Table 1. Open in new tab Patient...

Characteristics	Patient no.
Age at primary diagnosis, years	66.8	63.7	60.8	48.1	64.7	64.9	47.4	54.8	68.1
Sex	F	F	M	F	F	M	M	F	F
Smoking status	Former	Never	Former	Never	Current	Unknown	Never	Current	Former
Cardiac disease	No	Yes	Yes	Yes	No	No	No	Yes	Yes
Diabetes	No	Yes	Yes	Yes	No	No	No	No	No
Primary tumor location	ICC	ICC	ICC	ICC	ECC	ICC	ICC	GBC	ECC
Resection of primary	Yes	No	Yes	Yes	No	Yes	No	Yes	Yes
Metastatic sites prior to BM	Liver, lungs	Lungs, retroperitoneal	Liver, lungs	Liver, lungs, chest wall	None	Lungs	Lungs, bone	None	None
Chemotherapy prior to BM	Yes	No	Yes	Yes	Yes	No	Yes	Yes	Yes
Radiation to primary prior to BM	No	No	No	Yes	No	No	No	Yes	Yes
Presenting symptoms	Headache, dizziness	AMS, dizziness	Seizure	AMS, weakness	Headache, weakness	AMS	Seizure	Seizure	Dizziness, decreased sensation, facial pain
Number of BMs	1	3+	1	1	1	1	3+	2	1
Location of BM	Cerebellum	Cerebellum, parietal	Fronto‐parietal	Temporal	Frontal	Frontal	Cerebellum, all lobes	Cerebellum, frontal	Parietal
Resection of BM	Yes	No	No	Yes	No	Yes	No	No	Yes
BM radiation	WBRT, SRS	None	WBRT	SRS	WBRT	None	WBRT	SRS	WBRT, SRS
Time between primary tumor diagnosis and BM diagnosis, months	66.7	0.7	12.3	36.2	14.7	25.2	16.8	16	16.7
OS from BM diagnosis, months	16.9	0.1	1.3	3.1	1.5	1.5	3.8	3.2	10

Characteristics

Patient no.

Age at primary diagnosis, years

66.8

63.7

60.8

48.1

64.7

64.9

47.4

54.8

68.1

Sex

Smoking status

Former

Never

Former

Never

Current

Unknown

Never

Current

Former

Cardiac disease

Yes

Diabetes

Yes

Primary tumor location

ICC

ECC

ICC

GBC

ECC

Resection of primary

Yes

Metastatic sites prior to BM

Liver, lungs

Lungs, retroperitoneal

Liver, lungs

Liver, lungs, chest wall

None

Lungs

Lungs, bone

None

Chemotherapy prior to BM

Yes

Radiation to primary prior to BM

Yes

Presenting symptoms

Headache, dizziness

AMS, dizziness

Seizure

AMS, weakness

Headache, weakness

AMS

Seizure

Dizziness, decreased sensation, facial pain

Number of BMs

Location of BM

Cerebellum

Cerebellum, parietal

Fronto‐parietal

Temporal

Frontal

Cerebellum, all lobes

Cerebellum, frontal

Parietal

Resection of BM

Yes

BM radiation

WBRT, SRS

None

WBRT

SRS

WBRT

None

WBRT

SRS

WBRT, SRS

Time between primary tumor diagnosis and BM diagnosis, months

66.7

0.7

12.3

36.2

14.7

25.2

16.8

16.7

OS from BM diagnosis, months

16.9

0.1

1.3

3.1

1.5

3.8

3.2

Characteristics	Patient no.
Age at primary diagnosis, years	66.8	63.7	60.8	48.1	64.7	64.9	47.4	54.8	68.1
Sex	F	F	M	F	F	M	M	F	F
Smoking status	Former	Never	Former	Never	Current	Unknown	Never	Current	Former
Cardiac disease	No	Yes	Yes	Yes	No	No	No	Yes	Yes
Diabetes	No	Yes	Yes	Yes	No	No	No	No	No
Primary tumor location	ICC	ICC	ICC	ICC	ECC	ICC	ICC	GBC	ECC
Resection of primary	Yes	No	Yes	Yes	No	Yes	No	Yes	Yes
Metastatic sites prior to BM	Liver, lungs	Lungs, retroperitoneal	Liver, lungs	Liver, lungs, chest wall	None	Lungs	Lungs, bone	None	None
Chemotherapy prior to BM	Yes	No	Yes	Yes	Yes	No	Yes	Yes	Yes
Radiation to primary prior to BM	No	No	No	Yes	No	No	No	Yes	Yes
Presenting symptoms	Headache, dizziness	AMS, dizziness	Seizure	AMS, weakness	Headache, weakness	AMS	Seizure	Seizure	Dizziness, decreased sensation, facial pain
Number of BMs	1	3+	1	1	1	1	3+	2	1
Location of BM	Cerebellum	Cerebellum, parietal	Fronto‐parietal	Temporal	Frontal	Frontal	Cerebellum, all lobes	Cerebellum, frontal	Parietal
Resection of BM	Yes	No	No	Yes	No	Yes	No	No	Yes
BM radiation	WBRT, SRS	None	WBRT	SRS	WBRT	None	WBRT	SRS	WBRT, SRS
Time between primary tumor diagnosis and BM diagnosis, months	66.7	0.7	12.3	36.2	14.7	25.2	16.8	16	16.7
OS from BM diagnosis, months	16.9	0.1	1.3	3.1	1.5	1.5	3.8	3.2	10

Table 1.

Open in new tab

Patient characteristics

Characteristics	Patient no.
Characteristics	1	2	3	4	5	6	7	8	9
Age at primary diagnosis, years	66.8	63.7	60.8	48.1	64.7	64.9	47.4	54.8	68.1
Sex	F	F	M	F	F	M	M	F	F
Smoking status	Former	Never	Former	Never	Current	Unknown	Never	Current	Former
Cardiac disease	No	Yes	Yes	Yes	No	No	No	Yes	Yes
Diabetes	No	Yes	Yes	Yes	No	No	No	No	No
Primary tumor location	ICC	ICC	ICC	ICC	ECC	ICC	ICC	GBC	ECC
Resection of primary	Yes	No	Yes	Yes	No	Yes	No	Yes	Yes
Metastatic sites prior to BM	Liver, lungs	Lungs, retroperitoneal	Liver, lungs	Liver, lungs, chest wall	None	Lungs	Lungs, bone	None	None
Chemotherapy prior to BM	Yes	No	Yes	Yes	Yes	No	Yes	Yes	Yes
Radiation to primary prior to BM	No	No	No	Yes	No	No	No	Yes	Yes
Presenting symptoms	Headache, dizziness	AMS, dizziness	Seizure	AMS, weakness	Headache, weakness	AMS	Seizure	Seizure	Dizziness, decreased sensation, facial pain
Number of BMs	1	3+	1	1	1	1	3+	2	1
Location of BM	Cerebellum	Cerebellum, parietal	Fronto‐parietal	Temporal	Frontal	Frontal	Cerebellum, all lobes	Cerebellum, frontal	Parietal
Resection of BM	Yes	No	No	Yes	No	Yes	No	No	Yes
BM radiation	WBRT, SRS	None	WBRT	SRS	WBRT	None	WBRT	SRS	WBRT, SRS
Time between primary tumor diagnosis and BM diagnosis, months	66.7	0.7	12.3	36.2	14.7	25.2	16.8	16	16.7
OS from BM diagnosis, months	16.9	0.1	1.3	3.1	1.5	1.5	3.8	3.2	10

Characteristics	Patient no.
Characteristics	1	2	3	4	5	6	7	8	9
Age at primary diagnosis, years	66.8	63.7	60.8	48.1	64.7	64.9	47.4	54.8	68.1
Sex	F	F	M	F	F	M	M	F	F
Smoking status	Former	Never	Former	Never	Current	Unknown	Never	Current	Former
Cardiac disease	No	Yes	Yes	Yes	No	No	No	Yes	Yes
Diabetes	No	Yes	Yes	Yes	No	No	No	No	No
Primary tumor location	ICC	ICC	ICC	ICC	ECC	ICC	ICC	GBC	ECC
Resection of primary	Yes	No	Yes	Yes	No	Yes	No	Yes	Yes
Metastatic sites prior to BM	Liver, lungs	Lungs, retroperitoneal	Liver, lungs	Liver, lungs, chest wall	None	Lungs	Lungs, bone	None	None
Chemotherapy prior to BM	Yes	No	Yes	Yes	Yes	No	Yes	Yes	Yes
Radiation to primary prior to BM	No	No	No	Yes	No	No	No	Yes	Yes
Presenting symptoms	Headache, dizziness	AMS, dizziness	Seizure	AMS, weakness	Headache, weakness	AMS	Seizure	Seizure	Dizziness, decreased sensation, facial pain
Number of BMs	1	3+	1	1	1	1	3+	2	1
Location of BM	Cerebellum	Cerebellum, parietal	Fronto‐parietal	Temporal	Frontal	Frontal	Cerebellum, all lobes	Cerebellum, frontal	Parietal
Resection of BM	Yes	No	No	Yes	No	Yes	No	No	Yes
BM radiation	WBRT, SRS	None	WBRT	SRS	WBRT	None	WBRT	SRS	WBRT, SRS
Time between primary tumor diagnosis and BM diagnosis, months	66.7	0.7	12.3	36.2	14.7	25.2	16.8	16	16.7
OS from BM diagnosis, months	16.9	0.1	1.3	3.1	1.5	1.5	3.8	3.2	10

Abbreviations: AMS, altered mental status; BM, brain metastasis; ECC, extrahepatic cholangiocarcinoma; F, female; GBC, gallbladder cancer; ICC, intrahepatic cholangiocarcinoma; M, male; OS, overall survival; SRS, stereotactic radiosurgery; WBRT, whole‐brain radiation therapy.

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