Table 1.

Thyroid Cancer Incidence (2000–2017) and Incidence-Based Mortality (2000–2017)

IncidenceIncidence-Based Mortality
Thyroid CancerPapillary Thyroid CancerThyroid CancerPapillary Thyroid Cancer
Cases, No (%)Ratea (95%CI)Cases, No (%)Ratea (95%CI)Deaths, No (%)Ratea (95%CI)Deaths, No (%)Ratea (95%CI)
Overall69684 (100)10.06 (9.99-10.14)61203 (100)8.86 (8.79–8.94)2562 (100)0.34 (0.33-0.36)1157 (100)0.16 (0.15–0.16)
Sex
 Male16546 (23.7)4.68 (4.61-4.75)13845 (22.6)3.94 (3.87–4)1039 (40.6)0.27 (0.26-0.29)506 (43.7)0.13 (0.12–0.15)
 Female53138 (76.3)15.42 (15.29-15.55)47358 (77.4)13.78 (13.65-13.9)1523 (59.4)0.41 (0.39-0.43)651 (56.3)0.18 (0.16–0.19)
Race
 White54506 (78.2)10.55 (10.46-10.63)47868 (78.2)9.29 (9.21–9.37)1981 (77.3)0.36 (0.34-0.37)911 (78.7)0.16 (0.15–0.17)
 Black2694 (3.9)5.5 (5.29-5.71)2151 (3.5)4.41 (4.22–4.59)127 (5.0)0.24 (0.2-0.29)41 (3.5)0.08 (0.05–0.1)
 Asian11276 (16.2)11.65 (11.43-11.87)10118 (16.5)10.52 (10.31-10.72)449 (17.5)0.39 (0.35-0.43)201 (17.4)0.18 (0.15–0.2)
 Other  b1208 (1.7)3.75 (3.54-3.97)1066 (1.7)3.31 (3.12–3.51)NRcNRcNRcNRc
Ethnicity
 Hispanic18843 (27)7.12 (7.02-7.23)16916 (27.6)6.42 (6.33–6.52)642 (25.1)0.21 (0.19-0.23)346 (29.9)0.11 (0.1–0.12)
 Non-Hispanic50841 (73)11.55 (11.45-11.65)44287 (72.4)10.1 (10.01-10.19)1920 (74.9)0.4 (0.38-0.42)811 (70.1)0.17 (0.16–0.18)
Age at Diagnosis, year
 <201433 (2.1)0.77 (0.73-0.81)1254 (2.0)0.68 (0.64–0.71)NRcNRcNRcNRc
 20–3918061 (25.9)9.32 (9.18-9.45)16586 (27.1)8.56 (8.43–8.69)73 (2.8)0.01 (0.01-0.01)33 (2.9)0.01 (0–0.01)
 40–5930504 (43.8)17.5 (17.3-1 7.69)27548 (45.0)15.8 (15.61-15.99)563 (22)0.08 (0.07-0.09)291 (25.2)0.04 (0.04–0.05)
 60–7917210 (24.7)20.06 (19.76-20.36)14233 (23.3)16.59 (16.32-16.87)1316 (51.4)0.17 (0.16-0.18)622 (53.8)0.08 (0.08–0.09)
 80+2476 (3.6)11.89 (11.43-12.36)1582 (2.6)7.6 (7.23–7.97)607 (23.7)0.08 (0.07-0.09)209 (18.1)0.03 (0.02–0.03)
Thyroid Cancer Characteristics At Diagnosis
Histological subtype
 Papillary61203 (87.8)8.86 (8.79-8.94)1157 (45.2)0.16 (0.15-0.16)
 Follicular5044 (7.2)0.72 (0.7-0.74)282 (11.0)0.04 (0.03-0.04)
 Medullary1250 (1.8)0.18 (0.17-0.19)172 (6.7)0.02 (0.02-0.03)
 Anaplastic705 (1.0)0.09 (0.09-0.1)554 (21.6)0.07 (0.07-0.08)
 Other  d1482 (2.1)0.2 (0.19-0.22)397 (15.5)0.05 (0.05-0.06)
Papillary Thyroid Cancer, SEER Historic Stage A
 Localized43478 (62.4)6.26 (6.21-6.32)38219 (62.4)5.51 (5.46–5.57)243 (9.5)0.03 (0.03-0.04)128 (11.1)0.02 (0.01–0.02)
 Regional20940 (30.0)3.06 (3.02-3.1)19677 (32.2)2.89 (2.84–2.93)683 (26.7)0.09 (0.08-0.1)432 (37.3)0.05 (0.05–0.06)
 Distant3671 (5.3)0.51 (0.49-0.52)2220 (3.6)0.31 (0.3–0.32)1443 (56.3)0.19 (0.18-0.2)545 (47.1)0.07 (0.07–0.08)
 Unknown  e1595 (2.3)0.23 (0.22-0.24)1087 (1.8)0.16 (0.15–0.17)193 (7.5)0.03 (0.02-0.03)52 (4.5)0.01 (0.01-0.01)
Papillary Thyroid Cancer, Tumor size, cm
 ≤121530 (30.9)3.09 (3.05-3.13)20861 (34.1)2.99 (2.95–3.03)104 (4.1)0.01 (0.01-0.02)77 (6.7)0.01 (0.01-0.01)
 >1 to ≤218638 (26.7)2.71 (2.67-2.75)17429 (28.5)2.54 (2.5–2.57)180 (7.0)0.02 (0.02-0.03)137 (11.8)0.02 (0.02-0.02)
 >2 to ≤416630 (23.9)2.42 (2.39-2.46)14016 (22.9)2.05 (2.02–2.09)560 (21.9)0.07 (0.07-0.08)347 (30.0)0.05 (0.04–0.05)
 >47894 (11.3)1.13 (1.1-1.15)5281 (8.6)0.77 (0.74–0.79)1089 (42.5)0.15 (0.14-0.15)392 (33.9)0.05 (0.05–0.06)
 Unknown  e4992 (7.2)0.71 (0.69-0.73)3616 (5.9)0.52 (0.5–0.54)629 (24.6)0.08 (0.08-0.09)204 (17.6)0.03 (0.02–0.03)
IncidenceIncidence-Based Mortality
Thyroid CancerPapillary Thyroid CancerThyroid CancerPapillary Thyroid Cancer
Cases, No (%)Ratea (95%CI)Cases, No (%)Ratea (95%CI)Deaths, No (%)Ratea (95%CI)Deaths, No (%)Ratea (95%CI)
Overall69684 (100)10.06 (9.99-10.14)61203 (100)8.86 (8.79–8.94)2562 (100)0.34 (0.33-0.36)1157 (100)0.16 (0.15–0.16)
Sex
 Male16546 (23.7)4.68 (4.61-4.75)13845 (22.6)3.94 (3.87–4)1039 (40.6)0.27 (0.26-0.29)506 (43.7)0.13 (0.12–0.15)
 Female53138 (76.3)15.42 (15.29-15.55)47358 (77.4)13.78 (13.65-13.9)1523 (59.4)0.41 (0.39-0.43)651 (56.3)0.18 (0.16–0.19)
Race
 White54506 (78.2)10.55 (10.46-10.63)47868 (78.2)9.29 (9.21–9.37)1981 (77.3)0.36 (0.34-0.37)911 (78.7)0.16 (0.15–0.17)
 Black2694 (3.9)5.5 (5.29-5.71)2151 (3.5)4.41 (4.22–4.59)127 (5.0)0.24 (0.2-0.29)41 (3.5)0.08 (0.05–0.1)
 Asian11276 (16.2)11.65 (11.43-11.87)10118 (16.5)10.52 (10.31-10.72)449 (17.5)0.39 (0.35-0.43)201 (17.4)0.18 (0.15–0.2)
 Other  b1208 (1.7)3.75 (3.54-3.97)1066 (1.7)3.31 (3.12–3.51)NRcNRcNRcNRc
Ethnicity
 Hispanic18843 (27)7.12 (7.02-7.23)16916 (27.6)6.42 (6.33–6.52)642 (25.1)0.21 (0.19-0.23)346 (29.9)0.11 (0.1–0.12)
 Non-Hispanic50841 (73)11.55 (11.45-11.65)44287 (72.4)10.1 (10.01-10.19)1920 (74.9)0.4 (0.38-0.42)811 (70.1)0.17 (0.16–0.18)
Age at Diagnosis, year
 <201433 (2.1)0.77 (0.73-0.81)1254 (2.0)0.68 (0.64–0.71)NRcNRcNRcNRc
 20–3918061 (25.9)9.32 (9.18-9.45)16586 (27.1)8.56 (8.43–8.69)73 (2.8)0.01 (0.01-0.01)33 (2.9)0.01 (0–0.01)
 40–5930504 (43.8)17.5 (17.3-1 7.69)27548 (45.0)15.8 (15.61-15.99)563 (22)0.08 (0.07-0.09)291 (25.2)0.04 (0.04–0.05)
 60–7917210 (24.7)20.06 (19.76-20.36)14233 (23.3)16.59 (16.32-16.87)1316 (51.4)0.17 (0.16-0.18)622 (53.8)0.08 (0.08–0.09)
 80+2476 (3.6)11.89 (11.43-12.36)1582 (2.6)7.6 (7.23–7.97)607 (23.7)0.08 (0.07-0.09)209 (18.1)0.03 (0.02–0.03)
Thyroid Cancer Characteristics At Diagnosis
Histological subtype
 Papillary61203 (87.8)8.86 (8.79-8.94)1157 (45.2)0.16 (0.15-0.16)
 Follicular5044 (7.2)0.72 (0.7-0.74)282 (11.0)0.04 (0.03-0.04)
 Medullary1250 (1.8)0.18 (0.17-0.19)172 (6.7)0.02 (0.02-0.03)
 Anaplastic705 (1.0)0.09 (0.09-0.1)554 (21.6)0.07 (0.07-0.08)
 Other  d1482 (2.1)0.2 (0.19-0.22)397 (15.5)0.05 (0.05-0.06)
Papillary Thyroid Cancer, SEER Historic Stage A
 Localized43478 (62.4)6.26 (6.21-6.32)38219 (62.4)5.51 (5.46–5.57)243 (9.5)0.03 (0.03-0.04)128 (11.1)0.02 (0.01–0.02)
 Regional20940 (30.0)3.06 (3.02-3.1)19677 (32.2)2.89 (2.84–2.93)683 (26.7)0.09 (0.08-0.1)432 (37.3)0.05 (0.05–0.06)
 Distant3671 (5.3)0.51 (0.49-0.52)2220 (3.6)0.31 (0.3–0.32)1443 (56.3)0.19 (0.18-0.2)545 (47.1)0.07 (0.07–0.08)
 Unknown  e1595 (2.3)0.23 (0.22-0.24)1087 (1.8)0.16 (0.15–0.17)193 (7.5)0.03 (0.02-0.03)52 (4.5)0.01 (0.01-0.01)
Papillary Thyroid Cancer, Tumor size, cm
 ≤121530 (30.9)3.09 (3.05-3.13)20861 (34.1)2.99 (2.95–3.03)104 (4.1)0.01 (0.01-0.02)77 (6.7)0.01 (0.01-0.01)
 >1 to ≤218638 (26.7)2.71 (2.67-2.75)17429 (28.5)2.54 (2.5–2.57)180 (7.0)0.02 (0.02-0.03)137 (11.8)0.02 (0.02-0.02)
 >2 to ≤416630 (23.9)2.42 (2.39-2.46)14016 (22.9)2.05 (2.02–2.09)560 (21.9)0.07 (0.07-0.08)347 (30.0)0.05 (0.04–0.05)
 >47894 (11.3)1.13 (1.1-1.15)5281 (8.6)0.77 (0.74–0.79)1089 (42.5)0.15 (0.14-0.15)392 (33.9)0.05 (0.05–0.06)
 Unknown  e4992 (7.2)0.71 (0.69-0.73)3616 (5.9)0.52 (0.5–0.54)629 (24.6)0.08 (0.08-0.09)204 (17.6)0.03 (0.02–0.03)

Abbreviations: CI, confidence interval; NR, Not Represented; SEER, Surveillance, Epidemiology, and End Results.

aRates were calculated as number of cases or deaths per 100 000 person years and age adjusted to the 2000 California standard population.

bIncludes American Indian, Native or Pacific Islander, and two or more races

cNot Represented (not enough data for analysis)

dIncludes other specified and poorly differentiated thyroid cancer

eIncludes values which are missing from the data or unknown at time of diagnosis.

Table 1.

Thyroid Cancer Incidence (2000–2017) and Incidence-Based Mortality (2000–2017)

IncidenceIncidence-Based Mortality
Thyroid CancerPapillary Thyroid CancerThyroid CancerPapillary Thyroid Cancer
Cases, No (%)Ratea (95%CI)Cases, No (%)Ratea (95%CI)Deaths, No (%)Ratea (95%CI)Deaths, No (%)Ratea (95%CI)
Overall69684 (100)10.06 (9.99-10.14)61203 (100)8.86 (8.79–8.94)2562 (100)0.34 (0.33-0.36)1157 (100)0.16 (0.15–0.16)
Sex
 Male16546 (23.7)4.68 (4.61-4.75)13845 (22.6)3.94 (3.87–4)1039 (40.6)0.27 (0.26-0.29)506 (43.7)0.13 (0.12–0.15)
 Female53138 (76.3)15.42 (15.29-15.55)47358 (77.4)13.78 (13.65-13.9)1523 (59.4)0.41 (0.39-0.43)651 (56.3)0.18 (0.16–0.19)
Race
 White54506 (78.2)10.55 (10.46-10.63)47868 (78.2)9.29 (9.21–9.37)1981 (77.3)0.36 (0.34-0.37)911 (78.7)0.16 (0.15–0.17)
 Black2694 (3.9)5.5 (5.29-5.71)2151 (3.5)4.41 (4.22–4.59)127 (5.0)0.24 (0.2-0.29)41 (3.5)0.08 (0.05–0.1)
 Asian11276 (16.2)11.65 (11.43-11.87)10118 (16.5)10.52 (10.31-10.72)449 (17.5)0.39 (0.35-0.43)201 (17.4)0.18 (0.15–0.2)
 Other  b1208 (1.7)3.75 (3.54-3.97)1066 (1.7)3.31 (3.12–3.51)NRcNRcNRcNRc
Ethnicity
 Hispanic18843 (27)7.12 (7.02-7.23)16916 (27.6)6.42 (6.33–6.52)642 (25.1)0.21 (0.19-0.23)346 (29.9)0.11 (0.1–0.12)
 Non-Hispanic50841 (73)11.55 (11.45-11.65)44287 (72.4)10.1 (10.01-10.19)1920 (74.9)0.4 (0.38-0.42)811 (70.1)0.17 (0.16–0.18)
Age at Diagnosis, year
 <201433 (2.1)0.77 (0.73-0.81)1254 (2.0)0.68 (0.64–0.71)NRcNRcNRcNRc
 20–3918061 (25.9)9.32 (9.18-9.45)16586 (27.1)8.56 (8.43–8.69)73 (2.8)0.01 (0.01-0.01)33 (2.9)0.01 (0–0.01)
 40–5930504 (43.8)17.5 (17.3-1 7.69)27548 (45.0)15.8 (15.61-15.99)563 (22)0.08 (0.07-0.09)291 (25.2)0.04 (0.04–0.05)
 60–7917210 (24.7)20.06 (19.76-20.36)14233 (23.3)16.59 (16.32-16.87)1316 (51.4)0.17 (0.16-0.18)622 (53.8)0.08 (0.08–0.09)
 80+2476 (3.6)11.89 (11.43-12.36)1582 (2.6)7.6 (7.23–7.97)607 (23.7)0.08 (0.07-0.09)209 (18.1)0.03 (0.02–0.03)
Thyroid Cancer Characteristics At Diagnosis
Histological subtype
 Papillary61203 (87.8)8.86 (8.79-8.94)1157 (45.2)0.16 (0.15-0.16)
 Follicular5044 (7.2)0.72 (0.7-0.74)282 (11.0)0.04 (0.03-0.04)
 Medullary1250 (1.8)0.18 (0.17-0.19)172 (6.7)0.02 (0.02-0.03)
 Anaplastic705 (1.0)0.09 (0.09-0.1)554 (21.6)0.07 (0.07-0.08)
 Other  d1482 (2.1)0.2 (0.19-0.22)397 (15.5)0.05 (0.05-0.06)
Papillary Thyroid Cancer, SEER Historic Stage A
 Localized43478 (62.4)6.26 (6.21-6.32)38219 (62.4)5.51 (5.46–5.57)243 (9.5)0.03 (0.03-0.04)128 (11.1)0.02 (0.01–0.02)
 Regional20940 (30.0)3.06 (3.02-3.1)19677 (32.2)2.89 (2.84–2.93)683 (26.7)0.09 (0.08-0.1)432 (37.3)0.05 (0.05–0.06)
 Distant3671 (5.3)0.51 (0.49-0.52)2220 (3.6)0.31 (0.3–0.32)1443 (56.3)0.19 (0.18-0.2)545 (47.1)0.07 (0.07–0.08)
 Unknown  e1595 (2.3)0.23 (0.22-0.24)1087 (1.8)0.16 (0.15–0.17)193 (7.5)0.03 (0.02-0.03)52 (4.5)0.01 (0.01-0.01)
Papillary Thyroid Cancer, Tumor size, cm
 ≤121530 (30.9)3.09 (3.05-3.13)20861 (34.1)2.99 (2.95–3.03)104 (4.1)0.01 (0.01-0.02)77 (6.7)0.01 (0.01-0.01)
 >1 to ≤218638 (26.7)2.71 (2.67-2.75)17429 (28.5)2.54 (2.5–2.57)180 (7.0)0.02 (0.02-0.03)137 (11.8)0.02 (0.02-0.02)
 >2 to ≤416630 (23.9)2.42 (2.39-2.46)14016 (22.9)2.05 (2.02–2.09)560 (21.9)0.07 (0.07-0.08)347 (30.0)0.05 (0.04–0.05)
 >47894 (11.3)1.13 (1.1-1.15)5281 (8.6)0.77 (0.74–0.79)1089 (42.5)0.15 (0.14-0.15)392 (33.9)0.05 (0.05–0.06)
 Unknown  e4992 (7.2)0.71 (0.69-0.73)3616 (5.9)0.52 (0.5–0.54)629 (24.6)0.08 (0.08-0.09)204 (17.6)0.03 (0.02–0.03)
IncidenceIncidence-Based Mortality
Thyroid CancerPapillary Thyroid CancerThyroid CancerPapillary Thyroid Cancer
Cases, No (%)Ratea (95%CI)Cases, No (%)Ratea (95%CI)Deaths, No (%)Ratea (95%CI)Deaths, No (%)Ratea (95%CI)
Overall69684 (100)10.06 (9.99-10.14)61203 (100)8.86 (8.79–8.94)2562 (100)0.34 (0.33-0.36)1157 (100)0.16 (0.15–0.16)
Sex
 Male16546 (23.7)4.68 (4.61-4.75)13845 (22.6)3.94 (3.87–4)1039 (40.6)0.27 (0.26-0.29)506 (43.7)0.13 (0.12–0.15)
 Female53138 (76.3)15.42 (15.29-15.55)47358 (77.4)13.78 (13.65-13.9)1523 (59.4)0.41 (0.39-0.43)651 (56.3)0.18 (0.16–0.19)
Race
 White54506 (78.2)10.55 (10.46-10.63)47868 (78.2)9.29 (9.21–9.37)1981 (77.3)0.36 (0.34-0.37)911 (78.7)0.16 (0.15–0.17)
 Black2694 (3.9)5.5 (5.29-5.71)2151 (3.5)4.41 (4.22–4.59)127 (5.0)0.24 (0.2-0.29)41 (3.5)0.08 (0.05–0.1)
 Asian11276 (16.2)11.65 (11.43-11.87)10118 (16.5)10.52 (10.31-10.72)449 (17.5)0.39 (0.35-0.43)201 (17.4)0.18 (0.15–0.2)
 Other  b1208 (1.7)3.75 (3.54-3.97)1066 (1.7)3.31 (3.12–3.51)NRcNRcNRcNRc
Ethnicity
 Hispanic18843 (27)7.12 (7.02-7.23)16916 (27.6)6.42 (6.33–6.52)642 (25.1)0.21 (0.19-0.23)346 (29.9)0.11 (0.1–0.12)
 Non-Hispanic50841 (73)11.55 (11.45-11.65)44287 (72.4)10.1 (10.01-10.19)1920 (74.9)0.4 (0.38-0.42)811 (70.1)0.17 (0.16–0.18)
Age at Diagnosis, year
 <201433 (2.1)0.77 (0.73-0.81)1254 (2.0)0.68 (0.64–0.71)NRcNRcNRcNRc
 20–3918061 (25.9)9.32 (9.18-9.45)16586 (27.1)8.56 (8.43–8.69)73 (2.8)0.01 (0.01-0.01)33 (2.9)0.01 (0–0.01)
 40–5930504 (43.8)17.5 (17.3-1 7.69)27548 (45.0)15.8 (15.61-15.99)563 (22)0.08 (0.07-0.09)291 (25.2)0.04 (0.04–0.05)
 60–7917210 (24.7)20.06 (19.76-20.36)14233 (23.3)16.59 (16.32-16.87)1316 (51.4)0.17 (0.16-0.18)622 (53.8)0.08 (0.08–0.09)
 80+2476 (3.6)11.89 (11.43-12.36)1582 (2.6)7.6 (7.23–7.97)607 (23.7)0.08 (0.07-0.09)209 (18.1)0.03 (0.02–0.03)
Thyroid Cancer Characteristics At Diagnosis
Histological subtype
 Papillary61203 (87.8)8.86 (8.79-8.94)1157 (45.2)0.16 (0.15-0.16)
 Follicular5044 (7.2)0.72 (0.7-0.74)282 (11.0)0.04 (0.03-0.04)
 Medullary1250 (1.8)0.18 (0.17-0.19)172 (6.7)0.02 (0.02-0.03)
 Anaplastic705 (1.0)0.09 (0.09-0.1)554 (21.6)0.07 (0.07-0.08)
 Other  d1482 (2.1)0.2 (0.19-0.22)397 (15.5)0.05 (0.05-0.06)
Papillary Thyroid Cancer, SEER Historic Stage A
 Localized43478 (62.4)6.26 (6.21-6.32)38219 (62.4)5.51 (5.46–5.57)243 (9.5)0.03 (0.03-0.04)128 (11.1)0.02 (0.01–0.02)
 Regional20940 (30.0)3.06 (3.02-3.1)19677 (32.2)2.89 (2.84–2.93)683 (26.7)0.09 (0.08-0.1)432 (37.3)0.05 (0.05–0.06)
 Distant3671 (5.3)0.51 (0.49-0.52)2220 (3.6)0.31 (0.3–0.32)1443 (56.3)0.19 (0.18-0.2)545 (47.1)0.07 (0.07–0.08)
 Unknown  e1595 (2.3)0.23 (0.22-0.24)1087 (1.8)0.16 (0.15–0.17)193 (7.5)0.03 (0.02-0.03)52 (4.5)0.01 (0.01-0.01)
Papillary Thyroid Cancer, Tumor size, cm
 ≤121530 (30.9)3.09 (3.05-3.13)20861 (34.1)2.99 (2.95–3.03)104 (4.1)0.01 (0.01-0.02)77 (6.7)0.01 (0.01-0.01)
 >1 to ≤218638 (26.7)2.71 (2.67-2.75)17429 (28.5)2.54 (2.5–2.57)180 (7.0)0.02 (0.02-0.03)137 (11.8)0.02 (0.02-0.02)
 >2 to ≤416630 (23.9)2.42 (2.39-2.46)14016 (22.9)2.05 (2.02–2.09)560 (21.9)0.07 (0.07-0.08)347 (30.0)0.05 (0.04–0.05)
 >47894 (11.3)1.13 (1.1-1.15)5281 (8.6)0.77 (0.74–0.79)1089 (42.5)0.15 (0.14-0.15)392 (33.9)0.05 (0.05–0.06)
 Unknown  e4992 (7.2)0.71 (0.69-0.73)3616 (5.9)0.52 (0.5–0.54)629 (24.6)0.08 (0.08-0.09)204 (17.6)0.03 (0.02–0.03)

Abbreviations: CI, confidence interval; NR, Not Represented; SEER, Surveillance, Epidemiology, and End Results.

aRates were calculated as number of cases or deaths per 100 000 person years and age adjusted to the 2000 California standard population.

bIncludes American Indian, Native or Pacific Islander, and two or more races

cNot Represented (not enough data for analysis)

dIncludes other specified and poorly differentiated thyroid cancer

eIncludes values which are missing from the data or unknown at time of diagnosis.

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