Variable information for the sample [n = 1762 (NSHD) and n = 378 (INSIGHT)] prior to imputation
| . | NSHD (n = 1762) . | . | . | Insight 46 (n = 378) . | . |
|---|---|---|---|---|---|
| . | Aged 53 years . | Aged 60-64 years . | Aged 69 years . | Aged 69-71 . | P-valuea . |
| Exposures | |||||
| IGF-I levels (nmol/L) | 26.22 (9.00) | 23.00 (7.71) | <0.001 | ||
| IGFBP-3 levels (nmol/L) | 173.22 (39.31) | 120.11 (30.16) | <0.001 | ||
| IGF-I/IGFBP-3 molar ratio | 0.16 (0.06) | 0.20 (0.06) | <0.001 | ||
| IGF-II levels (nmol/L) | 99.82 (32.36) | 87.86 (38.60) | <0.001 | ||
| Cognitive tests | |||||
| Addenbrooke’s Cognitive Examination score | 91.52 (6.01) | ||||
| Visual letter search score | 283.52 (73.34) | 268.25 (70.54) | 263.56 (74.32) | <0.001 | |
| Word learning test score | 24.87 (6.12) | 24.68 (6.06) | 22.38 (6.13) | <0.001 | |
| Insight 46 MRI measures | |||||
| Age at scan | 70.67 (0.67) | ||||
| Hippocampal volume (ml) | 3.13 (0.33) | ||||
| Total intracranial volume (ml) | 1432.86 (127.58) | ||||
| White matter hyperintensity volumeb (ml) | 3.08 (5.19) | ||||
| Whole brain volume (ml) | 1101.38 (95.34) | ||||
| Model covariates | |||||
| Early life cognition | 0.14 (0.69) | ||||
| Affective symptoms case status, n (%) | |||||
| Noncase | 1313 (81) | 1247 (83) | 1505 (86) | ||
| Case | 316 (19) | 264 (17) | 251 (14) | ||
| Educational attainment, n (%) | |||||
| No qualifications/vocational only | 637 (36) | ||||
| O-level/A-level or equivalent | 835 (48) | ||||
| Higher | 272 (16) | ||||
| Smoking status, n (%) | |||||
| Current smoker | 315 (19) | 148 (10) | 525 (9) | ||
| Ex-smoker | 842 (51) | 875 (58) | 1061 (61) | ||
| Never smoker | 507 (30) | 489 (32) | 525 (30) |
| . | NSHD (n = 1762) . | . | . | Insight 46 (n = 378) . | . |
|---|---|---|---|---|---|
| . | Aged 53 years . | Aged 60-64 years . | Aged 69 years . | Aged 69-71 . | P-valuea . |
| Exposures | |||||
| IGF-I levels (nmol/L) | 26.22 (9.00) | 23.00 (7.71) | <0.001 | ||
| IGFBP-3 levels (nmol/L) | 173.22 (39.31) | 120.11 (30.16) | <0.001 | ||
| IGF-I/IGFBP-3 molar ratio | 0.16 (0.06) | 0.20 (0.06) | <0.001 | ||
| IGF-II levels (nmol/L) | 99.82 (32.36) | 87.86 (38.60) | <0.001 | ||
| Cognitive tests | |||||
| Addenbrooke’s Cognitive Examination score | 91.52 (6.01) | ||||
| Visual letter search score | 283.52 (73.34) | 268.25 (70.54) | 263.56 (74.32) | <0.001 | |
| Word learning test score | 24.87 (6.12) | 24.68 (6.06) | 22.38 (6.13) | <0.001 | |
| Insight 46 MRI measures | |||||
| Age at scan | 70.67 (0.67) | ||||
| Hippocampal volume (ml) | 3.13 (0.33) | ||||
| Total intracranial volume (ml) | 1432.86 (127.58) | ||||
| White matter hyperintensity volumeb (ml) | 3.08 (5.19) | ||||
| Whole brain volume (ml) | 1101.38 (95.34) | ||||
| Model covariates | |||||
| Early life cognition | 0.14 (0.69) | ||||
| Affective symptoms case status, n (%) | |||||
| Noncase | 1313 (81) | 1247 (83) | 1505 (86) | ||
| Case | 316 (19) | 264 (17) | 251 (14) | ||
| Educational attainment, n (%) | |||||
| No qualifications/vocational only | 637 (36) | ||||
| O-level/A-level or equivalent | 835 (48) | ||||
| Higher | 272 (16) | ||||
| Smoking status, n (%) | |||||
| Current smoker | 315 (19) | 148 (10) | 525 (9) | ||
| Ex-smoker | 842 (51) | 875 (58) | 1061 (61) | ||
| Never smoker | 507 (30) | 489 (32) | 525 (30) |
aP-values were calculated using a 1-way analysis of variance for continuous variables.
bMedian and interquartile range presented for nonnormally distributed variables.
Variable information for the sample [n = 1762 (NSHD) and n = 378 (INSIGHT)] prior to imputation
| . | NSHD (n = 1762) . | . | . | Insight 46 (n = 378) . | . |
|---|---|---|---|---|---|
| . | Aged 53 years . | Aged 60-64 years . | Aged 69 years . | Aged 69-71 . | P-valuea . |
| Exposures | |||||
| IGF-I levels (nmol/L) | 26.22 (9.00) | 23.00 (7.71) | <0.001 | ||
| IGFBP-3 levels (nmol/L) | 173.22 (39.31) | 120.11 (30.16) | <0.001 | ||
| IGF-I/IGFBP-3 molar ratio | 0.16 (0.06) | 0.20 (0.06) | <0.001 | ||
| IGF-II levels (nmol/L) | 99.82 (32.36) | 87.86 (38.60) | <0.001 | ||
| Cognitive tests | |||||
| Addenbrooke’s Cognitive Examination score | 91.52 (6.01) | ||||
| Visual letter search score | 283.52 (73.34) | 268.25 (70.54) | 263.56 (74.32) | <0.001 | |
| Word learning test score | 24.87 (6.12) | 24.68 (6.06) | 22.38 (6.13) | <0.001 | |
| Insight 46 MRI measures | |||||
| Age at scan | 70.67 (0.67) | ||||
| Hippocampal volume (ml) | 3.13 (0.33) | ||||
| Total intracranial volume (ml) | 1432.86 (127.58) | ||||
| White matter hyperintensity volumeb (ml) | 3.08 (5.19) | ||||
| Whole brain volume (ml) | 1101.38 (95.34) | ||||
| Model covariates | |||||
| Early life cognition | 0.14 (0.69) | ||||
| Affective symptoms case status, n (%) | |||||
| Noncase | 1313 (81) | 1247 (83) | 1505 (86) | ||
| Case | 316 (19) | 264 (17) | 251 (14) | ||
| Educational attainment, n (%) | |||||
| No qualifications/vocational only | 637 (36) | ||||
| O-level/A-level or equivalent | 835 (48) | ||||
| Higher | 272 (16) | ||||
| Smoking status, n (%) | |||||
| Current smoker | 315 (19) | 148 (10) | 525 (9) | ||
| Ex-smoker | 842 (51) | 875 (58) | 1061 (61) | ||
| Never smoker | 507 (30) | 489 (32) | 525 (30) |
| . | NSHD (n = 1762) . | . | . | Insight 46 (n = 378) . | . |
|---|---|---|---|---|---|
| . | Aged 53 years . | Aged 60-64 years . | Aged 69 years . | Aged 69-71 . | P-valuea . |
| Exposures | |||||
| IGF-I levels (nmol/L) | 26.22 (9.00) | 23.00 (7.71) | <0.001 | ||
| IGFBP-3 levels (nmol/L) | 173.22 (39.31) | 120.11 (30.16) | <0.001 | ||
| IGF-I/IGFBP-3 molar ratio | 0.16 (0.06) | 0.20 (0.06) | <0.001 | ||
| IGF-II levels (nmol/L) | 99.82 (32.36) | 87.86 (38.60) | <0.001 | ||
| Cognitive tests | |||||
| Addenbrooke’s Cognitive Examination score | 91.52 (6.01) | ||||
| Visual letter search score | 283.52 (73.34) | 268.25 (70.54) | 263.56 (74.32) | <0.001 | |
| Word learning test score | 24.87 (6.12) | 24.68 (6.06) | 22.38 (6.13) | <0.001 | |
| Insight 46 MRI measures | |||||
| Age at scan | 70.67 (0.67) | ||||
| Hippocampal volume (ml) | 3.13 (0.33) | ||||
| Total intracranial volume (ml) | 1432.86 (127.58) | ||||
| White matter hyperintensity volumeb (ml) | 3.08 (5.19) | ||||
| Whole brain volume (ml) | 1101.38 (95.34) | ||||
| Model covariates | |||||
| Early life cognition | 0.14 (0.69) | ||||
| Affective symptoms case status, n (%) | |||||
| Noncase | 1313 (81) | 1247 (83) | 1505 (86) | ||
| Case | 316 (19) | 264 (17) | 251 (14) | ||
| Educational attainment, n (%) | |||||
| No qualifications/vocational only | 637 (36) | ||||
| O-level/A-level or equivalent | 835 (48) | ||||
| Higher | 272 (16) | ||||
| Smoking status, n (%) | |||||
| Current smoker | 315 (19) | 148 (10) | 525 (9) | ||
| Ex-smoker | 842 (51) | 875 (58) | 1061 (61) | ||
| Never smoker | 507 (30) | 489 (32) | 525 (30) |
aP-values were calculated using a 1-way analysis of variance for continuous variables.
bMedian and interquartile range presented for nonnormally distributed variables.
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