| . | . | . | . | . | . | . | . | Training Group (Participant 930 and Control: 856) . | Testing Group (Participant 233 and control: 215) . | Total groups (Participant 1,163 and control: 1,071) . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genetic Variant (rs ID) . | Gene . | Chr . | Position . | Risk Allele . | Reference . | PMID Number . | Population . | OR . | 95% CI . | P Value . | OR . | 95% CI . | p value . | OR . | 95% CI . | p value . |
| rs2421992 | DNM3 | 1 | 172241251 | C | Wood AR et al, 2014 | 25282103 | European | 4.35 | (3.85-5.00) | 5.72E-93 | 5.00 | (3.7 - 6.67) | 1.37E-27 | 4.55 | (4.00 - 5.00) | 8.78E-119 |
| rs4974480 | ANAPC13 | 3 | 134178562 | A | Wood AR et al, 2014 | 25282103 | European | 1.33 | (1.14-1.54) | 3.05E-04 | 1.55 | (1.15 - 2.10) | 4.33E-03 | 1.37 | (1.20 - 1.57) | 6.21E-06 |
| rs13131350 | LCORL | 4 | 17877487 | G | He M et al, 2015 | 25429064 | European, East Asian | 1.30 | (1.12-1.49) | 3.92E-04 | 1.40 | (1.06 - 1.85) | 1.83E-02 | 1.32 | (1.16 - 1.50) | 2.31E-05 |
| rs7763064 | GPR126 | 6 | 142797289 | A | Lango Allen H et al, 2010 | 20881960 | European | 1.23 | (1.07-1.41) | 3.26E-03 | 1.19 | (0.91 - 1.55) | 1.99E-01 | 1.22 | (1.08 - 1.38) | 1.36E-03 |
| rs10858250 | QSOX2 | 9 | 139119215 | A | He M et al, 2015 | 25429064 | European, East Asian | 1.23 | (1.05-1.45) | 8.53E-03 | 1.37 | (1.00 - 1.85) | 5.08E-02 | 1.27 | (1.10 - 1.47) | 1.21E-03 |
| rs11170631 | ATF7-ATP5G2 | 12 | 54041192 | T | Okada Y et al, 2010 | 20189936 | Japanese | 1.35 | (1.18-1.56) | 1.57E-05 | 1.43 | (1.09 - 1.89) | 1.18E-02 | 1.37 | (1.20 - 1.56) | 6.08E-07 |
| rs258324 | CDK10 | 16 | 89754255 | G | He M et al, 2015 | 25429064 | East Asian | 1.19 | (1.03-1.39) | 1.61E-02 | 1.32 | (0.99 - 1.79) | 6.14E-02 | 1.22 | (1.08 - 1.39) | 2.80E-03 |
| rs8094261 | CABLES1 | 18 | 20746728 | G | Kim JJ et al, 2010 | 19893584 | Korean | 1.38 | (1.16-1.64) | 2.57E-04 | 1.33 | (0.94 - 1.88) | 1.05E-01 | 1.37 | (1.17 - 1.6) | 6.46E-05 |
| rs4911494 | UQCC1 | 20 | 33971914 | T | Soranzo N et al, 2009 | 19343178 | European | 1.33 | (1.15-1.54) | 1.26E-04 | 1.22 | (0.89 - 1.67) | 2.08E-01 | 1.32 | (1.15 - 1.49) | 6.12E-05 |
| . | . | . | . | . | . | . | . | Training Group (Participant 930 and Control: 856) . | Testing Group (Participant 233 and control: 215) . | Total groups (Participant 1,163 and control: 1,071) . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genetic Variant (rs ID) . | Gene . | Chr . | Position . | Risk Allele . | Reference . | PMID Number . | Population . | OR . | 95% CI . | P Value . | OR . | 95% CI . | p value . | OR . | 95% CI . | p value . |
| rs2421992 | DNM3 | 1 | 172241251 | C | Wood AR et al, 2014 | 25282103 | European | 4.35 | (3.85-5.00) | 5.72E-93 | 5.00 | (3.7 - 6.67) | 1.37E-27 | 4.55 | (4.00 - 5.00) | 8.78E-119 |
| rs4974480 | ANAPC13 | 3 | 134178562 | A | Wood AR et al, 2014 | 25282103 | European | 1.33 | (1.14-1.54) | 3.05E-04 | 1.55 | (1.15 - 2.10) | 4.33E-03 | 1.37 | (1.20 - 1.57) | 6.21E-06 |
| rs13131350 | LCORL | 4 | 17877487 | G | He M et al, 2015 | 25429064 | European, East Asian | 1.30 | (1.12-1.49) | 3.92E-04 | 1.40 | (1.06 - 1.85) | 1.83E-02 | 1.32 | (1.16 - 1.50) | 2.31E-05 |
| rs7763064 | GPR126 | 6 | 142797289 | A | Lango Allen H et al, 2010 | 20881960 | European | 1.23 | (1.07-1.41) | 3.26E-03 | 1.19 | (0.91 - 1.55) | 1.99E-01 | 1.22 | (1.08 - 1.38) | 1.36E-03 |
| rs10858250 | QSOX2 | 9 | 139119215 | A | He M et al, 2015 | 25429064 | European, East Asian | 1.23 | (1.05-1.45) | 8.53E-03 | 1.37 | (1.00 - 1.85) | 5.08E-02 | 1.27 | (1.10 - 1.47) | 1.21E-03 |
| rs11170631 | ATF7-ATP5G2 | 12 | 54041192 | T | Okada Y et al, 2010 | 20189936 | Japanese | 1.35 | (1.18-1.56) | 1.57E-05 | 1.43 | (1.09 - 1.89) | 1.18E-02 | 1.37 | (1.20 - 1.56) | 6.08E-07 |
| rs258324 | CDK10 | 16 | 89754255 | G | He M et al, 2015 | 25429064 | East Asian | 1.19 | (1.03-1.39) | 1.61E-02 | 1.32 | (0.99 - 1.79) | 6.14E-02 | 1.22 | (1.08 - 1.39) | 2.80E-03 |
| rs8094261 | CABLES1 | 18 | 20746728 | G | Kim JJ et al, 2010 | 19893584 | Korean | 1.38 | (1.16-1.64) | 2.57E-04 | 1.33 | (0.94 - 1.88) | 1.05E-01 | 1.37 | (1.17 - 1.6) | 6.46E-05 |
| rs4911494 | UQCC1 | 20 | 33971914 | T | Soranzo N et al, 2009 | 19343178 | European | 1.33 | (1.15-1.54) | 1.26E-04 | 1.22 | (0.89 - 1.67) | 2.08E-01 | 1.32 | (1.15 - 1.49) | 6.12E-05 |
OR calculation was conducted according to the defined risk alleles. Deviation from the additive model was tested. A P value for the additive test < 0.05 in the training group was considered significant.
Abbreviations: Chr, chromosome; CI, confidence interval; FSS, familial short stature; ID, identifier; PMID, PubMed identifier; OR, odds ratio.
| . | . | . | . | . | . | . | . | Training Group (Participant 930 and Control: 856) . | Testing Group (Participant 233 and control: 215) . | Total groups (Participant 1,163 and control: 1,071) . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genetic Variant (rs ID) . | Gene . | Chr . | Position . | Risk Allele . | Reference . | PMID Number . | Population . | OR . | 95% CI . | P Value . | OR . | 95% CI . | p value . | OR . | 95% CI . | p value . |
| rs2421992 | DNM3 | 1 | 172241251 | C | Wood AR et al, 2014 | 25282103 | European | 4.35 | (3.85-5.00) | 5.72E-93 | 5.00 | (3.7 - 6.67) | 1.37E-27 | 4.55 | (4.00 - 5.00) | 8.78E-119 |
| rs4974480 | ANAPC13 | 3 | 134178562 | A | Wood AR et al, 2014 | 25282103 | European | 1.33 | (1.14-1.54) | 3.05E-04 | 1.55 | (1.15 - 2.10) | 4.33E-03 | 1.37 | (1.20 - 1.57) | 6.21E-06 |
| rs13131350 | LCORL | 4 | 17877487 | G | He M et al, 2015 | 25429064 | European, East Asian | 1.30 | (1.12-1.49) | 3.92E-04 | 1.40 | (1.06 - 1.85) | 1.83E-02 | 1.32 | (1.16 - 1.50) | 2.31E-05 |
| rs7763064 | GPR126 | 6 | 142797289 | A | Lango Allen H et al, 2010 | 20881960 | European | 1.23 | (1.07-1.41) | 3.26E-03 | 1.19 | (0.91 - 1.55) | 1.99E-01 | 1.22 | (1.08 - 1.38) | 1.36E-03 |
| rs10858250 | QSOX2 | 9 | 139119215 | A | He M et al, 2015 | 25429064 | European, East Asian | 1.23 | (1.05-1.45) | 8.53E-03 | 1.37 | (1.00 - 1.85) | 5.08E-02 | 1.27 | (1.10 - 1.47) | 1.21E-03 |
| rs11170631 | ATF7-ATP5G2 | 12 | 54041192 | T | Okada Y et al, 2010 | 20189936 | Japanese | 1.35 | (1.18-1.56) | 1.57E-05 | 1.43 | (1.09 - 1.89) | 1.18E-02 | 1.37 | (1.20 - 1.56) | 6.08E-07 |
| rs258324 | CDK10 | 16 | 89754255 | G | He M et al, 2015 | 25429064 | East Asian | 1.19 | (1.03-1.39) | 1.61E-02 | 1.32 | (0.99 - 1.79) | 6.14E-02 | 1.22 | (1.08 - 1.39) | 2.80E-03 |
| rs8094261 | CABLES1 | 18 | 20746728 | G | Kim JJ et al, 2010 | 19893584 | Korean | 1.38 | (1.16-1.64) | 2.57E-04 | 1.33 | (0.94 - 1.88) | 1.05E-01 | 1.37 | (1.17 - 1.6) | 6.46E-05 |
| rs4911494 | UQCC1 | 20 | 33971914 | T | Soranzo N et al, 2009 | 19343178 | European | 1.33 | (1.15-1.54) | 1.26E-04 | 1.22 | (0.89 - 1.67) | 2.08E-01 | 1.32 | (1.15 - 1.49) | 6.12E-05 |
| . | . | . | . | . | . | . | . | Training Group (Participant 930 and Control: 856) . | Testing Group (Participant 233 and control: 215) . | Total groups (Participant 1,163 and control: 1,071) . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genetic Variant (rs ID) . | Gene . | Chr . | Position . | Risk Allele . | Reference . | PMID Number . | Population . | OR . | 95% CI . | P Value . | OR . | 95% CI . | p value . | OR . | 95% CI . | p value . |
| rs2421992 | DNM3 | 1 | 172241251 | C | Wood AR et al, 2014 | 25282103 | European | 4.35 | (3.85-5.00) | 5.72E-93 | 5.00 | (3.7 - 6.67) | 1.37E-27 | 4.55 | (4.00 - 5.00) | 8.78E-119 |
| rs4974480 | ANAPC13 | 3 | 134178562 | A | Wood AR et al, 2014 | 25282103 | European | 1.33 | (1.14-1.54) | 3.05E-04 | 1.55 | (1.15 - 2.10) | 4.33E-03 | 1.37 | (1.20 - 1.57) | 6.21E-06 |
| rs13131350 | LCORL | 4 | 17877487 | G | He M et al, 2015 | 25429064 | European, East Asian | 1.30 | (1.12-1.49) | 3.92E-04 | 1.40 | (1.06 - 1.85) | 1.83E-02 | 1.32 | (1.16 - 1.50) | 2.31E-05 |
| rs7763064 | GPR126 | 6 | 142797289 | A | Lango Allen H et al, 2010 | 20881960 | European | 1.23 | (1.07-1.41) | 3.26E-03 | 1.19 | (0.91 - 1.55) | 1.99E-01 | 1.22 | (1.08 - 1.38) | 1.36E-03 |
| rs10858250 | QSOX2 | 9 | 139119215 | A | He M et al, 2015 | 25429064 | European, East Asian | 1.23 | (1.05-1.45) | 8.53E-03 | 1.37 | (1.00 - 1.85) | 5.08E-02 | 1.27 | (1.10 - 1.47) | 1.21E-03 |
| rs11170631 | ATF7-ATP5G2 | 12 | 54041192 | T | Okada Y et al, 2010 | 20189936 | Japanese | 1.35 | (1.18-1.56) | 1.57E-05 | 1.43 | (1.09 - 1.89) | 1.18E-02 | 1.37 | (1.20 - 1.56) | 6.08E-07 |
| rs258324 | CDK10 | 16 | 89754255 | G | He M et al, 2015 | 25429064 | East Asian | 1.19 | (1.03-1.39) | 1.61E-02 | 1.32 | (0.99 - 1.79) | 6.14E-02 | 1.22 | (1.08 - 1.39) | 2.80E-03 |
| rs8094261 | CABLES1 | 18 | 20746728 | G | Kim JJ et al, 2010 | 19893584 | Korean | 1.38 | (1.16-1.64) | 2.57E-04 | 1.33 | (0.94 - 1.88) | 1.05E-01 | 1.37 | (1.17 - 1.6) | 6.46E-05 |
| rs4911494 | UQCC1 | 20 | 33971914 | T | Soranzo N et al, 2009 | 19343178 | European | 1.33 | (1.15-1.54) | 1.26E-04 | 1.22 | (0.89 - 1.67) | 2.08E-01 | 1.32 | (1.15 - 1.49) | 6.12E-05 |
OR calculation was conducted according to the defined risk alleles. Deviation from the additive model was tested. A P value for the additive test < 0.05 in the training group was considered significant.
Abbreviations: Chr, chromosome; CI, confidence interval; FSS, familial short stature; ID, identifier; PMID, PubMed identifier; OR, odds ratio.
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