The relationship between bone mineral density (BMD) and other characteristics via linear regression models, using BMD as the dependent variable, which is adjusted for age, sex, and ferritin. Regression coefficients (coef.) and P-values are shown (n = 27).
| . | BMD of lumbar spine, Z score (SD) . | BMD of femoral neck, Z score (SD) . | ||
|---|---|---|---|---|
| . | coef. . | P . | coef. . | P . |
| Age (year) | –0.022 | .757 | –0.053 | .266 |
| Gender | 0.226 | .776 | 0.002 | .997 |
| Body height (cm) | –0.008 | .883 | 0.083 | .089 |
| Body mass index (kg/m2) | –0.085 | .562 | 0.116 | .252 |
| Difference of real height from expected height (cm) | –0.005 | .909 | 0.081 | .070 |
| Fracturea | –0.309 | .696 | –0.889 | .162 |
| Calciumb (mmol/L) | 1.309 | .810 | 2.279 | .569 |
| Phosphorus (mg/dL) | 0.070 | .906 | 0.202 | .613 |
| 25(OH)D (ng/mL) | 0.074 | .247 | –0.111 | .283 |
| 25(OH)D deficiencyc | –1.984 | .260 | N/Ad | N/Ad |
| iPTH (pg/mL) | –0.017 | .264 | –0.028 | .016 |
| FGF23 (pg/mL) | –0.014 | .118 | –0.016 | .025 |
| FGF23 statuse | –1.682 | .025 | –0.921 | .166 |
| Hypothyroidismf | –1.053 | .024 | –1.070 | .004 |
| fT4 (ng/dL) | 3.358 | .219 | 1.758 | .367 |
| TSH (μU/mL) | –0.323 | .284 | –0.408 | .043 |
| Hypogonadismg | –0.649 | .416 | –0.639 | .318 |
| Estradiol in female (pg/mL) | 0.053 | .164 | 0.011 | .470 |
| Testosterone in male (ng/mL) | 0.440 | .011 | 0.173 | .490 |
| IGF-1 (ng/mL) | 0.041 | .028 | –0.003 | .818 |
| Growth hormone deficiencyh | –0.944 | .386 | 0.498 | .480 |
| DMi | –0.461 | .581 | –0.096 | .868 |
| HbA1C (%) | –0.747 | .042 | –0.344 | .276 |
| Hb (g/dL) | 0.274 | .302 | –0.016 | .943 |
| ACTH (pg/mL) | 0.074 | .024 | 0.054 | .034 |
| Cortisol (μg/dL) | 0.045 | .644 | –0.045 | .572 |
| Ferritin (ng/mL) | 0.0002 | .436 | –0.0001 | .193 |
| . | BMD of lumbar spine, Z score (SD) . | BMD of femoral neck, Z score (SD) . | ||
|---|---|---|---|---|
| . | coef. . | P . | coef. . | P . |
| Age (year) | –0.022 | .757 | –0.053 | .266 |
| Gender | 0.226 | .776 | 0.002 | .997 |
| Body height (cm) | –0.008 | .883 | 0.083 | .089 |
| Body mass index (kg/m2) | –0.085 | .562 | 0.116 | .252 |
| Difference of real height from expected height (cm) | –0.005 | .909 | 0.081 | .070 |
| Fracturea | –0.309 | .696 | –0.889 | .162 |
| Calciumb (mmol/L) | 1.309 | .810 | 2.279 | .569 |
| Phosphorus (mg/dL) | 0.070 | .906 | 0.202 | .613 |
| 25(OH)D (ng/mL) | 0.074 | .247 | –0.111 | .283 |
| 25(OH)D deficiencyc | –1.984 | .260 | N/Ad | N/Ad |
| iPTH (pg/mL) | –0.017 | .264 | –0.028 | .016 |
| FGF23 (pg/mL) | –0.014 | .118 | –0.016 | .025 |
| FGF23 statuse | –1.682 | .025 | –0.921 | .166 |
| Hypothyroidismf | –1.053 | .024 | –1.070 | .004 |
| fT4 (ng/dL) | 3.358 | .219 | 1.758 | .367 |
| TSH (μU/mL) | –0.323 | .284 | –0.408 | .043 |
| Hypogonadismg | –0.649 | .416 | –0.639 | .318 |
| Estradiol in female (pg/mL) | 0.053 | .164 | 0.011 | .470 |
| Testosterone in male (ng/mL) | 0.440 | .011 | 0.173 | .490 |
| IGF-1 (ng/mL) | 0.041 | .028 | –0.003 | .818 |
| Growth hormone deficiencyh | –0.944 | .386 | 0.498 | .480 |
| DMi | –0.461 | .581 | –0.096 | .868 |
| HbA1C (%) | –0.747 | .042 | –0.344 | .276 |
| Hb (g/dL) | 0.274 | .302 | –0.016 | .943 |
| ACTH (pg/mL) | 0.074 | .024 | 0.054 | .034 |
| Cortisol (μg/dL) | 0.045 | .644 | –0.045 | .572 |
| Ferritin (ng/mL) | 0.0002 | .436 | –0.0001 | .193 |
25(OH)D, 25-hydroxyvitamin D; ACTH, adrenocorticotropin; DM, diabetes mellitus; FGF23, fibroblast growth factor 23; fT4, free thyroxine; iPTH, intact parathyroid hormone; N/A: not available; TSH, thyroid stimulating hormone.
aFracture: 0, no fracture; 1, fracture.
bCalcium was corrected by: calcium (mmol/L) + 0.2 × (albumin (g/dL) – 4).
c25(OH)D ≤ 24 ng/mL was defined as deficiency (1). 25(OH)D higher than 24 ng/mL was defined as normal (0).
dN/A, not available. This is because all of the 20 patients who had 25(OH)D and BMD of the femoral neck checked had 25(OH)D deficiency.
eFGF23 status: FGF23 < 8.2 pg/mL was defined as low (–1), FGF23 between 8.2 and 54.3 pg/mL was defined as normal (0), and FGF23 > 54.3 pg/mL was defined as high (1).
fHypothyroidism: 0, euthyroid; 1, subclinical hypothyroidism; 2, hypothyroidism.
gHypogonadism: 0, normal gonad function; 1, hypogonadism.
hGrowth hormone deficiency: 0, normal; 1, deficiency.
iDM: 0, euglycemia; 1, pre-DM; 2: DM.
The relationship between bone mineral density (BMD) and other characteristics via linear regression models, using BMD as the dependent variable, which is adjusted for age, sex, and ferritin. Regression coefficients (coef.) and P-values are shown (n = 27).
| . | BMD of lumbar spine, Z score (SD) . | BMD of femoral neck, Z score (SD) . | ||
|---|---|---|---|---|
| . | coef. . | P . | coef. . | P . |
| Age (year) | –0.022 | .757 | –0.053 | .266 |
| Gender | 0.226 | .776 | 0.002 | .997 |
| Body height (cm) | –0.008 | .883 | 0.083 | .089 |
| Body mass index (kg/m2) | –0.085 | .562 | 0.116 | .252 |
| Difference of real height from expected height (cm) | –0.005 | .909 | 0.081 | .070 |
| Fracturea | –0.309 | .696 | –0.889 | .162 |
| Calciumb (mmol/L) | 1.309 | .810 | 2.279 | .569 |
| Phosphorus (mg/dL) | 0.070 | .906 | 0.202 | .613 |
| 25(OH)D (ng/mL) | 0.074 | .247 | –0.111 | .283 |
| 25(OH)D deficiencyc | –1.984 | .260 | N/Ad | N/Ad |
| iPTH (pg/mL) | –0.017 | .264 | –0.028 | .016 |
| FGF23 (pg/mL) | –0.014 | .118 | –0.016 | .025 |
| FGF23 statuse | –1.682 | .025 | –0.921 | .166 |
| Hypothyroidismf | –1.053 | .024 | –1.070 | .004 |
| fT4 (ng/dL) | 3.358 | .219 | 1.758 | .367 |
| TSH (μU/mL) | –0.323 | .284 | –0.408 | .043 |
| Hypogonadismg | –0.649 | .416 | –0.639 | .318 |
| Estradiol in female (pg/mL) | 0.053 | .164 | 0.011 | .470 |
| Testosterone in male (ng/mL) | 0.440 | .011 | 0.173 | .490 |
| IGF-1 (ng/mL) | 0.041 | .028 | –0.003 | .818 |
| Growth hormone deficiencyh | –0.944 | .386 | 0.498 | .480 |
| DMi | –0.461 | .581 | –0.096 | .868 |
| HbA1C (%) | –0.747 | .042 | –0.344 | .276 |
| Hb (g/dL) | 0.274 | .302 | –0.016 | .943 |
| ACTH (pg/mL) | 0.074 | .024 | 0.054 | .034 |
| Cortisol (μg/dL) | 0.045 | .644 | –0.045 | .572 |
| Ferritin (ng/mL) | 0.0002 | .436 | –0.0001 | .193 |
| . | BMD of lumbar spine, Z score (SD) . | BMD of femoral neck, Z score (SD) . | ||
|---|---|---|---|---|
| . | coef. . | P . | coef. . | P . |
| Age (year) | –0.022 | .757 | –0.053 | .266 |
| Gender | 0.226 | .776 | 0.002 | .997 |
| Body height (cm) | –0.008 | .883 | 0.083 | .089 |
| Body mass index (kg/m2) | –0.085 | .562 | 0.116 | .252 |
| Difference of real height from expected height (cm) | –0.005 | .909 | 0.081 | .070 |
| Fracturea | –0.309 | .696 | –0.889 | .162 |
| Calciumb (mmol/L) | 1.309 | .810 | 2.279 | .569 |
| Phosphorus (mg/dL) | 0.070 | .906 | 0.202 | .613 |
| 25(OH)D (ng/mL) | 0.074 | .247 | –0.111 | .283 |
| 25(OH)D deficiencyc | –1.984 | .260 | N/Ad | N/Ad |
| iPTH (pg/mL) | –0.017 | .264 | –0.028 | .016 |
| FGF23 (pg/mL) | –0.014 | .118 | –0.016 | .025 |
| FGF23 statuse | –1.682 | .025 | –0.921 | .166 |
| Hypothyroidismf | –1.053 | .024 | –1.070 | .004 |
| fT4 (ng/dL) | 3.358 | .219 | 1.758 | .367 |
| TSH (μU/mL) | –0.323 | .284 | –0.408 | .043 |
| Hypogonadismg | –0.649 | .416 | –0.639 | .318 |
| Estradiol in female (pg/mL) | 0.053 | .164 | 0.011 | .470 |
| Testosterone in male (ng/mL) | 0.440 | .011 | 0.173 | .490 |
| IGF-1 (ng/mL) | 0.041 | .028 | –0.003 | .818 |
| Growth hormone deficiencyh | –0.944 | .386 | 0.498 | .480 |
| DMi | –0.461 | .581 | –0.096 | .868 |
| HbA1C (%) | –0.747 | .042 | –0.344 | .276 |
| Hb (g/dL) | 0.274 | .302 | –0.016 | .943 |
| ACTH (pg/mL) | 0.074 | .024 | 0.054 | .034 |
| Cortisol (μg/dL) | 0.045 | .644 | –0.045 | .572 |
| Ferritin (ng/mL) | 0.0002 | .436 | –0.0001 | .193 |
25(OH)D, 25-hydroxyvitamin D; ACTH, adrenocorticotropin; DM, diabetes mellitus; FGF23, fibroblast growth factor 23; fT4, free thyroxine; iPTH, intact parathyroid hormone; N/A: not available; TSH, thyroid stimulating hormone.
aFracture: 0, no fracture; 1, fracture.
bCalcium was corrected by: calcium (mmol/L) + 0.2 × (albumin (g/dL) – 4).
c25(OH)D ≤ 24 ng/mL was defined as deficiency (1). 25(OH)D higher than 24 ng/mL was defined as normal (0).
dN/A, not available. This is because all of the 20 patients who had 25(OH)D and BMD of the femoral neck checked had 25(OH)D deficiency.
eFGF23 status: FGF23 < 8.2 pg/mL was defined as low (–1), FGF23 between 8.2 and 54.3 pg/mL was defined as normal (0), and FGF23 > 54.3 pg/mL was defined as high (1).
fHypothyroidism: 0, euthyroid; 1, subclinical hypothyroidism; 2, hypothyroidism.
gHypogonadism: 0, normal gonad function; 1, hypogonadism.
hGrowth hormone deficiency: 0, normal; 1, deficiency.
iDM: 0, euglycemia; 1, pre-DM; 2: DM.
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