Patient and tumor characteristics
| Characteristic . | Value . |
|---|---|
| Median age (range), yr | 56 (20–100) |
| Median body weight (range), kg | 70 (40–178) |
| ECOG performance status | |
| 0 | 2,411 (62) |
| 1 | 1,412 (36) |
| 2–4 | 70 (2) |
| Primary tumor stage | |
| pTis | 306 (8) |
| pT1 | 1,559 (40) |
| pT2 | 1,559 (40) |
| pT3 | 205 (5) |
| pT4 | 124 (3) |
| TX | 101 (3) |
| Lymph node stage | |
| pN0 | 2,065 (53) |
| pN1 | 1,056 (27) |
| pN2 | 439 (11) |
| pN3 | 272 (7) |
| NX | 94 (2) |
| Involved nodes, mean number | 2.2 |
| Grading | |
| G1 | 109 (3) |
| G2 | 1,747 (45) |
| G3 | 2,030 (52) |
| GX | 36 (1) |
| Hormone‐receptor status | |
| Estrogen receptor‐positive | 2,364 (60) |
| Progesterone receptor‐positive | 1,931 (49) |
| At least one positive | 2,490 (63) |
| IHC staining for HER2 | |
| 2+/FISH/CISH positive | 422 (11) |
| Pathological finding on echocardiography and/or ECG | 260 (7) |
| Median LVEF (range), %a | 65 (10–98) |
| Characteristic . | Value . |
|---|---|
| Median age (range), yr | 56 (20–100) |
| Median body weight (range), kg | 70 (40–178) |
| ECOG performance status | |
| 0 | 2,411 (62) |
| 1 | 1,412 (36) |
| 2–4 | 70 (2) |
| Primary tumor stage | |
| pTis | 306 (8) |
| pT1 | 1,559 (40) |
| pT2 | 1,559 (40) |
| pT3 | 205 (5) |
| pT4 | 124 (3) |
| TX | 101 (3) |
| Lymph node stage | |
| pN0 | 2,065 (53) |
| pN1 | 1,056 (27) |
| pN2 | 439 (11) |
| pN3 | 272 (7) |
| NX | 94 (2) |
| Involved nodes, mean number | 2.2 |
| Grading | |
| G1 | 109 (3) |
| G2 | 1,747 (45) |
| G3 | 2,030 (52) |
| GX | 36 (1) |
| Hormone‐receptor status | |
| Estrogen receptor‐positive | 2,364 (60) |
| Progesterone receptor‐positive | 1,931 (49) |
| At least one positive | 2,490 (63) |
| IHC staining for HER2 | |
| 2+/FISH/CISH positive | 422 (11) |
| Pathological finding on echocardiography and/or ECG | 260 (7) |
| Median LVEF (range), %a | 65 (10–98) |
Unless otherwise noted, values are the number (percentage) of patients. Total patient numbers may deviate from n=3940 in case of missing values in individual parameters.
aQuantitative data available in 2508 patients only
Abbreviations: CISH, chromogenic in situ hybridization; ECG, electrocardiography; ECOG, Eastern Cooperative Oncology Group; FISH, fluorescent in situ hybridization; HER2, human epidermal growth factor receptor 2; IHC, immunohistochemistry; LVEF, left ventricular ejection fraction.
Patient and tumor characteristics
| Characteristic . | Value . |
|---|---|
| Median age (range), yr | 56 (20–100) |
| Median body weight (range), kg | 70 (40–178) |
| ECOG performance status | |
| 0 | 2,411 (62) |
| 1 | 1,412 (36) |
| 2–4 | 70 (2) |
| Primary tumor stage | |
| pTis | 306 (8) |
| pT1 | 1,559 (40) |
| pT2 | 1,559 (40) |
| pT3 | 205 (5) |
| pT4 | 124 (3) |
| TX | 101 (3) |
| Lymph node stage | |
| pN0 | 2,065 (53) |
| pN1 | 1,056 (27) |
| pN2 | 439 (11) |
| pN3 | 272 (7) |
| NX | 94 (2) |
| Involved nodes, mean number | 2.2 |
| Grading | |
| G1 | 109 (3) |
| G2 | 1,747 (45) |
| G3 | 2,030 (52) |
| GX | 36 (1) |
| Hormone‐receptor status | |
| Estrogen receptor‐positive | 2,364 (60) |
| Progesterone receptor‐positive | 1,931 (49) |
| At least one positive | 2,490 (63) |
| IHC staining for HER2 | |
| 2+/FISH/CISH positive | 422 (11) |
| Pathological finding on echocardiography and/or ECG | 260 (7) |
| Median LVEF (range), %a | 65 (10–98) |
| Characteristic . | Value . |
|---|---|
| Median age (range), yr | 56 (20–100) |
| Median body weight (range), kg | 70 (40–178) |
| ECOG performance status | |
| 0 | 2,411 (62) |
| 1 | 1,412 (36) |
| 2–4 | 70 (2) |
| Primary tumor stage | |
| pTis | 306 (8) |
| pT1 | 1,559 (40) |
| pT2 | 1,559 (40) |
| pT3 | 205 (5) |
| pT4 | 124 (3) |
| TX | 101 (3) |
| Lymph node stage | |
| pN0 | 2,065 (53) |
| pN1 | 1,056 (27) |
| pN2 | 439 (11) |
| pN3 | 272 (7) |
| NX | 94 (2) |
| Involved nodes, mean number | 2.2 |
| Grading | |
| G1 | 109 (3) |
| G2 | 1,747 (45) |
| G3 | 2,030 (52) |
| GX | 36 (1) |
| Hormone‐receptor status | |
| Estrogen receptor‐positive | 2,364 (60) |
| Progesterone receptor‐positive | 1,931 (49) |
| At least one positive | 2,490 (63) |
| IHC staining for HER2 | |
| 2+/FISH/CISH positive | 422 (11) |
| Pathological finding on echocardiography and/or ECG | 260 (7) |
| Median LVEF (range), %a | 65 (10–98) |
Unless otherwise noted, values are the number (percentage) of patients. Total patient numbers may deviate from n=3940 in case of missing values in individual parameters.
aQuantitative data available in 2508 patients only
Abbreviations: CISH, chromogenic in situ hybridization; ECG, electrocardiography; ECOG, Eastern Cooperative Oncology Group; FISH, fluorescent in situ hybridization; HER2, human epidermal growth factor receptor 2; IHC, immunohistochemistry; LVEF, left ventricular ejection fraction.
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