Table 5.
Open in new tab

Sensitivity Analysis 1 of Total Stroke Risks by Different Levels of Body Mass Index among Patients with Type 2 Diabetes

Body Mass Index, kg/m2P for TrendEach 1 kg/m2 Increase
18.5–24.925.0–29.930.0–34.935.0–39.9≥40.0
Excluding patients who were diagnosed stroke within 6 months after first diagnosis of type 2 diabetes
Baseline
 No. of patients730217 71818 23311 2999948
 No. of cases99220281789913610
 Person-years27 07168 37171 46045 02938 912
 Hazard ratios (95% CI)
  Model 11.000.96 (0.89–1.03)0.93 (0.86–1.00)0.83 (0.76–0.91)0.73 (0.66–0.81)<0.0010.987 (0.983–0.991)
  Model 21.000.95 (0.88–1.01)0.90 (0.84–0.99)0.80 (0.73–0.88)0.70 (0.63–0.78)<0.0010.983 (0.979–0.987)
Follow-up
 No. of patients755317 65618 22411 2179850
 No. of Cases102420221781902603
 Person-years27 42268 19471 47644 72938 532
 Hazard ratios (95% CI)
  Model 11.000.94 (0.87–1.02)0.91 (0.84–0.99)0.81 (0.74–0.89)0.72 (0.65–0.80)<0.0010.986 (0.983–0.990)
  Model 21.000.94 (0.87–1.01)0.89 (0.82–0.97)0.78 (0.71–0.87)0.69 (0.62–0.77)<0.0010.983 (0.978–0.987)
Body Mass Index, kg/m2P for TrendEach 1 kg/m2 Increase
18.5–24.925.0–29.930.0–34.935.0–39.9≥40.0
Excluding patients who were diagnosed stroke within 6 months after first diagnosis of type 2 diabetes
Baseline
 No. of patients730217 71818 23311 2999948
 No. of cases99220281789913610
 Person-years27 07168 37171 46045 02938 912
 Hazard ratios (95% CI)
  Model 11.000.96 (0.89–1.03)0.93 (0.86–1.00)0.83 (0.76–0.91)0.73 (0.66–0.81)<0.0010.987 (0.983–0.991)
  Model 21.000.95 (0.88–1.01)0.90 (0.84–0.99)0.80 (0.73–0.88)0.70 (0.63–0.78)<0.0010.983 (0.979–0.987)
Follow-up
 No. of patients755317 65618 22411 2179850
 No. of Cases102420221781902603
 Person-years27 42268 19471 47644 72938 532
 Hazard ratios (95% CI)
  Model 11.000.94 (0.87–1.02)0.91 (0.84–0.99)0.81 (0.74–0.89)0.72 (0.65–0.80)<0.0010.986 (0.983–0.990)
  Model 21.000.94 (0.87–1.01)0.89 (0.82–0.97)0.78 (0.71–0.87)0.69 (0.62–0.77)<0.0010.983 (0.978–0.987)

Model 1 adjusted for age, sex and race; Model 2 is additionally adjusted for insurance, smoking, systolic blood pressure, HbA1c, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, eGFR, use of antihypertensive drugs, use of thiazolidinediones, use of lipid-lowering agents, use of antiplatelet agents and use of anticoagulant agents.

Abbreviations: CI, confidence interval; eGFR, estimated glomerular filtration rate; HbA1c, hemoglobin A1C.

Table 5.
Open in new tab

Sensitivity Analysis 1 of Total Stroke Risks by Different Levels of Body Mass Index among Patients with Type 2 Diabetes

Body Mass Index, kg/m2P for TrendEach 1 kg/m2 Increase
18.5–24.925.0–29.930.0–34.935.0–39.9≥40.0
Excluding patients who were diagnosed stroke within 6 months after first diagnosis of type 2 diabetes
Baseline
 No. of patients730217 71818 23311 2999948
 No. of cases99220281789913610
 Person-years27 07168 37171 46045 02938 912
 Hazard ratios (95% CI)
  Model 11.000.96 (0.89–1.03)0.93 (0.86–1.00)0.83 (0.76–0.91)0.73 (0.66–0.81)<0.0010.987 (0.983–0.991)
  Model 21.000.95 (0.88–1.01)0.90 (0.84–0.99)0.80 (0.73–0.88)0.70 (0.63–0.78)<0.0010.983 (0.979–0.987)
Follow-up
 No. of patients755317 65618 22411 2179850
 No. of Cases102420221781902603
 Person-years27 42268 19471 47644 72938 532
 Hazard ratios (95% CI)
  Model 11.000.94 (0.87–1.02)0.91 (0.84–0.99)0.81 (0.74–0.89)0.72 (0.65–0.80)<0.0010.986 (0.983–0.990)
  Model 21.000.94 (0.87–1.01)0.89 (0.82–0.97)0.78 (0.71–0.87)0.69 (0.62–0.77)<0.0010.983 (0.978–0.987)
Body Mass Index, kg/m2P for TrendEach 1 kg/m2 Increase
18.5–24.925.0–29.930.0–34.935.0–39.9≥40.0
Excluding patients who were diagnosed stroke within 6 months after first diagnosis of type 2 diabetes
Baseline
 No. of patients730217 71818 23311 2999948
 No. of cases99220281789913610
 Person-years27 07168 37171 46045 02938 912
 Hazard ratios (95% CI)
  Model 11.000.96 (0.89–1.03)0.93 (0.86–1.00)0.83 (0.76–0.91)0.73 (0.66–0.81)<0.0010.987 (0.983–0.991)
  Model 21.000.95 (0.88–1.01)0.90 (0.84–0.99)0.80 (0.73–0.88)0.70 (0.63–0.78)<0.0010.983 (0.979–0.987)
Follow-up
 No. of patients755317 65618 22411 2179850
 No. of Cases102420221781902603
 Person-years27 42268 19471 47644 72938 532
 Hazard ratios (95% CI)
  Model 11.000.94 (0.87–1.02)0.91 (0.84–0.99)0.81 (0.74–0.89)0.72 (0.65–0.80)<0.0010.986 (0.983–0.990)
  Model 21.000.94 (0.87–1.01)0.89 (0.82–0.97)0.78 (0.71–0.87)0.69 (0.62–0.77)<0.0010.983 (0.978–0.987)

Model 1 adjusted for age, sex and race; Model 2 is additionally adjusted for insurance, smoking, systolic blood pressure, HbA1c, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, eGFR, use of antihypertensive drugs, use of thiazolidinediones, use of lipid-lowering agents, use of antiplatelet agents and use of anticoagulant agents.

Abbreviations: CI, confidence interval; eGFR, estimated glomerular filtration rate; HbA1c, hemoglobin A1C.

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