Table 2 Open in new tab Grade 3/4... | Oxford Academic

Table 2

Open in new tab

Grade 3/4 adverse events in the first cycle of the phase I portion (n = 17)

	DHP107 dose level								Total
	150 mg/m² b.i.d. (n = 3)		200 mg/m² b.i.d. (n = 6)		225 mg/m² b.i.d. (n = 4)		250 mg/m² b.i.d. (n = 4)
Adverse events	Grade 3	Grade 4	Grade 3	Grade 4	Grade 3	Grade 4	Grade 3	Grade 4
Anemia	2	0	0	0	0	0	1	1	4
Neutropenia	2	0	2	1	0	0	3	1	10
Febrile neutropenia	0	0	0	0	2	0	1	0	3
Hypoalbuminemia	0	0	0	0	0	0	1	0	1
Hypocalcemia	0	0	0	0	0	0	1	0	1
Hypokalemia	0	0	0	0	0	0	1	0	1
Hypophosphatemia	0	0	0	0	0	0	1	0	1
Hypotension	0	0	0	0	0	0	1	0	1
Leukopenia	1	0	2	0	0	0	3	1	7
Worsening anemia	0	0	0	0	0	0	1	0	1

	DHP107 dose level								Total
	150 mg/m² b.i.d. (n = 3)		200 mg/m² b.i.d. (n = 6)		225 mg/m² b.i.d. (n = 4)		250 mg/m² b.i.d. (n = 4)
Adverse events	Grade 3	Grade 4	Grade 3	Grade 4	Grade 3	Grade 4	Grade 3	Grade 4
Anemia	2	0	0	0	0	0	1	1	4
Neutropenia	2	0	2	1	0	0	3	1	10
Febrile neutropenia	0	0	0	0	2	0	1	0	3
Hypoalbuminemia	0	0	0	0	0	0	1	0	1
Hypocalcemia	0	0	0	0	0	0	1	0	1
Hypokalemia	0	0	0	0	0	0	1	0	1
Hypophosphatemia	0	0	0	0	0	0	1	0	1
Hypotension	0	0	0	0	0	0	1	0	1
Leukopenia	1	0	2	0	0	0	3	1	7
Worsening anemia	0	0	0	0	0	0	1	0	1

Dose‐limiting toxicity.

Table 2

Open in new tab

Grade 3/4 adverse events in the first cycle of the phase I portion (n = 17)

	DHP107 dose level								Total
	150 mg/m² b.i.d. (n = 3)		200 mg/m² b.i.d. (n = 6)		225 mg/m² b.i.d. (n = 4)		250 mg/m² b.i.d. (n = 4)
Adverse events	Grade 3	Grade 4	Grade 3	Grade 4	Grade 3	Grade 4	Grade 3	Grade 4
Anemia	2	0	0	0	0	0	1	1	4
Neutropenia	2	0	2	1	0	0	3	1	10
Febrile neutropenia	0	0	0	0	2	0	1	0	3
Hypoalbuminemia	0	0	0	0	0	0	1	0	1
Hypocalcemia	0	0	0	0	0	0	1	0	1
Hypokalemia	0	0	0	0	0	0	1	0	1
Hypophosphatemia	0	0	0	0	0	0	1	0	1
Hypotension	0	0	0	0	0	0	1	0	1
Leukopenia	1	0	2	0	0	0	3	1	7
Worsening anemia	0	0	0	0	0	0	1	0	1

	DHP107 dose level								Total
	150 mg/m² b.i.d. (n = 3)		200 mg/m² b.i.d. (n = 6)		225 mg/m² b.i.d. (n = 4)		250 mg/m² b.i.d. (n = 4)
Adverse events	Grade 3	Grade 4	Grade 3	Grade 4	Grade 3	Grade 4	Grade 3	Grade 4
Anemia	2	0	0	0	0	0	1	1	4
Neutropenia	2	0	2	1	0	0	3	1	10
Febrile neutropenia	0	0	0	0	2	0	1	0	3
Hypoalbuminemia	0	0	0	0	0	0	1	0	1
Hypocalcemia	0	0	0	0	0	0	1	0	1
Hypokalemia	0	0	0	0	0	0	1	0	1
Hypophosphatemia	0	0	0	0	0	0	1	0	1
Hypotension	0	0	0	0	0	0	1	0	1
Leukopenia	1	0	2	0	0	0	3	1	7
Worsening anemia	0	0	0	0	0	0	1	0	1

Dose‐limiting toxicity.