Table 3.
Open in new tab

False-positive report probability values for SNPs in patients with HT and controls

Prior Probability
SNPOR (95% CI) Reported P ValueStatistical Power under Recessive Model a0.250.10.010.0010.00010.00001
rs12658831.59 (1.42–1.78)3.67 × 10-161.00 1.10 × 10  -153.30 × 10  -153.63 × 10  -143.66 × 10  -133.67 × 10  -123.67 × 10  -11
rs18811451.19 (1.11–1.28)2.00 × 10-61.00 6.00 × 10  -61.80 × 10  -51.98 × 10  -41.99 × 10  -30.020.17
rs10241611.31 (1.21–1.42)2.31 × 10-111.00 6.94 × 10  -112.08 × 10  -102.29 × 10  -92.31 × 10  -82.31 × 10  -72.31 × 10  -6
rs130931101.14 (1.06–1.22)5.89 × 10-41.00 1.76 × 10  -35.27 × 10  -30.06 0.37 0.85 0.98
rs68321511.16 (1.07–1.24)1.06 × 10-41.00 3.18 × 10  -49.53 × 10  -40.010.10 0.51 0.91
rs15211.55 (1.42–1.70)2.81 × 10-21- ------
rs24746191.12 (1.04–1.21)2.75 × 10-31.00 8.20 × 10  -30.020.21 0.73 0.96 1.00
rs93556101.15 (1.07–1.23)1.34 × 10-41.00 4.03 × 10  -41.21 × 10  -30.010.12 0.57 0.93
rs125756361.28 (1.14–1.45)3.59 × 10-50.99 1.09 × 10  -43.27 × 10  -43.58 × 10  -30.040.27 0.78
rs2295271.22 (1.12–1.32)3.00 × 10-61.00 9.00 × 10  -62.70 × 10  -52.97 × 10  -42.99 × 10  -30.030.23
rs59128381.26 (1.17–1.35)1.58 × 10-101.00 4.75 × 10  -101.43 × 10  -91.57 × 10  -81.58 × 10  -71.58 × 10  -61.58 × 10  -5
Prior Probability
SNPOR (95% CI) Reported P ValueStatistical Power under Recessive Model a0.250.10.010.0010.00010.00001
rs12658831.59 (1.42–1.78)3.67 × 10-161.00 1.10 × 10  -153.30 × 10  -153.63 × 10  -143.66 × 10  -133.67 × 10  -123.67 × 10  -11
rs18811451.19 (1.11–1.28)2.00 × 10-61.00 6.00 × 10  -61.80 × 10  -51.98 × 10  -41.99 × 10  -30.020.17
rs10241611.31 (1.21–1.42)2.31 × 10-111.00 6.94 × 10  -112.08 × 10  -102.29 × 10  -92.31 × 10  -82.31 × 10  -72.31 × 10  -6
rs130931101.14 (1.06–1.22)5.89 × 10-41.00 1.76 × 10  -35.27 × 10  -30.06 0.37 0.85 0.98
rs68321511.16 (1.07–1.24)1.06 × 10-41.00 3.18 × 10  -49.53 × 10  -40.010.10 0.51 0.91
rs15211.55 (1.42–1.70)2.81 × 10-21- ------
rs24746191.12 (1.04–1.21)2.75 × 10-31.00 8.20 × 10  -30.020.21 0.73 0.96 1.00
rs93556101.15 (1.07–1.23)1.34 × 10-41.00 4.03 × 10  -41.21 × 10  -30.010.12 0.57 0.93
rs125756361.28 (1.14–1.45)3.59 × 10-50.99 1.09 × 10  -43.27 × 10  -43.58 × 10  -30.040.27 0.78
rs2295271.22 (1.12–1.32)3.00 × 10-61.00 9.00 × 10  -62.70 × 10  -52.97 × 10  -42.99 × 10  -30.030.23
rs59128381.26 (1.17–1.35)1.58 × 10-101.00 4.75 × 10  -101.43 × 10  -91.57 × 10  -81.58 × 10  -71.58 × 10  -61.58 × 10  -5

False-positive report probability values below 0.05 are in bold.

Abbreviations: CI, confidence interval; OR, odds ratio for the risk allele; SNP, single nucleotide polymorphism.

a Statistical power is the power to detect an OR of 1.5 for the homozygotes with the rare genetic variant, with an α level equal to the reported P value.

Table 3.
Open in new tab

False-positive report probability values for SNPs in patients with HT and controls

Prior Probability
SNPOR (95% CI) Reported P ValueStatistical Power under Recessive Model a0.250.10.010.0010.00010.00001
rs12658831.59 (1.42–1.78)3.67 × 10-161.00 1.10 × 10  -153.30 × 10  -153.63 × 10  -143.66 × 10  -133.67 × 10  -123.67 × 10  -11
rs18811451.19 (1.11–1.28)2.00 × 10-61.00 6.00 × 10  -61.80 × 10  -51.98 × 10  -41.99 × 10  -30.020.17
rs10241611.31 (1.21–1.42)2.31 × 10-111.00 6.94 × 10  -112.08 × 10  -102.29 × 10  -92.31 × 10  -82.31 × 10  -72.31 × 10  -6
rs130931101.14 (1.06–1.22)5.89 × 10-41.00 1.76 × 10  -35.27 × 10  -30.06 0.37 0.85 0.98
rs68321511.16 (1.07–1.24)1.06 × 10-41.00 3.18 × 10  -49.53 × 10  -40.010.10 0.51 0.91
rs15211.55 (1.42–1.70)2.81 × 10-21- ------
rs24746191.12 (1.04–1.21)2.75 × 10-31.00 8.20 × 10  -30.020.21 0.73 0.96 1.00
rs93556101.15 (1.07–1.23)1.34 × 10-41.00 4.03 × 10  -41.21 × 10  -30.010.12 0.57 0.93
rs125756361.28 (1.14–1.45)3.59 × 10-50.99 1.09 × 10  -43.27 × 10  -43.58 × 10  -30.040.27 0.78
rs2295271.22 (1.12–1.32)3.00 × 10-61.00 9.00 × 10  -62.70 × 10  -52.97 × 10  -42.99 × 10  -30.030.23
rs59128381.26 (1.17–1.35)1.58 × 10-101.00 4.75 × 10  -101.43 × 10  -91.57 × 10  -81.58 × 10  -71.58 × 10  -61.58 × 10  -5
Prior Probability
SNPOR (95% CI) Reported P ValueStatistical Power under Recessive Model a0.250.10.010.0010.00010.00001
rs12658831.59 (1.42–1.78)3.67 × 10-161.00 1.10 × 10  -153.30 × 10  -153.63 × 10  -143.66 × 10  -133.67 × 10  -123.67 × 10  -11
rs18811451.19 (1.11–1.28)2.00 × 10-61.00 6.00 × 10  -61.80 × 10  -51.98 × 10  -41.99 × 10  -30.020.17
rs10241611.31 (1.21–1.42)2.31 × 10-111.00 6.94 × 10  -112.08 × 10  -102.29 × 10  -92.31 × 10  -82.31 × 10  -72.31 × 10  -6
rs130931101.14 (1.06–1.22)5.89 × 10-41.00 1.76 × 10  -35.27 × 10  -30.06 0.37 0.85 0.98
rs68321511.16 (1.07–1.24)1.06 × 10-41.00 3.18 × 10  -49.53 × 10  -40.010.10 0.51 0.91
rs15211.55 (1.42–1.70)2.81 × 10-21- ------
rs24746191.12 (1.04–1.21)2.75 × 10-31.00 8.20 × 10  -30.020.21 0.73 0.96 1.00
rs93556101.15 (1.07–1.23)1.34 × 10-41.00 4.03 × 10  -41.21 × 10  -30.010.12 0.57 0.93
rs125756361.28 (1.14–1.45)3.59 × 10-50.99 1.09 × 10  -43.27 × 10  -43.58 × 10  -30.040.27 0.78
rs2295271.22 (1.12–1.32)3.00 × 10-61.00 9.00 × 10  -62.70 × 10  -52.97 × 10  -42.99 × 10  -30.030.23
rs59128381.26 (1.17–1.35)1.58 × 10-101.00 4.75 × 10  -101.43 × 10  -91.57 × 10  -81.58 × 10  -71.58 × 10  -61.58 × 10  -5

False-positive report probability values below 0.05 are in bold.

Abbreviations: CI, confidence interval; OR, odds ratio for the risk allele; SNP, single nucleotide polymorphism.

a Statistical power is the power to detect an OR of 1.5 for the homozygotes with the rare genetic variant, with an α level equal to the reported P value.

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