Table 2: Open in new tab Procedural...

	All patients (n = 1510)	LM patients (n = 648)	3VD patients (n = 861)
Time from treatment allocation to CABG (days)	1 IQR 1–3 (259)	6 IQR 2–17 (1251)	<0.001	1 IQR 0–3 (145)	4 IQR 1–11 (503)	<0.001	1 IQR 1–4 (114)	7 IQR 2–23 (747)	<0.001
Off-pump (%)	32% (83/258)	13% (167/1250)	<0.001	28% (41/145)	16% (78/503)	0.002	37% (42/114)	12% (89/747)	<0.001
Cardioplegia
Crystalloid (%)	17% (43/258)	38% (474/1250)	<0.001	19% (28/145)	37% (189/502)	<0.001	13% (15/114)	38% (285/747)	<0.001
Blood (%)	53% (138/258)	45% (565/1250)	0.054	54% (79/145)	44% (221/502)	0.073	52% (59/114)	46% (343/747)	0.25
Both (%)	5% (12/258)	1% (15/1250)	<0.001	5% (7/145)	2% (10/502)	0.059	4% (5/114)	1% (5/747)	0.005
Aprotinin given (%)	15% (38/258)	39% (492/1250)	<0.001	18% (26/145)	38% (190/502)	<0.001	11% (12/114)	40% (302/747)	<0.001
Grafts
Arterial graft to LAD (%)	95% (245/259)	95% (1193/1251)	0.60	94% (135/145)	95% (476/503)	0.49	96% (110/114)	96% (716/747)	>0.99
LIMA use (%)	96% (249/259)	97% (1209/1251)	0.69	95% (138/145)	96% (485/503)	0.49	97% (111/114)	97% (723/747)	>0.99
BIMA use (%)	10% (26/259)	25% (314/1251)	<0.001	8% (11/145)	24% (122/503)	<0.001	13% (15/114)	26% (192/747)	0.004
Radial artery use (%)	9% (24/259)	14% (169/1251)	0.063	8% (12/145)	11% (57/503)	0.29	11% (12/114)	15% (112/747)	0.21
Complete arterial (%)	5% (12/259)	18% (221/1251)	<0.001	4% (6/145)	22% (109/503)	<0.001	5% (6/114)	15% (112/747)	0.005
At least one arterial graft (%)	96% (249/259)	97% (1217/1251)	0.32	95% (138/145)	97% (488/503)	0.28	97% (111/114)	97% (728/747)	>0.99
More than one arterial graft (%)	17% (43/259)	33% (417/1251)	<0.001	16% (23/145)	31% (158/503)	<0.001	18% (20/114)	34% (259/747)	<0.001
Venous grafts only (%)	4% (10/259)	3% (33/1251)	0.25	5% (7/145)	2% (14/503)	0.22	3% (3/114)	3% (19/747)	>0.99
Grafts per patient, n	3 IQR 3–4 (259)	3 IQR 2–3 (1251)	<0.001	3 IQR 2–4 (145)	3 IQR 2–3 (503)	<0.001	3 IQR 3–4 (114)	3 IQR 2–3 (747)	<0.001
Arterial, n	1 IQR 1–1 (259)	1 IQR 1–2 (1251)	<0.001	1 IQR 1–1 (145)	1 IQR 1–2 (503)	<0.001	1 IQR 1–1 (114)	1 IQR 1–2 (747)	0.008
Venous, n	2 IQR 1–3 (259)	1 IQR 1–2 (1251)	<0.001	2 IQR1–3 (145)	1 IQR 1–2 (503)	<0.001	2 IQR 2–3 (114)	1 IQR 1–2 (747)	<0.001
Incomplete revascularization (%)	20% (52/259)	34% (420/1251)	<0.001	19% (27/145)	27% (136/503)	0.040	22% (25/114)	38% (283/747)	0.001
Procedure time (h)	3.8 IQR 3.2–4.5 (259)	3.3 IQR 2.8–4.0 (1241)	<0.001	3.8 IQR 3.1–4.5 (145)	3.3 IQR 2.6–3.9 (501)	<0.001	3.8 IQR 3.3–4.5 (114)	3.4 IQR 2.8–4.0 (739)	<0.001
Bypass time (min)	29 IQR 16–45 (177)	30 IQR 13–43 (1060)	<0.001	34 IQR 17–46 (104)	30 IQR 13–43 (414)	<0.001	26 IQR 11–42 (73)	29 IQR 14–43 (645)	0.002
Cross-clamp time (min)	30 IQR 15–43 (162)	35 IQR 20–46 (974)	<0.001	31 IQR 18–43 (94)	35 IQR 22–46 (384)	<0.001	28 IQR 14–46 (68)	36 IQR 18–46 (589)	<0.001
Distal anastomoses/patient, n	4 IQR 3–4 (259)	3 IQR 3–4 (1251)	<0.001	3 IQR 3–4 (145)	3 IQR 2–4 (503)	0.001	4 IQR 3–4 (114)	3 IQR 3–4 (747)	0.001
Graft to LAD territory, any (%)	98% (255/259)	98% (1227/1251)	0.69	98% (143/145)	98% (494/503)	0.74	98% (112/114)	98% (732/747)	0.86
Graft to Cx territory, any (%)	95% (247/251)	92% (1149/1251)	0.051	94% (135/145)	92% (461/503)	0.40	97% (111/114)	93% (691/747)	0.055
Graft to RCA territory, any (%)	77% (199/259)	73% (912/1251)	0.19	68% (99/145)	58% (293/503)	0.030	88% (100/114)	83% (619/747)	0.19
Endarterectomy, any	4% (11/259)	4% (45/1251)	0.61	4% (6/145)	4% (20/503)	0.93	4% (5/114)	3% (25/747)	0.58
Use of Y-graft, any	5% (13/259)	11% (132/1251)	0.006	4% (6/145)	11% (53/503)	0.018	6% (7/114)	11% (79/747)	0.14
Use of jump-graft, any	29% (76/259)	36% (456/1251)	0.029	23% (34/145)	32% (162/503)	0.043	37% (42/114)	39% (294/747)	0.61
Intra-aortic balloon pump (%)	4% (10/258)	4% (47/1250)	0.90	6% (8/145)	6% (29/503)	0.86	2% (2/114)	2% (18/747)	<0.99
Postprocedural hospital stay (days)	5 IQR 4–7 (259)	7 IQR 6–10 (1251)	<0.001	5 IQR 4–6 (145)	7 IQR 6–10 (503)	<0.001	5 IQR 4–7(145)	8 IQR 6–10 (747)	<0.001

All patients (n = 1510)

LM patients (n = 648)

3VD patients (n = 861)

USA (n = 259)

Europe (n = 1251)

P-value

USA (n = 145)

Europe (n = 503)

P-value

USA (n = 114)

Europe (n = 747)

P-value

Time from treatment allocation to CABG (days)

1 IQR 1–3 (259)

6 IQR 2–17 (1251)

<0.001

1 IQR 0–3 (145)

4 IQR 1–11 (503)

<0.001

1 IQR 1–4 (114)

7 IQR 2–23 (747)

<0.001

Off-pump (%)

32% (83/258)

13% (167/1250)

<0.001

28% (41/145)

16% (78/503)

0.002

37% (42/114)

12% (89/747)

<0.001

Cardioplegia

Crystalloid (%)

17% (43/258)

38% (474/1250)

<0.001

19% (28/145)

37% (189/502)

<0.001

13% (15/114)

38% (285/747)

<0.001

Blood (%)

53% (138/258)

45% (565/1250)

0.054

54% (79/145)

44% (221/502)

0.073

52% (59/114)

46% (343/747)

0.25

Both (%)

5% (12/258)

1% (15/1250)

<0.001

5% (7/145)

2% (10/502)

0.059

4% (5/114)

1% (5/747)

0.005

Aprotinin given (%)

15% (38/258)

39% (492/1250)

<0.001

18% (26/145)

38% (190/502)

<0.001

11% (12/114)

40% (302/747)

<0.001

Grafts

Arterial graft to LAD (%)

95% (245/259)

95% (1193/1251)

0.60

94% (135/145)

95% (476/503)

0.49

96% (110/114)

96% (716/747)

>0.99

LIMA use (%)

96% (249/259)

97% (1209/1251)

0.69

95% (138/145)

96% (485/503)

0.49

97% (111/114)

97% (723/747)

>0.99

BIMA use (%)

10% (26/259)

25% (314/1251)

<0.001

8% (11/145)

24% (122/503)

<0.001

13% (15/114)

26% (192/747)

0.004

Radial artery use (%)

9% (24/259)

14% (169/1251)

0.063

8% (12/145)

11% (57/503)

0.29

11% (12/114)

15% (112/747)

0.21

Complete arterial (%)

5% (12/259)

18% (221/1251)

<0.001

4% (6/145)

22% (109/503)

<0.001

5% (6/114)

15% (112/747)

0.005

At least one arterial graft (%)

96% (249/259)

97% (1217/1251)

0.32

95% (138/145)

97% (488/503)

0.28

97% (111/114)

97% (728/747)

>0.99

More than one arterial graft (%)

17% (43/259)

33% (417/1251)

<0.001

16% (23/145)

31% (158/503)

<0.001

18% (20/114)

34% (259/747)

<0.001

Venous grafts only (%)

4% (10/259)

3% (33/1251)

0.25

5% (7/145)

2% (14/503)

0.22

3% (3/114)

3% (19/747)

>0.99

Grafts per patient, n

3 IQR 3–4 (259)

3 IQR 2–3 (1251)

<0.001

3 IQR 2–4 (145)

3 IQR 2–3 (503)

<0.001

3 IQR 3–4 (114)

3 IQR 2–3 (747)

<0.001

Arterial, n

1 IQR 1–1 (259)

1 IQR 1–2 (1251)

<0.001

1 IQR 1–1 (145)

1 IQR 1–2 (503)

<0.001

1 IQR 1–1 (114)

1 IQR 1–2 (747)

0.008

Venous, n

2 IQR 1–3 (259)

1 IQR 1–2 (1251)

<0.001

2 IQR1–3 (145)

1 IQR 1–2 (503)

<0.001

2 IQR 2–3 (114)

1 IQR 1–2 (747)

<0.001

Incomplete revascularization (%)

20% (52/259)

34% (420/1251)

<0.001

19% (27/145)

27% (136/503)

0.040

22% (25/114)

38% (283/747)

0.001

Procedure time (h)

3.8 IQR 3.2–4.5 (259)

3.3 IQR 2.8–4.0 (1241)

<0.001

3.8 IQR 3.1–4.5 (145)

3.3 IQR 2.6–3.9 (501)

<0.001

3.8 IQR 3.3–4.5 (114)

3.4 IQR 2.8–4.0 (739)

<0.001

Bypass time (min)

29 IQR 16–45 (177)

30 IQR 13–43 (1060)

<0.001

34 IQR 17–46 (104)

30 IQR 13–43 (414)

<0.001

26 IQR 11–42 (73)

29 IQR 14–43 (645)

0.002

Cross-clamp time (min)

30 IQR 15–43 (162)

35 IQR 20–46 (974)

<0.001

31 IQR 18–43 (94)

35 IQR 22–46 (384)

<0.001

28 IQR 14–46 (68)

36 IQR 18–46 (589)

<0.001

Distal anastomoses/patient, n

4 IQR 3–4 (259)

3 IQR 3–4 (1251)

<0.001

3 IQR 3–4 (145)

3 IQR 2–4 (503)

0.001

4 IQR 3–4 (114)

3 IQR 3–4 (747)

0.001

Graft to LAD territory, any (%)

98% (255/259)

98% (1227/1251)

0.69

98% (143/145)

98% (494/503)

0.74

98% (112/114)

98% (732/747)

0.86

Graft to Cx territory, any (%)

95% (247/251)

92% (1149/1251)

0.051

94% (135/145)

92% (461/503)

0.40

97% (111/114)

93% (691/747)

0.055

Graft to RCA territory, any (%)

77% (199/259)

73% (912/1251)

0.19

68% (99/145)

58% (293/503)

0.030

88% (100/114)

83% (619/747)

0.19

Endarterectomy, any

4% (11/259)

4% (45/1251)

0.61

4% (6/145)

4% (20/503)

0.93

4% (5/114)

3% (25/747)

0.58

Use of Y-graft, any

5% (13/259)

11% (132/1251)

0.006

4% (6/145)

11% (53/503)

0.018

6% (7/114)

11% (79/747)

0.14

Use of jump-graft, any

29% (76/259)

36% (456/1251)

0.029

23% (34/145)

32% (162/503)

0.043

37% (42/114)

39% (294/747)

0.61

Intra-aortic balloon pump (%)

4% (10/258)

4% (47/1250)

0.90

6% (8/145)

6% (29/503)

0.86

2% (2/114)

2% (18/747)

<0.99

Postprocedural hospital stay (days)

5 IQR 4–7 (259)

7 IQR 6–10 (1251)

<0.001

5 IQR 4–6 (145)

7 IQR 6–10 (503)

<0.001

5 IQR 4–7(145)

8 IQR 6–10 (747)

<0.001

	All patients (n = 1510)	LM patients (n = 648)	3VD patients (n = 861)
Time from treatment allocation to CABG (days)	1 IQR 1–3 (259)	6 IQR 2–17 (1251)	<0.001	1 IQR 0–3 (145)	4 IQR 1–11 (503)	<0.001	1 IQR 1–4 (114)	7 IQR 2–23 (747)	<0.001
Off-pump (%)	32% (83/258)	13% (167/1250)	<0.001	28% (41/145)	16% (78/503)	0.002	37% (42/114)	12% (89/747)	<0.001
Cardioplegia
Crystalloid (%)	17% (43/258)	38% (474/1250)	<0.001	19% (28/145)	37% (189/502)	<0.001	13% (15/114)	38% (285/747)	<0.001
Blood (%)	53% (138/258)	45% (565/1250)	0.054	54% (79/145)	44% (221/502)	0.073	52% (59/114)	46% (343/747)	0.25
Both (%)	5% (12/258)	1% (15/1250)	<0.001	5% (7/145)	2% (10/502)	0.059	4% (5/114)	1% (5/747)	0.005
Aprotinin given (%)	15% (38/258)	39% (492/1250)	<0.001	18% (26/145)	38% (190/502)	<0.001	11% (12/114)	40% (302/747)	<0.001
Grafts
Arterial graft to LAD (%)	95% (245/259)	95% (1193/1251)	0.60	94% (135/145)	95% (476/503)	0.49	96% (110/114)	96% (716/747)	>0.99
LIMA use (%)	96% (249/259)	97% (1209/1251)	0.69	95% (138/145)	96% (485/503)	0.49	97% (111/114)	97% (723/747)	>0.99
BIMA use (%)	10% (26/259)	25% (314/1251)	<0.001	8% (11/145)	24% (122/503)	<0.001	13% (15/114)	26% (192/747)	0.004
Radial artery use (%)	9% (24/259)	14% (169/1251)	0.063	8% (12/145)	11% (57/503)	0.29	11% (12/114)	15% (112/747)	0.21
Complete arterial (%)	5% (12/259)	18% (221/1251)	<0.001	4% (6/145)	22% (109/503)	<0.001	5% (6/114)	15% (112/747)	0.005
At least one arterial graft (%)	96% (249/259)	97% (1217/1251)	0.32	95% (138/145)	97% (488/503)	0.28	97% (111/114)	97% (728/747)	>0.99
More than one arterial graft (%)	17% (43/259)	33% (417/1251)	<0.001	16% (23/145)	31% (158/503)	<0.001	18% (20/114)	34% (259/747)	<0.001
Venous grafts only (%)	4% (10/259)	3% (33/1251)	0.25	5% (7/145)	2% (14/503)	0.22	3% (3/114)	3% (19/747)	>0.99
Grafts per patient, n	3 IQR 3–4 (259)	3 IQR 2–3 (1251)	<0.001	3 IQR 2–4 (145)	3 IQR 2–3 (503)	<0.001	3 IQR 3–4 (114)	3 IQR 2–3 (747)	<0.001
Arterial, n	1 IQR 1–1 (259)	1 IQR 1–2 (1251)	<0.001	1 IQR 1–1 (145)	1 IQR 1–2 (503)	<0.001	1 IQR 1–1 (114)	1 IQR 1–2 (747)	0.008
Venous, n	2 IQR 1–3 (259)	1 IQR 1–2 (1251)	<0.001	2 IQR1–3 (145)	1 IQR 1–2 (503)	<0.001	2 IQR 2–3 (114)	1 IQR 1–2 (747)	<0.001
Incomplete revascularization (%)	20% (52/259)	34% (420/1251)	<0.001	19% (27/145)	27% (136/503)	0.040	22% (25/114)	38% (283/747)	0.001
Procedure time (h)	3.8 IQR 3.2–4.5 (259)	3.3 IQR 2.8–4.0 (1241)	<0.001	3.8 IQR 3.1–4.5 (145)	3.3 IQR 2.6–3.9 (501)	<0.001	3.8 IQR 3.3–4.5 (114)	3.4 IQR 2.8–4.0 (739)	<0.001
Bypass time (min)	29 IQR 16–45 (177)	30 IQR 13–43 (1060)	<0.001	34 IQR 17–46 (104)	30 IQR 13–43 (414)	<0.001	26 IQR 11–42 (73)	29 IQR 14–43 (645)	0.002
Cross-clamp time (min)	30 IQR 15–43 (162)	35 IQR 20–46 (974)	<0.001	31 IQR 18–43 (94)	35 IQR 22–46 (384)	<0.001	28 IQR 14–46 (68)	36 IQR 18–46 (589)	<0.001
Distal anastomoses/patient, n	4 IQR 3–4 (259)	3 IQR 3–4 (1251)	<0.001	3 IQR 3–4 (145)	3 IQR 2–4 (503)	0.001	4 IQR 3–4 (114)	3 IQR 3–4 (747)	0.001
Graft to LAD territory, any (%)	98% (255/259)	98% (1227/1251)	0.69	98% (143/145)	98% (494/503)	0.74	98% (112/114)	98% (732/747)	0.86
Graft to Cx territory, any (%)	95% (247/251)	92% (1149/1251)	0.051	94% (135/145)	92% (461/503)	0.40	97% (111/114)	93% (691/747)	0.055
Graft to RCA territory, any (%)	77% (199/259)	73% (912/1251)	0.19	68% (99/145)	58% (293/503)	0.030	88% (100/114)	83% (619/747)	0.19
Endarterectomy, any	4% (11/259)	4% (45/1251)	0.61	4% (6/145)	4% (20/503)	0.93	4% (5/114)	3% (25/747)	0.58
Use of Y-graft, any	5% (13/259)	11% (132/1251)	0.006	4% (6/145)	11% (53/503)	0.018	6% (7/114)	11% (79/747)	0.14
Use of jump-graft, any	29% (76/259)	36% (456/1251)	0.029	23% (34/145)	32% (162/503)	0.043	37% (42/114)	39% (294/747)	0.61
Intra-aortic balloon pump (%)	4% (10/258)	4% (47/1250)	0.90	6% (8/145)	6% (29/503)	0.86	2% (2/114)	2% (18/747)	<0.99
Postprocedural hospital stay (days)	5 IQR 4–7 (259)	7 IQR 6–10 (1251)	<0.001	5 IQR 4–6 (145)	7 IQR 6–10 (503)	<0.001	5 IQR 4–7(145)	8 IQR 6–10 (747)	<0.001

All patients (n = 1510)

LM patients (n = 648)

3VD patients (n = 861)

USA (n = 259)

Europe (n = 1251)

P-value

USA (n = 145)

Europe (n = 503)

P-value

USA (n = 114)

Europe (n = 747)

P-value

Time from treatment allocation to CABG (days)

1 IQR 1–3 (259)

6 IQR 2–17 (1251)

<0.001

1 IQR 0–3 (145)

4 IQR 1–11 (503)

<0.001

1 IQR 1–4 (114)

7 IQR 2–23 (747)

<0.001

Off-pump (%)

32% (83/258)

13% (167/1250)

<0.001

28% (41/145)

16% (78/503)

0.002

37% (42/114)

12% (89/747)

<0.001

Cardioplegia

Crystalloid (%)

17% (43/258)

38% (474/1250)

<0.001

19% (28/145)

37% (189/502)

<0.001

13% (15/114)

38% (285/747)

<0.001

Blood (%)

53% (138/258)

45% (565/1250)

0.054

54% (79/145)

44% (221/502)

0.073

52% (59/114)

46% (343/747)

0.25

Both (%)

5% (12/258)

1% (15/1250)

<0.001

5% (7/145)

2% (10/502)

0.059

4% (5/114)

1% (5/747)

0.005

Aprotinin given (%)

15% (38/258)

39% (492/1250)

<0.001

18% (26/145)

38% (190/502)

<0.001

11% (12/114)

40% (302/747)

<0.001

Grafts

Arterial graft to LAD (%)

95% (245/259)

95% (1193/1251)

0.60

94% (135/145)

95% (476/503)

0.49

96% (110/114)

96% (716/747)

>0.99

LIMA use (%)

96% (249/259)

97% (1209/1251)

0.69

95% (138/145)

96% (485/503)

0.49

97% (111/114)

97% (723/747)

>0.99

BIMA use (%)

10% (26/259)

25% (314/1251)

<0.001

8% (11/145)

24% (122/503)

<0.001

13% (15/114)

26% (192/747)

0.004

Radial artery use (%)

9% (24/259)

14% (169/1251)

0.063

8% (12/145)

11% (57/503)

0.29

11% (12/114)

15% (112/747)

0.21

Complete arterial (%)

5% (12/259)

18% (221/1251)

<0.001

4% (6/145)

22% (109/503)

<0.001

5% (6/114)

15% (112/747)

0.005

At least one arterial graft (%)

96% (249/259)

97% (1217/1251)

0.32

95% (138/145)

97% (488/503)

0.28

97% (111/114)

97% (728/747)

>0.99

More than one arterial graft (%)

17% (43/259)

33% (417/1251)

<0.001

16% (23/145)

31% (158/503)

<0.001

18% (20/114)

34% (259/747)

<0.001

Venous grafts only (%)

4% (10/259)

3% (33/1251)

0.25

5% (7/145)

2% (14/503)

0.22

3% (3/114)

3% (19/747)

>0.99

Grafts per patient, n

3 IQR 3–4 (259)

3 IQR 2–3 (1251)

<0.001

3 IQR 2–4 (145)

3 IQR 2–3 (503)

<0.001

3 IQR 3–4 (114)

3 IQR 2–3 (747)

<0.001

Arterial, n

1 IQR 1–1 (259)

1 IQR 1–2 (1251)

<0.001

1 IQR 1–1 (145)

1 IQR 1–2 (503)

<0.001

1 IQR 1–1 (114)

1 IQR 1–2 (747)

0.008

Venous, n

2 IQR 1–3 (259)

1 IQR 1–2 (1251)

<0.001

2 IQR1–3 (145)

1 IQR 1–2 (503)

<0.001

2 IQR 2–3 (114)

1 IQR 1–2 (747)

<0.001

Incomplete revascularization (%)

20% (52/259)

34% (420/1251)

<0.001

19% (27/145)

27% (136/503)

0.040

22% (25/114)

38% (283/747)

0.001

Procedure time (h)

3.8 IQR 3.2–4.5 (259)

3.3 IQR 2.8–4.0 (1241)

<0.001

3.8 IQR 3.1–4.5 (145)

3.3 IQR 2.6–3.9 (501)

<0.001

3.8 IQR 3.3–4.5 (114)

3.4 IQR 2.8–4.0 (739)

<0.001

Bypass time (min)

29 IQR 16–45 (177)

30 IQR 13–43 (1060)

<0.001

34 IQR 17–46 (104)

30 IQR 13–43 (414)

<0.001

26 IQR 11–42 (73)

29 IQR 14–43 (645)

0.002

Cross-clamp time (min)

30 IQR 15–43 (162)

35 IQR 20–46 (974)

<0.001

31 IQR 18–43 (94)

35 IQR 22–46 (384)

<0.001

28 IQR 14–46 (68)

36 IQR 18–46 (589)

<0.001

Distal anastomoses/patient, n

4 IQR 3–4 (259)

3 IQR 3–4 (1251)

<0.001

3 IQR 3–4 (145)

3 IQR 2–4 (503)

0.001

4 IQR 3–4 (114)

3 IQR 3–4 (747)

0.001

Graft to LAD territory, any (%)

98% (255/259)

98% (1227/1251)

0.69

98% (143/145)

98% (494/503)

0.74

98% (112/114)

98% (732/747)

0.86

Graft to Cx territory, any (%)

95% (247/251)

92% (1149/1251)

0.051

94% (135/145)

92% (461/503)

0.40

97% (111/114)

93% (691/747)

0.055

Graft to RCA territory, any (%)

77% (199/259)

73% (912/1251)

0.19

68% (99/145)

58% (293/503)

0.030

88% (100/114)

83% (619/747)

0.19

Endarterectomy, any

4% (11/259)

4% (45/1251)

0.61

4% (6/145)

4% (20/503)

0.93

4% (5/114)

3% (25/747)

0.58

Use of Y-graft, any

5% (13/259)

11% (132/1251)

0.006

4% (6/145)

11% (53/503)

0.018

6% (7/114)

11% (79/747)

0.14

Use of jump-graft, any

29% (76/259)

36% (456/1251)

0.029

23% (34/145)

32% (162/503)

0.043

37% (42/114)

39% (294/747)

0.61

Intra-aortic balloon pump (%)

4% (10/258)

4% (47/1250)

0.90

6% (8/145)

6% (29/503)

0.86

2% (2/114)

2% (18/747)

<0.99

Postprocedural hospital stay (days)

5 IQR 4–7 (259)

7 IQR 6–10 (1251)

<0.001

5 IQR 4–6 (145)

7 IQR 6–10 (503)

<0.001

5 IQR 4–7(145)

8 IQR 6–10 (747)

<0.001

Table 2:

Open in new tab

Procedural characteristics

	All patients (n = 1510)			LM patients (n = 648)			3VD patients (n = 861)
	USA (n = 259)	Europe (n = 1251)	P-value	USA (n = 145)	Europe (n = 503)	P-value	USA (n = 114)	Europe (n = 747)	P-value
Time from treatment allocation to CABG (days)	1 IQR 1–3 (259)	6 IQR 2–17 (1251)	<0.001	1 IQR 0–3 (145)	4 IQR 1–11 (503)	<0.001	1 IQR 1–4 (114)	7 IQR 2–23 (747)	<0.001
Off-pump (%)	32% (83/258)	13% (167/1250)	<0.001	28% (41/145)	16% (78/503)	0.002	37% (42/114)	12% (89/747)	<0.001
Cardioplegia
Crystalloid (%)	17% (43/258)	38% (474/1250)	<0.001	19% (28/145)	37% (189/502)	<0.001	13% (15/114)	38% (285/747)	<0.001
Blood (%)	53% (138/258)	45% (565/1250)	0.054	54% (79/145)	44% (221/502)	0.073	52% (59/114)	46% (343/747)	0.25
Both (%)	5% (12/258)	1% (15/1250)	<0.001	5% (7/145)	2% (10/502)	0.059	4% (5/114)	1% (5/747)	0.005
Aprotinin given (%)	15% (38/258)	39% (492/1250)	<0.001	18% (26/145)	38% (190/502)	<0.001	11% (12/114)	40% (302/747)	<0.001
Grafts
Arterial graft to LAD (%)	95% (245/259)	95% (1193/1251)	0.60	94% (135/145)	95% (476/503)	0.49	96% (110/114)	96% (716/747)	>0.99
LIMA use (%)	96% (249/259)	97% (1209/1251)	0.69	95% (138/145)	96% (485/503)	0.49	97% (111/114)	97% (723/747)	>0.99
BIMA use (%)	10% (26/259)	25% (314/1251)	<0.001	8% (11/145)	24% (122/503)	<0.001	13% (15/114)	26% (192/747)	0.004
Radial artery use (%)	9% (24/259)	14% (169/1251)	0.063	8% (12/145)	11% (57/503)	0.29	11% (12/114)	15% (112/747)	0.21
Complete arterial (%)	5% (12/259)	18% (221/1251)	<0.001	4% (6/145)	22% (109/503)	<0.001	5% (6/114)	15% (112/747)	0.005
At least one arterial graft (%)	96% (249/259)	97% (1217/1251)	0.32	95% (138/145)	97% (488/503)	0.28	97% (111/114)	97% (728/747)	>0.99
More than one arterial graft (%)	17% (43/259)	33% (417/1251)	<0.001	16% (23/145)	31% (158/503)	<0.001	18% (20/114)	34% (259/747)	<0.001
Venous grafts only (%)	4% (10/259)	3% (33/1251)	0.25	5% (7/145)	2% (14/503)	0.22	3% (3/114)	3% (19/747)	>0.99
Grafts per patient, n	3 IQR 3–4 (259)	3 IQR 2–3 (1251)	<0.001	3 IQR 2–4 (145)	3 IQR 2–3 (503)	<0.001	3 IQR 3–4 (114)	3 IQR 2–3 (747)	<0.001
Arterial, n	1 IQR 1–1 (259)	1 IQR 1–2 (1251)	<0.001	1 IQR 1–1 (145)	1 IQR 1–2 (503)	<0.001	1 IQR 1–1 (114)	1 IQR 1–2 (747)	0.008
Venous, n	2 IQR 1–3 (259)	1 IQR 1–2 (1251)	<0.001	2 IQR1–3 (145)	1 IQR 1–2 (503)	<0.001	2 IQR 2–3 (114)	1 IQR 1–2 (747)	<0.001
Incomplete revascularization (%)	20% (52/259)	34% (420/1251)	<0.001	19% (27/145)	27% (136/503)	0.040	22% (25/114)	38% (283/747)	0.001
Procedure time (h)	3.8 IQR 3.2–4.5 (259)	3.3 IQR 2.8–4.0 (1241)	<0.001	3.8 IQR 3.1–4.5 (145)	3.3 IQR 2.6–3.9 (501)	<0.001	3.8 IQR 3.3–4.5 (114)	3.4 IQR 2.8–4.0 (739)	<0.001
Bypass time (min)	29 IQR 16–45 (177)	30 IQR 13–43 (1060)	<0.001	34 IQR 17–46 (104)	30 IQR 13–43 (414)	<0.001	26 IQR 11–42 (73)	29 IQR 14–43 (645)	0.002
Cross-clamp time (min)	30 IQR 15–43 (162)	35 IQR 20–46 (974)	<0.001	31 IQR 18–43 (94)	35 IQR 22–46 (384)	<0.001	28 IQR 14–46 (68)	36 IQR 18–46 (589)	<0.001
Distal anastomoses/patient, n	4 IQR 3–4 (259)	3 IQR 3–4 (1251)	<0.001	3 IQR 3–4 (145)	3 IQR 2–4 (503)	0.001	4 IQR 3–4 (114)	3 IQR 3–4 (747)	0.001
Graft to LAD territory, any (%)	98% (255/259)	98% (1227/1251)	0.69	98% (143/145)	98% (494/503)	0.74	98% (112/114)	98% (732/747)	0.86
Graft to Cx territory, any (%)	95% (247/251)	92% (1149/1251)	0.051	94% (135/145)	92% (461/503)	0.40	97% (111/114)	93% (691/747)	0.055
Graft to RCA territory, any (%)	77% (199/259)	73% (912/1251)	0.19	68% (99/145)	58% (293/503)	0.030	88% (100/114)	83% (619/747)	0.19
Endarterectomy, any	4% (11/259)	4% (45/1251)	0.61	4% (6/145)	4% (20/503)	0.93	4% (5/114)	3% (25/747)	0.58
Use of Y-graft, any	5% (13/259)	11% (132/1251)	0.006	4% (6/145)	11% (53/503)	0.018	6% (7/114)	11% (79/747)	0.14
Use of jump-graft, any	29% (76/259)	36% (456/1251)	0.029	23% (34/145)	32% (162/503)	0.043	37% (42/114)	39% (294/747)	0.61
Intra-aortic balloon pump (%)	4% (10/258)	4% (47/1250)	0.90	6% (8/145)	6% (29/503)	0.86	2% (2/114)	2% (18/747)	<0.99
Postprocedural hospital stay (days)	5 IQR 4–7 (259)	7 IQR 6–10 (1251)	<0.001	5 IQR 4–6 (145)	7 IQR 6–10 (503)	<0.001	5 IQR 4–7(145)	8 IQR 6–10 (747)	<0.001

	All patients (n = 1510)			LM patients (n = 648)			3VD patients (n = 861)
	USA (n = 259)	Europe (n = 1251)	P-value	USA (n = 145)	Europe (n = 503)	P-value	USA (n = 114)	Europe (n = 747)	P-value
Time from treatment allocation to CABG (days)	1 IQR 1–3 (259)	6 IQR 2–17 (1251)	<0.001	1 IQR 0–3 (145)	4 IQR 1–11 (503)	<0.001	1 IQR 1–4 (114)	7 IQR 2–23 (747)	<0.001
Off-pump (%)	32% (83/258)	13% (167/1250)	<0.001	28% (41/145)	16% (78/503)	0.002	37% (42/114)	12% (89/747)	<0.001
Cardioplegia
Crystalloid (%)	17% (43/258)	38% (474/1250)	<0.001	19% (28/145)	37% (189/502)	<0.001	13% (15/114)	38% (285/747)	<0.001
Blood (%)	53% (138/258)	45% (565/1250)	0.054	54% (79/145)	44% (221/502)	0.073	52% (59/114)	46% (343/747)	0.25
Both (%)	5% (12/258)	1% (15/1250)	<0.001	5% (7/145)	2% (10/502)	0.059	4% (5/114)	1% (5/747)	0.005
Aprotinin given (%)	15% (38/258)	39% (492/1250)	<0.001	18% (26/145)	38% (190/502)	<0.001	11% (12/114)	40% (302/747)	<0.001
Grafts
Arterial graft to LAD (%)	95% (245/259)	95% (1193/1251)	0.60	94% (135/145)	95% (476/503)	0.49	96% (110/114)	96% (716/747)	>0.99
LIMA use (%)	96% (249/259)	97% (1209/1251)	0.69	95% (138/145)	96% (485/503)	0.49	97% (111/114)	97% (723/747)	>0.99
BIMA use (%)	10% (26/259)	25% (314/1251)	<0.001	8% (11/145)	24% (122/503)	<0.001	13% (15/114)	26% (192/747)	0.004
Radial artery use (%)	9% (24/259)	14% (169/1251)	0.063	8% (12/145)	11% (57/503)	0.29	11% (12/114)	15% (112/747)	0.21
Complete arterial (%)	5% (12/259)	18% (221/1251)	<0.001	4% (6/145)	22% (109/503)	<0.001	5% (6/114)	15% (112/747)	0.005
At least one arterial graft (%)	96% (249/259)	97% (1217/1251)	0.32	95% (138/145)	97% (488/503)	0.28	97% (111/114)	97% (728/747)	>0.99
More than one arterial graft (%)	17% (43/259)	33% (417/1251)	<0.001	16% (23/145)	31% (158/503)	<0.001	18% (20/114)	34% (259/747)	<0.001
Venous grafts only (%)	4% (10/259)	3% (33/1251)	0.25	5% (7/145)	2% (14/503)	0.22	3% (3/114)	3% (19/747)	>0.99
Grafts per patient, n	3 IQR 3–4 (259)	3 IQR 2–3 (1251)	<0.001	3 IQR 2–4 (145)	3 IQR 2–3 (503)	<0.001	3 IQR 3–4 (114)	3 IQR 2–3 (747)	<0.001
Arterial, n	1 IQR 1–1 (259)	1 IQR 1–2 (1251)	<0.001	1 IQR 1–1 (145)	1 IQR 1–2 (503)	<0.001	1 IQR 1–1 (114)	1 IQR 1–2 (747)	0.008
Venous, n	2 IQR 1–3 (259)	1 IQR 1–2 (1251)	<0.001	2 IQR1–3 (145)	1 IQR 1–2 (503)	<0.001	2 IQR 2–3 (114)	1 IQR 1–2 (747)	<0.001
Incomplete revascularization (%)	20% (52/259)	34% (420/1251)	<0.001	19% (27/145)	27% (136/503)	0.040	22% (25/114)	38% (283/747)	0.001
Procedure time (h)	3.8 IQR 3.2–4.5 (259)	3.3 IQR 2.8–4.0 (1241)	<0.001	3.8 IQR 3.1–4.5 (145)	3.3 IQR 2.6–3.9 (501)	<0.001	3.8 IQR 3.3–4.5 (114)	3.4 IQR 2.8–4.0 (739)	<0.001
Bypass time (min)	29 IQR 16–45 (177)	30 IQR 13–43 (1060)	<0.001	34 IQR 17–46 (104)	30 IQR 13–43 (414)	<0.001	26 IQR 11–42 (73)	29 IQR 14–43 (645)	0.002
Cross-clamp time (min)	30 IQR 15–43 (162)	35 IQR 20–46 (974)	<0.001	31 IQR 18–43 (94)	35 IQR 22–46 (384)	<0.001	28 IQR 14–46 (68)	36 IQR 18–46 (589)	<0.001
Distal anastomoses/patient, n	4 IQR 3–4 (259)	3 IQR 3–4 (1251)	<0.001	3 IQR 3–4 (145)	3 IQR 2–4 (503)	0.001	4 IQR 3–4 (114)	3 IQR 3–4 (747)	0.001
Graft to LAD territory, any (%)	98% (255/259)	98% (1227/1251)	0.69	98% (143/145)	98% (494/503)	0.74	98% (112/114)	98% (732/747)	0.86
Graft to Cx territory, any (%)	95% (247/251)	92% (1149/1251)	0.051	94% (135/145)	92% (461/503)	0.40	97% (111/114)	93% (691/747)	0.055
Graft to RCA territory, any (%)	77% (199/259)	73% (912/1251)	0.19	68% (99/145)	58% (293/503)	0.030	88% (100/114)	83% (619/747)	0.19
Endarterectomy, any	4% (11/259)	4% (45/1251)	0.61	4% (6/145)	4% (20/503)	0.93	4% (5/114)	3% (25/747)	0.58
Use of Y-graft, any	5% (13/259)	11% (132/1251)	0.006	4% (6/145)	11% (53/503)	0.018	6% (7/114)	11% (79/747)	0.14
Use of jump-graft, any	29% (76/259)	36% (456/1251)	0.029	23% (34/145)	32% (162/503)	0.043	37% (42/114)	39% (294/747)	0.61
Intra-aortic balloon pump (%)	4% (10/258)	4% (47/1250)	0.90	6% (8/145)	6% (29/503)	0.86	2% (2/114)	2% (18/747)	<0.99
Postprocedural hospital stay (days)	5 IQR 4–7 (259)	7 IQR 6–10 (1251)	<0.001	5 IQR 4–6 (145)	7 IQR 6–10 (503)	<0.001	5 IQR 4–7(145)	8 IQR 6–10 (747)	<0.001

3VD: three-vessel disease; BIMA: bilateral internal mammary artery; CABG: coronary artery bypass grafting; Cx: circumflex artery; IQR: interquartile range; LAD: left anterior descending; LIMA: left internal mammary artery; LM: left main; RCA: right coronary artery.

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