Table 4.
Open in new tab

Hazard Ratios of Total Stroke by Different Levels of Body Mass Index at Baseline among Subpopulation of Patients with Type 2 Diabetes

Body Mass Index, kg/m2P for Trend
18.5–24.925.0–29.930.0–34.935.0–39.9≥40.0
Age (years)
 <501.000.95 (0.55–1.61)0.84 (0.49–1.42)0.68 (0.39–1.18)0.48 (0.27–0.84)0.003
 50–591.000.76 (0.60–0.96)0.73 (0.58–0.92)0.62 (0.48–0.79)0.53 (0.41–0.68)<0.001
 ≥601.000.89 (0.83–0.95)0.79 (0.74–0.85)0.69 (0.63–0.75)0.57 (0.52–0.63)<0.001
Sex
 Male1.000.91 (0.83–0.99)0.85 (0.77–0.93)0.68 (0.61–0.77)0.62 (0.53–0.72)<0.001
 Female1.000.92 (0.84–1.00)0.83 (0.76–0.91)0.78 (0.70–0.87)0.62 (0.55–0.69)<0.001
Race
 African Americans1.000.85 (0.77–0.94)0.80 (0.72–0.89)0.69 (0.61–0.78)0.57 (0.50–0.66)<0.001
 Whites1.000.96 (0.88–1.04)0.87 (0.80–0.95)0.78 (0.70–0.86)0.65 (0.58–0.74)<0.001
HbA1c (%)
 <6.51.000.95 (0.86–1.06)0.84 (0.75–0.93)0.78 (0.69–0.90)0.62 (0.53–0.72)<0.001
 ≥6.51.000.88 (0.81–0.96)0.83 (0.76–0.90)0.71 (0.64–0.78)0.61 (0.54–0.68)<0.001
eGFR (mL/min/1.73 m2) (%)
 ≥901.000.79 (0.64–0.98)0.71 (0.57–0.89)0.58 (0.44–0.76)0.41 (0.31–0.56)<0.001
 60–891.000.93 (0.84–1.02)0.86 (0.77–0.95)0.76 (0.68–0.86)0.71 (0.62–0.81)<0.001
 30–591.000.96 (0.86–1.06)0.88 (0.79–0.99)0.78 (0.68–0.89)0.63 (0.54–0.74)<0.001
 <301.000.95 (0.78–1.17)0.91 (0.73–1.12)0.74 (0.57–0.97)0.55 (0.39–0.77)0.001
Smoking status
 Never smoking1.000.93 (0.82–1.05)0.86 (0.75–0.98)0.76 (0.65–0.89)0.61 (0.51–0.74)<0.001
 Past and current smoking1.000.91 (0.84–0.98)0.84 (0.77–0.90)0.73 (0.66–0.80)0.62 (0.56–0.69)<0.001
Using antidiabetic medications
 No1.000.98 (0.87–1.11)0.92 (0.81–1.04)0.83 (0.71–0.97)0.69 (0.57–0.83)<0.001
 Yes1.000.88 (0.82–0.95)0.80 (0.74–0.87)0.70 (0.63–0.76)0.59 (0.53–0.65)<0.001
  Thiazolidinediones1.001.33 (0.81–2.18)1.10 (0.66–1.81)1.19 (0.70–2.03)0.65 (0.34–1.25)0.087
  Other glucose-lowering drugs1.000.87 (0.81–0.94)0.81 (0.74–0.87)0.69 (0.63–0.76)0.59 (0.54–0.66)<0.001
Using lipid-lowering medications*
 No1.000.85 (0.76–0.95)0.80 (0.71–0.91)0.73 (0.63–0.85)0.53 (0.45–0.63)<0.001
 Yes1.000.95 (0.88–1.02)0.87 (0.80–0.94)0.75 (0.68–0.82)0.66 (0.59–0.74)<0.001
Using anti-hypertensive medications*
 No1.000.73 (0.61–0.86)0.72 (0.60–0.86)0.60 (0.48–0.74)0.46 (0.36–0.60)<0.001
 Yes1.000.95 (0.88–1.02)0.86 (0.80–0.92)0.76 (0.70–0.82)0.64 (0.58–0.71)<0.001
Using antiplatelet agents*
 No1.000.83 (0.75–0.92)0.77 (0.70–0.86)0.70 (0.52–0.69)0.60 (0.52–0.69)<0.001
 Yes1.000.97 (0.89–1.06)0.89 (0.82–0.97)0.77 (0.70–0.85)0.64 (0.57–0.72)<0.001
Using anticoagulant agents
 No1.000.90 (0.84–0.97)0.85 (0.79–0.92)0.74 (0.68–0.81)0.64 (0.58–0.71)<0.001
 Yes1.000.98 (0.85–1.12)0.83 (0.72–0.95)0.75 (0.64–0.88)0.56 (0.46–0.67)<0.001
Body Mass Index, kg/m2P for Trend
18.5–24.925.0–29.930.0–34.935.0–39.9≥40.0
Age (years)
 <501.000.95 (0.55–1.61)0.84 (0.49–1.42)0.68 (0.39–1.18)0.48 (0.27–0.84)0.003
 50–591.000.76 (0.60–0.96)0.73 (0.58–0.92)0.62 (0.48–0.79)0.53 (0.41–0.68)<0.001
 ≥601.000.89 (0.83–0.95)0.79 (0.74–0.85)0.69 (0.63–0.75)0.57 (0.52–0.63)<0.001
Sex
 Male1.000.91 (0.83–0.99)0.85 (0.77–0.93)0.68 (0.61–0.77)0.62 (0.53–0.72)<0.001
 Female1.000.92 (0.84–1.00)0.83 (0.76–0.91)0.78 (0.70–0.87)0.62 (0.55–0.69)<0.001
Race
 African Americans1.000.85 (0.77–0.94)0.80 (0.72–0.89)0.69 (0.61–0.78)0.57 (0.50–0.66)<0.001
 Whites1.000.96 (0.88–1.04)0.87 (0.80–0.95)0.78 (0.70–0.86)0.65 (0.58–0.74)<0.001
HbA1c (%)
 <6.51.000.95 (0.86–1.06)0.84 (0.75–0.93)0.78 (0.69–0.90)0.62 (0.53–0.72)<0.001
 ≥6.51.000.88 (0.81–0.96)0.83 (0.76–0.90)0.71 (0.64–0.78)0.61 (0.54–0.68)<0.001
eGFR (mL/min/1.73 m2) (%)
 ≥901.000.79 (0.64–0.98)0.71 (0.57–0.89)0.58 (0.44–0.76)0.41 (0.31–0.56)<0.001
 60–891.000.93 (0.84–1.02)0.86 (0.77–0.95)0.76 (0.68–0.86)0.71 (0.62–0.81)<0.001
 30–591.000.96 (0.86–1.06)0.88 (0.79–0.99)0.78 (0.68–0.89)0.63 (0.54–0.74)<0.001
 <301.000.95 (0.78–1.17)0.91 (0.73–1.12)0.74 (0.57–0.97)0.55 (0.39–0.77)0.001
Smoking status
 Never smoking1.000.93 (0.82–1.05)0.86 (0.75–0.98)0.76 (0.65–0.89)0.61 (0.51–0.74)<0.001
 Past and current smoking1.000.91 (0.84–0.98)0.84 (0.77–0.90)0.73 (0.66–0.80)0.62 (0.56–0.69)<0.001
Using antidiabetic medications
 No1.000.98 (0.87–1.11)0.92 (0.81–1.04)0.83 (0.71–0.97)0.69 (0.57–0.83)<0.001
 Yes1.000.88 (0.82–0.95)0.80 (0.74–0.87)0.70 (0.63–0.76)0.59 (0.53–0.65)<0.001
  Thiazolidinediones1.001.33 (0.81–2.18)1.10 (0.66–1.81)1.19 (0.70–2.03)0.65 (0.34–1.25)0.087
  Other glucose-lowering drugs1.000.87 (0.81–0.94)0.81 (0.74–0.87)0.69 (0.63–0.76)0.59 (0.54–0.66)<0.001
Using lipid-lowering medications*
 No1.000.85 (0.76–0.95)0.80 (0.71–0.91)0.73 (0.63–0.85)0.53 (0.45–0.63)<0.001
 Yes1.000.95 (0.88–1.02)0.87 (0.80–0.94)0.75 (0.68–0.82)0.66 (0.59–0.74)<0.001
Using anti-hypertensive medications*
 No1.000.73 (0.61–0.86)0.72 (0.60–0.86)0.60 (0.48–0.74)0.46 (0.36–0.60)<0.001
 Yes1.000.95 (0.88–1.02)0.86 (0.80–0.92)0.76 (0.70–0.82)0.64 (0.58–0.71)<0.001
Using antiplatelet agents*
 No1.000.83 (0.75–0.92)0.77 (0.70–0.86)0.70 (0.52–0.69)0.60 (0.52–0.69)<0.001
 Yes1.000.97 (0.89–1.06)0.89 (0.82–0.97)0.77 (0.70–0.85)0.64 (0.57–0.72)<0.001
Using anticoagulant agents
 No1.000.90 (0.84–0.97)0.85 (0.79–0.92)0.74 (0.68–0.81)0.64 (0.58–0.71)<0.001
 Yes1.000.98 (0.85–1.12)0.83 (0.72–0.95)0.75 (0.64–0.88)0.56 (0.46–0.67)<0.001

Data are hazard ratios (95% confidence intervals) unless otherwise indicated. All hazard ratios were adjusted for age, race, sex, insurance, smoking, systolic blood pressure, HbA1c, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, eGFR, use of antihypertensive drugs, use of thiazolidinediones, use of lipid-lowering agents, use of antiplatelet agents and use of anticoagulant agents other than the variable for stratification. *P-value for interaction <0.01.

Abbreviations: CI, confidence interval; eGFR, estimated glomerular filtration rate; HbA1c, hemoglobin A1C.

Table 4.
Open in new tab

Hazard Ratios of Total Stroke by Different Levels of Body Mass Index at Baseline among Subpopulation of Patients with Type 2 Diabetes

Body Mass Index, kg/m2P for Trend
18.5–24.925.0–29.930.0–34.935.0–39.9≥40.0
Age (years)
 <501.000.95 (0.55–1.61)0.84 (0.49–1.42)0.68 (0.39–1.18)0.48 (0.27–0.84)0.003
 50–591.000.76 (0.60–0.96)0.73 (0.58–0.92)0.62 (0.48–0.79)0.53 (0.41–0.68)<0.001
 ≥601.000.89 (0.83–0.95)0.79 (0.74–0.85)0.69 (0.63–0.75)0.57 (0.52–0.63)<0.001
Sex
 Male1.000.91 (0.83–0.99)0.85 (0.77–0.93)0.68 (0.61–0.77)0.62 (0.53–0.72)<0.001
 Female1.000.92 (0.84–1.00)0.83 (0.76–0.91)0.78 (0.70–0.87)0.62 (0.55–0.69)<0.001
Race
 African Americans1.000.85 (0.77–0.94)0.80 (0.72–0.89)0.69 (0.61–0.78)0.57 (0.50–0.66)<0.001
 Whites1.000.96 (0.88–1.04)0.87 (0.80–0.95)0.78 (0.70–0.86)0.65 (0.58–0.74)<0.001
HbA1c (%)
 <6.51.000.95 (0.86–1.06)0.84 (0.75–0.93)0.78 (0.69–0.90)0.62 (0.53–0.72)<0.001
 ≥6.51.000.88 (0.81–0.96)0.83 (0.76–0.90)0.71 (0.64–0.78)0.61 (0.54–0.68)<0.001
eGFR (mL/min/1.73 m2) (%)
 ≥901.000.79 (0.64–0.98)0.71 (0.57–0.89)0.58 (0.44–0.76)0.41 (0.31–0.56)<0.001
 60–891.000.93 (0.84–1.02)0.86 (0.77–0.95)0.76 (0.68–0.86)0.71 (0.62–0.81)<0.001
 30–591.000.96 (0.86–1.06)0.88 (0.79–0.99)0.78 (0.68–0.89)0.63 (0.54–0.74)<0.001
 <301.000.95 (0.78–1.17)0.91 (0.73–1.12)0.74 (0.57–0.97)0.55 (0.39–0.77)0.001
Smoking status
 Never smoking1.000.93 (0.82–1.05)0.86 (0.75–0.98)0.76 (0.65–0.89)0.61 (0.51–0.74)<0.001
 Past and current smoking1.000.91 (0.84–0.98)0.84 (0.77–0.90)0.73 (0.66–0.80)0.62 (0.56–0.69)<0.001
Using antidiabetic medications
 No1.000.98 (0.87–1.11)0.92 (0.81–1.04)0.83 (0.71–0.97)0.69 (0.57–0.83)<0.001
 Yes1.000.88 (0.82–0.95)0.80 (0.74–0.87)0.70 (0.63–0.76)0.59 (0.53–0.65)<0.001
  Thiazolidinediones1.001.33 (0.81–2.18)1.10 (0.66–1.81)1.19 (0.70–2.03)0.65 (0.34–1.25)0.087
  Other glucose-lowering drugs1.000.87 (0.81–0.94)0.81 (0.74–0.87)0.69 (0.63–0.76)0.59 (0.54–0.66)<0.001
Using lipid-lowering medications*
 No1.000.85 (0.76–0.95)0.80 (0.71–0.91)0.73 (0.63–0.85)0.53 (0.45–0.63)<0.001
 Yes1.000.95 (0.88–1.02)0.87 (0.80–0.94)0.75 (0.68–0.82)0.66 (0.59–0.74)<0.001
Using anti-hypertensive medications*
 No1.000.73 (0.61–0.86)0.72 (0.60–0.86)0.60 (0.48–0.74)0.46 (0.36–0.60)<0.001
 Yes1.000.95 (0.88–1.02)0.86 (0.80–0.92)0.76 (0.70–0.82)0.64 (0.58–0.71)<0.001
Using antiplatelet agents*
 No1.000.83 (0.75–0.92)0.77 (0.70–0.86)0.70 (0.52–0.69)0.60 (0.52–0.69)<0.001
 Yes1.000.97 (0.89–1.06)0.89 (0.82–0.97)0.77 (0.70–0.85)0.64 (0.57–0.72)<0.001
Using anticoagulant agents
 No1.000.90 (0.84–0.97)0.85 (0.79–0.92)0.74 (0.68–0.81)0.64 (0.58–0.71)<0.001
 Yes1.000.98 (0.85–1.12)0.83 (0.72–0.95)0.75 (0.64–0.88)0.56 (0.46–0.67)<0.001
Body Mass Index, kg/m2P for Trend
18.5–24.925.0–29.930.0–34.935.0–39.9≥40.0
Age (years)
 <501.000.95 (0.55–1.61)0.84 (0.49–1.42)0.68 (0.39–1.18)0.48 (0.27–0.84)0.003
 50–591.000.76 (0.60–0.96)0.73 (0.58–0.92)0.62 (0.48–0.79)0.53 (0.41–0.68)<0.001
 ≥601.000.89 (0.83–0.95)0.79 (0.74–0.85)0.69 (0.63–0.75)0.57 (0.52–0.63)<0.001
Sex
 Male1.000.91 (0.83–0.99)0.85 (0.77–0.93)0.68 (0.61–0.77)0.62 (0.53–0.72)<0.001
 Female1.000.92 (0.84–1.00)0.83 (0.76–0.91)0.78 (0.70–0.87)0.62 (0.55–0.69)<0.001
Race
 African Americans1.000.85 (0.77–0.94)0.80 (0.72–0.89)0.69 (0.61–0.78)0.57 (0.50–0.66)<0.001
 Whites1.000.96 (0.88–1.04)0.87 (0.80–0.95)0.78 (0.70–0.86)0.65 (0.58–0.74)<0.001
HbA1c (%)
 <6.51.000.95 (0.86–1.06)0.84 (0.75–0.93)0.78 (0.69–0.90)0.62 (0.53–0.72)<0.001
 ≥6.51.000.88 (0.81–0.96)0.83 (0.76–0.90)0.71 (0.64–0.78)0.61 (0.54–0.68)<0.001
eGFR (mL/min/1.73 m2) (%)
 ≥901.000.79 (0.64–0.98)0.71 (0.57–0.89)0.58 (0.44–0.76)0.41 (0.31–0.56)<0.001
 60–891.000.93 (0.84–1.02)0.86 (0.77–0.95)0.76 (0.68–0.86)0.71 (0.62–0.81)<0.001
 30–591.000.96 (0.86–1.06)0.88 (0.79–0.99)0.78 (0.68–0.89)0.63 (0.54–0.74)<0.001
 <301.000.95 (0.78–1.17)0.91 (0.73–1.12)0.74 (0.57–0.97)0.55 (0.39–0.77)0.001
Smoking status
 Never smoking1.000.93 (0.82–1.05)0.86 (0.75–0.98)0.76 (0.65–0.89)0.61 (0.51–0.74)<0.001
 Past and current smoking1.000.91 (0.84–0.98)0.84 (0.77–0.90)0.73 (0.66–0.80)0.62 (0.56–0.69)<0.001
Using antidiabetic medications
 No1.000.98 (0.87–1.11)0.92 (0.81–1.04)0.83 (0.71–0.97)0.69 (0.57–0.83)<0.001
 Yes1.000.88 (0.82–0.95)0.80 (0.74–0.87)0.70 (0.63–0.76)0.59 (0.53–0.65)<0.001
  Thiazolidinediones1.001.33 (0.81–2.18)1.10 (0.66–1.81)1.19 (0.70–2.03)0.65 (0.34–1.25)0.087
  Other glucose-lowering drugs1.000.87 (0.81–0.94)0.81 (0.74–0.87)0.69 (0.63–0.76)0.59 (0.54–0.66)<0.001
Using lipid-lowering medications*
 No1.000.85 (0.76–0.95)0.80 (0.71–0.91)0.73 (0.63–0.85)0.53 (0.45–0.63)<0.001
 Yes1.000.95 (0.88–1.02)0.87 (0.80–0.94)0.75 (0.68–0.82)0.66 (0.59–0.74)<0.001
Using anti-hypertensive medications*
 No1.000.73 (0.61–0.86)0.72 (0.60–0.86)0.60 (0.48–0.74)0.46 (0.36–0.60)<0.001
 Yes1.000.95 (0.88–1.02)0.86 (0.80–0.92)0.76 (0.70–0.82)0.64 (0.58–0.71)<0.001
Using antiplatelet agents*
 No1.000.83 (0.75–0.92)0.77 (0.70–0.86)0.70 (0.52–0.69)0.60 (0.52–0.69)<0.001
 Yes1.000.97 (0.89–1.06)0.89 (0.82–0.97)0.77 (0.70–0.85)0.64 (0.57–0.72)<0.001
Using anticoagulant agents
 No1.000.90 (0.84–0.97)0.85 (0.79–0.92)0.74 (0.68–0.81)0.64 (0.58–0.71)<0.001
 Yes1.000.98 (0.85–1.12)0.83 (0.72–0.95)0.75 (0.64–0.88)0.56 (0.46–0.67)<0.001

Data are hazard ratios (95% confidence intervals) unless otherwise indicated. All hazard ratios were adjusted for age, race, sex, insurance, smoking, systolic blood pressure, HbA1c, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, eGFR, use of antihypertensive drugs, use of thiazolidinediones, use of lipid-lowering agents, use of antiplatelet agents and use of anticoagulant agents other than the variable for stratification. *P-value for interaction <0.01.

Abbreviations: CI, confidence interval; eGFR, estimated glomerular filtration rate; HbA1c, hemoglobin A1C.

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