| Marker . | Evidence . |
|---|---|
| Inflammatory index [24]: the sum of the log of circulating IL6 and that of TNFR1 [24] | Associated with risk of mortality and disability over 10 years in two large cohort studies |
| Redox status [25] assessed as D‐ROM and TTL | Associated with mortality and disability in two large cohort studies but not more sensitive than clinical evaluation |
| Epigenetic clock : AR‐DNAm | Associated with chronologic age and mortality in four cohort studies; association with mortality has been questioned [39] |
| Telomere length [29] | It declines with chronologic age but has high degree of variability |
| Concentration of P16INK4a in T lymphocytes [30] | Associated with chronologic age |
| Vitamin D concentration | Inversely associated with mortality in cross‐sectional studies |
| Marker . | Evidence . |
|---|---|
| Inflammatory index [24]: the sum of the log of circulating IL6 and that of TNFR1 [24] | Associated with risk of mortality and disability over 10 years in two large cohort studies |
| Redox status [25] assessed as D‐ROM and TTL | Associated with mortality and disability in two large cohort studies but not more sensitive than clinical evaluation |
| Epigenetic clock : AR‐DNAm | Associated with chronologic age and mortality in four cohort studies; association with mortality has been questioned [39] |
| Telomere length [29] | It declines with chronologic age but has high degree of variability |
| Concentration of P16INK4a in T lymphocytes [30] | Associated with chronologic age |
| Vitamin D concentration | Inversely associated with mortality in cross‐sectional studies |
Abbreviations: AR‐DNAm, age‐related DNA methylation; D‐ROMS, reactive oxygen metabolites; IL6, interleukin 6; TNFR1, tissue necrosis factor receptor 1; TTL, total thiols levels; TNFR1, tissue necrosis factor receptor 1.
| Marker . | Evidence . |
|---|---|
| Inflammatory index [24]: the sum of the log of circulating IL6 and that of TNFR1 [24] | Associated with risk of mortality and disability over 10 years in two large cohort studies |
| Redox status [25] assessed as D‐ROM and TTL | Associated with mortality and disability in two large cohort studies but not more sensitive than clinical evaluation |
| Epigenetic clock : AR‐DNAm | Associated with chronologic age and mortality in four cohort studies; association with mortality has been questioned [39] |
| Telomere length [29] | It declines with chronologic age but has high degree of variability |
| Concentration of P16INK4a in T lymphocytes [30] | Associated with chronologic age |
| Vitamin D concentration | Inversely associated with mortality in cross‐sectional studies |
| Marker . | Evidence . |
|---|---|
| Inflammatory index [24]: the sum of the log of circulating IL6 and that of TNFR1 [24] | Associated with risk of mortality and disability over 10 years in two large cohort studies |
| Redox status [25] assessed as D‐ROM and TTL | Associated with mortality and disability in two large cohort studies but not more sensitive than clinical evaluation |
| Epigenetic clock : AR‐DNAm | Associated with chronologic age and mortality in four cohort studies; association with mortality has been questioned [39] |
| Telomere length [29] | It declines with chronologic age but has high degree of variability |
| Concentration of P16INK4a in T lymphocytes [30] | Associated with chronologic age |
| Vitamin D concentration | Inversely associated with mortality in cross‐sectional studies |
Abbreviations: AR‐DNAm, age‐related DNA methylation; D‐ROMS, reactive oxygen metabolites; IL6, interleukin 6; TNFR1, tissue necrosis factor receptor 1; TTL, total thiols levels; TNFR1, tissue necrosis factor receptor 1.
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