Table 1 Open in new tab Breast...

Study

Sample size

Primary objective and FU

Results

Cardonick et al., 2010 [10]

n = 130 BCDP

FU, 3.14 (±2.5) yr

Survival similar to that of nonpregnant, staged‐matched women (stage I, 100%; stage II, 86%; stage III, 86%; and stage IV, 0%)

Rodriguez et al., 2008 [13]

n = 797 PABC (of these, n=179 BCDP)

n = 4,177 NPABC

Higher death rates for PABC (39.2%) vs. NPABC (33.4%); p = .002

Ali et al., 2012 [14]

n = 40 PABC

(of these, n = 17 BCDP)

n = 40 NPABC

Median FU, 100/103 months

DFS

Survival worse for PABC (4.9 yr) vs. NPABC (6 yr), p = .002

DFS worse for PABC (2.7 yr) vs NPABC (5.1 yr), p = .01

Azim et al., 2012 [15]

n = 3,628 PABC

n = 37,100 NPABC

Very mixed cohorts: includes up to 2 yr after pregnancy

Meta‐analysis

DFS

Survival worse for PABC vs. NPABC (HR, 1.44)

DFS worse for PABC vs. NPABC (HR, 1.6)

Litton et al.,

2013 [12]

n = 75 BCDP

n = 150 NPABC

FU, 4.2 yr

DFS

Survival similar to/better than that in nonpregnant, staged and age‐matched women

5‐year OS: BCDP, 77%; NBCDP, 71% (p = .0461)

DFS at 5 yr: BCDP, 72%; NBCDP, 57% (p = .0115)

Amant et al.,

2013 [11]

n = 311 BCDP

n = 865 NBCDP

FU, 61 months

DFS

Survival similar to that in nonpregnant patient

HR for OS, 1.34 (p = .14)

HR for DFS, 1.19 (p = .51)

Table 1

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Breast cancer‐associated outcomes for women diagnosed with breast cancer during pregnancy

Study	Sample size	Primary objective and FU	Results
Cardonick et al., 2010 [10]	n = 130 BCDP FU, 3.14 (±2.5) yr	OS	Survival similar to that of nonpregnant, staged‐matched women (stage I, 100%; stage II, 86%; stage III, 86%; and stage IV, 0%)
Rodriguez et al., 2008 [13]	n = 797 PABC (of these, n=179 BCDP) n = 4,177 NPABC	OS	Higher death rates for PABC (39.2%) vs. NPABC (33.4%); p = .002
Ali et al., 2012 [14]	n = 40 PABC (of these, n = 17 BCDP) n = 40 NPABC Median FU, 100/103 months	OS DFS	Survival worse for PABC (4.9 yr) vs. NPABC (6 yr), p = .002 DFS worse for PABC (2.7 yr) vs NPABC (5.1 yr), p = .01
Azim et al., 2012 [15]	n = 3,628 PABC n = 37,100 NPABC Very mixed cohorts: includes up to 2 yr after pregnancy	Meta‐analysis OS DFS	Survival worse for PABC vs. NPABC (HR, 1.44) DFS worse for PABC vs. NPABC (HR, 1.6)
Litton et al., 2013 [12]	n = 75 BCDP n = 150 NPABC FU, 4.2 yr	OS DFS	Survival similar to/better than that in nonpregnant, staged and age‐matched women 5‐year OS: BCDP, 77%; NBCDP, 71% (p = .0461) DFS at 5 yr: BCDP, 72%; NBCDP, 57% (p = .0115)
Amant et al., 2013 [11]	n = 311 BCDP n = 865 NBCDP FU, 61 months	OS DFS	Survival similar to that in nonpregnant patient HR for OS, 1.34 (p = .14) HR for DFS, 1.19 (p = .51)