Table 2 Open in new tab Changes from...

	Baseline (n = 119)	2-year follow-up (n = 119)	P-value
Clinical measures
Tender joints count (0–28), median (IQR)	0 (0–0)	0 (0–0)	<0.001*
Swollen joints count (0–28), median (IQR)	0 (0–0)	0 (0–0)	0.005*
Patient global (0–100), median (IQR)	12 (4–25)	13 (5–26)	0.159
Patient pain (0–100), median (IQR)	11 (3–20)	11 (5–24)	0.001*
Physician global (0–100), median (IQR)	0 (0–4)	2 (0–6)	0.003*
CRP (mg/l), median (IQR)	5 (2–6)	4 (1–7)	0.540
HAQ (0–3), median (IQR)	0.2 (0.0–0.8)	0.4 (0.0–0.9)	0.285
DAS28-CRP, median (IQR)	1.8 (1.6–2.1)	1.9 (1.6–2.3)	0.011*
SDAI, median (IQR)	2.2 (1.2–3.5)	2.4 (1.3–5.0)	0.011*
CDAI, median (IQR)	1.7 (0.6–3.0)	2.0 (0.8–4.5)	0.008*
ACR/EULAR remission	37%	34%	0.735
Radiographic measures
TSS (0–448), median (IQR)	14 (4–45)	14 (3–47)	0.451
JSN (0–84), median (IQR)	9 (2–34)	9 (2–34)	0.513
X-ray erosion, median (IQR)	3 (0–12)	4 (0–13)	0.402
Presence of X-ray erosion	73%	71%	0.617
Ultrasound inflammatory measures
Grey-scale sum score hands-only (0–30), median (IQR)	2 (0–5)	2 (1–5)	0.229
Grey-scale sum score (0–72), median (IQR)	5 (2–9)	7 (3–10)	0.001*
Doppler sum score hands-only (0–30), median (IQR)	0 (0–1)	0 (0–1)	0.993
Doppler sum score (0–72), median (IQR)	0 (0–2)	0 (0–2)	0.628
GLOESS hands-only (0–30), median (IQR)	2 (0–5)	3 (1–5)	0.246
GLOESS (0–72), median (IQR)	5 (2–9)	7 (3–10)	0.001*
Ultrasound strict remission, %	8	4	0.267
Ultrasound semi-strict remission, %	14	8	0.383
Ultrasound Doppler remission, %	56	57	1

Baseline (n = 119)

2-year follow-up (n = 119)

P-value

Clinical measures

Tender joints count (0–28), median (IQR)

0 (0–0)

<0.001*

Swollen joints count (0–28), median (IQR)

0 (0–0)

0.005*

Patient global (0–100), median (IQR)

12 (4–25)

13 (5–26)

0.159

Patient pain (0–100), median (IQR)

11 (3–20)

11 (5–24)

0.001*

Physician global (0–100), median (IQR)

0 (0–4)

2 (0–6)

0.003*

CRP (mg/l), median (IQR)

5 (2–6)

4 (1–7)

0.540

HAQ (0–3), median (IQR)

0.2 (0.0–0.8)

0.4 (0.0–0.9)

0.285

DAS28-CRP, median (IQR)

1.8 (1.6–2.1)

1.9 (1.6–2.3)

0.011*

SDAI, median (IQR)

2.2 (1.2–3.5)

2.4 (1.3–5.0)

0.011*

CDAI, median (IQR)

1.7 (0.6–3.0)

2.0 (0.8–4.5)

0.008*

ACR/EULAR remission

37%

34%

0.735

Radiographic measures

TSS (0–448), median (IQR)

14 (4–45)

14 (3–47)

0.451

JSN (0–84), median (IQR)

9 (2–34)

0.513

X-ray erosion, median (IQR)

3 (0–12)

4 (0–13)

0.402

Presence of X-ray erosion

73%

71%

0.617

Ultrasound inflammatory measures

Grey-scale sum score hands-only (0–30), median (IQR)

2 (0–5)

2 (1–5)

0.229

Grey-scale sum score (0–72), median (IQR)

5 (2–9)

7 (3–10)

0.001*

Doppler sum score hands-only (0–30), median (IQR)

0 (0–1)

0.993

Doppler sum score (0–72), median (IQR)

0 (0–2)

0.628

GLOESS hands-only (0–30), median (IQR)

2 (0–5)

3 (1–5)

0.246

GLOESS (0–72), median (IQR)

5 (2–9)

7 (3–10)

0.001*

Ultrasound strict remission, %

0.267

Ultrasound semi-strict remission, %

0.383

Ultrasound Doppler remission, %

	Baseline (n = 119)	2-year follow-up (n = 119)	P-value
Clinical measures
Tender joints count (0–28), median (IQR)	0 (0–0)	0 (0–0)	<0.001*
Swollen joints count (0–28), median (IQR)	0 (0–0)	0 (0–0)	0.005*
Patient global (0–100), median (IQR)	12 (4–25)	13 (5–26)	0.159
Patient pain (0–100), median (IQR)	11 (3–20)	11 (5–24)	0.001*
Physician global (0–100), median (IQR)	0 (0–4)	2 (0–6)	0.003*
CRP (mg/l), median (IQR)	5 (2–6)	4 (1–7)	0.540
HAQ (0–3), median (IQR)	0.2 (0.0–0.8)	0.4 (0.0–0.9)	0.285
DAS28-CRP, median (IQR)	1.8 (1.6–2.1)	1.9 (1.6–2.3)	0.011*
SDAI, median (IQR)	2.2 (1.2–3.5)	2.4 (1.3–5.0)	0.011*
CDAI, median (IQR)	1.7 (0.6–3.0)	2.0 (0.8–4.5)	0.008*
ACR/EULAR remission	37%	34%	0.735
Radiographic measures
TSS (0–448), median (IQR)	14 (4–45)	14 (3–47)	0.451
JSN (0–84), median (IQR)	9 (2–34)	9 (2–34)	0.513
X-ray erosion, median (IQR)	3 (0–12)	4 (0–13)	0.402
Presence of X-ray erosion	73%	71%	0.617
Ultrasound inflammatory measures
Grey-scale sum score hands-only (0–30), median (IQR)	2 (0–5)	2 (1–5)	0.229
Grey-scale sum score (0–72), median (IQR)	5 (2–9)	7 (3–10)	0.001*
Doppler sum score hands-only (0–30), median (IQR)	0 (0–1)	0 (0–1)	0.993
Doppler sum score (0–72), median (IQR)	0 (0–2)	0 (0–2)	0.628
GLOESS hands-only (0–30), median (IQR)	2 (0–5)	3 (1–5)	0.246
GLOESS (0–72), median (IQR)	5 (2–9)	7 (3–10)	0.001*
Ultrasound strict remission, %	8	4	0.267
Ultrasound semi-strict remission, %	14	8	0.383
Ultrasound Doppler remission, %	56	57	1

Table 2

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Changes from baseline to 2-year follow-up

	Baseline (n = 119)	2-year follow-up (n = 119)	P-value
Clinical measures
Tender joints count (0–28), median (IQR)	0 (0–0)	0 (0–0)	<0.001*
Swollen joints count (0–28), median (IQR)	0 (0–0)	0 (0–0)	0.005*
Patient global (0–100), median (IQR)	12 (4–25)	13 (5–26)	0.159
Patient pain (0–100), median (IQR)	11 (3–20)	11 (5–24)	0.001*
Physician global (0–100), median (IQR)	0 (0–4)	2 (0–6)	0.003*
CRP (mg/l), median (IQR)	5 (2–6)	4 (1–7)	0.540
HAQ (0–3), median (IQR)	0.2 (0.0–0.8)	0.4 (0.0–0.9)	0.285
DAS28-CRP, median (IQR)	1.8 (1.6–2.1)	1.9 (1.6–2.3)	0.011*
SDAI, median (IQR)	2.2 (1.2–3.5)	2.4 (1.3–5.0)	0.011*
CDAI, median (IQR)	1.7 (0.6–3.0)	2.0 (0.8–4.5)	0.008*
ACR/EULAR remission	37%	34%	0.735
Radiographic measures
TSS (0–448), median (IQR)	14 (4–45)	14 (3–47)	0.451
JSN (0–84), median (IQR)	9 (2–34)	9 (2–34)	0.513
X-ray erosion, median (IQR)	3 (0–12)	4 (0–13)	0.402
Presence of X-ray erosion	73%	71%	0.617
Ultrasound inflammatory measures
Grey-scale sum score hands-only (0–30), median (IQR)	2 (0–5)	2 (1–5)	0.229
Grey-scale sum score (0–72), median (IQR)	5 (2–9)	7 (3–10)	0.001*
Doppler sum score hands-only (0–30), median (IQR)	0 (0–1)	0 (0–1)	0.993
Doppler sum score (0–72), median (IQR)	0 (0–2)	0 (0–2)	0.628
GLOESS hands-only (0–30), median (IQR)	2 (0–5)	3 (1–5)	0.246
GLOESS (0–72), median (IQR)	5 (2–9)	7 (3–10)	0.001*
Ultrasound strict remission, %	8	4	0.267
Ultrasound semi-strict remission, %	14	8	0.383
Ultrasound Doppler remission, %	56	57	1

	Baseline (n = 119)	2-year follow-up (n = 119)	P-value
Clinical measures
Tender joints count (0–28), median (IQR)	0 (0–0)	0 (0–0)	<0.001*
Swollen joints count (0–28), median (IQR)	0 (0–0)	0 (0–0)	0.005*
Patient global (0–100), median (IQR)	12 (4–25)	13 (5–26)	0.159
Patient pain (0–100), median (IQR)	11 (3–20)	11 (5–24)	0.001*
Physician global (0–100), median (IQR)	0 (0–4)	2 (0–6)	0.003*
CRP (mg/l), median (IQR)	5 (2–6)	4 (1–7)	0.540
HAQ (0–3), median (IQR)	0.2 (0.0–0.8)	0.4 (0.0–0.9)	0.285
DAS28-CRP, median (IQR)	1.8 (1.6–2.1)	1.9 (1.6–2.3)	0.011*
SDAI, median (IQR)	2.2 (1.2–3.5)	2.4 (1.3–5.0)	0.011*
CDAI, median (IQR)	1.7 (0.6–3.0)	2.0 (0.8–4.5)	0.008*
ACR/EULAR remission	37%	34%	0.735
Radiographic measures
TSS (0–448), median (IQR)	14 (4–45)	14 (3–47)	0.451
JSN (0–84), median (IQR)	9 (2–34)	9 (2–34)	0.513
X-ray erosion, median (IQR)	3 (0–12)	4 (0–13)	0.402
Presence of X-ray erosion	73%	71%	0.617
Ultrasound inflammatory measures
Grey-scale sum score hands-only (0–30), median (IQR)	2 (0–5)	2 (1–5)	0.229
Grey-scale sum score (0–72), median (IQR)	5 (2–9)	7 (3–10)	0.001*
Doppler sum score hands-only (0–30), median (IQR)	0 (0–1)	0 (0–1)	0.993
Doppler sum score (0–72), median (IQR)	0 (0–2)	0 (0–2)	0.628
GLOESS hands-only (0–30), median (IQR)	2 (0–5)	3 (1–5)	0.246
GLOESS (0–72), median (IQR)	5 (2–9)	7 (3–10)	0.001*
Ultrasound strict remission, %	8	4	0.267
Ultrasound semi-strict remission, %	14	8	0.383
Ultrasound Doppler remission, %	56	57	1

P-values for differences between visits from modified Wilcoxon signed-rank test (Pratt method to handle ties) for numeric variables and McNemar’s test for binary variables; *P < 0.05.

CDAI: Clinical Disease Activity Index; GLOESS: Global OMERACT/EULAR ultrasound Synovitis Score; IQR: Interquartile Range; JSN: Joint Space Narrowing; SDAI: Simple Disease Activity Index; TSS: Total Sharp van der Heijde Score. Ultrasound strict remission: Grey-scale sum score equal to 0 and Doppler sum score equal to 0. Ultrasound semi-strict remission: Grey-scale sum score less than or equal to 1 and Doppler sum score equal to 0. Ultrasound Doppler remission: Doppler sum score equal to 0.

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