Effect of cosyntropin and placebo infusions on baroreflex sensitivity and hemodynamic measures obtained during modified Oxford and on QT interval measured before each modified Oxford
| . | Cosyntropin infusion . | Placebo infusion . | ||||
|---|---|---|---|---|---|---|
| . | Baseline . | During AM infusion . | Next day . | Baseline . | During AM infusion . | Next day . |
| SBP, mm Hg | ||||||
| Minimum | 111 ± 3.5 | 113 ± 1.9 | 113 ± 3.1 | 109 ± 3.1 | 109 ± 3.1 | 109 ± 3.1 |
| Maximum | 137 ± 4.5 | 142 ± 3.5 | 142 ± 4.3 | 140 ± 3.7 | 137 ± 3.7 | 134 ± 4.7 |
| R-R interval, ms | ||||||
| Minimum | 796 ± 39.3 | 785 ± 32.7 | 816 ± 31.2 | 783 ± 25.1 | 778 ± 32.1 | 816 ± 26.9 |
| Maximum | 1304 ± 54.8 | 1245 ± 48.5 | 1292 ± 53.7 | 1354 ± 65.3 | 1317 ± 56.2 | 1312 ± 53.6 |
| Range | 508 ± 41.0 | 460 ± 33.7 | 476 ± 47.2 | 571 ± 54.0 | 539 ± 48.9 | 496 ± 49.0 |
| BRS, mm Hg/ms | 17.8 ± 1.38 | 14.4 ± 1.43a,b | 14.8 ± 1.42a,c | 17.0 ± 2.07 | 17.3 ± 1.65 | 18.9 ± 2.04 |
| QTc, ms | 409 ± 6.2 | 409 ± 6.8 | 409 ± 5.8 | 408 ± 5.6 | 411 ± 6.8 | 405 ± 5.9 |
| . | Cosyntropin infusion . | Placebo infusion . | ||||
|---|---|---|---|---|---|---|
| . | Baseline . | During AM infusion . | Next day . | Baseline . | During AM infusion . | Next day . |
| SBP, mm Hg | ||||||
| Minimum | 111 ± 3.5 | 113 ± 1.9 | 113 ± 3.1 | 109 ± 3.1 | 109 ± 3.1 | 109 ± 3.1 |
| Maximum | 137 ± 4.5 | 142 ± 3.5 | 142 ± 4.3 | 140 ± 3.7 | 137 ± 3.7 | 134 ± 4.7 |
| R-R interval, ms | ||||||
| Minimum | 796 ± 39.3 | 785 ± 32.7 | 816 ± 31.2 | 783 ± 25.1 | 778 ± 32.1 | 816 ± 26.9 |
| Maximum | 1304 ± 54.8 | 1245 ± 48.5 | 1292 ± 53.7 | 1354 ± 65.3 | 1317 ± 56.2 | 1312 ± 53.6 |
| Range | 508 ± 41.0 | 460 ± 33.7 | 476 ± 47.2 | 571 ± 54.0 | 539 ± 48.9 | 496 ± 49.0 |
| BRS, mm Hg/ms | 17.8 ± 1.38 | 14.4 ± 1.43a,b | 14.8 ± 1.42a,c | 17.0 ± 2.07 | 17.3 ± 1.65 | 18.9 ± 2.04 |
| QTc, ms | 409 ± 6.2 | 409 ± 6.8 | 409 ± 5.8 | 408 ± 5.6 | 411 ± 6.8 | 405 ± 5.9 |
Data are mean ± SEM.
Abbreviations: am, morning; BRS, baroreflex sensitivity; SBP, systolic blood pressure; QTc, corrected QT interval.
a P less than .05 cosyntropin vs placebo infusion, time × treatment interaction (analysis of variance).
b P equal to .008 cosyntropin vs baseline (preinfusion) (post hoc t test, Bonferroni-corrected).
c P equal to .022 cosyntropin vs baseline (preinfusion) (post hoc t test, Bonferroni-corrected).
Effect of cosyntropin and placebo infusions on baroreflex sensitivity and hemodynamic measures obtained during modified Oxford and on QT interval measured before each modified Oxford
| . | Cosyntropin infusion . | Placebo infusion . | ||||
|---|---|---|---|---|---|---|
| . | Baseline . | During AM infusion . | Next day . | Baseline . | During AM infusion . | Next day . |
| SBP, mm Hg | ||||||
| Minimum | 111 ± 3.5 | 113 ± 1.9 | 113 ± 3.1 | 109 ± 3.1 | 109 ± 3.1 | 109 ± 3.1 |
| Maximum | 137 ± 4.5 | 142 ± 3.5 | 142 ± 4.3 | 140 ± 3.7 | 137 ± 3.7 | 134 ± 4.7 |
| R-R interval, ms | ||||||
| Minimum | 796 ± 39.3 | 785 ± 32.7 | 816 ± 31.2 | 783 ± 25.1 | 778 ± 32.1 | 816 ± 26.9 |
| Maximum | 1304 ± 54.8 | 1245 ± 48.5 | 1292 ± 53.7 | 1354 ± 65.3 | 1317 ± 56.2 | 1312 ± 53.6 |
| Range | 508 ± 41.0 | 460 ± 33.7 | 476 ± 47.2 | 571 ± 54.0 | 539 ± 48.9 | 496 ± 49.0 |
| BRS, mm Hg/ms | 17.8 ± 1.38 | 14.4 ± 1.43a,b | 14.8 ± 1.42a,c | 17.0 ± 2.07 | 17.3 ± 1.65 | 18.9 ± 2.04 |
| QTc, ms | 409 ± 6.2 | 409 ± 6.8 | 409 ± 5.8 | 408 ± 5.6 | 411 ± 6.8 | 405 ± 5.9 |
| . | Cosyntropin infusion . | Placebo infusion . | ||||
|---|---|---|---|---|---|---|
| . | Baseline . | During AM infusion . | Next day . | Baseline . | During AM infusion . | Next day . |
| SBP, mm Hg | ||||||
| Minimum | 111 ± 3.5 | 113 ± 1.9 | 113 ± 3.1 | 109 ± 3.1 | 109 ± 3.1 | 109 ± 3.1 |
| Maximum | 137 ± 4.5 | 142 ± 3.5 | 142 ± 4.3 | 140 ± 3.7 | 137 ± 3.7 | 134 ± 4.7 |
| R-R interval, ms | ||||||
| Minimum | 796 ± 39.3 | 785 ± 32.7 | 816 ± 31.2 | 783 ± 25.1 | 778 ± 32.1 | 816 ± 26.9 |
| Maximum | 1304 ± 54.8 | 1245 ± 48.5 | 1292 ± 53.7 | 1354 ± 65.3 | 1317 ± 56.2 | 1312 ± 53.6 |
| Range | 508 ± 41.0 | 460 ± 33.7 | 476 ± 47.2 | 571 ± 54.0 | 539 ± 48.9 | 496 ± 49.0 |
| BRS, mm Hg/ms | 17.8 ± 1.38 | 14.4 ± 1.43a,b | 14.8 ± 1.42a,c | 17.0 ± 2.07 | 17.3 ± 1.65 | 18.9 ± 2.04 |
| QTc, ms | 409 ± 6.2 | 409 ± 6.8 | 409 ± 5.8 | 408 ± 5.6 | 411 ± 6.8 | 405 ± 5.9 |
Data are mean ± SEM.
Abbreviations: am, morning; BRS, baroreflex sensitivity; SBP, systolic blood pressure; QTc, corrected QT interval.
a P less than .05 cosyntropin vs placebo infusion, time × treatment interaction (analysis of variance).
b P equal to .008 cosyntropin vs baseline (preinfusion) (post hoc t test, Bonferroni-corrected).
c P equal to .022 cosyntropin vs baseline (preinfusion) (post hoc t test, Bonferroni-corrected).
This PDF is available to Subscribers Only
View Article Abstract & Purchase OptionsFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.
