Table 1. Open in new tab Baseline...

	Body Mass Index, kg/m²					P for Trend
Participants (n)	7756	18 593	18 933	11 648	10 156
Age (years)	73.0 ± 12.7	69.4 ± 11.8	66.1 ± 11.3	63.5 ± 11.0	60.2 ± 10.6	<0.001
Male (%)	47.8	53.5	50.2	44.2	35.3	<0.001
Race (%)						<0.001
African American	38.4	38.4	39.4	40.8	44.9
White	61.6	61.6	60.6	59.2	55.1
Blood pressure (mmHg)
Systolic	132 ± 15	133 ± 13	133 ± 12	133 ± 12	135 ± 12	<0.001
Diastolic	72 ± 8	74 ± 8	76 ± 8	77 ± 8	78 ± 8	<0.001
HbA1c (%)	7.2 ± 2.1	7.5 ± 1.9	7.6 ± 1.9	7.7 ± 2.0	7.6 ± 1.9	<0.001
Total cholesterol (mg/dL)	166 ± 42.9	169 ± 40.3	171 ± 39.7	173 ± 39.1	172 ± 36.3	<0.001
Low-density lipoprotein cholesterol (mg/dL)	94.7 ± 34.3	97.1 ± 32.7	98.5 ± 32.7	99.8 ± 32.5	101 ± 30.5	<0.001
High-density lipoprotein cholesterol (mg/dL)	48.0 ± 15.6	44.6 ± 12.7	43.4 ± 11.8	42.9 ± 11.6	43.0 ± 11.0	<0.001
Triglycerides (mg/dL)	120 ± 67.7	141 ± 85.3	153 ± 92.3	156 ± 104	145 ± 76.6	<0.001
eGFR (mL/min/1.73 m²) (%)						<0.001
≥90	12.2	12.0	13.0	15.6	19.5
60–89	50.3	55.5	58.3	57.4	57.2
30–59	29.0	26.2	23.5	22.4	19.8
15–29	4.7	3.4	2.8	2.3	2.6
<15	3.8	3.0	2.4	2.3	0.9
Current smoker (%)	22.7	21.0	20.1	19.1	17.1	<0.001
Insurance type (%)						<0.001
Commercial/private	20.8	30.8	39.2	45.0	49.1
Medicare	70.8	61.4	52.1	45.4	38.6
Medicaid	5.5	4.2	4.8	5.6	8.5
Self-pay	1.7	2.1	2.1	2.1	2.3
Others	1.2	1.5	1.8	1.9	1.5
Use of medications (%)
Lipid-lowering	56.2	62.0	63.2	62.7	57.3	<0.001
Antihypertensive	74.4	76.3	77.9	79.2	79.0	<0.001
Glucose-lowering	63.6	69.5	73.8	76.2	76.7	<0.001
Thiazolidinediones	1.8	2.7	3.4	3.8	3.5	<0.001
Other glucose lowering drugs	61.8	66.8	70.4	72.4	73.2	<0.001
Antiplatelet	38.6	34.6	32.4	30.7	29.3	<0.001
Anticoagulant	13.3	12.7	12.3	12.6	13.1	0.902

Body Mass Index, kg/m²

P for Trend

18.5–24.9

25.0–29.9

30.0–34.9

35.0–39.9

≥40.0

Participants (n)

7756

18 593

18 933

11 648

10 156

Age (years)

73.0 ± 12.7

69.4 ± 11.8

66.1 ± 11.3

63.5 ± 11.0

60.2 ± 10.6

<0.001

Male (%)

47.8

53.5

50.2

44.2

35.3

<0.001

Race (%)

<0.001

African American

38.4

39.4

40.8

44.9

White

61.6

60.6

59.2

55.1

Blood pressure (mmHg)

Systolic

132 ± 15

133 ± 13

133 ± 12

135 ± 12

<0.001

Diastolic

72 ± 8

74 ± 8

76 ± 8

77 ± 8

78 ± 8

<0.001

HbA1c (%)

7.2 ± 2.1

7.5 ± 1.9

7.6 ± 1.9

7.7 ± 2.0

7.6 ± 1.9

<0.001

Total cholesterol (mg/dL)

166 ± 42.9

169 ± 40.3

171 ± 39.7

173 ± 39.1

172 ± 36.3

<0.001

Low-density lipoprotein cholesterol (mg/dL)

94.7 ± 34.3

97.1 ± 32.7

98.5 ± 32.7

99.8 ± 32.5

101 ± 30.5

<0.001

High-density lipoprotein cholesterol (mg/dL)

48.0 ± 15.6

44.6 ± 12.7

43.4 ± 11.8

42.9 ± 11.6

43.0 ± 11.0

<0.001

Triglycerides (mg/dL)

120 ± 67.7

141 ± 85.3

153 ± 92.3

156 ± 104

145 ± 76.6

<0.001

eGFR (mL/min/1.73 m²) (%)

<0.001

≥90

12.2

12.0

13.0

15.6

19.5

60–89

50.3

55.5

58.3

57.4

57.2

30–59

29.0

26.2

23.5

22.4

19.8

15–29

4.7

3.4

2.8

2.3

2.6

<15

3.8

3.0

2.4

2.3

0.9

Current smoker (%)

22.7

21.0

20.1

19.1

17.1

<0.001

Insurance type (%)

<0.001

Commercial/private

20.8

30.8

39.2

45.0

49.1

Medicare

70.8

61.4

52.1

45.4

38.6

Medicaid

5.5

4.2

4.8

5.6

8.5

Self-pay

1.7

2.1

2.3

Others

1.2

1.5

1.8

1.9

1.5

Use of medications (%)

Lipid-lowering

56.2

62.0

63.2

62.7

57.3

<0.001

Antihypertensive

74.4

76.3

77.9

79.2

79.0

<0.001

Glucose-lowering

63.6

69.5

73.8

76.2

76.7

<0.001

Thiazolidinediones

1.8

2.7

3.4

3.8

3.5

<0.001

Other glucose lowering drugs

61.8

66.8

70.4

72.4

73.2

<0.001

Antiplatelet

38.6

34.6

32.4

30.7

29.3

<0.001

Anticoagulant

13.3

12.7

12.3

12.6

13.1

0.902

	Body Mass Index, kg/m²					P for Trend
Participants (n)	7756	18 593	18 933	11 648	10 156
Age (years)	73.0 ± 12.7	69.4 ± 11.8	66.1 ± 11.3	63.5 ± 11.0	60.2 ± 10.6	<0.001
Male (%)	47.8	53.5	50.2	44.2	35.3	<0.001
Race (%)						<0.001
African American	38.4	38.4	39.4	40.8	44.9
White	61.6	61.6	60.6	59.2	55.1
Blood pressure (mmHg)
Systolic	132 ± 15	133 ± 13	133 ± 12	133 ± 12	135 ± 12	<0.001
Diastolic	72 ± 8	74 ± 8	76 ± 8	77 ± 8	78 ± 8	<0.001
HbA1c (%)	7.2 ± 2.1	7.5 ± 1.9	7.6 ± 1.9	7.7 ± 2.0	7.6 ± 1.9	<0.001
Total cholesterol (mg/dL)	166 ± 42.9	169 ± 40.3	171 ± 39.7	173 ± 39.1	172 ± 36.3	<0.001
Low-density lipoprotein cholesterol (mg/dL)	94.7 ± 34.3	97.1 ± 32.7	98.5 ± 32.7	99.8 ± 32.5	101 ± 30.5	<0.001
High-density lipoprotein cholesterol (mg/dL)	48.0 ± 15.6	44.6 ± 12.7	43.4 ± 11.8	42.9 ± 11.6	43.0 ± 11.0	<0.001
Triglycerides (mg/dL)	120 ± 67.7	141 ± 85.3	153 ± 92.3	156 ± 104	145 ± 76.6	<0.001
eGFR (mL/min/1.73 m²) (%)						<0.001
≥90	12.2	12.0	13.0	15.6	19.5
60–89	50.3	55.5	58.3	57.4	57.2
30–59	29.0	26.2	23.5	22.4	19.8
15–29	4.7	3.4	2.8	2.3	2.6
<15	3.8	3.0	2.4	2.3	0.9
Current smoker (%)	22.7	21.0	20.1	19.1	17.1	<0.001
Insurance type (%)						<0.001
Commercial/private	20.8	30.8	39.2	45.0	49.1
Medicare	70.8	61.4	52.1	45.4	38.6
Medicaid	5.5	4.2	4.8	5.6	8.5
Self-pay	1.7	2.1	2.1	2.1	2.3
Others	1.2	1.5	1.8	1.9	1.5
Use of medications (%)
Lipid-lowering	56.2	62.0	63.2	62.7	57.3	<0.001
Antihypertensive	74.4	76.3	77.9	79.2	79.0	<0.001
Glucose-lowering	63.6	69.5	73.8	76.2	76.7	<0.001
Thiazolidinediones	1.8	2.7	3.4	3.8	3.5	<0.001
Other glucose lowering drugs	61.8	66.8	70.4	72.4	73.2	<0.001
Antiplatelet	38.6	34.6	32.4	30.7	29.3	<0.001
Anticoagulant	13.3	12.7	12.3	12.6	13.1	0.902

Table 1.

Open in new tab

Baseline Characteristics by Different Levels of Body Mass Index among Patients with Type 2 Diabetes

	Body Mass Index, kg/m²					P for Trend
	18.5–24.9	25.0–29.9	30.0–34.9	35.0–39.9	≥40.0
Participants (n)	7756	18 593	18 933	11 648	10 156
Age (years)	73.0 ± 12.7	69.4 ± 11.8	66.1 ± 11.3	63.5 ± 11.0	60.2 ± 10.6	<0.001
Male (%)	47.8	53.5	50.2	44.2	35.3	<0.001
Race (%)						<0.001
African American	38.4	38.4	39.4	40.8	44.9
White	61.6	61.6	60.6	59.2	55.1
Blood pressure (mmHg)
Systolic	132 ± 15	133 ± 13	133 ± 12	133 ± 12	135 ± 12	<0.001
Diastolic	72 ± 8	74 ± 8	76 ± 8	77 ± 8	78 ± 8	<0.001
HbA1c (%)	7.2 ± 2.1	7.5 ± 1.9	7.6 ± 1.9	7.7 ± 2.0	7.6 ± 1.9	<0.001
Total cholesterol (mg/dL)	166 ± 42.9	169 ± 40.3	171 ± 39.7	173 ± 39.1	172 ± 36.3	<0.001
Low-density lipoprotein cholesterol (mg/dL)	94.7 ± 34.3	97.1 ± 32.7	98.5 ± 32.7	99.8 ± 32.5	101 ± 30.5	<0.001
High-density lipoprotein cholesterol (mg/dL)	48.0 ± 15.6	44.6 ± 12.7	43.4 ± 11.8	42.9 ± 11.6	43.0 ± 11.0	<0.001
Triglycerides (mg/dL)	120 ± 67.7	141 ± 85.3	153 ± 92.3	156 ± 104	145 ± 76.6	<0.001
eGFR (mL/min/1.73 m²) (%)						<0.001
≥90	12.2	12.0	13.0	15.6	19.5
60–89	50.3	55.5	58.3	57.4	57.2
30–59	29.0	26.2	23.5	22.4	19.8
15–29	4.7	3.4	2.8	2.3	2.6
<15	3.8	3.0	2.4	2.3	0.9
Current smoker (%)	22.7	21.0	20.1	19.1	17.1	<0.001
Insurance type (%)						<0.001
Commercial/private	20.8	30.8	39.2	45.0	49.1
Medicare	70.8	61.4	52.1	45.4	38.6
Medicaid	5.5	4.2	4.8	5.6	8.5
Self-pay	1.7	2.1	2.1	2.1	2.3
Others	1.2	1.5	1.8	1.9	1.5
Use of medications (%)
Lipid-lowering	56.2	62.0	63.2	62.7	57.3	<0.001
Antihypertensive	74.4	76.3	77.9	79.2	79.0	<0.001
Glucose-lowering	63.6	69.5	73.8	76.2	76.7	<0.001
Thiazolidinediones	1.8	2.7	3.4	3.8	3.5	<0.001
Other glucose lowering drugs	61.8	66.8	70.4	72.4	73.2	<0.001
Antiplatelet	38.6	34.6	32.4	30.7	29.3	<0.001
Anticoagulant	13.3	12.7	12.3	12.6	13.1	0.902

	Body Mass Index, kg/m²					P for Trend
	18.5–24.9	25.0–29.9	30.0–34.9	35.0–39.9	≥40.0
Participants (n)	7756	18 593	18 933	11 648	10 156
Age (years)	73.0 ± 12.7	69.4 ± 11.8	66.1 ± 11.3	63.5 ± 11.0	60.2 ± 10.6	<0.001
Male (%)	47.8	53.5	50.2	44.2	35.3	<0.001
Race (%)						<0.001
African American	38.4	38.4	39.4	40.8	44.9
White	61.6	61.6	60.6	59.2	55.1
Blood pressure (mmHg)
Systolic	132 ± 15	133 ± 13	133 ± 12	133 ± 12	135 ± 12	<0.001
Diastolic	72 ± 8	74 ± 8	76 ± 8	77 ± 8	78 ± 8	<0.001
HbA1c (%)	7.2 ± 2.1	7.5 ± 1.9	7.6 ± 1.9	7.7 ± 2.0	7.6 ± 1.9	<0.001
Total cholesterol (mg/dL)	166 ± 42.9	169 ± 40.3	171 ± 39.7	173 ± 39.1	172 ± 36.3	<0.001
Low-density lipoprotein cholesterol (mg/dL)	94.7 ± 34.3	97.1 ± 32.7	98.5 ± 32.7	99.8 ± 32.5	101 ± 30.5	<0.001
High-density lipoprotein cholesterol (mg/dL)	48.0 ± 15.6	44.6 ± 12.7	43.4 ± 11.8	42.9 ± 11.6	43.0 ± 11.0	<0.001
Triglycerides (mg/dL)	120 ± 67.7	141 ± 85.3	153 ± 92.3	156 ± 104	145 ± 76.6	<0.001
eGFR (mL/min/1.73 m²) (%)						<0.001
≥90	12.2	12.0	13.0	15.6	19.5
60–89	50.3	55.5	58.3	57.4	57.2
30–59	29.0	26.2	23.5	22.4	19.8
15–29	4.7	3.4	2.8	2.3	2.6
<15	3.8	3.0	2.4	2.3	0.9
Current smoker (%)	22.7	21.0	20.1	19.1	17.1	<0.001
Insurance type (%)						<0.001
Commercial/private	20.8	30.8	39.2	45.0	49.1
Medicare	70.8	61.4	52.1	45.4	38.6
Medicaid	5.5	4.2	4.8	5.6	8.5
Self-pay	1.7	2.1	2.1	2.1	2.3
Others	1.2	1.5	1.8	1.9	1.5
Use of medications (%)
Lipid-lowering	56.2	62.0	63.2	62.7	57.3	<0.001
Antihypertensive	74.4	76.3	77.9	79.2	79.0	<0.001
Glucose-lowering	63.6	69.5	73.8	76.2	76.7	<0.001
Thiazolidinediones	1.8	2.7	3.4	3.8	3.5	<0.001
Other glucose lowering drugs	61.8	66.8	70.4	72.4	73.2	<0.001
Antiplatelet	38.6	34.6	32.4	30.7	29.3	<0.001
Anticoagulant	13.3	12.7	12.3	12.6	13.1	0.902

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