Table 4. Open in new tab Pearson...

IKKβ Protein Content iAUC

Activated NFκB iAUC

p105 mRNA Content iAUC

p65 mRNA Content iAUC

IκBα mRNA Content iAUC

TNFα mRNA Content iAUC

p65 Protein Content iAUC

IκBα Protein Content iAUC

Plasma CRP iAUC

Combined groups

LH (iU/mL)

0.543

0.395

0.433

0.213

0.470

0.328

0.468

–0.477

0.527

0.0008*

0.016*

0.005*

0.188

0.003*

0.044

0.003*

0.002*

0.0005*

Testosterone (ng/dL)

0.421

0.375

0.439

0.355

0.497

0.357

0.324

–0.454

0.606

0.007*

0.019*

0.005*

0.026

0.001*

0.028

0.047

0.004*

0.0001*

Androstenedione (ng/mL)

0.631

0.388

0.479

0.514

0.576

0.591

0.548

–0.665

0.604

0.0001*

0.015*

0.002*

0.008*

0.0002*

0.0001*

0.0008*

0.0001*

DHEA-S (ug/dL)

0.075

0.081

0.089

0.082

0.014

0.029

0.016

–0.082

0.111

0.645

0.618

0.585

0.614

0.933

0.857

0.924

0.616

0.494

Testosterone AUC

0.583

0.525

0.448

0.275

0.436

0.360

0.465

–0.478

0.594

0.0002*

0.0005*

0.004*

0.086

0.006*

0.022

0.004*

0.002*

0.0001*

Androstenedione AUC

0.605

0.500

0.707

0.354

0.551

0.587

0.449

–0.601

0.701

0.0001*

0.001*

0.0001*

0.025

0.0003*

0.0001*

0.004*

0.0001*

17OH-progesterone AUC

0.486

0.437

0.417

0.504

0.457

0.526

0.412

–0.487

0.380

0.002*

0.005*

0.010*

0.001*

0.003*

0.0008*

0.008*

0.002*

0.019*

PCOS

LH (iU/mL)

0.187

0.512

0.031

0.512

0.116

0.278

0.077

–0.103

0.28

0.431

0.036

0.896

0.021

0.625

0.236

0.748

0.665

0.273

Testosterone (ng/dL)

0.078

0.751

0.013

0.168

0.493

0.047

0.278

–0.135

0.771

0.744

0.0005*

0.956

0.479

0.027

0.845

0.235

0.571

0.0002*

Androstenedione (ng/ mL)

0.511

0.577

0.013

0.489

0.446

0.274

0.006

–0.631

0.077

0.030

0.015*

0.957

0.047

0.049

0.242

0.978

0.005*

0.746

DHEA-S (ug/dL)

0.159

0.325

0.060

0.311

0.188

0.175

0.202

–0.003

0.150

0.504

0.162

0.800

0.181

0.427

0.461

0.393

0.989

0.528

Testosterone AUC

0.099

0.634

0.081

0.180

0.235

0.088

0.134

–0.023

0.638

0.677

0.005*

0.732

0.448

0.319

0.711

0.575

0.923

0.004*

Androstenedione AUC

0.565

0.636

0.562

0.008

0.473

0.476

0.103

–0.167

0.174

0.015*

0.006*

0.015*

0.974

0.035

0.046

0.666

0.481

0.464

17OH-progesterone AUC

0.217

0.573

0.140

0.479

0.343

0.140

0.025

–0.008

0.263

0.359

0.016*

0.556

0.048

0.139

0.557

0.917

0.973

0.263

Table 4.

Open in new tab

Pearson correlations of inflammation markers iAUC during the cream challenge test with circulating LH and androgens

	IKKβ Protein Content iAUC	Activated NFκB iAUC	p105 mRNA Content iAUC	p65 mRNA Content iAUC	IκBα mRNA Content iAUC	TNFα mRNA Content iAUC	p65 Protein Content iAUC	IκBα Protein Content iAUC	Plasma CRP iAUC
Combined groups
LH (iU/mL)
r	0.543	0.395	0.433	0.213	0.470	0.328	0.468	–0.477	0.527
P	0.0008*	0.016*	0.005*	0.188	0.003*	0.044	0.003*	0.002*	0.0005*
Testosterone (ng/dL)
r	0.421	0.375	0.439	0.355	0.497	0.357	0.324	–0.454	0.606
P	0.007*	0.019*	0.005*	0.026	0.001*	0.028	0.047	0.004*	0.0001*
Androstenedione (ng/mL)
r	0.631	0.388	0.479	0.514	0.576	0.591	0.548	–0.665	0.604
P	0.0001*	0.015*	0.002*	0.008*	0.0002*	0.0001*	0.0008*	0.0001*	0.0001*
DHEA-S (ug/dL)
r	0.075	0.081	0.089	0.082	0.014	0.029	0.016	–0.082	0.111
P	0.645	0.618	0.585	0.614	0.933	0.857	0.924	0.616	0.494
Testosterone AUC
r	0.583	0.525	0.448	0.275	0.436	0.360	0.465	–0.478	0.594
P	0.0002*	0.0005*	0.004*	0.086	0.006*	0.022	0.004*	0.002*	0.0001*
Androstenedione AUC
r	0.605	0.500	0.707	0.354	0.551	0.587	0.449	–0.601	0.701
P	0.0001*	0.001*	0.0001*	0.025	0.0003*	0.0001*	0.004*	0.0001*	0.0001*
17OH-progesterone AUC
r	0.486	0.437	0.417	0.504	0.457	0.526	0.412	–0.487	0.380
P	0.002*	0.005*	0.010*	0.001*	0.003*	0.0008*	0.008*	0.002*	0.019*
PCOS
LH (iU/mL)
r	0.187	0.512	0.031	0.512	0.116	0.278	0.077	–0.103	0.28
P	0.431	0.036	0.896	0.021	0.625	0.236	0.748	0.665	0.273
Testosterone (ng/dL)
r	0.078	0.751	0.013	0.168	0.493	0.047	0.278	–0.135	0.771
P	0.744	0.0005*	0.956	0.479	0.027	0.845	0.235	0.571	0.0002*
Androstenedione (ng/ mL)
r	0.511	0.577	0.013	0.489	0.446	0.274	0.006	–0.631	0.077
P	0.030	0.015*	0.957	0.047	0.049	0.242	0.978	0.005*	0.746
DHEA-S (ug/dL)
r	0.159	0.325	0.060	0.311	0.188	0.175	0.202	–0.003	0.150
P	0.504	0.162	0.800	0.181	0.427	0.461	0.393	0.989	0.528
Testosterone AUC
r	0.099	0.634	0.081	0.180	0.235	0.088	0.134	–0.023	0.638
P	0.677	0.005*	0.732	0.448	0.319	0.711	0.575	0.923	0.004*
Androstenedione AUC
r	0.565	0.636	0.562	0.008	0.473	0.476	0.103	–0.167	0.174
P	0.015*	0.006*	0.015*	0.974	0.035	0.046	0.666	0.481	0.464
17OH-progesterone AUC
r	0.217	0.573	0.140	0.479	0.343	0.140	0.025	–0.008	0.263
P	0.359	0.016*	0.556	0.048	0.139	0.557	0.917	0.973	0.263

	IKKβ Protein Content iAUC	Activated NFκB iAUC	p105 mRNA Content iAUC	p65 mRNA Content iAUC	IκBα mRNA Content iAUC	TNFα mRNA Content iAUC	p65 Protein Content iAUC	IκBα Protein Content iAUC	Plasma CRP iAUC
Combined groups
LH (iU/mL)
r	0.543	0.395	0.433	0.213	0.470	0.328	0.468	–0.477	0.527
P	0.0008*	0.016*	0.005*	0.188	0.003*	0.044	0.003*	0.002*	0.0005*
Testosterone (ng/dL)
r	0.421	0.375	0.439	0.355	0.497	0.357	0.324	–0.454	0.606
P	0.007*	0.019*	0.005*	0.026	0.001*	0.028	0.047	0.004*	0.0001*
Androstenedione (ng/mL)
r	0.631	0.388	0.479	0.514	0.576	0.591	0.548	–0.665	0.604
P	0.0001*	0.015*	0.002*	0.008*	0.0002*	0.0001*	0.0008*	0.0001*	0.0001*
DHEA-S (ug/dL)
r	0.075	0.081	0.089	0.082	0.014	0.029	0.016	–0.082	0.111
P	0.645	0.618	0.585	0.614	0.933	0.857	0.924	0.616	0.494
Testosterone AUC
r	0.583	0.525	0.448	0.275	0.436	0.360	0.465	–0.478	0.594
P	0.0002*	0.0005*	0.004*	0.086	0.006*	0.022	0.004*	0.002*	0.0001*
Androstenedione AUC
r	0.605	0.500	0.707	0.354	0.551	0.587	0.449	–0.601	0.701
P	0.0001*	0.001*	0.0001*	0.025	0.0003*	0.0001*	0.004*	0.0001*	0.0001*
17OH-progesterone AUC
r	0.486	0.437	0.417	0.504	0.457	0.526	0.412	–0.487	0.380
P	0.002*	0.005*	0.010*	0.001*	0.003*	0.0008*	0.008*	0.002*	0.019*
PCOS
LH (iU/mL)
r	0.187	0.512	0.031	0.512	0.116	0.278	0.077	–0.103	0.28
P	0.431	0.036	0.896	0.021	0.625	0.236	0.748	0.665	0.273
Testosterone (ng/dL)
r	0.078	0.751	0.013	0.168	0.493	0.047	0.278	–0.135	0.771
P	0.744	0.0005*	0.956	0.479	0.027	0.845	0.235	0.571	0.0002*
Androstenedione (ng/ mL)
r	0.511	0.577	0.013	0.489	0.446	0.274	0.006	–0.631	0.077
P	0.030	0.015*	0.957	0.047	0.049	0.242	0.978	0.005*	0.746
DHEA-S (ug/dL)
r	0.159	0.325	0.060	0.311	0.188	0.175	0.202	–0.003	0.150
P	0.504	0.162	0.800	0.181	0.427	0.461	0.393	0.989	0.528
Testosterone AUC
r	0.099	0.634	0.081	0.180	0.235	0.088	0.134	–0.023	0.638
P	0.677	0.005*	0.732	0.448	0.319	0.711	0.575	0.923	0.004*
Androstenedione AUC
r	0.565	0.636	0.562	0.008	0.473	0.476	0.103	–0.167	0.174
P	0.015*	0.006*	0.015*	0.974	0.035	0.046	0.666	0.481	0.464
17OH-progesterone AUC
r	0.217	0.573	0.140	0.479	0.343	0.140	0.025	–0.008	0.263
P	0.359	0.016*	0.556	0.048	0.139	0.557	0.917	0.973	0.263

Abbreviations: AUC, HCG-stimulated area under the curve. CRP, C-reactive protein; iAUC, incremental area under the curve; IκBα, inhibitor κBα; IKKβ, inhibitor of nuclear factor κB kinase β; LH, luteinizing hormone; NFκB, nuclear factor κB; TNFα, tumor necrosis factor-α.

*P < .02.

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