Tabel 3. Open in new tab Univariate and...

Variable	Univariate analysis	Multivariate analysis
Age, yr
≤ 61	Ref
> 61	0.95 (0.68–1.32)	.75
Sex
Male	Ref
Female	0.74 (0.52–1.05)	.09
Duration of metastatic disease, mo
≤ 7	1.52 (1.09–2.11)	.01
> 7	Ref
Admission SOFA score
≤ 5	Ref		Ref
6 to 10	1.87 (1.26–2.79)	.002	1.75 (1.12–2.73)	.01
> 10	3.67 (2.31–5.83)	<.0001	3.97 (2.32–6.80)	<.0001
Tumor type
Intestinal	Ref
Hepatobiliary/pancreatic	1.54 (1.04–2.29)	.03
Gastroesophageal	2.06 (1.32–3.21)	.001
Unknown primary	2.10 (0.75–5.87)	.16
Grade
Well or moderate	Ref		Ref
Poor	2.43 (1.66–3.57)	<.0001	2.49 (1.64–3.76)	<.0001
Number of metastatic sites
0 to 2	Ref
≥ 3	1.16 (0.80–1.67)	.43
Code status at ICU admission
Do not resuscitate	Ref
Full	0.28 (0.18–0.42)	<.0001
Chemotherapy status
On treatment	Ref		Ref
Off treatment
Treatment completed	1.89 (1.07–3.34)	.03	1.46 (0.87–2.47)	.15
Poor performance status	2.62 (1.28–5.37)	.009	2.42 (1.26–4.63)	.008

Variable	Univariate analysis	Multivariate analysis
Age, yr
≤ 61	Ref
> 61	0.95 (0.68–1.32)	.75
Sex
Male	Ref
Female	0.74 (0.52–1.05)	.09
Duration of metastatic disease, mo
≤ 7	1.52 (1.09–2.11)	.01
> 7	Ref
Admission SOFA score
≤ 5	Ref		Ref
6 to 10	1.87 (1.26–2.79)	.002	1.75 (1.12–2.73)	.01
> 10	3.67 (2.31–5.83)	<.0001	3.97 (2.32–6.80)	<.0001
Tumor type
Intestinal	Ref
Hepatobiliary/pancreatic	1.54 (1.04–2.29)	.03
Gastroesophageal	2.06 (1.32–3.21)	.001
Unknown primary	2.10 (0.75–5.87)	.16
Grade
Well or moderate	Ref		Ref
Poor	2.43 (1.66–3.57)	<.0001	2.49 (1.64–3.76)	<.0001
Number of metastatic sites
0 to 2	Ref
≥ 3	1.16 (0.80–1.67)	.43
Code status at ICU admission
Do not resuscitate	Ref
Full	0.28 (0.18–0.42)	<.0001
Chemotherapy status
On treatment	Ref		Ref
Off treatment
Treatment completed	1.89 (1.07–3.34)	.03	1.46 (0.87–2.47)	.15
Poor performance status	2.62 (1.28–5.37)	.009	2.42 (1.26–4.63)	.008

Tabel 3.

Univariate and multivariate Cox regression model for overall survival

Variable	Univariate analysis		Multivariate analysis
Variable	Hazard ratio (95% CI)	p value	Hazard ratio (95% CI)	p value
Age, yr
≤ 61	Ref
> 61	0.95 (0.68–1.32)	.75
Sex
Male	Ref
Female	0.74 (0.52–1.05)	.09
Duration of metastatic disease, mo
≤ 7	1.52 (1.09–2.11)	.01
> 7	Ref
Admission SOFA score
≤ 5	Ref		Ref
6 to 10	1.87 (1.26–2.79)	.002	1.75 (1.12–2.73)	.01
> 10	3.67 (2.31–5.83)	<.0001	3.97 (2.32–6.80)	<.0001
Tumor type
Intestinal	Ref
Hepatobiliary/pancreatic	1.54 (1.04–2.29)	.03
Gastroesophageal	2.06 (1.32–3.21)	.001
Unknown primary	2.10 (0.75–5.87)	.16
Grade
Well or moderate	Ref		Ref
Poor	2.43 (1.66–3.57)	<.0001	2.49 (1.64–3.76)	<.0001
Number of metastatic sites
0 to 2	Ref
≥ 3	1.16 (0.80–1.67)	.43
Code status at ICU admission
Do not resuscitate	Ref
Full	0.28 (0.18–0.42)	<.0001
Chemotherapy status
On treatment	Ref		Ref
Off treatment
Treatment completed	1.89 (1.07–3.34)	.03	1.46 (0.87–2.47)	.15
Poor performance status	2.62 (1.28–5.37)	.009	2.42 (1.26–4.63)	.008

Variable	Univariate analysis		Multivariate analysis
Variable	Hazard ratio (95% CI)	p value	Hazard ratio (95% CI)	p value
Age, yr
≤ 61	Ref
> 61	0.95 (0.68–1.32)	.75
Sex
Male	Ref
Female	0.74 (0.52–1.05)	.09
Duration of metastatic disease, mo
≤ 7	1.52 (1.09–2.11)	.01
> 7	Ref
Admission SOFA score
≤ 5	Ref		Ref
6 to 10	1.87 (1.26–2.79)	.002	1.75 (1.12–2.73)	.01
> 10	3.67 (2.31–5.83)	<.0001	3.97 (2.32–6.80)	<.0001
Tumor type
Intestinal	Ref
Hepatobiliary/pancreatic	1.54 (1.04–2.29)	.03
Gastroesophageal	2.06 (1.32–3.21)	.001
Unknown primary	2.10 (0.75–5.87)	.16
Grade
Well or moderate	Ref		Ref
Poor	2.43 (1.66–3.57)	<.0001	2.49 (1.64–3.76)	<.0001
Number of metastatic sites
0 to 2	Ref
≥ 3	1.16 (0.80–1.67)	.43
Code status at ICU admission
Do not resuscitate	Ref
Full	0.28 (0.18–0.42)	<.0001
Chemotherapy status
On treatment	Ref		Ref
Off treatment
Treatment completed	1.89 (1.07–3.34)	.03	1.46 (0.87–2.47)	.15
Poor performance status	2.62 (1.28–5.37)	.009	2.42 (1.26–4.63)	.008

Duration of disease, admission SOFA, grade, tumor, and chemo stop reason were initially included in a multivariate cox regression model and reduced by backward elimination.

Abbreviations: CI, confidence interval; ICU, intensive care unit; SOFA, Sequential Organ Failure Assessment.

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