ROC Curve Analysis of Basal PAC and ARR as Predictors of Positive Confirmatory Tests for Primary Aldosteronism
| . | Captopril Challenge Test . | Saline Infusion Test . | ||
|---|---|---|---|---|
| . | Plasma aldosterone (ng/dL) . | ARR (PAC/PRA) . | Plasma aldosterone (ng/dL) . | ARR (PAC/PRA) . |
| Area under the curve (95% CI) | 0.554 (0.524–0.584) | 0.785 (0.762–0.809) | 0.764 (0.732–0.795) | 0.626 (0.590–0.662) |
| Optimal cutoff value | 27.95 | 44.42 | 18.25 | 77.15 |
| Sensitivity, % | 26.0 | 68.9 | 57.7 | 39.1 |
| Specificity, % | 87.2 | 75.0 | 79.7 | 82.3 |
| Positive predictive value, % | 91.9 | 93.9 | 92.1 | 90.1 |
| Negative predictive value, % | 17.5 | 30.3 | 31.3 | 24.7 |
| Cutoff value with 100% specificity | 86.25 | 564.00 | 33.55 | 308.50 |
| Sensitivity of the cutoff value with 100% specificity, % (n) | 1.6 (31) | 1.8 (35) | 18.8 (179) | 7.2 (69) |
| . | Captopril Challenge Test . | Saline Infusion Test . | ||
|---|---|---|---|---|
| . | Plasma aldosterone (ng/dL) . | ARR (PAC/PRA) . | Plasma aldosterone (ng/dL) . | ARR (PAC/PRA) . |
| Area under the curve (95% CI) | 0.554 (0.524–0.584) | 0.785 (0.762–0.809) | 0.764 (0.732–0.795) | 0.626 (0.590–0.662) |
| Optimal cutoff value | 27.95 | 44.42 | 18.25 | 77.15 |
| Sensitivity, % | 26.0 | 68.9 | 57.7 | 39.1 |
| Specificity, % | 87.2 | 75.0 | 79.7 | 82.3 |
| Positive predictive value, % | 91.9 | 93.9 | 92.1 | 90.1 |
| Negative predictive value, % | 17.5 | 30.3 | 31.3 | 24.7 |
| Cutoff value with 100% specificity | 86.25 | 564.00 | 33.55 | 308.50 |
| Sensitivity of the cutoff value with 100% specificity, % (n) | 1.6 (31) | 1.8 (35) | 18.8 (179) | 7.2 (69) |
Abbreviations: ARR, aldosterone-to-renin ratio; CI; confidence interval; PAC, plasma aldosterone concentration; PRA, plasma renin activity; ROC, receiver operating characteristic.
ROC Curve Analysis of Basal PAC and ARR as Predictors of Positive Confirmatory Tests for Primary Aldosteronism
| . | Captopril Challenge Test . | Saline Infusion Test . | ||
|---|---|---|---|---|
| . | Plasma aldosterone (ng/dL) . | ARR (PAC/PRA) . | Plasma aldosterone (ng/dL) . | ARR (PAC/PRA) . |
| Area under the curve (95% CI) | 0.554 (0.524–0.584) | 0.785 (0.762–0.809) | 0.764 (0.732–0.795) | 0.626 (0.590–0.662) |
| Optimal cutoff value | 27.95 | 44.42 | 18.25 | 77.15 |
| Sensitivity, % | 26.0 | 68.9 | 57.7 | 39.1 |
| Specificity, % | 87.2 | 75.0 | 79.7 | 82.3 |
| Positive predictive value, % | 91.9 | 93.9 | 92.1 | 90.1 |
| Negative predictive value, % | 17.5 | 30.3 | 31.3 | 24.7 |
| Cutoff value with 100% specificity | 86.25 | 564.00 | 33.55 | 308.50 |
| Sensitivity of the cutoff value with 100% specificity, % (n) | 1.6 (31) | 1.8 (35) | 18.8 (179) | 7.2 (69) |
| . | Captopril Challenge Test . | Saline Infusion Test . | ||
|---|---|---|---|---|
| . | Plasma aldosterone (ng/dL) . | ARR (PAC/PRA) . | Plasma aldosterone (ng/dL) . | ARR (PAC/PRA) . |
| Area under the curve (95% CI) | 0.554 (0.524–0.584) | 0.785 (0.762–0.809) | 0.764 (0.732–0.795) | 0.626 (0.590–0.662) |
| Optimal cutoff value | 27.95 | 44.42 | 18.25 | 77.15 |
| Sensitivity, % | 26.0 | 68.9 | 57.7 | 39.1 |
| Specificity, % | 87.2 | 75.0 | 79.7 | 82.3 |
| Positive predictive value, % | 91.9 | 93.9 | 92.1 | 90.1 |
| Negative predictive value, % | 17.5 | 30.3 | 31.3 | 24.7 |
| Cutoff value with 100% specificity | 86.25 | 564.00 | 33.55 | 308.50 |
| Sensitivity of the cutoff value with 100% specificity, % (n) | 1.6 (31) | 1.8 (35) | 18.8 (179) | 7.2 (69) |
Abbreviations: ARR, aldosterone-to-renin ratio; CI; confidence interval; PAC, plasma aldosterone concentration; PRA, plasma renin activity; ROC, receiver operating characteristic.
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