Table 1.

Baseline Characteristics of Study Subjects

Overall (N = 221)Female (N = 122)Male (N = 99)
Age, years71 ± 4.769.9 ± 3.772.4 ± 5.5
BMI, kg/m230.2 ± 4.531.5 ± 4.928.7 ± 3.3
Total 25(OH)D, ng/mL20.4 ± 7.421.1 ± 8.219.5 ± 6.3
Vitamin D binding protein, mg/L284.6 ± 34.9289.83 ± 36.4278.1 ± 32.1
Albumin (g/L)44.1 ± 2.944.2 ± 3.244.1 ± 2.6
Bioavailable 25(OH)D (Biklea), μg/L2.1 ± 0.82.2 ± 0.92.1 ± 0.7
Bioavailable 25(OH)D (Vermeulena), μg/L2.2 ± 0.82.2 ± 0.92.1 ± 0.7
Free 25(OH)D (Biklea), ng/L5.4 ± 2.05.5 ± 2.25.2 ± 1.7
Free 25(OH)D (Vermeulena), ng/L5.4 ± 2.05.5 ± 2.35.3 ± 1.7
PTH, pg/mL68 ± 32.668.1 ± 31.167.8 ± 34.4
Calcium, mg/dL9.5 ± 0.49.5 ± 0.49.4 ± 0.4
Calcium or vitamin D supplementation, N (%)22 (10%)21 (17.2%)1 (1%)
Creatinine, mg/dL0.8 ± 0.20.7 ± 0.10.9 0.2
eGFRb, mL/min/1.73m281.34 ± 13.183.2 ± 12.879 ± 13.1
Overall (N = 221)Female (N = 122)Male (N = 99)
Age, years71 ± 4.769.9 ± 3.772.4 ± 5.5
BMI, kg/m230.2 ± 4.531.5 ± 4.928.7 ± 3.3
Total 25(OH)D, ng/mL20.4 ± 7.421.1 ± 8.219.5 ± 6.3
Vitamin D binding protein, mg/L284.6 ± 34.9289.83 ± 36.4278.1 ± 32.1
Albumin (g/L)44.1 ± 2.944.2 ± 3.244.1 ± 2.6
Bioavailable 25(OH)D (Biklea), μg/L2.1 ± 0.82.2 ± 0.92.1 ± 0.7
Bioavailable 25(OH)D (Vermeulena), μg/L2.2 ± 0.82.2 ± 0.92.1 ± 0.7
Free 25(OH)D (Biklea), ng/L5.4 ± 2.05.5 ± 2.25.2 ± 1.7
Free 25(OH)D (Vermeulena), ng/L5.4 ± 2.05.5 ± 2.35.3 ± 1.7
PTH, pg/mL68 ± 32.668.1 ± 31.167.8 ± 34.4
Calcium, mg/dL9.5 ± 0.49.5 ± 0.49.4 ± 0.4
Calcium or vitamin D supplementation, N (%)22 (10%)21 (17.2%)1 (1%)
Creatinine, mg/dL0.8 ± 0.20.7 ± 0.10.9 0.2
eGFRb, mL/min/1.73m281.34 ± 13.183.2 ± 12.879 ± 13.1

Abbreviations: 25(OH)D, 25-hydroxyvitamin D; BMI, body mass index; eGFR, estimated glomerular filtration rate; PTH, parathyroid hormone.

*Values are expressed as mean ± SD

aValues were derived from the Bikle equation using a spreadsheet supplied by the laboratory of Dr. Roger Bouillon (9).

beGFR was estimated using the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation. (GFR = 141 * min(Scr/κ,1)α * max(Scr/κ, 1)-1.209 * 0.993Age * 1.018 [if female] * 1.159 [if black])

Table 1.

Baseline Characteristics of Study Subjects

Overall (N = 221)Female (N = 122)Male (N = 99)
Age, years71 ± 4.769.9 ± 3.772.4 ± 5.5
BMI, kg/m230.2 ± 4.531.5 ± 4.928.7 ± 3.3
Total 25(OH)D, ng/mL20.4 ± 7.421.1 ± 8.219.5 ± 6.3
Vitamin D binding protein, mg/L284.6 ± 34.9289.83 ± 36.4278.1 ± 32.1
Albumin (g/L)44.1 ± 2.944.2 ± 3.244.1 ± 2.6
Bioavailable 25(OH)D (Biklea), μg/L2.1 ± 0.82.2 ± 0.92.1 ± 0.7
Bioavailable 25(OH)D (Vermeulena), μg/L2.2 ± 0.82.2 ± 0.92.1 ± 0.7
Free 25(OH)D (Biklea), ng/L5.4 ± 2.05.5 ± 2.25.2 ± 1.7
Free 25(OH)D (Vermeulena), ng/L5.4 ± 2.05.5 ± 2.35.3 ± 1.7
PTH, pg/mL68 ± 32.668.1 ± 31.167.8 ± 34.4
Calcium, mg/dL9.5 ± 0.49.5 ± 0.49.4 ± 0.4
Calcium or vitamin D supplementation, N (%)22 (10%)21 (17.2%)1 (1%)
Creatinine, mg/dL0.8 ± 0.20.7 ± 0.10.9 0.2
eGFRb, mL/min/1.73m281.34 ± 13.183.2 ± 12.879 ± 13.1
Overall (N = 221)Female (N = 122)Male (N = 99)
Age, years71 ± 4.769.9 ± 3.772.4 ± 5.5
BMI, kg/m230.2 ± 4.531.5 ± 4.928.7 ± 3.3
Total 25(OH)D, ng/mL20.4 ± 7.421.1 ± 8.219.5 ± 6.3
Vitamin D binding protein, mg/L284.6 ± 34.9289.83 ± 36.4278.1 ± 32.1
Albumin (g/L)44.1 ± 2.944.2 ± 3.244.1 ± 2.6
Bioavailable 25(OH)D (Biklea), μg/L2.1 ± 0.82.2 ± 0.92.1 ± 0.7
Bioavailable 25(OH)D (Vermeulena), μg/L2.2 ± 0.82.2 ± 0.92.1 ± 0.7
Free 25(OH)D (Biklea), ng/L5.4 ± 2.05.5 ± 2.25.2 ± 1.7
Free 25(OH)D (Vermeulena), ng/L5.4 ± 2.05.5 ± 2.35.3 ± 1.7
PTH, pg/mL68 ± 32.668.1 ± 31.167.8 ± 34.4
Calcium, mg/dL9.5 ± 0.49.5 ± 0.49.4 ± 0.4
Calcium or vitamin D supplementation, N (%)22 (10%)21 (17.2%)1 (1%)
Creatinine, mg/dL0.8 ± 0.20.7 ± 0.10.9 0.2
eGFRb, mL/min/1.73m281.34 ± 13.183.2 ± 12.879 ± 13.1

Abbreviations: 25(OH)D, 25-hydroxyvitamin D; BMI, body mass index; eGFR, estimated glomerular filtration rate; PTH, parathyroid hormone.

*Values are expressed as mean ± SD

aValues were derived from the Bikle equation using a spreadsheet supplied by the laboratory of Dr. Roger Bouillon (9).

beGFR was estimated using the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation. (GFR = 141 * min(Scr/κ,1)α * max(Scr/κ, 1)-1.209 * 0.993Age * 1.018 [if female] * 1.159 [if black])

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