0.6–5.9)1.3 (0.4–4.0)2.1 (1.2–7.6)<0.001
IL-2R (Pg/ml)740 (433–1179)666.5 (393.5–1063.5)973 (566–1376)<0.001
IL-6 (Pg/ml)12.3 (3.2–51.5)9.8 (2.28–45.43)25.6 (5.8–72.0)<0.001
IL-8 (Pg/ml)13.4 (6.2–28.4)12.3 (6.2–26.1)19.0 (6.5–42.2)0.012
IL-10 (Pg/ml)5.0 (5.0–9.1)5.0 (5.0–8.4)5.0 (5.0–10.7)0.081
TNF-α (Pg/ml)8.3 (5.7–12.0)7.5 (5.5–11.3)10.7 (6.7–14.4)<0.001
Close
This Feature Is Available To Subscribers Only

Sign In or Create an Account

Close

This PDF is available to Subscribers Only

View Article Abstract & Purchase Options

For full access to this pdf, sign in to an existing account, or purchase an annual subscription.

Close