| . | Subclinical Hypothyroidism . | Euthyroidism . | Subclinical Hyperthyroidism . | P-value . |
|---|---|---|---|---|
| Participants, n (%) | 226 (6.8) | 3039 (92) | 39 (1.2) | |
| Women (%) | 57.1 | 51.4 | 64.1 | <0.001 |
| Age (years) | 52.7 ± 9.1 | 50.2 ± 8.6 | 52.9 ± 9.3 | <0.001 |
| Race (%) | <0.001 | |||
| White | 60.0 | 50.8 | 39.2 | |
| Brown | 26.3 | 29.1 | 29.0 | |
| Black | 9.7 | 16.6 | 27.3 | |
| Other | 4.0 | 3.5 | 4.5 | |
| Educational level | <0.001 | |||
| Less than high school | 14.4 | 12 | 15 | |
| High School | 33.5 | 34.7 | 36.1 | |
| College or higher | 52.1 | 53.3 | 48.9 | |
| Diabetes (%) | 18.1 | 16.7 | 23.1 | 0.819 |
| Hypertension (%) | 29.2 | 25.5 | 33.3 | 0.262 |
| Alcohol use (%) | 0.401 | |||
| Never | 13.7 | 11.85 | 15.4 | |
| Former | 18.6 | 19.3 | 33.3 | |
| Current | 67.7 | 68.9 | 51.3 | |
| Smoking (%) | <0.001 | |||
| Never | 57 | 58 | 48.9 | |
| Former | 34.5 | 28.4 | 31.7 | |
| Current | 8.5 | 13.6 | 19.4 | |
| BMI (kg/m2) | 27.6 ± 5.5 | 27.0 ± 4.8 | 26.9 ± 5.0 | 0.082 |
| Waist circumference (cm) | 89.6 ± 12.9 | 89.3 ± 12.4 | 88.4 ± 12.5 | 0.940 |
| SBP (mmHg) | 121.6 ± 17.9 | 119.0 ± 16.1 | 119.5 ± 17.8 | 0.032 |
| DBP (mmHg) | 75.6 ± 11.2 | 75.0 ± 10.8 | 72.9 ± 8.9 | 0.053 |
| Total cholesterol (mg/dL) | 219.6 ± 40.8 | 215.1 ± 41.8 | 208.3 ± 36.6 | 0.086 |
| HDL-c (mg/dL) | 57.5 ± 14.6 | 56.3 ± 14.7 | 56.7 ± 11.1 | 0.016 |
| LDL-c (mg/dL) | 133.7 ± 33.2 | 132.5 ± 34 | 129.6 ± 30 | 0.363 |
| Triglycerides (mg/dL) | 146.1 ± 100.4 | 133.3 ± 94.8 | 110.1 ± 58.8 | 0.035 |
| Fasting Plasma glucose (mg/dL) | 112.8 ± 36.2 | 109.6 ± 27.2 | 114.9 ± 30.5 | 0.085 |
| HbA1c (%) | 5.4 ± 1.1 | 5.4 ± 0.9 | 5.7 ± 0.9 | 0.120 |
| TSH (mUI/L) | 5.91 ± 2.90 | 1.72 ± 0.83 | 0.23 ± 0.13 | 0.005 |
| FT4 (ng/dL)a | 1.09 ± 0.17 | 1.11 ± 0.17 | 1.32 ± 0.27 | <0.001 |
| Total TRLP (nmol/L) | 158.41 ± 75.85 | 149.17 ± 74.03 | 120.49 ± 71.80 | 0.005 |
| Very small TRLP (nmol/L) | 87.18 ± 69.28 | 77.76 ± 62.29 | 56.43 ± 62.65 | 0.009 |
| Small TRLP (nmol/L) | 44.73 ± 33.11 | 46.56 ± 36.52 | 45.94 ± 30.20 | 0.868 |
| Medium TRLP (nmol/L) | 21.65 ± 19.03 | 20.59 ± 17.64 | 14.94 ± 14.05 | 0.244 |
| Large TRLP (nmol/L) | 4.57 ± 6.68 | 4.02 ± 6.09 | 2.97 ± 4.08 | 0.118 |
| Very Large TRLP (nmol/L) | 0.29 ± 0.94 | 0.24 ± 1,25 | 0.18 ± 0.29 | 0.055 |
| TRLP mean size (nm) | 47.20 ± 9.87 | 46.33 ± 9.10 | 46.30 ± 10.08 | 0.440 |
| . | Subclinical Hypothyroidism . | Euthyroidism . | Subclinical Hyperthyroidism . | P-value . |
|---|---|---|---|---|
| Participants, n (%) | 226 (6.8) | 3039 (92) | 39 (1.2) | |
| Women (%) | 57.1 | 51.4 | 64.1 | <0.001 |
| Age (years) | 52.7 ± 9.1 | 50.2 ± 8.6 | 52.9 ± 9.3 | <0.001 |
| Race (%) | <0.001 | |||
| White | 60.0 | 50.8 | 39.2 | |
| Brown | 26.3 | 29.1 | 29.0 | |
| Black | 9.7 | 16.6 | 27.3 | |
| Other | 4.0 | 3.5 | 4.5 | |
| Educational level | <0.001 | |||
| Less than high school | 14.4 | 12 | 15 | |
| High School | 33.5 | 34.7 | 36.1 | |
| College or higher | 52.1 | 53.3 | 48.9 | |
| Diabetes (%) | 18.1 | 16.7 | 23.1 | 0.819 |
| Hypertension (%) | 29.2 | 25.5 | 33.3 | 0.262 |
| Alcohol use (%) | 0.401 | |||
| Never | 13.7 | 11.85 | 15.4 | |
| Former | 18.6 | 19.3 | 33.3 | |
| Current | 67.7 | 68.9 | 51.3 | |
| Smoking (%) | <0.001 | |||
| Never | 57 | 58 | 48.9 | |
| Former | 34.5 | 28.4 | 31.7 | |
| Current | 8.5 | 13.6 | 19.4 | |
| BMI (kg/m2) | 27.6 ± 5.5 | 27.0 ± 4.8 | 26.9 ± 5.0 | 0.082 |
| Waist circumference (cm) | 89.6 ± 12.9 | 89.3 ± 12.4 | 88.4 ± 12.5 | 0.940 |
| SBP (mmHg) | 121.6 ± 17.9 | 119.0 ± 16.1 | 119.5 ± 17.8 | 0.032 |
| DBP (mmHg) | 75.6 ± 11.2 | 75.0 ± 10.8 | 72.9 ± 8.9 | 0.053 |
| Total cholesterol (mg/dL) | 219.6 ± 40.8 | 215.1 ± 41.8 | 208.3 ± 36.6 | 0.086 |
| HDL-c (mg/dL) | 57.5 ± 14.6 | 56.3 ± 14.7 | 56.7 ± 11.1 | 0.016 |
| LDL-c (mg/dL) | 133.7 ± 33.2 | 132.5 ± 34 | 129.6 ± 30 | 0.363 |
| Triglycerides (mg/dL) | 146.1 ± 100.4 | 133.3 ± 94.8 | 110.1 ± 58.8 | 0.035 |
| Fasting Plasma glucose (mg/dL) | 112.8 ± 36.2 | 109.6 ± 27.2 | 114.9 ± 30.5 | 0.085 |
| HbA1c (%) | 5.4 ± 1.1 | 5.4 ± 0.9 | 5.7 ± 0.9 | 0.120 |
| TSH (mUI/L) | 5.91 ± 2.90 | 1.72 ± 0.83 | 0.23 ± 0.13 | 0.005 |
| FT4 (ng/dL)a | 1.09 ± 0.17 | 1.11 ± 0.17 | 1.32 ± 0.27 | <0.001 |
| Total TRLP (nmol/L) | 158.41 ± 75.85 | 149.17 ± 74.03 | 120.49 ± 71.80 | 0.005 |
| Very small TRLP (nmol/L) | 87.18 ± 69.28 | 77.76 ± 62.29 | 56.43 ± 62.65 | 0.009 |
| Small TRLP (nmol/L) | 44.73 ± 33.11 | 46.56 ± 36.52 | 45.94 ± 30.20 | 0.868 |
| Medium TRLP (nmol/L) | 21.65 ± 19.03 | 20.59 ± 17.64 | 14.94 ± 14.05 | 0.244 |
| Large TRLP (nmol/L) | 4.57 ± 6.68 | 4.02 ± 6.09 | 2.97 ± 4.08 | 0.118 |
| Very Large TRLP (nmol/L) | 0.29 ± 0.94 | 0.24 ± 1,25 | 0.18 ± 0.29 | 0.055 |
| TRLP mean size (nm) | 47.20 ± 9.87 | 46.33 ± 9.10 | 46.30 ± 10.08 | 0.440 |
Abbreviations: BMI, body mass index; DBP, diastolic blood pressure; FT4, free thyroxine; SBP, systolic blood pressure; TRLP, triglyceride-rich lipoprotein; TSH, thyroid-stimulating hormone; HbA1c, Glycated hemoglobin; LDL-c, low-density lipoprotein cholesterol; HDL-c, high-density lipoprotein cholesterol.
aFT4 (Free Thyroxine) was measured only when TSH levels were out of the reference range.
| . | Subclinical Hypothyroidism . | Euthyroidism . | Subclinical Hyperthyroidism . | P-value . |
|---|---|---|---|---|
| Participants, n (%) | 226 (6.8) | 3039 (92) | 39 (1.2) | |
| Women (%) | 57.1 | 51.4 | 64.1 | <0.001 |
| Age (years) | 52.7 ± 9.1 | 50.2 ± 8.6 | 52.9 ± 9.3 | <0.001 |
| Race (%) | <0.001 | |||
| White | 60.0 | 50.8 | 39.2 | |
| Brown | 26.3 | 29.1 | 29.0 | |
| Black | 9.7 | 16.6 | 27.3 | |
| Other | 4.0 | 3.5 | 4.5 | |
| Educational level | <0.001 | |||
| Less than high school | 14.4 | 12 | 15 | |
| High School | 33.5 | 34.7 | 36.1 | |
| College or higher | 52.1 | 53.3 | 48.9 | |
| Diabetes (%) | 18.1 | 16.7 | 23.1 | 0.819 |
| Hypertension (%) | 29.2 | 25.5 | 33.3 | 0.262 |
| Alcohol use (%) | 0.401 | |||
| Never | 13.7 | 11.85 | 15.4 | |
| Former | 18.6 | 19.3 | 33.3 | |
| Current | 67.7 | 68.9 | 51.3 | |
| Smoking (%) | <0.001 | |||
| Never | 57 | 58 | 48.9 | |
| Former | 34.5 | 28.4 | 31.7 | |
| Current | 8.5 | 13.6 | 19.4 | |
| BMI (kg/m2) | 27.6 ± 5.5 | 27.0 ± 4.8 | 26.9 ± 5.0 | 0.082 |
| Waist circumference (cm) | 89.6 ± 12.9 | 89.3 ± 12.4 | 88.4 ± 12.5 | 0.940 |
| SBP (mmHg) | 121.6 ± 17.9 | 119.0 ± 16.1 | 119.5 ± 17.8 | 0.032 |
| DBP (mmHg) | 75.6 ± 11.2 | 75.0 ± 10.8 | 72.9 ± 8.9 | 0.053 |
| Total cholesterol (mg/dL) | 219.6 ± 40.8 | 215.1 ± 41.8 | 208.3 ± 36.6 | 0.086 |
| HDL-c (mg/dL) | 57.5 ± 14.6 | 56.3 ± 14.7 | 56.7 ± 11.1 | 0.016 |
| LDL-c (mg/dL) | 133.7 ± 33.2 | 132.5 ± 34 | 129.6 ± 30 | 0.363 |
| Triglycerides (mg/dL) | 146.1 ± 100.4 | 133.3 ± 94.8 | 110.1 ± 58.8 | 0.035 |
| Fasting Plasma glucose (mg/dL) | 112.8 ± 36.2 | 109.6 ± 27.2 | 114.9 ± 30.5 | 0.085 |
| HbA1c (%) | 5.4 ± 1.1 | 5.4 ± 0.9 | 5.7 ± 0.9 | 0.120 |
| TSH (mUI/L) | 5.91 ± 2.90 | 1.72 ± 0.83 | 0.23 ± 0.13 | 0.005 |
| FT4 (ng/dL)a | 1.09 ± 0.17 | 1.11 ± 0.17 | 1.32 ± 0.27 | <0.001 |
| Total TRLP (nmol/L) | 158.41 ± 75.85 | 149.17 ± 74.03 | 120.49 ± 71.80 | 0.005 |
| Very small TRLP (nmol/L) | 87.18 ± 69.28 | 77.76 ± 62.29 | 56.43 ± 62.65 | 0.009 |
| Small TRLP (nmol/L) | 44.73 ± 33.11 | 46.56 ± 36.52 | 45.94 ± 30.20 | 0.868 |
| Medium TRLP (nmol/L) | 21.65 ± 19.03 | 20.59 ± 17.64 | 14.94 ± 14.05 | 0.244 |
| Large TRLP (nmol/L) | 4.57 ± 6.68 | 4.02 ± 6.09 | 2.97 ± 4.08 | 0.118 |
| Very Large TRLP (nmol/L) | 0.29 ± 0.94 | 0.24 ± 1,25 | 0.18 ± 0.29 | 0.055 |
| TRLP mean size (nm) | 47.20 ± 9.87 | 46.33 ± 9.10 | 46.30 ± 10.08 | 0.440 |
| . | Subclinical Hypothyroidism . | Euthyroidism . | Subclinical Hyperthyroidism . | P-value . |
|---|---|---|---|---|
| Participants, n (%) | 226 (6.8) | 3039 (92) | 39 (1.2) | |
| Women (%) | 57.1 | 51.4 | 64.1 | <0.001 |
| Age (years) | 52.7 ± 9.1 | 50.2 ± 8.6 | 52.9 ± 9.3 | <0.001 |
| Race (%) | <0.001 | |||
| White | 60.0 | 50.8 | 39.2 | |
| Brown | 26.3 | 29.1 | 29.0 | |
| Black | 9.7 | 16.6 | 27.3 | |
| Other | 4.0 | 3.5 | 4.5 | |
| Educational level | <0.001 | |||
| Less than high school | 14.4 | 12 | 15 | |
| High School | 33.5 | 34.7 | 36.1 | |
| College or higher | 52.1 | 53.3 | 48.9 | |
| Diabetes (%) | 18.1 | 16.7 | 23.1 | 0.819 |
| Hypertension (%) | 29.2 | 25.5 | 33.3 | 0.262 |
| Alcohol use (%) | 0.401 | |||
| Never | 13.7 | 11.85 | 15.4 | |
| Former | 18.6 | 19.3 | 33.3 | |
| Current | 67.7 | 68.9 | 51.3 | |
| Smoking (%) | <0.001 | |||
| Never | 57 | 58 | 48.9 | |
| Former | 34.5 | 28.4 | 31.7 | |
| Current | 8.5 | 13.6 | 19.4 | |
| BMI (kg/m2) | 27.6 ± 5.5 | 27.0 ± 4.8 | 26.9 ± 5.0 | 0.082 |
| Waist circumference (cm) | 89.6 ± 12.9 | 89.3 ± 12.4 | 88.4 ± 12.5 | 0.940 |
| SBP (mmHg) | 121.6 ± 17.9 | 119.0 ± 16.1 | 119.5 ± 17.8 | 0.032 |
| DBP (mmHg) | 75.6 ± 11.2 | 75.0 ± 10.8 | 72.9 ± 8.9 | 0.053 |
| Total cholesterol (mg/dL) | 219.6 ± 40.8 | 215.1 ± 41.8 | 208.3 ± 36.6 | 0.086 |
| HDL-c (mg/dL) | 57.5 ± 14.6 | 56.3 ± 14.7 | 56.7 ± 11.1 | 0.016 |
| LDL-c (mg/dL) | 133.7 ± 33.2 | 132.5 ± 34 | 129.6 ± 30 | 0.363 |
| Triglycerides (mg/dL) | 146.1 ± 100.4 | 133.3 ± 94.8 | 110.1 ± 58.8 | 0.035 |
| Fasting Plasma glucose (mg/dL) | 112.8 ± 36.2 | 109.6 ± 27.2 | 114.9 ± 30.5 | 0.085 |
| HbA1c (%) | 5.4 ± 1.1 | 5.4 ± 0.9 | 5.7 ± 0.9 | 0.120 |
| TSH (mUI/L) | 5.91 ± 2.90 | 1.72 ± 0.83 | 0.23 ± 0.13 | 0.005 |
| FT4 (ng/dL)a | 1.09 ± 0.17 | 1.11 ± 0.17 | 1.32 ± 0.27 | <0.001 |
| Total TRLP (nmol/L) | 158.41 ± 75.85 | 149.17 ± 74.03 | 120.49 ± 71.80 | 0.005 |
| Very small TRLP (nmol/L) | 87.18 ± 69.28 | 77.76 ± 62.29 | 56.43 ± 62.65 | 0.009 |
| Small TRLP (nmol/L) | 44.73 ± 33.11 | 46.56 ± 36.52 | 45.94 ± 30.20 | 0.868 |
| Medium TRLP (nmol/L) | 21.65 ± 19.03 | 20.59 ± 17.64 | 14.94 ± 14.05 | 0.244 |
| Large TRLP (nmol/L) | 4.57 ± 6.68 | 4.02 ± 6.09 | 2.97 ± 4.08 | 0.118 |
| Very Large TRLP (nmol/L) | 0.29 ± 0.94 | 0.24 ± 1,25 | 0.18 ± 0.29 | 0.055 |
| TRLP mean size (nm) | 47.20 ± 9.87 | 46.33 ± 9.10 | 46.30 ± 10.08 | 0.440 |
Abbreviations: BMI, body mass index; DBP, diastolic blood pressure; FT4, free thyroxine; SBP, systolic blood pressure; TRLP, triglyceride-rich lipoprotein; TSH, thyroid-stimulating hormone; HbA1c, Glycated hemoglobin; LDL-c, low-density lipoprotein cholesterol; HDL-c, high-density lipoprotein cholesterol.
aFT4 (Free Thyroxine) was measured only when TSH levels were out of the reference range.
This PDF is available to Subscribers Only
View Article Abstract & Purchase OptionsFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.
