Observed (Obs) and Expected (Exp) Number of Deaths and Standardized Mortality Ratios (SMRs) With 95% Confidence Intervals (CIs) in Different Categories of Causes of Death Among Finnish Patients With APECED
| . | Female . | Male . | Total . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cause of death . | Obs . | Exp . | SMR . | 95% CI . | Obs . | Exp . | SMR . | 95% CI . | Obs . | Exp . | SMR . | 95% CI . |
| All diseases | 9 | 0.78 | 12 | 5.3-22 *** | 16 | 1.48 | 11 | 6.2-18 *** | 25 | 2.25 | 11 | 7.2-16 *** |
| Endocrine and metabolic diseases1 | 4 | 0.01 | 480 | 130-1200 *** | 6 | 0.01 | 650 | 240-1400 *** | 10 | 0.02 | 570 | 270-1000 *** |
| Malignant neoplasms | 1 | 0.35 | 2.9 | 0.07-16 | 4 | 0.38 | 11 | 2.9-27 ** | 5 | 0.73 | 6.9 | 2.2-16 ** |
| Oral and esophageal malignancy | 1 | 0.01 | 140 | 7.1-650 * | 4 | 0.02 | 180 | 63-420 *** | 5 | 0.03 | 170 | 69-360*** |
| Diseases of digestive system | - | 0.02 | 0.0 | 0.0-190 | 2 | 0.03 | 58 | 7.0-210 ** | 2 | 0.05 | 37 | 4.5-130 ** |
| Infectious diseases2 | 1 | 0.02 | 52 | 2.7-250 * | 1 | 0.04 | 27 | 1.4-130 * | 2 | 0.06 | 36 | 6.4-110 ** |
| Diseases of the circulatory system | - | 0.13 | 0.0 | 0.0-28 | 2 | 0.52 | 3.8 | 0.46-14 | 2 | 0.65 | 3.1 | 0.37-11 |
| Neurological diseases | 1 | 0.04 | 24 | 0.61-130 | - | 0.05 | 0.0 | 0.0-69 | 1 | 0.09 | 11 | 0.27-59 |
| All alcohol related deaths | 2 | 0.10 | 20 | 2.5-73 * | 1 | 0.28 | 3.6 | 0.09-20 | 3 | 0.38 | 8.0 | 1.7-23 * |
| Accidents 3 | 1 | 0.12 | 8.2 | 0.21-46 | 3 | 0.44 | 6.9 | 1.4-20 * | 4 | 0.56 | 7.2 | 2.0-18 * |
| . | Female . | Male . | Total . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cause of death . | Obs . | Exp . | SMR . | 95% CI . | Obs . | Exp . | SMR . | 95% CI . | Obs . | Exp . | SMR . | 95% CI . |
| All diseases | 9 | 0.78 | 12 | 5.3-22 *** | 16 | 1.48 | 11 | 6.2-18 *** | 25 | 2.25 | 11 | 7.2-16 *** |
| Endocrine and metabolic diseases1 | 4 | 0.01 | 480 | 130-1200 *** | 6 | 0.01 | 650 | 240-1400 *** | 10 | 0.02 | 570 | 270-1000 *** |
| Malignant neoplasms | 1 | 0.35 | 2.9 | 0.07-16 | 4 | 0.38 | 11 | 2.9-27 ** | 5 | 0.73 | 6.9 | 2.2-16 ** |
| Oral and esophageal malignancy | 1 | 0.01 | 140 | 7.1-650 * | 4 | 0.02 | 180 | 63-420 *** | 5 | 0.03 | 170 | 69-360*** |
| Diseases of digestive system | - | 0.02 | 0.0 | 0.0-190 | 2 | 0.03 | 58 | 7.0-210 ** | 2 | 0.05 | 37 | 4.5-130 ** |
| Infectious diseases2 | 1 | 0.02 | 52 | 2.7-250 * | 1 | 0.04 | 27 | 1.4-130 * | 2 | 0.06 | 36 | 6.4-110 ** |
| Diseases of the circulatory system | - | 0.13 | 0.0 | 0.0-28 | 2 | 0.52 | 3.8 | 0.46-14 | 2 | 0.65 | 3.1 | 0.37-11 |
| Neurological diseases | 1 | 0.04 | 24 | 0.61-130 | - | 0.05 | 0.0 | 0.0-69 | 1 | 0.09 | 11 | 0.27-59 |
| All alcohol related deaths | 2 | 0.10 | 20 | 2.5-73 * | 1 | 0.28 | 3.6 | 0.09-20 | 3 | 0.38 | 8.0 | 1.7-23 * |
| Accidents 3 | 1 | 0.12 | 8.2 | 0.21-46 | 3 | 0.44 | 6.9 | 1.4-20 * | 4 | 0.56 | 7.2 | 2.0-18 * |
* P < 0.05; ** P < 0.01; *** P < 0.001; 1 Diabetes excluded; 2 HIV and tuberculosis excluded; 3 Alcohol related accidents excluded.
Observed (Obs) and Expected (Exp) Number of Deaths and Standardized Mortality Ratios (SMRs) With 95% Confidence Intervals (CIs) in Different Categories of Causes of Death Among Finnish Patients With APECED
| . | Female . | Male . | Total . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cause of death . | Obs . | Exp . | SMR . | 95% CI . | Obs . | Exp . | SMR . | 95% CI . | Obs . | Exp . | SMR . | 95% CI . |
| All diseases | 9 | 0.78 | 12 | 5.3-22 *** | 16 | 1.48 | 11 | 6.2-18 *** | 25 | 2.25 | 11 | 7.2-16 *** |
| Endocrine and metabolic diseases1 | 4 | 0.01 | 480 | 130-1200 *** | 6 | 0.01 | 650 | 240-1400 *** | 10 | 0.02 | 570 | 270-1000 *** |
| Malignant neoplasms | 1 | 0.35 | 2.9 | 0.07-16 | 4 | 0.38 | 11 | 2.9-27 ** | 5 | 0.73 | 6.9 | 2.2-16 ** |
| Oral and esophageal malignancy | 1 | 0.01 | 140 | 7.1-650 * | 4 | 0.02 | 180 | 63-420 *** | 5 | 0.03 | 170 | 69-360*** |
| Diseases of digestive system | - | 0.02 | 0.0 | 0.0-190 | 2 | 0.03 | 58 | 7.0-210 ** | 2 | 0.05 | 37 | 4.5-130 ** |
| Infectious diseases2 | 1 | 0.02 | 52 | 2.7-250 * | 1 | 0.04 | 27 | 1.4-130 * | 2 | 0.06 | 36 | 6.4-110 ** |
| Diseases of the circulatory system | - | 0.13 | 0.0 | 0.0-28 | 2 | 0.52 | 3.8 | 0.46-14 | 2 | 0.65 | 3.1 | 0.37-11 |
| Neurological diseases | 1 | 0.04 | 24 | 0.61-130 | - | 0.05 | 0.0 | 0.0-69 | 1 | 0.09 | 11 | 0.27-59 |
| All alcohol related deaths | 2 | 0.10 | 20 | 2.5-73 * | 1 | 0.28 | 3.6 | 0.09-20 | 3 | 0.38 | 8.0 | 1.7-23 * |
| Accidents 3 | 1 | 0.12 | 8.2 | 0.21-46 | 3 | 0.44 | 6.9 | 1.4-20 * | 4 | 0.56 | 7.2 | 2.0-18 * |
| . | Female . | Male . | Total . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cause of death . | Obs . | Exp . | SMR . | 95% CI . | Obs . | Exp . | SMR . | 95% CI . | Obs . | Exp . | SMR . | 95% CI . |
| All diseases | 9 | 0.78 | 12 | 5.3-22 *** | 16 | 1.48 | 11 | 6.2-18 *** | 25 | 2.25 | 11 | 7.2-16 *** |
| Endocrine and metabolic diseases1 | 4 | 0.01 | 480 | 130-1200 *** | 6 | 0.01 | 650 | 240-1400 *** | 10 | 0.02 | 570 | 270-1000 *** |
| Malignant neoplasms | 1 | 0.35 | 2.9 | 0.07-16 | 4 | 0.38 | 11 | 2.9-27 ** | 5 | 0.73 | 6.9 | 2.2-16 ** |
| Oral and esophageal malignancy | 1 | 0.01 | 140 | 7.1-650 * | 4 | 0.02 | 180 | 63-420 *** | 5 | 0.03 | 170 | 69-360*** |
| Diseases of digestive system | - | 0.02 | 0.0 | 0.0-190 | 2 | 0.03 | 58 | 7.0-210 ** | 2 | 0.05 | 37 | 4.5-130 ** |
| Infectious diseases2 | 1 | 0.02 | 52 | 2.7-250 * | 1 | 0.04 | 27 | 1.4-130 * | 2 | 0.06 | 36 | 6.4-110 ** |
| Diseases of the circulatory system | - | 0.13 | 0.0 | 0.0-28 | 2 | 0.52 | 3.8 | 0.46-14 | 2 | 0.65 | 3.1 | 0.37-11 |
| Neurological diseases | 1 | 0.04 | 24 | 0.61-130 | - | 0.05 | 0.0 | 0.0-69 | 1 | 0.09 | 11 | 0.27-59 |
| All alcohol related deaths | 2 | 0.10 | 20 | 2.5-73 * | 1 | 0.28 | 3.6 | 0.09-20 | 3 | 0.38 | 8.0 | 1.7-23 * |
| Accidents 3 | 1 | 0.12 | 8.2 | 0.21-46 | 3 | 0.44 | 6.9 | 1.4-20 * | 4 | 0.56 | 7.2 | 2.0-18 * |
* P < 0.05; ** P < 0.01; *** P < 0.001; 1 Diabetes excluded; 2 HIV and tuberculosis excluded; 3 Alcohol related accidents excluded.
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