Table 2. Open in new tab Multiple...

Model 1 (P < 0.001*)	Dependent: PRC
MC total daily dose	0.001	–0.001	0.002	0.515
K ⁺	0.044	–0.201	0.289	0.723
Na ⁺	–0.091	–0.126	–0.055	<0.001*
MAP	0.005	–0.006	0.016	0.351
Age	–0.006	–0.013	0.001	0.072
BMI	0.004	–0.012	0.020	0.591
*Model 2 (P = 0.017)**	Dependent: MC total daily dose
*Independent*	B	*95% CI lower bound*	*95% CI upper bound*	P
K ⁺	–17.523	–43.350	8.303	0.182
Na ⁺	1.026	–3.072	5.123	0.621
PRC	5.846	–11.873	23.565	0.515
MAP	0.566	–0.593	1.726	0.336
Age	0.030	–0.722	0.781	0.938
BMI	2.812	1.183	4.441	0.001*

Model 1 (P < 0.001*)	Dependent: PRC
MC total daily dose	0.001	–0.001	0.002	0.515
K ⁺	0.044	–0.201	0.289	0.723
Na ⁺	–0.091	–0.126	–0.055	<0.001*
MAP	0.005	–0.006	0.016	0.351
Age	–0.006	–0.013	0.001	0.072
BMI	0.004	–0.012	0.020	0.591
*Model 2 (P = 0.017)**	Dependent: MC total daily dose
*Independent*	B	*95% CI lower bound*	*95% CI upper bound*	P
K ⁺	–17.523	–43.350	8.303	0.182
Na ⁺	1.026	–3.072	5.123	0.621
PRC	5.846	–11.873	23.565	0.515
MAP	0.566	–0.593	1.726	0.336
Age	0.030	–0.722	0.781	0.938
BMI	2.812	1.183	4.441	0.001*

Table 2.

Multiple Regression Modeling in Adult Patients With Adrenal Insufficiency (147 complete clinical assessments from 117 patients)

Model 1 (P < 0.001*)	Dependent: PRC
Independent	B	95% CI lower bound	95% CI upper bound	P
MC total daily dose	0.001	–0.001	0.002	0.515
K ⁺	0.044	–0.201	0.289	0.723
Na ⁺	–0.091	–0.126	–0.055	<0.001*
MAP	0.005	–0.006	0.016	0.351
Age	–0.006	–0.013	0.001	0.072
BMI	0.004	–0.012	0.020	0.591
*Model 2 (P = 0.017)**	Dependent: MC total daily dose
*Independent*	B	*95% CI lower bound*	*95% CI upper bound*	P
K ⁺	–17.523	–43.350	8.303	0.182
Na ⁺	1.026	–3.072	5.123	0.621
PRC	5.846	–11.873	23.565	0.515
MAP	0.566	–0.593	1.726	0.336
Age	0.030	–0.722	0.781	0.938
BMI	2.812	1.183	4.441	0.001*

Model 1 (P < 0.001*)	Dependent: PRC
Independent	B	95% CI lower bound	95% CI upper bound	P
MC total daily dose	0.001	–0.001	0.002	0.515
K ⁺	0.044	–0.201	0.289	0.723
Na ⁺	–0.091	–0.126	–0.055	<0.001*
MAP	0.005	–0.006	0.016	0.351
Age	–0.006	–0.013	0.001	0.072
BMI	0.004	–0.012	0.020	0.591
*Model 2 (P = 0.017)**	Dependent: MC total daily dose
*Independent*	B	*95% CI lower bound*	*95% CI upper bound*	P
K ⁺	–17.523	–43.350	8.303	0.182
Na ⁺	1.026	–3.072	5.123	0.621
PRC	5.846	–11.873	23.565	0.515
MAP	0.566	–0.593	1.726	0.336
Age	0.030	–0.722	0.781	0.938
BMI	2.812	1.183	4.441	0.001*

The dependent variables assessed were plasma renin concentration, sodium, potassium, mineralocorticoid dose, and mean arterial pressure. P values should be interpreted with Bonferroni correction; when significant, they are highlighted in bold and marked with an asterisk. Abbreviations: BMI, body mass index; K+, serum potassium; MAP, mean arterial blood pressure; Na+, serum sodium; PRC, plasma renin concentration.

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